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The map label for this gene is thrA [H]

Identifier: 116515067

GI number: 116515067

Start: 143574

End: 146036

Strand: Reverse

Name: thrA [H]

Synonym: BCc_127

Alternate gene names: 116515067

Gene position: 146036-143574 (Counterclockwise)

Preceding gene: 116515068

Following gene: 116515066

Centisome position: 35.07

GC content: 18.8

Gene sequence:

>2463_bases
ATGAAAACATTAAAATTTGGAGGTACTTCACTTGCAAACGCAAAAAAATTTATACAAGTATCTTCAATTATAATTCAAAA
ATTAAATCATGATCAAATATCTGTTGTATTATCTGCACCTGCTACTATTACAAATTATTTAGAAGATTCTATTAAACTCT
TTGTTAAAAAAAAAATTATTCCTAGTAAAATCTTAAGAATAATTAAAAATTTTTTTTTAAATATAATTTTAAATATTTAT
AAAAAAGAAAAAGAATACCCAATAAAAAAACTAAATAAAAAAATCATTAAAAAACACAAAAAACTAAAAAAAATATTTAA
AAAAATTAAAATTTTACAAAAATGTTCAGAAAAAAAACAAGCACGAATAATTAGTACAGGAGAAAATGTTTCTGTTTTAC
TAATGAAAGAATTATTACAAATAAAAGGATTTAACACAATCATTATTAATCCTATAAAATATTTTTTAGCAAATAATAAT
TATTTAAATGCAAATGTAAATATTAAAAAATCCAAAAAAAACTTTGAAAAATTAAAAATTTCAAAAAAAAAAATTATTCT
TATGCCTGGATTTATAGCCGGAAATAATAAAAAAGAATTAGTAGTTTTAGGAAGAAACGGATCTGATTATTCTGCAAGCA
TTTTATCTATTTGTACAAATTCTAATATATGTGAAATTTGGACTGATGTAAATGGAATTTATACAGGTGATCCAAATATT
ATAAAAAAAGCTCAATTAGTATCAAAGATTTCTTATCAAGAAGCATTAGAATTAGCTTATTTTGGTGCTAAAGTAATTCA
TCCGTCTACTATAGAACCATTAAAAAAAAATAATATTTGTTGTATTATTAAAAATACAAATAATCCAGAGTATCCAGGAA
CTAAAATAATAAATAGAAAAAAGACAAAAAAAGAAAAAAAAAATCAAATAAAAGGAATTACATATCTAAAAAACATTATT
TTTATAAAAATATTTTGTAAAAAAAATTTACAAATAAAAAAAGTTCTTAAAAAAATACTTTCATATTTTTTTAAGAAAAA
TATACCATTATATTTATTAAATCAATCTCTATCACAAAATATAATTAGTTTTTATATACAAAAAAAAAACTTAATTTATA
TCAAAAAAATAAAAAAACTATTAACTCTAAATATAAAAAGAAAAAGATTATTATCAATTATCAAAATAAAAAAATTAAGT
ATTATAACAATTGTAGGATCTTTTTTAAAAAAATATACTACTAAAATTTTAGAAAAAATCCATTTAATTATCTATAGATT
TAATAATAAAATATTTAATATTTCACATAATATATCAAATATATCTTTATCAATTGTAATTTATGATAAAAATGTTATAT
CAATTATGAAAAAAATACATAACACAATTATAAATTATCATGTATCCATTAATATTTTTTTAATTGGTATAGGTGGAGTT
GGTCTAGAATTTTTAAAAATATTTTTTAAACAAAGAGAAAGAATAAAAAAAAAATTTATTAAATTAAATATTAATCTTAT
TGCAAATTCAAAAAAATATATTATTAGTAAAAAAAATATTAATTATAAAAAATGGGAAAAAAAATTTAAAAATTCTAAAA
AAAAATTTTTATTAAAAAAAATTCTCCAAATTATTGAAAATAATGGTTATTTAAATCCTATTTTTATAGATTGTACAGCT
AGTCAAGAAATTTCTAACAATTATAAAAAAATAATTAAATCCGGATGTCATATCATAACAGCTAATAAAAAATCTAATTC
GTCATTAACATTACAATATACAGAAATTAGAAAAACAGCAAAAAAAAATAATAAAAAATTTTTTTATGAAACTCATGTCG
GTGCGGGATTACCCATTCTTCAAAATTTTAAACATTTAATAGAATCAGGAGATAAATTAATCAAATTTCAAGGTATCCTT
TCTGGTTCTATGTCATATATTTTCGGAGAATTAGATAATAATAATATTACATTATCACATGCTATTAAAAAAGCTCAAAA
ATTAGGATTTACAGAACCACATCCAAAAGATGATCTTTCTGGAATTGATATTGCAAGAAAATTATTAATTTTAGCACGAG
AAGCAGGATATTCAATAGAATTACCTGATATAAAAATAGAAAAAATTCTTCCAAATTCATTTAAAAAAATAAAAAATAAA
AAAATATTTCTTAAAAAACTTAAAGAATTAGATAATTTATTTCTTCAAAAAATTATTCAAGCAAAAAAAGAAAAAAAAGT
ACTTAGATGTATAGGAACAATAAATAAAAATGGAAATTGTTGTGTTAAAATACATTCCGTAAACTATAAAAATCCACTTT
ATCATGTAAAAAATGGAGAAAACATATTTGTTTTTTATACTAAATATTATCAACCGATTCCTTTAATAATACGTGGTTAT
GGAGCAGGGAATAAAGTTACAGCATCAGGAATTTTCTCTGATTTATTACGCATTGTATTATAA

Upstream 100 bases:

>100_bases
ATAATAATCATAATACTATAAAAAATATACATTATAAAACTACTATAAATACGATATATAAAAAAAATTTAAACAATAAT
TTAAAAATGAGATTATTTTT

Downstream 100 bases:

>100_bases
TCTTATGAGTTTAAAAATAATGATAAAAATTTATGCTCCTGCTTCTATTGGAAATGTAGGTGTTGGTTTTGATATTTTAG
GAATAGCTATCAAACCAATT

Product: hypothetical protein

Products: NA

Alternate protein names: AK-HD; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 820; Mature: 820

Protein sequence:

>820_residues
MKTLKFGGTSLANAKKFIQVSSIIIQKLNHDQISVVLSAPATITNYLEDSIKLFVKKKIIPSKILRIIKNFFLNIILNIY
KKEKEYPIKKLNKKIIKKHKKLKKIFKKIKILQKCSEKKQARIISTGENVSVLLMKELLQIKGFNTIIINPIKYFLANNN
YLNANVNIKKSKKNFEKLKISKKKIILMPGFIAGNNKKELVVLGRNGSDYSASILSICTNSNICEIWTDVNGIYTGDPNI
IKKAQLVSKISYQEALELAYFGAKVIHPSTIEPLKKNNICCIIKNTNNPEYPGTKIINRKKTKKEKKNQIKGITYLKNII
FIKIFCKKNLQIKKVLKKILSYFFKKNIPLYLLNQSLSQNIISFYIQKKNLIYIKKIKKLLTLNIKRKRLLSIIKIKKLS
IITIVGSFLKKYTTKILEKIHLIIYRFNNKIFNISHNISNISLSIVIYDKNVISIMKKIHNTIINYHVSINIFLIGIGGV
GLEFLKIFFKQRERIKKKFIKLNINLIANSKKYIISKKNINYKKWEKKFKNSKKKFLLKKILQIIENNGYLNPIFIDCTA
SQEISNNYKKIIKSGCHIITANKKSNSSLTLQYTEIRKTAKKNNKKFFYETHVGAGLPILQNFKHLIESGDKLIKFQGIL
SGSMSYIFGELDNNNITLSHAIKKAQKLGFTEPHPKDDLSGIDIARKLLILAREAGYSIELPDIKIEKILPNSFKKIKNK
KIFLKKLKELDNLFLQKIIQAKKEKKVLRCIGTINKNGNCCVKIHSVNYKNPLYHVKNGENIFVFYTKYYQPIPLIIRGY
GAGNKVTASGIFSDLLRIVL

Sequences:

>Translated_820_residues
MKTLKFGGTSLANAKKFIQVSSIIIQKLNHDQISVVLSAPATITNYLEDSIKLFVKKKIIPSKILRIIKNFFLNIILNIY
KKEKEYPIKKLNKKIIKKHKKLKKIFKKIKILQKCSEKKQARIISTGENVSVLLMKELLQIKGFNTIIINPIKYFLANNN
YLNANVNIKKSKKNFEKLKISKKKIILMPGFIAGNNKKELVVLGRNGSDYSASILSICTNSNICEIWTDVNGIYTGDPNI
IKKAQLVSKISYQEALELAYFGAKVIHPSTIEPLKKNNICCIIKNTNNPEYPGTKIINRKKTKKEKKNQIKGITYLKNII
FIKIFCKKNLQIKKVLKKILSYFFKKNIPLYLLNQSLSQNIISFYIQKKNLIYIKKIKKLLTLNIKRKRLLSIIKIKKLS
IITIVGSFLKKYTTKILEKIHLIIYRFNNKIFNISHNISNISLSIVIYDKNVISIMKKIHNTIINYHVSINIFLIGIGGV
GLEFLKIFFKQRERIKKKFIKLNINLIANSKKYIISKKNINYKKWEKKFKNSKKKFLLKKILQIIENNGYLNPIFIDCTA
SQEISNNYKKIIKSGCHIITANKKSNSSLTLQYTEIRKTAKKNNKKFFYETHVGAGLPILQNFKHLIESGDKLIKFQGIL
SGSMSYIFGELDNNNITLSHAIKKAQKLGFTEPHPKDDLSGIDIARKLLILAREAGYSIELPDIKIEKILPNSFKKIKNK
KIFLKKLKELDNLFLQKIIQAKKEKKVLRCIGTINKNGNCCVKIHSVNYKNPLYHVKNGENIFVFYTKYYQPIPLIIRGY
GAGNKVTASGIFSDLLRIVL
>Mature_820_residues
MKTLKFGGTSLANAKKFIQVSSIIIQKLNHDQISVVLSAPATITNYLEDSIKLFVKKKIIPSKILRIIKNFFLNIILNIY
KKEKEYPIKKLNKKIIKKHKKLKKIFKKIKILQKCSEKKQARIISTGENVSVLLMKELLQIKGFNTIIINPIKYFLANNN
YLNANVNIKKSKKNFEKLKISKKKIILMPGFIAGNNKKELVVLGRNGSDYSASILSICTNSNICEIWTDVNGIYTGDPNI
IKKAQLVSKISYQEALELAYFGAKVIHPSTIEPLKKNNICCIIKNTNNPEYPGTKIINRKKTKKEKKNQIKGITYLKNII
FIKIFCKKNLQIKKVLKKILSYFFKKNIPLYLLNQSLSQNIISFYIQKKNLIYIKKIKKLLTLNIKRKRLLSIIKIKKLS
IITIVGSFLKKYTTKILEKIHLIIYRFNNKIFNISHNISNISLSIVIYDKNVISIMKKIHNTIINYHVSINIFLIGIGGV
GLEFLKIFFKQRERIKKKFIKLNINLIANSKKYIISKKNINYKKWEKKFKNSKKKFLLKKILQIIENNGYLNPIFIDCTA
SQEISNNYKKIIKSGCHIITANKKSNSSLTLQYTEIRKTAKKNNKKFFYETHVGAGLPILQNFKHLIESGDKLIKFQGIL
SGSMSYIFGELDNNNITLSHAIKKAQKLGFTEPHPKDDLSGIDIARKLLILAREAGYSIELPDIKIEKILPNSFKKIKNK
KIFLKKLKELDNLFLQKIIQAKKEKKVLRCIGTINKNGNCCVKIHSVNYKNPLYHVKNGENIFVFYTKYYQPIPLIIRGY
GAGNKVTASGIFSDLLRIVL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=821, Percent_Identity=38.489646772229, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1790376, Length=824, Percent_Identity=25.2427184466019, Blast_Score=322, Evalue=5e-89,
Organism=Escherichia coli, GI1790455, Length=471, Percent_Identity=23.7791932059448, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322599, Length=340, Percent_Identity=32.9411764705882, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320893, Length=506, Percent_Identity=24.3083003952569, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 94499; Mature: 94499

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLKFGGTSLANAKKFIQVSSIIIQKLNHDQISVVLSAPATITNYLEDSIKLFVKKKII
CCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCC
PSKILRIIKNFFLNIILNIYKKEKEYPIKKLNKKIIKKHKKLKKIFKKIKILQKCSEKKQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARIISTGENVSVLLMKELLQIKGFNTIIINPIKYFLANNNYLNANVNIKKSKKNFEKLKI
CEEEECCCCEEHHHHHHHHHHCCCCEEEECCHHHHEECCCEEEEEEEEECCCCCHHHHEE
SKKKIILMPGFIAGNNKKELVVLGRNGSDYSASILSICTNSNICEIWTDVNGIYTGDPNI
CCCEEEEECCEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCEECCCCHH
IKKAQLVSKISYQEALELAYFGAKVIHPSTIEPLKKNNICCIIKNTNNPEYPGTKIINRK
HHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEECCCCCCCCCCHHCCCH
KTKKEKKNQIKGITYLKNIIFIKIFCKKNLQIKKVLKKILSYFFKKNIPLYLLNQSLSQN
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHH
IISFYIQKKNLIYIKKIKKLLTLNIKRKRLLSIIKIKKLSIITIVGSFLKKYTTKILEKI
HHHHHHHCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLIIYRFNNKIFNISHNISNISLSIVIYDKNVISIMKKIHNTIINYHVSINIFLIGIGGV
HHEEEEECCEEEEEECCCCEEEEEEEEECCHHHHHHHHHHHHHEEEEEEEEEEEEEECCH
GLEFLKIFFKQRERIKKKFIKLNINLIANSKKYIISKKNINYKKWEKKFKNSKKKFLLKK
HHHHHHHHHHHHHHHHHHHEEEEEEEEECCCEEEEEECCCCHHHHHHHHHCHHHHHHHHH
ILQIIENNGYLNPIFIDCTASQEISNNYKKIIKSGCHIITANKKSNSSLTLQYTEIRKTA
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEHHHHHHH
KKNNKKFFYETHVGAGLPILQNFKHLIESGDKLIKFQGILSGSMSYIFGELDNNNITLSH
HCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCEEEEEEECCCCEEHHH
AIKKAQKLGFTEPHPKDDLSGIDIARKLLILAREAGYSIELPDIKIEKILPNSFKKIKNK
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEHHHCCHHHHHHCCH
KIFLKKLKELDNLFLQKIIQAKKEKKVLRCIGTINKNGNCCVKIHSVNYKNPLYHVKNGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEECCC
NIFVFYTKYYQPIPLIIRGYGAGNKVTASGIFSDLLRIVL
EEEEEEECCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHC
>Mature Secondary Structure
MKTLKFGGTSLANAKKFIQVSSIIIQKLNHDQISVVLSAPATITNYLEDSIKLFVKKKII
CCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCC
PSKILRIIKNFFLNIILNIYKKEKEYPIKKLNKKIIKKHKKLKKIFKKIKILQKCSEKKQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARIISTGENVSVLLMKELLQIKGFNTIIINPIKYFLANNNYLNANVNIKKSKKNFEKLKI
CEEEECCCCEEHHHHHHHHHHCCCCEEEECCHHHHEECCCEEEEEEEEECCCCCHHHHEE
SKKKIILMPGFIAGNNKKELVVLGRNGSDYSASILSICTNSNICEIWTDVNGIYTGDPNI
CCCEEEEECCEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCEECCCCHH
IKKAQLVSKISYQEALELAYFGAKVIHPSTIEPLKKNNICCIIKNTNNPEYPGTKIINRK
HHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEECCCCCCCCCCHHCCCH
KTKKEKKNQIKGITYLKNIIFIKIFCKKNLQIKKVLKKILSYFFKKNIPLYLLNQSLSQN
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHH
IISFYIQKKNLIYIKKIKKLLTLNIKRKRLLSIIKIKKLSIITIVGSFLKKYTTKILEKI
HHHHHHHCCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLIIYRFNNKIFNISHNISNISLSIVIYDKNVISIMKKIHNTIINYHVSINIFLIGIGGV
HHEEEEECCEEEEEECCCCEEEEEEEEECCHHHHHHHHHHHHHEEEEEEEEEEEEEECCH
GLEFLKIFFKQRERIKKKFIKLNINLIANSKKYIISKKNINYKKWEKKFKNSKKKFLLKK
HHHHHHHHHHHHHHHHHHHEEEEEEEEECCCEEEEEECCCCHHHHHHHHHCHHHHHHHHH
ILQIIENNGYLNPIFIDCTASQEISNNYKKIIKSGCHIITANKKSNSSLTLQYTEIRKTA
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEHHHHHHH
KKNNKKFFYETHVGAGLPILQNFKHLIESGDKLIKFQGILSGSMSYIFGELDNNNITLSH
HCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCEEEEEEECCCCEEHHH
AIKKAQKLGFTEPHPKDDLSGIDIARKLLILAREAGYSIELPDIKIEKILPNSFKKIKNK
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEHHHCCHHHHHHCCH
KIFLKKLKELDNLFLQKIIQAKKEKKVLRCIGTINKNGNCCVKIHSVNYKNPLYHVKNGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEECCC
NIFVFYTKYYQPIPLIIRGYGAGNKVTASGIFSDLLRIVL
EEEEEEECCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]