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The map label for this gene is hisB [H]

Identifier: 116515008

GI number: 116515008

Start: 73488

End: 74555

Strand: Direct

Name: hisB [H]

Synonym: BCc_066

Alternate gene names: 116515008

Gene position: 73488-74555 (Clockwise)

Preceding gene: 116515007

Following gene: 116515009

Centisome position: 17.65

GC content: 22.47

Gene sequence:

>1068_bases
ATGAAAAAAAAATTTTTATTTATTGATCGTGATGGTACTTTAATTAAAGAGCCTAAAAAAACATTTCAAATTGATTCTTT
AAACAAATTTTTTTTAGAAAGAAATGTTATTTCATCTCTTTTAAAATTAATTCATTTAGACTATCAATTAGTTATGATTA
CTAATCAGGATGGATTAGGTAGTTCGTCTTTTCCAATTAGTAAATTTAGTAAAATACAAAATTTAATGTTAAATATTTTT
TCTTCTGAAAATATTTTTTTTAAAACTATTTTAATTTGCCCACATTTTCTTAATAATTATTGTAACTGTAGAAAACCAAA
TATTTCTTTAGTTCAAAATTTAATAAATGATATTGAATTTGATAAGAAAAATAGTTATGTAATTGGAGATAGAGATACTG
ATATACAACTAGCTAAAAATATAGGAATTAAAAGTTTTTTGTATCATTCAAAATATTTTACTTGGAAAGATATTGTTAAA
AAATTGACTTACCCTAATCGTATATCAGAAATTTCAAGAAATACATTAGAAACAAAAATATTTGTTAAAATAAGTTTAGA
TTTCCCCATTAAGAATTATATTTTTACTGGAATTAATTTTTTAAATCATATGCTTGATCAAATTAGAATACATAGTGGAA
TTTTTATGTATATTAATGTTATTGGAGATTTATCAATTGATGATCATCATACAATAGAAGATCTTGGAATAACACTAGGT
TTAGCTTTAAAAAAAGCTATTGGAAATAAAATTGGTATTGCAAGATATGGTTTTACTTTACCTATGGATGAAAGTATTTG
TTCTTGTATTATTGATTTATCCGGTCGTTCATTTTTATCTTTTTATACAAACTTTAAATATAAATATATTGGTGATTTGA
ATGCATGTATGATTGAGCATTTTTTTTATTCTTTAAGTCAATCTATGAAAGCTACAATTCATTTACACGCTACTGGAAAA
AATGATCATCATTGTGCAGAAAGTTTATTTAAAGCATTTGGACGTGCTTTAAAACAAGCTATTTTTTTAGAAGGAACTAT
TTTACCGACATCAAAAGGTTTATTTTAA

Upstream 100 bases:

>100_bases
AACTTAGGTTTAAAAAATTGTTTAAGAATATCTATAGGCACCATTCATGAATGTCAAGAATTAATTAATGTTTTATCTAT
ATATAAAGGAAAAATATAAG

Downstream 100 bases:

>100_bases
ATGTCTATTGTAATTATTAATACTGGTTGTTCTAATCTTTTTTCACTGTATAGTTCTATTAAAAGATTAGGTTATAATGT
TAATGTTACTGATTCAATAT

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKKKFLFIDRDGTLIKEPKKTFQIDSLNKFFLERNVISSLLKLIHLDYQLVMITNQDGLGSSSFPISKFSKIQNLMLNIF
SSENIFFKTILICPHFLNNYCNCRKPNISLVQNLINDIEFDKKNSYVIGDRDTDIQLAKNIGIKSFLYHSKYFTWKDIVK
KLTYPNRISEISRNTLETKIFVKISLDFPIKNYIFTGINFLNHMLDQIRIHSGIFMYINVIGDLSIDDHHTIEDLGITLG
LALKKAIGNKIGIARYGFTLPMDESICSCIIDLSGRSFLSFYTNFKYKYIGDLNACMIEHFFYSLSQSMKATIHLHATGK
NDHHCAESLFKAFGRALKQAIFLEGTILPTSKGLF

Sequences:

>Translated_355_residues
MKKKFLFIDRDGTLIKEPKKTFQIDSLNKFFLERNVISSLLKLIHLDYQLVMITNQDGLGSSSFPISKFSKIQNLMLNIF
SSENIFFKTILICPHFLNNYCNCRKPNISLVQNLINDIEFDKKNSYVIGDRDTDIQLAKNIGIKSFLYHSKYFTWKDIVK
KLTYPNRISEISRNTLETKIFVKISLDFPIKNYIFTGINFLNHMLDQIRIHSGIFMYINVIGDLSIDDHHTIEDLGITLG
LALKKAIGNKIGIARYGFTLPMDESICSCIIDLSGRSFLSFYTNFKYKYIGDLNACMIEHFFYSLSQSMKATIHLHATGK
NDHHCAESLFKAFGRALKQAIFLEGTILPTSKGLF
>Mature_355_residues
MKKKFLFIDRDGTLIKEPKKTFQIDSLNKFFLERNVISSLLKLIHLDYQLVMITNQDGLGSSSFPISKFSKIQNLMLNIF
SSENIFFKTILICPHFLNNYCNCRKPNISLVQNLINDIEFDKKNSYVIGDRDTDIQLAKNIGIKSFLYHSKYFTWKDIVK
KLTYPNRISEISRNTLETKIFVKISLDFPIKNYIFTGINFLNHMLDQIRIHSGIFMYINVIGDLSIDDHHTIEDLGITLG
LALKKAIGNKIGIARYGFTLPMDESICSCIIDLSGRSFLSFYTNFKYKYIGDLNACMIEHFFYSLSQSMKATIHLHATGK
NDHHCAESLFKAFGRALKQAIFLEGTILPTSKGLF

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=53.2394366197183, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1786399, Length=158, Percent_Identity=27.2151898734177, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324776, Length=212, Percent_Identity=37.7358490566038, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 40832; Mature: 40832

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKFLFIDRDGTLIKEPKKTFQIDSLNKFFLERNVISSLLKLIHLDYQLVMITNQDGLG
CCCEEEEEECCCCEECCCHHHEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
SSSFPISKFSKIQNLMLNIFSSENIFFKTILICPHFLNNYCNCRKPNISLVQNLINDIEF
CCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
DKKNSYVIGDRDTDIQLAKNIGIKSFLYHSKYFTWKDIVKKLTYPNRISEISRNTLETKI
CCCCCEEECCCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHCCCCEEE
FVKISLDFPIKNYIFTGINFLNHMLDQIRIHSGIFMYINVIGDLSIDDHHTIEDLGITLG
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHH
LALKKAIGNKIGIARYGFTLPMDESICSCIIDLSGRSFLSFYTNFKYKYIGDLNACMIEH
HHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEECCHHHHHHHH
FFYSLSQSMKATIHLHATGKNDHHCAESLFKAFGRALKQAIFLEGTILPTSKGLF
HHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCC
>Mature Secondary Structure
MKKKFLFIDRDGTLIKEPKKTFQIDSLNKFFLERNVISSLLKLIHLDYQLVMITNQDGLG
CCCEEEEEECCCCEECCCHHHEEECCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCC
SSSFPISKFSKIQNLMLNIFSSENIFFKTILICPHFLNNYCNCRKPNISLVQNLINDIEF
CCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCC
DKKNSYVIGDRDTDIQLAKNIGIKSFLYHSKYFTWKDIVKKLTYPNRISEISRNTLETKI
CCCCCEEECCCCCCHHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHCCCCEEE
FVKISLDFPIKNYIFTGINFLNHMLDQIRIHSGIFMYINVIGDLSIDDHHTIEDLGITLG
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHH
LALKKAIGNKIGIARYGFTLPMDESICSCIIDLSGRSFLSFYTNFKYKYIGDLNACMIEH
HHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEECCHHHHHHHH
FFYSLSQSMKATIHLHATGKNDHHCAESLFKAFGRALKQAIFLEGTILPTSKGLF
HHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767718; 12089438 [H]