Click here to switch to the map view.

The map label for this gene is thrB

Identifier: 116515066

GI number: 116515066

Start: 142607

End: 143554

Strand: Reverse

Name: thrB

Synonym: BCc_126

Alternate gene names: 116515066

Gene position: 143554-142607 (Counterclockwise)

Preceding gene: 116515067

Following gene: 116515065

Centisome position: 34.48

GC content: 25.95

Gene sequence:

>948_bases
ATGATAAAAATTTATGCTCCTGCTTCTATTGGAAATGTAGGTGTTGGTTTTGATATTTTAGGAATAGCTATCAAACCAAT
TGATAAAACGTTGTTAGGAGATTGTATCTCAATAAAACCATCAAAAAAATTTCAATTAAAAAATCATGGAAATTTTTCTA
AACAATTACCTGTAAATATAAAAGAAAATATTATATGGAAAGCATGGAAATATTTTAATAAAAAAGCAAAAAAAAAAAAA
ACAGTTAAAATTGTTCTAGAAAAAAATATGCCAATTGGTTCAGGACTAGGATCTAGTGCTTCTTCTATAGTAGCTTGTGT
TATTGCATTAAATAAATTCTATAAAACTAAACTATCAAAAACAAAATTACTAAAAATAATGGGAAAATTAGAAGGAATAA
TATCCGGAGAAGTTCATTATGACAATGTTGCTCCATGTTATTTAGGTGGTCTACAATTAATTACTAACGATCAAAAAAAC
ATCACACAAAAACTACCCATTTTTACTGATTGGTTATGGGTTATTGCTTGGCCAGGAGTCACCTTATCTACTTCTCAAGC
AAGAAATATTCTTCCATTAAAATATAAAAAAAAAACATGTATTCATAATAGTCGAAATTTAGCTACATTTATTCATGCTT
TATATACTAAACAATCAGAATTAGCAATTCGATATATGAAAGATATAATTGCTGAACCATATAGAATTCCATTAATACCA
AAATTTTTAATATCAAAAAAAAAAATAATAGAACTAGGAGCCTTAACATGTAATATTTCAGGTTCAGGACCTACTTTATT
TTCTGTATGTCCGAACATTTCTATAGCAAAAAAAGTAAAGATATGGTTAAAAAAAAACTATATGGAGAATCAAACAGGAT
TCGTTCATATTTGTAAAATTGATCAATCAGGTGCTAGAAAAATGGAAAAAAAAAATGAAATTATATAA

Upstream 100 bases:

>100_bases
TTAATAATACGTGGTTATGGAGCAGGGAATAAAGTTACAGCATCAGGAATTTTCTCTGATTTATTACGCATTGTATTATA
ATCTTATGAGTTTAAAAATA

Downstream 100 bases:

>100_bases
TTTAAAAGATATAAATGAAGAAGTAAATTTTTTAAATGCAATAAAATACGGATTAGGAAAAAAACAAGGATTATTTTTTC
CAAAATATTTACCAAAATTT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MIKIYAPASIGNVGVGFDILGIAIKPIDKTLLGDCISIKPSKKFQLKNHGNFSKQLPVNIKENIIWKAWKYFNKKAKKKK
TVKIVLEKNMPIGSGLGSSASSIVACVIALNKFYKTKLSKTKLLKIMGKLEGIISGEVHYDNVAPCYLGGLQLITNDQKN
ITQKLPIFTDWLWVIAWPGVTLSTSQARNILPLKYKKKTCIHNSRNLATFIHALYTKQSELAIRYMKDIIAEPYRIPLIP
KFLISKKKIIELGALTCNISGSGPTLFSVCPNISIAKKVKIWLKKNYMENQTGFVHICKIDQSGARKMEKKNEII

Sequences:

>Translated_315_residues
MIKIYAPASIGNVGVGFDILGIAIKPIDKTLLGDCISIKPSKKFQLKNHGNFSKQLPVNIKENIIWKAWKYFNKKAKKKK
TVKIVLEKNMPIGSGLGSSASSIVACVIALNKFYKTKLSKTKLLKIMGKLEGIISGEVHYDNVAPCYLGGLQLITNDQKN
ITQKLPIFTDWLWVIAWPGVTLSTSQARNILPLKYKKKTCIHNSRNLATFIHALYTKQSELAIRYMKDIIAEPYRIPLIP
KFLISKKKIIELGALTCNISGSGPTLFSVCPNISIAKKVKIWLKKNYMENQTGFVHICKIDQSGARKMEKKNEII
>Mature_315_residues
MIKIYAPASIGNVGVGFDILGIAIKPIDKTLLGDCISIKPSKKFQLKNHGNFSKQLPVNIKENIIWKAWKYFNKKAKKKK
TVKIVLEKNMPIGSGLGSSASSIVACVIALNKFYKTKLSKTKLLKIMGKLEGIISGEVHYDNVAPCYLGGLQLITNDQKN
ITQKLPIFTDWLWVIAWPGVTLSTSQARNILPLKYKKKTCIHNSRNLATFIHALYTKQSELAIRYMKDIIAEPYRIPLIP
KFLISKKKIIELGALTCNISGSGPTLFSVCPNISIAKKVKIWLKKNYMENQTGFVHICKIDQSGARKMEKKNEII

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=309, Percent_Identity=51.1326860841424, Blast_Score=370, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_BUCCC (Q057U7)

Other databases:

- EMBL:   CP000263
- RefSeq:   YP_802695.1
- ProteinModelPortal:   Q057U7
- SMR:   Q057U7
- STRING:   Q057U7
- EnsemblBacteria:   EBBUCT00000001435
- GeneID:   4440836
- GenomeReviews:   CP000263_GR
- KEGG:   bcc:BCc_126
- eggNOG:   COG0083
- GeneTree:   EBGT00050000007703
- HOGENOM:   HBG646290
- OMA:   GSAHADN
- ProtClustDB:   PRK01212
- BioCyc:   BAPH372461:BCC_126-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 35320; Mature: 35320

Theoretical pI: Translated: 10.61; Mature: 10.61

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIYAPASIGNVGVGFDILGIAIKPIDKTLLGDCISIKPSKKFQLKNHGNFSKQLPVNI
CEEEEECCCCCCCCCCCEEEEEEECCCCHHHHCHHEECCCCCEEEECCCCCCCCCCCCCH
KENIIWKAWKYFNKKAKKKKTVKIVLEKNMPIGSGLGSSASSIVACVIALNKFYKTKLSK
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TKLLKIMGKLEGIISGEVHYDNVAPCYLGGLQLITNDQKNITQKLPIFTDWLWVIAWPGV
HHHHHHHHHHHHEEECCEECCCCCHHHHCCEEEEECCHHHHHHHCCHHHHEEEEEECCCC
TLSTSQARNILPLKYKKKTCIHNSRNLATFIHALYTKQSELAIRYMKDIIAEPYRIPLIP
EEEHHCCCCCCCEEECCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCH
KFLISKKKIIELGALTCNISGSGPTLFSVCPNISIAKKVKIWLKKNYMENQTGFVHICKI
HHHHCHHHEEEEEEEEEEECCCCCEEEEECCCCCHHHHEEEEHHHCCCCCCCCEEEEEEE
DQSGARKMEKKNEII
CCHHHHHHHHHCCCC
>Mature Secondary Structure
MIKIYAPASIGNVGVGFDILGIAIKPIDKTLLGDCISIKPSKKFQLKNHGNFSKQLPVNI
CEEEEECCCCCCCCCCCEEEEEEECCCCHHHHCHHEECCCCCEEEECCCCCCCCCCCCCH
KENIIWKAWKYFNKKAKKKKTVKIVLEKNMPIGSGLGSSASSIVACVIALNKFYKTKLSK
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TKLLKIMGKLEGIISGEVHYDNVAPCYLGGLQLITNDQKNITQKLPIFTDWLWVIAWPGV
HHHHHHHHHHHHEEECCEECCCCCHHHHCCEEEEECCHHHHHHHCCHHHHEEEEEECCCC
TLSTSQARNILPLKYKKKTCIHNSRNLATFIHALYTKQSELAIRYMKDIIAEPYRIPLIP
EEEHHCCCCCCCEEECCHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCH
KFLISKKKIIELGALTCNISGSGPTLFSVCPNISIAKKVKIWLKKNYMENQTGFVHICKI
HHHHCHHHEEEEEEEEEEECCCCCEEEEECCCCCHHHHEEEEHHHCCCCCCCCEEEEEEE
DQSGARKMEKKNEII
CCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA