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The map label for this gene is thrC [H]

Identifier: 116515065

GI number: 116515065

Start: 141328

End: 142620

Strand: Reverse

Name: thrC [H]

Synonym: BCc_125

Alternate gene names: 116515065

Gene position: 142620-141328 (Counterclockwise)

Preceding gene: 116515066

Following gene: 116515062

Centisome position: 34.25

GC content: 23.9

Gene sequence:

>1293_bases
ATGAAATTATATAATTTAAAAGATATAAATGAAGAAGTAAATTTTTTAAATGCAATAAAATACGGATTAGGAAAAAAACA
AGGATTATTTTTTCCAAAATATTTACCAAAATTTACACCTGAAACATTAAAGAAATTAATTCAAATGGATTTTATTACTA
GAAGTACTCATATACTATCACATTTTATCTCCGATGAAATATCATTTGTTGACTTAAAAAAACAAATAAAAAAAGCTTTT
TCATTTACTAAACCTATAATTGTTCATGTTAAAAAAAATATTTCATGTTTAGAATTATTTCACGGACCAACATTAGCATT
TAAAGATTTTGGAGCTAGATTTATGGCTCAAATGCTTTCATATTGGAAAAAAGAAAATTCTATTATGACTATATTAACTG
CTACTTCTGGAGATACCGGTGCTGCTGTTGCGCATGCATTTTATCGTATGAATAATATTCGTGTAGTTATTTTATATCCT
AAAGGAAGAATTAGTACATTACAAGAAAAACTATTTTGTACATTAGGAGAAAATATACATACCATTGCAATTGATGGTAG
TTTTGATGATTGTCAATATTTGGTAAAAAAATCTTTTAATGATAAAAAACTAAAAAAAAATATTGGCTTAAATTCAGCTA
ATTCTATTAATATTAGTAGATTATTAGCTCAAATATGTTATTATTTTGAAGCATTTGCATTAATACCAACAGACTTTCAT
AAAAATATTGTTATTTCAATTCCATGTGGTAATTTTGGTAATTTAACAGCTGGATTAATAGCAAAATCTCTTGGATTACC
AATAAAATCTTTTATCGCAGCTACTAATGCTAACGATACTGTTCCAAGATTTTTAAAAAATGGAAAATGGAAACCAAATA
AAACAATATCAACTATTTCTAATGCTATGGATATTAGTCAACCTAATAATTGGCCAAGAGTTGAAGAATTATTTAAAAGA
AAAAAATGGAATTTAAAAACACTAAAATCTTATAGTGTGTCAGATAAAGAAACAGAGAGAGCGATAAAAAAATTATATAA
AATTGGATATTTATCAGAACCGCATGCAGCTATAGCATATACAATACTAAAGAAAAATATTAAAAAAGAAGATTTTGGTT
TATTTTTAGGAACAGCGCATCCATCTAAATTTCAAGATACTGTAGAAAAAATATTAAAAATTTCATTAAAATTACCAATA
TCCTTAAAATCCAGAGTAAATTTAAAAAATTTATCATACCATATGAAACCTGATTTTTTAAAATTAAAAGAATTTTTATT
AAAAAAAATTTAA

Upstream 100 bases:

>100_bases
GTAAAGATATGGTTAAAAAAAAACTATATGGAGAATCAAACAGGATTCGTTCATATTTGTAAAATTGATCAATCAGGTGC
TAGAAAAATGGAAAAAAAAA

Downstream 100 bases:

>100_bases
TGCATATATATATTCAGAGAGGAATTTATTATTTCCTCTCTAAAATTATAAAAAATTTTATTATTAAAAAAGAAAAAACT
TATATGTTAAATAAAAAATT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKLYNLKDINEEVNFLNAIKYGLGKKQGLFFPKYLPKFTPETLKKLIQMDFITRSTHILSHFISDEISFVDLKKQIKKAF
SFTKPIIVHVKKNISCLELFHGPTLAFKDFGARFMAQMLSYWKKENSIMTILTATSGDTGAAVAHAFYRMNNIRVVILYP
KGRISTLQEKLFCTLGENIHTIAIDGSFDDCQYLVKKSFNDKKLKKNIGLNSANSINISRLLAQICYYFEAFALIPTDFH
KNIVISIPCGNFGNLTAGLIAKSLGLPIKSFIAATNANDTVPRFLKNGKWKPNKTISTISNAMDISQPNNWPRVEELFKR
KKWNLKTLKSYSVSDKETERAIKKLYKIGYLSEPHAAIAYTILKKNIKKEDFGLFLGTAHPSKFQDTVEKILKISLKLPI
SLKSRVNLKNLSYHMKPDFLKLKEFLLKKI

Sequences:

>Translated_430_residues
MKLYNLKDINEEVNFLNAIKYGLGKKQGLFFPKYLPKFTPETLKKLIQMDFITRSTHILSHFISDEISFVDLKKQIKKAF
SFTKPIIVHVKKNISCLELFHGPTLAFKDFGARFMAQMLSYWKKENSIMTILTATSGDTGAAVAHAFYRMNNIRVVILYP
KGRISTLQEKLFCTLGENIHTIAIDGSFDDCQYLVKKSFNDKKLKKNIGLNSANSINISRLLAQICYYFEAFALIPTDFH
KNIVISIPCGNFGNLTAGLIAKSLGLPIKSFIAATNANDTVPRFLKNGKWKPNKTISTISNAMDISQPNNWPRVEELFKR
KKWNLKTLKSYSVSDKETERAIKKLYKIGYLSEPHAAIAYTILKKNIKKEDFGLFLGTAHPSKFQDTVEKILKISLKLPI
SLKSRVNLKNLSYHMKPDFLKLKEFLLKKI
>Mature_430_residues
MKLYNLKDINEEVNFLNAIKYGLGKKQGLFFPKYLPKFTPETLKKLIQMDFITRSTHILSHFISDEISFVDLKKQIKKAF
SFTKPIIVHVKKNISCLELFHGPTLAFKDFGARFMAQMLSYWKKENSIMTILTATSGDTGAAVAHAFYRMNNIRVVILYP
KGRISTLQEKLFCTLGENIHTIAIDGSFDDCQYLVKKSFNDKKLKKNIGLNSANSINISRLLAQICYYFEAFALIPTDFH
KNIVISIPCGNFGNLTAGLIAKSLGLPIKSFIAATNANDTVPRFLKNGKWKPNKTISTISNAMDISQPNNWPRVEELFKR
KKWNLKTLKSYSVSDKETERAIKKLYKIGYLSEPHAAIAYTILKKNIKKEDFGLFLGTAHPSKFQDTVEKILKISLKLPI
SLKSRVNLKNLSYHMKPDFLKLKEFLLKKI

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=442, Percent_Identity=31.447963800905, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI149193323, Length=429, Percent_Identity=30.0699300699301, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1786185, Length=427, Percent_Identity=59.2505854800937, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6319901, Length=446, Percent_Identity=34.0807174887892, Blast_Score=224, Evalue=2e-59,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 49098; Mature: 49098

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNLKDINEEVNFLNAIKYGLGKKQGLFFPKYLPKFTPETLKKLIQMDFITRSTHILS
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
HFISDEISFVDLKKQIKKAFSFTKPIIVHVKKNISCLELFHGPTLAFKDFGARFMAQMLS
HHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHCCCCHHHHHHHHHHHHHHHH
YWKKENSIMTILTATSGDTGAAVAHAFYRMNNIRVVILYPKGRISTLQEKLFCTLGENIH
HHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCCCEE
TIAIDGSFDDCQYLVKKSFNDKKLKKNIGLNSANSINISRLLAQICYYFEAFALIPTDFH
EEEEECCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
KNIVISIPCGNFGNLTAGLIAKSLGLPIKSFIAATNANDTVPRFLKNGKWKPNKTISTIS
CCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHH
NAMDISQPNNWPRVEELFKRKKWNLKTLKSYSVSDKETERAIKKLYKIGYLSEPHAAIAY
HHHHCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
TILKKNIKKEDFGLFLGTAHPSKFQDTVEKILKISLKLPISLKSRVNLKNLSYHMKPDFL
HHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEEHHCCCCHHHCEECCCCCHH
KLKEFLLKKI
HHHHHHHHCC
>Mature Secondary Structure
MKLYNLKDINEEVNFLNAIKYGLGKKQGLFFPKYLPKFTPETLKKLIQMDFITRSTHILS
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
HFISDEISFVDLKKQIKKAFSFTKPIIVHVKKNISCLELFHGPTLAFKDFGARFMAQMLS
HHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEHHHCCCCHHHHHHHHHHHHHHHH
YWKKENSIMTILTATSGDTGAAVAHAFYRMNNIRVVILYPKGRISTLQEKLFCTLGENIH
HHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCCCEE
TIAIDGSFDDCQYLVKKSFNDKKLKKNIGLNSANSINISRLLAQICYYFEAFALIPTDFH
EEEEECCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
KNIVISIPCGNFGNLTAGLIAKSLGLPIKSFIAATNANDTVPRFLKNGKWKPNKTISTIS
CCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHH
NAMDISQPNNWPRVEELFKRKKWNLKTLKSYSVSDKETERAIKKLYKIGYLSEPHAAIAY
HHHHCCCCCCCHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHH
TILKKNIKKEDFGLFLGTAHPSKFQDTVEKILKISLKLPISLKSRVNLKNLSYHMKPDFL
HHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEEHHCCCCHHHCEECCCCCHH
KLKEFLLKKI
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]