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The map label for this gene is hisD [H]

Identifier: 116515006

GI number: 116515006

Start: 71094

End: 72389

Strand: Direct

Name: hisD [H]

Synonym: BCc_064

Alternate gene names: 116515006

Gene position: 71094-72389 (Clockwise)

Preceding gene: 116515005

Following gene: 116515007

Centisome position: 17.07

GC content: 25.15

Gene sequence:

>1296_bases
ATGTTGAATATAAATAAAAATATTTTTTACTGGAATATATTAACTAAAAAAGAAAAAATTCATGTATTATCTCGACCTCA
TATCAATAGTAATAAAAATATTAAAGAATTAGTTTTTAAAATTATAGATAATGTTAAAAAACATGGAGATTTAGCTTTAC
ATTCATATAATTTAGAATTTGATAATTTTAAATGTAAAAGTTTTTATATTTCTAGAAAAAAAATTGACAATTCTTCTAAT
TTAGTATCTAAAAAATTTAAAGATGCTATTTCTATTGCTTTAAGTAATATTAATAATTTTCATTCTAAACAAATTCTTTC
AGATTTAATTGTAGAAACATATCCCGGAGTATATTGTAAACATATATATAGACCAATTCAGTCAGTAGGATTATATGTAC
CTAAAGGAAATCATCCATTAGTTTCTACTGCGTTAATGTTATCTATTCCAGCAAAATTAGCTGGTTGTCATAATATTACA
TTATGTTCTCCGCCTCCTATTAGTAATGAAATTTTATATATTGCTAAGATATTAAAAATTTATACTGTTCTTCAATTGGG
AGGAGCTCATTCTATTGCTGCATTAGCATTAGGTACTGAGACAGTAAAATTTGTAGATAAAATTTTTGGACCGGGTAATA
TTTTTGTTACAGAAGCTAAATTACAAGTTAGTCAATGTTCGTTAACATCTATTGATATGCCTGCAGGCCCTTCTGAAATG
TTAGTAATTGCAGATGATTTATCAAATCCTGCTTTTATTGCTTCAGATTTGCTTTCTCAAGCTGAACACAGTCAAAATTC
ACAAGTAATCTTATTGTGTACAAAAAATTTTATAGTTAAAAATGTTATTAAAGAAATTCAAAAACAATTATTATTAATAC
CTAACAAAAACATTATTTTACATTCTTTAAAAAATAGTAGATTTATTGTTGTTAATTCTTTAAAAGAATGTTTTAAAATA
TCTAATTTATATTCCCCTGAACATCTTATTCTACATATTAAAAATTCAAAGAATTTTTTGAAATATATTAATAATGCGGG
ATCAGTATTTTTAGGAAAGTGGACACCTGGAGCTGCAGGTGATTATATTACAGGAGCCAATCATGTGTTACCCACATATG
GATACGCTAACTCTTATTCTTCTTTACGTGTTTCCGACTTTCAGAAAATAATTACAGTACAAAAAATGACTAAAATAGCA
TTACAATCATTATCAAAGAGTATTGCAACTTTATCTCTTATGGAAGGAATGAATGCTCATAATCAATCAATAGTAACTAG
AATAAAATTTTTATAA

Upstream 100 bases:

>100_bases
AGTGAAATAATTTTCTGGGAAACTATGGAACAATTAAAATCTTTAGGAGCTAGTTCTATTTTGGTATTACCAATAGAAAA
GATGATGGAATGAAATTATT

Downstream 100 bases:

>100_bases
AAATAAAAATTTTATTATGTAAGAGTCACAATAATATGAAAAGATTAATTCCAAAACATATAAGTATTTTAAAACCATAT
CAATCAGCACGTCGTATCGG

Product: hypothetical protein

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLNINKNIFYWNILTKKEKIHVLSRPHINSNKNIKELVFKIIDNVKKHGDLALHSYNLEFDNFKCKSFYISRKKIDNSSN
LVSKKFKDAISIALSNINNFHSKQILSDLIVETYPGVYCKHIYRPIQSVGLYVPKGNHPLVSTALMLSIPAKLAGCHNIT
LCSPPPISNEILYIAKILKIYTVLQLGGAHSIAALALGTETVKFVDKIFGPGNIFVTEAKLQVSQCSLTSIDMPAGPSEM
LVIADDLSNPAFIASDLLSQAEHSQNSQVILLCTKNFIVKNVIKEIQKQLLLIPNKNIILHSLKNSRFIVVNSLKECFKI
SNLYSPEHLILHIKNSKNFLKYINNAGSVFLGKWTPGAAGDYITGANHVLPTYGYANSYSSLRVSDFQKIITVQKMTKIA
LQSLSKSIATLSLMEGMNAHNQSIVTRIKFL

Sequences:

>Translated_431_residues
MLNINKNIFYWNILTKKEKIHVLSRPHINSNKNIKELVFKIIDNVKKHGDLALHSYNLEFDNFKCKSFYISRKKIDNSSN
LVSKKFKDAISIALSNINNFHSKQILSDLIVETYPGVYCKHIYRPIQSVGLYVPKGNHPLVSTALMLSIPAKLAGCHNIT
LCSPPPISNEILYIAKILKIYTVLQLGGAHSIAALALGTETVKFVDKIFGPGNIFVTEAKLQVSQCSLTSIDMPAGPSEM
LVIADDLSNPAFIASDLLSQAEHSQNSQVILLCTKNFIVKNVIKEIQKQLLLIPNKNIILHSLKNSRFIVVNSLKECFKI
SNLYSPEHLILHIKNSKNFLKYINNAGSVFLGKWTPGAAGDYITGANHVLPTYGYANSYSSLRVSDFQKIITVQKMTKIA
LQSLSKSIATLSLMEGMNAHNQSIVTRIKFL
>Mature_431_residues
MLNINKNIFYWNILTKKEKIHVLSRPHINSNKNIKELVFKIIDNVKKHGDLALHSYNLEFDNFKCKSFYISRKKIDNSSN
LVSKKFKDAISIALSNINNFHSKQILSDLIVETYPGVYCKHIYRPIQSVGLYVPKGNHPLVSTALMLSIPAKLAGCHNIT
LCSPPPISNEILYIAKILKIYTVLQLGGAHSIAALALGTETVKFVDKIFGPGNIFVTEAKLQVSQCSLTSIDMPAGPSEM
LVIADDLSNPAFIASDLLSQAEHSQNSQVILLCTKNFIVKNVIKEIQKQLLLIPNKNIILHSLKNSRFIVVNSLKECFKI
SNLYSPEHLILHIKNSKNFLKYINNAGSVFLGKWTPGAAGDYITGANHVLPTYGYANSYSSLRVSDFQKIITVQKMTKIA
LQSLSKSIATLSLMEGMNAHNQSIVTRIKFL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=47.887323943662, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319819, Length=437, Percent_Identity=40.5034324942792, Blast_Score=335, Evalue=9e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48068; Mature: 48068

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNINKNIFYWNILTKKEKIHVLSRPHINSNKNIKELVFKIIDNVKKHGDLALHSYNLEF
CCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCC
DNFKCKSFYISRKKIDNSSNLVSKKFKDAISIALSNINNFHSKQILSDLIVETYPGVYCK
CCEEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
HIYRPIQSVGLYVPKGNHPLVSTALMLSIPAKLAGCHNITLCSPPPISNEILYIAKILKI
HHHHHHHHCEEEECCCCCCHHHHHHHHHCCHHHCCCCEEEECCCCCCCCHHHHHHHHHHH
YTVLQLGGAHSIAALALGTETVKFVDKIFGPGNIFVTEAKLQVSQCSLTSIDMPAGPSEM
HHHHHCCCCCHHHHHHHCHHHHHHHHHHCCCCCEEEEEEEEEEECCCEEECCCCCCCCCE
LVIADDLSNPAFIASDLLSQAEHSQNSQVILLCTKNFIVKNVIKEIQKQLLLIPNKNIIL
EEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHEEECCCCCEEE
HSLKNSRFIVVNSLKECFKISNLYSPEHLILHIKNSKNFLKYINNAGSVFLGKWTPGAAG
EECCCCCEEEEHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCCCCEEEECCCCCCCC
DYITGANHVLPTYGYANSYSSLRVSDFQKIITVQKMTKIALQSLSKSIATLSLMEGMNAH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NQSIVTRIKFL
CHHHHHHEECC
>Mature Secondary Structure
MLNINKNIFYWNILTKKEKIHVLSRPHINSNKNIKELVFKIIDNVKKHGDLALHSYNLEF
CCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCC
DNFKCKSFYISRKKIDNSSNLVSKKFKDAISIALSNINNFHSKQILSDLIVETYPGVYCK
CCEEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
HIYRPIQSVGLYVPKGNHPLVSTALMLSIPAKLAGCHNITLCSPPPISNEILYIAKILKI
HHHHHHHHCEEEECCCCCCHHHHHHHHHCCHHHCCCCEEEECCCCCCCCHHHHHHHHHHH
YTVLQLGGAHSIAALALGTETVKFVDKIFGPGNIFVTEAKLQVSQCSLTSIDMPAGPSEM
HHHHHCCCCCHHHHHHHCHHHHHHHHHHCCCCCEEEEEEEEEEECCCEEECCCCCCCCCE
LVIADDLSNPAFIASDLLSQAEHSQNSQVILLCTKNFIVKNVIKEIQKQLLLIPNKNIIL
EEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHEEECCCCCEEE
HSLKNSRFIVVNSLKECFKISNLYSPEHLILHIKNSKNFLKYINNAGSVFLGKWTPGAAG
EECCCCCEEEEHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCCCCEEEECCCCCCCC
DYITGANHVLPTYGYANSYSSLRVSDFQKIITVQKMTKIALQSLSKSIATLSLMEGMNAH
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NQSIVTRIKFL
CHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796 [H]