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The map label for this gene is serS [H]

Identifier: 116515129

GI number: 116515129

Start: 226809

End: 228110

Strand: Reverse

Name: serS [H]

Synonym: BCc_193

Alternate gene names: 116515129

Gene position: 228110-226809 (Counterclockwise)

Preceding gene: 116515134

Following gene: 116515128

Centisome position: 54.78

GC content: 20.97

Gene sequence:

>1302_bases
ATGTTAAATTTCAAAGATATTAAAAATAACTATTCTTTTTTTAAAAAAAAACTAGAAAAAAAAAATTATTTCTTAAATAT
AAAAAAATTTAAAAAATTAGATTATATACGTAAAAATTTACAAATTAATACTGAGATCAAAATTTCAGAACATAAAAAAT
TATCTAAATATATGATTTTTTATAAAAAAATCTATACTAATACATATTTATTGAAAAATAAATTAATTAATTCTAGAAAT
AAAATATTTTTATTAAAAAAAAAATTAGAAAAAATAAAAAAAAAAATACACAATATGTTAATATTAATTCCTAATATACC
ATATGATGATGTACCTTTAGGTAATAAAGAAAAAAACAATAAAGAAATTTTTCGATGGGGAAAAATAAAAAAATATAATT
TTCCTATTCTGAATCATATAGAAATTGGAAATAAATTACAAGGATTTGATTGGAAAGTTTCATCAAACATTTCTGGGTCA
GGATTTTCTATAATGAAAGGTTCAATTGCATATTTACATCGTGCATTAGGTCAATTTATGTTAAATATTCATACTAAAAT
TCATGGATATAAAGAAATTTATGTACCTTTTATTGTAAAAAAAAAATGTATGTATGGAACAGGACAATTACCAAAATTTA
AAAACGATCTATTTCATATACAAAATATGCATCATTTAAATAAAAAAAACAATTATGATAATTTTTTTTTAATACCAACT
TCAGAAGTATCTTTAATTAATTTAGTACAAAATAAAATATTATTATCTCATGAATTACCCTTAAAGTTTACAGCATTAAG
TGCCTGTTTTAGAGCAGAACCTAATACTTATGGTAAAGATGCACAAGGTCTAATTCGAAATCATCAATTTGATAAAGTAG
AAATTGTTCAAATTGTTCATCCTAAAGATTCTGAAAAAACTTTAGAAGAATTAACTAATCATGCTGAAAAAATTTTACAG
CTATTAAAATTACCTTATAGAAAAATGTTATTATGTGAAGGAGAACTTGGTTTTTCATCTAAAAAAACATATGATTTAGA
AGTATGGTTACCATCGCAAAAATTATATAGAGAAATATCATCATGTTCCATGATTGGAGATTTTCAATCTAGAAGGATAA
ATGCTAAATATAAAGATAAGAAAAAAAATAAAAATTTTTTTTTACATACATTAAATGGTTCTGGATTAGCAGTAGGAAGA
ACATTAGCAGCTATTTTAGAAAATTTTCAGTGTTCTAATGGAACAGTTAAAATACCCAAAGTATTACGAAATCCATATAT
GAATGGAATGAAATTTTTATAA

Upstream 100 bases:

>100_bases
TTTTATTTATAAAATAAATTAAAAAAATCTTTAATATTATAATATTTATTTATTAAATATTAATATTCTAAAAATTTATA
TACTCAAAAATTAAAAAATT

Downstream 100 bases:

>100_bases
TAATATTTATAAATATTTTTTTAAAAAATAATATTATTTATATGATGAATTATTAATCATATTTAATATATAAATATTAA
TATTGGTAATTAATATGTCA

Product: hypothetical protein

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLNFKDIKNNYSFFKKKLEKKNYFLNIKKFKKLDYIRKNLQINTEIKISEHKKLSKYMIFYKKIYTNTYLLKNKLINSRN
KIFLLKKKLEKIKKKIHNMLILIPNIPYDDVPLGNKEKNNKEIFRWGKIKKYNFPILNHIEIGNKLQGFDWKVSSNISGS
GFSIMKGSIAYLHRALGQFMLNIHTKIHGYKEIYVPFIVKKKCMYGTGQLPKFKNDLFHIQNMHHLNKKNNYDNFFLIPT
SEVSLINLVQNKILLSHELPLKFTALSACFRAEPNTYGKDAQGLIRNHQFDKVEIVQIVHPKDSEKTLEELTNHAEKILQ
LLKLPYRKMLLCEGELGFSSKKTYDLEVWLPSQKLYREISSCSMIGDFQSRRINAKYKDKKKNKNFFLHTLNGSGLAVGR
TLAAILENFQCSNGTVKIPKVLRNPYMNGMKFL

Sequences:

>Translated_433_residues
MLNFKDIKNNYSFFKKKLEKKNYFLNIKKFKKLDYIRKNLQINTEIKISEHKKLSKYMIFYKKIYTNTYLLKNKLINSRN
KIFLLKKKLEKIKKKIHNMLILIPNIPYDDVPLGNKEKNNKEIFRWGKIKKYNFPILNHIEIGNKLQGFDWKVSSNISGS
GFSIMKGSIAYLHRALGQFMLNIHTKIHGYKEIYVPFIVKKKCMYGTGQLPKFKNDLFHIQNMHHLNKKNNYDNFFLIPT
SEVSLINLVQNKILLSHELPLKFTALSACFRAEPNTYGKDAQGLIRNHQFDKVEIVQIVHPKDSEKTLEELTNHAEKILQ
LLKLPYRKMLLCEGELGFSSKKTYDLEVWLPSQKLYREISSCSMIGDFQSRRINAKYKDKKKNKNFFLHTLNGSGLAVGR
TLAAILENFQCSNGTVKIPKVLRNPYMNGMKFL
>Mature_433_residues
MLNFKDIKNNYSFFKKKLEKKNYFLNIKKFKKLDYIRKNLQINTEIKISEHKKLSKYMIFYKKIYTNTYLLKNKLINSRN
KIFLLKKKLEKIKKKIHNMLILIPNIPYDDVPLGNKEKNNKEIFRWGKIKKYNFPILNHIEIGNKLQGFDWKVSSNISGS
GFSIMKGSIAYLHRALGQFMLNIHTKIHGYKEIYVPFIVKKKCMYGTGQLPKFKNDLFHIQNMHHLNKKNNYDNFFLIPT
SEVSLINLVQNKILLSHELPLKFTALSACFRAEPNTYGKDAQGLIRNHQFDKVEIVQIVHPKDSEKTLEELTNHAEKILQ
LLKLPYRKMLLCEGELGFSSKKTYDLEVWLPSQKLYREISSCSMIGDFQSRRINAKYKDKKKNKNFFLHTLNGSGLAVGR
TLAAILENFQCSNGTVKIPKVLRNPYMNGMKFL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=361, Percent_Identity=33.5180055401662, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI8923421, Length=349, Percent_Identity=28.3667621776504, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI225579074, Length=337, Percent_Identity=28.7833827893175, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1787120, Length=433, Percent_Identity=45.9584295612009, Blast_Score=437, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17539260, Length=336, Percent_Identity=32.7380952380952, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=344, Percent_Identity=28.7790697674419, Blast_Score=144, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6321799, Length=413, Percent_Identity=30.5084745762712, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320226, Length=359, Percent_Identity=31.1977715877437, Blast_Score=163, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24581334, Length=343, Percent_Identity=29.7376093294461, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI17737985, Length=359, Percent_Identity=29.5264623955432, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 50877; Mature: 50877

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNFKDIKNNYSFFKKKLEKKNYFLNIKKFKKLDYIRKNLQINTEIKISEHKKLSKYMIF
CCCHHHHHCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCEECEEEEEHHHHHHHHHHHH
YKKIYTNTYLLKNKLINSRNKIFLLKKKLEKIKKKIHNMLILIPNIPYDDVPLGNKEKNN
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCC
KEIFRWGKIKKYNFPILNHIEIGNKLQGFDWKVSSNISGSGFSIMKGSIAYLHRALGQFM
CHHEEECCEEEECCCCEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
LNIHTKIHGYKEIYVPFIVKKKCMYGTGQLPKFKNDLFHIQNMHHLNKKNNYDNFFLIPT
HHHHHHHCCCHHEEEEHEEHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEC
SEVSLINLVQNKILLSHELPLKFTALSACFRAEPNTYGKDAQGLIRNHQFDKVEIVQIVH
CCHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEEEEC
PKDSEKTLEELTNHAEKILQLLKLPYRKMLLCEGELGFSSKKTYDLEVWLPSQKLYREIS
CCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCEEEEEEEECCHHHHHHHH
SCSMIGDFQSRRINAKYKDKKKNKNFFLHTLNGSGLAVGRTLAAILENFQCSNGTVKIPK
HHHHHCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEECHH
VLRNPYMNGMKFL
HHCCCCCCCCCCC
>Mature Secondary Structure
MLNFKDIKNNYSFFKKKLEKKNYFLNIKKFKKLDYIRKNLQINTEIKISEHKKLSKYMIF
CCCHHHHHCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCEECEEEEEHHHHHHHHHHHH
YKKIYTNTYLLKNKLINSRNKIFLLKKKLEKIKKKIHNMLILIPNIPYDDVPLGNKEKNN
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCC
KEIFRWGKIKKYNFPILNHIEIGNKLQGFDWKVSSNISGSGFSIMKGSIAYLHRALGQFM
CHHEEECCEEEECCCCEEEEECCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
LNIHTKIHGYKEIYVPFIVKKKCMYGTGQLPKFKNDLFHIQNMHHLNKKNNYDNFFLIPT
HHHHHHHCCCHHEEEEHEEHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEC
SEVSLINLVQNKILLSHELPLKFTALSACFRAEPNTYGKDAQGLIRNHQFDKVEIVQIVH
CCHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEEEEEEC
PKDSEKTLEELTNHAEKILQLLKLPYRKMLLCEGELGFSSKKTYDLEVWLPSQKLYREIS
CCCHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCEEEEEEEECCHHHHHHHH
SCSMIGDFQSRRINAKYKDKKKNKNFFLHTLNGSGLAVGRTLAAILENFQCSNGTVKIPK
HHHHHCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEECHH
VLRNPYMNGMKFL
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]