Click here to switch to the map view.

The map label for this gene is hisC

Identifier: 116515007

GI number: 116515007

Start: 72425

End: 73486

Strand: Direct

Name: hisC

Synonym: BCc_065

Alternate gene names: 116515007

Gene position: 72425-73486 (Clockwise)

Preceding gene: 116515006

Following gene: 116515008

Centisome position: 17.39

GC content: 19.87

Gene sequence:

>1062_bases
ATGAAAAGATTAATTCCAAAACATATAAGTATTTTAAAACCATATCAATCAGCACGTCGTATCGGAATACAAGGGCGTAT
TTATTTAAATGCTAATGAATCTCCATGGATAAATAATATTCAATATAAATTTAATAATTTAAATCGATATCCAGAATTTC
AACCATATAAATTATTAAAAAAATATTCTCTATATTCCGGAGTACCTATTAATCAAATTTTAATAACTAGAGGTGCTGAT
GAAGGAATTGAAATTATAACTCGTACTTTTTGTGAATCTAATATTGATAAGATTATGTTTTTTCCACCTACTTATGATAT
GTATAATGTAATTGCTAATATTTTTAATATTAAAAAAATTATTATTCCGATTTTATCTAATTTTCAATTAGATATAAAAA
ATATAAAAAAAAAAATTAATAATGTTAAAATTATTTATATTTGTTATCCGAATAATCCTACTGGTAATTTTTTTTCACGC
AATAAAATTATCAGAATTATTAATTCAGTTTCTAAAACTACTTTAATCGTTATTGATGAAGCATATATTGATTTTTCTAT
TAAATATAGTTTTGTTTCCGAATTAAATAATTTTGATAATTTAATTATTTTAAGAACTTTATCTAAATCATTTGGTTTAT
CTGCTATTCGGTGCGGTTTTGTTTTATCTAATGTTAAAATTATTAAAATTTTAAAAAAAGTATTAGCTCCTTATCCTATA
TCTATACCTGTATCTGATATTGCTATACAATCTTTATGTTCTCAAAATATTTTTTTAATGCAAAAAAATATATTAAGAAT
TTTAAAAAATAAAAAATTTTTAATTGATCAATTAAAAAAAATTTCATATATAAAAAATATTTTTCATAGTGAAGCAAATT
TTATTCTTATAAAATTTGCTGAATCTAAAACTATTTTTAAATATTTAATATCTAAAGGAATTATAGTCCGTGATCAATCA
CATAACTTAGGTTTAAAAAATTGTTTAAGAATATCTATAGGCACCATTCATGAATGTCAAGAATTAATTAATGTTTTATC
TATATATAAAGGAAAAATATAA

Upstream 100 bases:

>100_bases
TATCTCTTATGGAAGGAATGAATGCTCATAATCAATCAATAGTAACTAGAATAAAATTTTTATAAAAATAAAAATTTTAT
TATGTAAGAGTCACAATAAT

Downstream 100 bases:

>100_bases
GATGAAAAAAAAATTTTTATTTATTGATCGTGATGGTACTTTAATTAAAGAGCCTAAAAAAACATTTCAAATTGATTCTT
TAAACAAATTTTTTTTAGAA

Product: hypothetical protein

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKRLIPKHISILKPYQSARRIGIQGRIYLNANESPWINNIQYKFNNLNRYPEFQPYKLLKKYSLYSGVPINQILITRGAD
EGIEIITRTFCESNIDKIMFFPPTYDMYNVIANIFNIKKIIIPILSNFQLDIKNIKKKINNVKIIYICYPNNPTGNFFSR
NKIIRIINSVSKTTLIVIDEAYIDFSIKYSFVSELNNFDNLIILRTLSKSFGLSAIRCGFVLSNVKIIKILKKVLAPYPI
SIPVSDIAIQSLCSQNIFLMQKNILRILKNKKFLIDQLKKISYIKNIFHSEANFILIKFAESKTIFKYLISKGIIVRDQS
HNLGLKNCLRISIGTIHECQELINVLSIYKGKI

Sequences:

>Translated_353_residues
MKRLIPKHISILKPYQSARRIGIQGRIYLNANESPWINNIQYKFNNLNRYPEFQPYKLLKKYSLYSGVPINQILITRGAD
EGIEIITRTFCESNIDKIMFFPPTYDMYNVIANIFNIKKIIIPILSNFQLDIKNIKKKINNVKIIYICYPNNPTGNFFSR
NKIIRIINSVSKTTLIVIDEAYIDFSIKYSFVSELNNFDNLIILRTLSKSFGLSAIRCGFVLSNVKIIKILKKVLAPYPI
SIPVSDIAIQSLCSQNIFLMQKNILRILKNKKFLIDQLKKISYIKNIFHSEANFILIKFAESKTIFKYLISKGIIVRDQS
HNLGLKNCLRISIGTIHECQELINVLSIYKGKI
>Mature_353_residues
MKRLIPKHISILKPYQSARRIGIQGRIYLNANESPWINNIQYKFNNLNRYPEFQPYKLLKKYSLYSGVPINQILITRGAD
EGIEIITRTFCESNIDKIMFFPPTYDMYNVIANIFNIKKIIIPILSNFQLDIKNIKKKINNVKIIYICYPNNPTGNFFSR
NKIIRIINSVSKTTLIVIDEAYIDFSIKYSFVSELNNFDNLIILRTLSKSFGLSAIRCGFVLSNVKIIKILKKVLAPYPI
SIPVSDIAIQSLCSQNIFLMQKNILRILKNKKFLIDQLKKISYIKNIFHSEANFILIKFAESKTIFKYLISKGIIVRDQS
HNLGLKNCLRISIGTIHECQELINVLSIYKGKI

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=343, Percent_Identity=43.731778425656, Blast_Score=335, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6322075, Length=373, Percent_Identity=31.0991957104558, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BUCCC (Q058A6)

Other databases:

- EMBL:   CP000263
- RefSeq:   YP_802636.1
- ProteinModelPortal:   Q058A6
- SMR:   Q058A6
- STRING:   Q058A6
- EnsemblBacteria:   EBBUCT00000001222
- GeneID:   4440769
- GenomeReviews:   CP000263_GR
- KEGG:   bcc:BCc_065
- eggNOG:   COG0079
- GeneTree:   EBGT00050000007997
- HOGENOM:   HBG646350
- OMA:   FKTLWDQ
- BioCyc:   BAPH372461:BCC_065-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40901; Mature: 40901

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLIPKHISILKPYQSARRIGIQGRIYLNANESPWINNIQYKFNNLNRYPEFQPYKLLK
CCCCCHHHHHHHCCHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
KYSLYSGVPINQILITRGADEGIEIITRTFCESNIDKIMFFPPTYDMYNVIANIFNIKKI
HHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHH
IIPILSNFQLDIKNIKKKINNVKIIYICYPNNPTGNFFSRNKIIRIINSVSKTTLIVIDE
HHHHHCCCEEHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEEE
AYIDFSIKYSFVSELNNFDNLIILRTLSKSFGLSAIRCGFVLSNVKIIKILKKVLAPYPI
EEEEEEEEHHHHHHCCCCCCEEEEEEHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCC
SIPVSDIAIQSLCSQNIFLMQKNILRILKNKKFLIDQLKKISYIKNIFHSEANFILIKFA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
ESKTIFKYLISKGIIVRDQSHNLGLKNCLRISIGTIHECQELINVLSIYKGKI
CCHHHHHHHHHCCEEEEECCCCCCHHHHHEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRLIPKHISILKPYQSARRIGIQGRIYLNANESPWINNIQYKFNNLNRYPEFQPYKLLK
CCCCCHHHHHHHCCHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
KYSLYSGVPINQILITRGADEGIEIITRTFCESNIDKIMFFPPTYDMYNVIANIFNIKKI
HHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHH
IIPILSNFQLDIKNIKKKINNVKIIYICYPNNPTGNFFSRNKIIRIINSVSKTTLIVIDE
HHHHHCCCEEHHHHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEEE
AYIDFSIKYSFVSELNNFDNLIILRTLSKSFGLSAIRCGFVLSNVKIIKILKKVLAPYPI
EEEEEEEEHHHHHHCCCCCCEEEEEEHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCC
SIPVSDIAIQSLCSQNIFLMQKNILRILKNKKFLIDQLKKISYIKNIFHSEANFILIKFA
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
ESKTIFKYLISKGIIVRDQSHNLGLKNCLRISIGTIHECQELINVLSIYKGKI
CCHHHHHHHHHCCEEEEECCCCCCHHHHHEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA