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The map label for this gene is nuoCD

Identifier: 116515040

GI number: 116515040

Start: 112466

End: 114202

Strand: Direct

Name: nuoCD

Synonym: BCc_099

Alternate gene names: 116515040

Gene position: 112466-114202 (Clockwise)

Preceding gene: 116515039

Following gene: 116515041

Centisome position: 27.01

GC content: 26.6

Gene sequence:

>1737_bases
ATTATTTTAAGTTTATTTAAATTATTCGGAAAAGAAAATTTTTTTATACAAGATTCTTATTTAGAATCTCCTATTTTATG
GATTGATAGTACTATACTAATTCAAGTAATTGGTTTTTTAAAAAAAAATAATACTTGTTCTTATGAAATTTTATTTGATT
TATTTGGAATAGATGAACGTACAAGAAAAAATGTTAAAAGTTTTCCGAATGCTGATTTTACAGTATCTTATTATTTTTTT
TCAATTTCTAATAATTCTGATTTAATATTAAAAGTTGCTTTGTTAAAAGAACATTTACAATTACCAACAATTTCATCAAT
TTTTTTAAATGCTAATTGGTATGAACGTGAGATTTGGGATATGTTTGGAATTGTCTTTAATAATCATCCATATTTAACTC
GTATTTTGATGCCTAAAAATTGGGTAGGACATCCTTTACGAAAAGATTATTCTTCTCATGCAACAGAATTTGATGAATTT
TATTTCACTAAACAAAAAGAAGATTTAGCAATGGAATCTTTAAAATTCTGCCCTAAATCATGGGGTTTAGAAAATAATGA
TTCTAATAATTCAGAATATATGTTTTTAAATTTCGGACCTAATCATCCTTCTTCTCATGGAGCTTTTCGTATAGTTCTGC
AATTACATGGGGAAAAAATTATAAATTGTATTCCAGATATTGGTTATCATCATCGTGGAGCTGAAAAAATTGCTGAAAGA
CAAACATGGCATAGTTATATTCCATATACCGATCGTATAGAATATTTAGGTGGATGTGTTAATGAAATGCCTTATATATT
AGCTGTAGAAAAGTTAGCAGGAATTGTTGTGCCTGAAAAAGTTCAAGTAATTAGAATATTATTATCTGAATTATTTAGAA
TTAATAGTCATTTATTATTTTTATCTACTTTTATTCAAGATATAGGAAGTATGAGTACTGTTTTTTTAGCATTTACAGAT
CGTCAAAAAATTTATGATTTAATCGAATCTATTACTGGAGCTCGTATGCATCCAGCATGGTTTAGAATTGGAGGAGTAGC
AAAAGATTTACCGAAGAATTGGAATTCTTTATTAAAGAAATTTTTAATTTGGATGCCTAAACGATTAGATTATTATGTTA
ATATTGCAATAAAAAATAAGATTTTAATATCACGTTCAAAAGGTATTGCGGCTTATGGAAAAAAAGAAGCTTTATCATGG
GGAATTACTGGAGCAGGTTTACGTGCAACTGGAGTGAATTTTGATGTAAGAAAAAATAGACCATATTCTGGTTATCAAAA
TTTTGATTTTGAAGTTCCAATTGGAAATAATATTAGTGATGCATATACGCGAGTATTATTAAAAATTGAAGAGATTAGAC
AAAGTTTAAAAATATTAAATCAATGTTTATTACATATGCCTTTAGGTTCATATAAATCTGATCATCCGTTAAGTACACCT
CAAAAAAAAAATAAATCTTTATTTCATATTGAAAGAATGATTACACATTTTTTGCAAATGTCTTGGGGACCAATAATTCC
TAGTAATGAAAGTTTTCAGATGATTGAAGCAACAAAAGGAATCAATAGTTATTATTTAATAAGTGATGGATTAACTACAA
GTTATAGAACAAGAATTCGGACTCCTAGTTTTGCTCATTTACAACAAATTCCTTCTGTTATAAGAGGTTATGTAATATCA
GATTTGATTGTTTATTTAGGTAGTATTGATTTTGTGATGTCAGATGTAGATAGATAA

Upstream 100 bases:

>100_bases
TATTGCTTATTATAAGGATAATAAATATGTCTCATATGGATTTAAAAAAAAAAAAAATTTTTTAGATGATAGAAAAAATA
AATTTTTTAAAAATAACCCT

Downstream 100 bases:

>100_bases
ATTTATTTGTATAAAAATTAGGAAAAATAAAGTGTTTGAATTAAGTAAATTAGAGATTTCTAAAATTTTAAAAAAAAAAA
AATGTTATGTTAATTCACAA

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MILSLFKLFGKENFFIQDSYLESPILWIDSTILIQVIGFLKKNNTCSYEILFDLFGIDERTRKNVKSFPNADFTVSYYFF
SISNNSDLILKVALLKEHLQLPTISSIFLNANWYEREIWDMFGIVFNNHPYLTRILMPKNWVGHPLRKDYSSHATEFDEF
YFTKQKEDLAMESLKFCPKSWGLENNDSNNSEYMFLNFGPNHPSSHGAFRIVLQLHGEKIINCIPDIGYHHRGAEKIAER
QTWHSYIPYTDRIEYLGGCVNEMPYILAVEKLAGIVVPEKVQVIRILLSELFRINSHLLFLSTFIQDIGSMSTVFLAFTD
RQKIYDLIESITGARMHPAWFRIGGVAKDLPKNWNSLLKKFLIWMPKRLDYYVNIAIKNKILISRSKGIAAYGKKEALSW
GITGAGLRATGVNFDVRKNRPYSGYQNFDFEVPIGNNISDAYTRVLLKIEEIRQSLKILNQCLLHMPLGSYKSDHPLSTP
QKKNKSLFHIERMITHFLQMSWGPIIPSNESFQMIEATKGINSYYLISDGLTTSYRTRIRTPSFAHLQQIPSVIRGYVIS
DLIVYLGSIDFVMSDVDR

Sequences:

>Translated_578_residues
MILSLFKLFGKENFFIQDSYLESPILWIDSTILIQVIGFLKKNNTCSYEILFDLFGIDERTRKNVKSFPNADFTVSYYFF
SISNNSDLILKVALLKEHLQLPTISSIFLNANWYEREIWDMFGIVFNNHPYLTRILMPKNWVGHPLRKDYSSHATEFDEF
YFTKQKEDLAMESLKFCPKSWGLENNDSNNSEYMFLNFGPNHPSSHGAFRIVLQLHGEKIINCIPDIGYHHRGAEKIAER
QTWHSYIPYTDRIEYLGGCVNEMPYILAVEKLAGIVVPEKVQVIRILLSELFRINSHLLFLSTFIQDIGSMSTVFLAFTD
RQKIYDLIESITGARMHPAWFRIGGVAKDLPKNWNSLLKKFLIWMPKRLDYYVNIAIKNKILISRSKGIAAYGKKEALSW
GITGAGLRATGVNFDVRKNRPYSGYQNFDFEVPIGNNISDAYTRVLLKIEEIRQSLKILNQCLLHMPLGSYKSDHPLSTP
QKKNKSLFHIERMITHFLQMSWGPIIPSNESFQMIEATKGINSYYLISDGLTTSYRTRIRTPSFAHLQQIPSVIRGYVIS
DLIVYLGSIDFVMSDVDR
>Mature_578_residues
MILSLFKLFGKENFFIQDSYLESPILWIDSTILIQVIGFLKKNNTCSYEILFDLFGIDERTRKNVKSFPNADFTVSYYFF
SISNNSDLILKVALLKEHLQLPTISSIFLNANWYEREIWDMFGIVFNNHPYLTRILMPKNWVGHPLRKDYSSHATEFDEF
YFTKQKEDLAMESLKFCPKSWGLENNDSNNSEYMFLNFGPNHPSSHGAFRIVLQLHGEKIINCIPDIGYHHRGAEKIAER
QTWHSYIPYTDRIEYLGGCVNEMPYILAVEKLAGIVVPEKVQVIRILLSELFRINSHLLFLSTFIQDIGSMSTVFLAFTD
RQKIYDLIESITGARMHPAWFRIGGVAKDLPKNWNSLLKKFLIWMPKRLDYYVNIAIKNKILISRSKGIAAYGKKEALSW
GITGAGLRATGVNFDVRKNRPYSGYQNFDFEVPIGNNISDAYTRVLLKIEEIRQSLKILNQCLLHMPLGSYKSDHPLSTP
QKKNKSLFHIERMITHFLQMSWGPIIPSNESFQMIEATKGINSYYLISDGLTTSYRTRIRTPSFAHLQQIPSVIRGYVIS
DLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=383, Percent_Identity=38.9033942558747, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI260898743, Length=377, Percent_Identity=38.4615384615385, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4758788, Length=118, Percent_Identity=39.8305084745763, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI145693162, Length=578, Percent_Identity=66.4359861591695, Blast_Score=842, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=530, Percent_Identity=26.0377358490566, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788832, Length=535, Percent_Identity=25.0467289719626, Blast_Score=142, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17555284, Length=428, Percent_Identity=38.785046728972, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17568379, Length=428, Percent_Identity=39.018691588785, Blast_Score=319, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI32563621, Length=125, Percent_Identity=35.2, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71990788, Length=125, Percent_Identity=35.2, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24638644, Length=385, Percent_Identity=38.1818181818182, Blast_Score=309, Evalue=4e-84,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=37.5, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24656494, Length=145, Percent_Identity=33.7931034482759, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOCD_BUCCC (Q057X3)

Other databases:

- EMBL:   CP000263
- RefSeq:   YP_802669.1
- ProteinModelPortal:   Q057X3
- SMR:   Q057X3
- STRING:   Q057X3
- EnsemblBacteria:   EBBUCT00000001512
- GeneID:   4440809
- GenomeReviews:   CP000263_GR
- KEGG:   bcc:BCc_099
- eggNOG:   COG0649
- GeneTree:   EBGT00050000007742
- HOGENOM:   HBG459705
- OMA:   PHLQQIP
- ProtClustDB:   PRK11742
- BioCyc:   BAPH372461:BCC_099-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01359
- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01961
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 66850; Mature: 66850

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSLFKLFGKENFFIQDSYLESPILWIDSTILIQVIGFLKKNNTCSYEILFDLFGIDER
CHHHHHHHHCCCCEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCCCEEEEHHHCCCHH
TRKNVKSFPNADFTVSYYFFSISNNSDLILKVALLKEHLQLPTISSIFLNANWYEREIWD
HHHHHHHCCCCCEEEEEEEEEECCCCCEEEEEHHHHHHHCCCCHHHEEECCCCHHHHHHH
MFGIVFNNHPYLTRILMPKNWVGHPLRKDYSSHATEFDEFYFTKQKEDLAMESLKFCPKS
HHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHCHHH
WGLENNDSNNSEYMFLNFGPNHPSSHGAFRIVLQLHGEKIINCIPDIGYHHRGAEKIAER
CCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCHHHHHHH
QTWHSYIPYTDRIEYLGGCVNEMPYILAVEKLAGIVVPEKVQVIRILLSELFRINSHLLF
HHHHHCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHH
LSTFIQDIGSMSTVFLAFTDRQKIYDLIESITGARMHPAWFRIGGVAKDLPKNWNSLLKK
HHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
FLIWMPKRLDYYVNIAIKNKILISRSKGIAAYGKKEALSWGITGAGLRATGVNFDVRKNR
HHHHCCCCCCEEEEEEEECEEEEEECCCCCCCCCHHHHCCCCCCCCCEEECCCEEEECCC
PYSGYQNFDFEVPIGNNISDAYTRVLLKIEEIRQSLKILNQCLLHMPLGSYKSDHPLSTP
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QKKNKSLFHIERMITHFLQMSWGPIIPSNESFQMIEATKGINSYYLISDGLTTSYRTRIR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHCC
TPSFAHLQQIPSVIRGYVISDLIVYLGSIDFVMSDVDR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MILSLFKLFGKENFFIQDSYLESPILWIDSTILIQVIGFLKKNNTCSYEILFDLFGIDER
CHHHHHHHHCCCCEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCCCEEEEHHHCCCHH
TRKNVKSFPNADFTVSYYFFSISNNSDLILKVALLKEHLQLPTISSIFLNANWYEREIWD
HHHHHHHCCCCCEEEEEEEEEECCCCCEEEEEHHHHHHHCCCCHHHEEECCCCHHHHHHH
MFGIVFNNHPYLTRILMPKNWVGHPLRKDYSSHATEFDEFYFTKQKEDLAMESLKFCPKS
HHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHCHHH
WGLENNDSNNSEYMFLNFGPNHPSSHGAFRIVLQLHGEKIINCIPDIGYHHRGAEKIAER
CCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCHHHHHHHCCCCCCCCCHHHHHHH
QTWHSYIPYTDRIEYLGGCVNEMPYILAVEKLAGIVVPEKVQVIRILLSELFRINSHLLF
HHHHHCCCCHHHHHHHHHHHHHCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHH
LSTFIQDIGSMSTVFLAFTDRQKIYDLIESITGARMHPAWFRIGGVAKDLPKNWNSLLKK
HHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHHH
FLIWMPKRLDYYVNIAIKNKILISRSKGIAAYGKKEALSWGITGAGLRATGVNFDVRKNR
HHHHCCCCCCEEEEEEEECEEEEEECCCCCCCCCHHHHCCCCCCCCCEEECCCEEEECCC
PYSGYQNFDFEVPIGNNISDAYTRVLLKIEEIRQSLKILNQCLLHMPLGSYKSDHPLSTP
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
QKKNKSLFHIERMITHFLQMSWGPIIPSNESFQMIEATKGINSYYLISDGLTTSYRTRIR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHCC
TPSFAHLQQIPSVIRGYVISDLIVYLGSIDFVMSDVDR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA