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The map label for this gene is hisG [H]

Identifier: 116515005

GI number: 116515005

Start: 70187

End: 71086

Strand: Direct

Name: hisG [H]

Synonym: BCc_063

Alternate gene names: 116515005

Gene position: 70187-71086 (Clockwise)

Preceding gene: 116515004

Following gene: 116515006

Centisome position: 16.86

GC content: 26.33

Gene sequence:

>900_bases
TTGAATAAAAATCGTATACGTTTAGCAATACAAAAATCTGGTAGATTAAGTTATGATTCACAAAATTTATTAAAAAGTTG
TGGAGTTAAAGTTAATTTACAAAAATCTAGTTTAATTGCATTTGCTGAAAATATGCCAATTGATGTTATGTTAGTTCGTG
ATGATGATATTCCTGGTTTAATTATGGATGGTGTAGTAGAATTAGGAATTATCGGTTTGAATGTTTTAGAAGAAAAACGT
TTAACTAGATTATTTTCAGAAGAAACAGTTTCATATGCTATTTTACAAAATCTTGATTTTGGTATTTGTCGTTTATCATT
ATCAGTTCCTTTTGATATGAAATATTCTGGAATTTTATGTTTAAAAAATTCTCGTATTGCGACTTCATATCCAAATTTAT
TAAAAAGATATTTTGATAAAAAAAATATTCCTTTTAAACCTTTTGTATTAAATGGTTCTGTAGAAGTTGCTTATAATTCT
GGTTTATCTGATGCTATTTGTGATTTAGTTTCCACTGGAGCAACATTAGAAGCTAATGGATTAAGAGAAGTAGAAACAAT
TTATAATTCTCGAGCATGTTTGATTTCTCGTGAAGAAAAATATATGATACCTGAAAAAAGACATTTTATTAAAAAATTAT
TAAATCGTATTCAAGGTGTTATTAAAGCTCGAGAATCAAAATATATTATGTTACATATTGAAAAGAGTAAGTTAAATAAA
GTAACTGATTTATTAAAAGGTGCAGAAAGACCGACGATTTTAGAATTATTCGGTAATCCAGATAAAGTAGCATTACATAT
GGTTAGTAGTGAAATAATTTTCTGGGAAACTATGGAACAATTAAAATCTTTAGGAGCTAGTTCTATTTTGGTATTACCAA
TAGAAAAGATGATGGAATGA

Upstream 100 bases:

>100_bases
TATTTATAGTGTAATAAATAATTTTTATTAATTTATTTATTATAAATATAATATTATTTCTGTATTAAATTTATTTTTTA
TAGTAAATAAGGTAATAAAA

Downstream 100 bases:

>100_bases
AATTATTATGTTGAATATAAATAAAAATATTTTTTACTGGAATATATTAACTAAAAAAGAAAAAATTCATGTATTATCTC
GACCTCATATCAATAGTAAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNKNRIRLAIQKSGRLSYDSQNLLKSCGVKVNLQKSSLIAFAENMPIDVMLVRDDDIPGLIMDGVVELGIIGLNVLEEKR
LTRLFSEETVSYAILQNLDFGICRLSLSVPFDMKYSGILCLKNSRIATSYPNLLKRYFDKKNIPFKPFVLNGSVEVAYNS
GLSDAICDLVSTGATLEANGLREVETIYNSRACLISREEKYMIPEKRHFIKKLLNRIQGVIKARESKYIMLHIEKSKLNK
VTDLLKGAERPTILELFGNPDKVALHMVSSEIIFWETMEQLKSLGASSILVLPIEKMME

Sequences:

>Translated_299_residues
MNKNRIRLAIQKSGRLSYDSQNLLKSCGVKVNLQKSSLIAFAENMPIDVMLVRDDDIPGLIMDGVVELGIIGLNVLEEKR
LTRLFSEETVSYAILQNLDFGICRLSLSVPFDMKYSGILCLKNSRIATSYPNLLKRYFDKKNIPFKPFVLNGSVEVAYNS
GLSDAICDLVSTGATLEANGLREVETIYNSRACLISREEKYMIPEKRHFIKKLLNRIQGVIKARESKYIMLHIEKSKLNK
VTDLLKGAERPTILELFGNPDKVALHMVSSEIIFWETMEQLKSLGASSILVLPIEKMME
>Mature_299_residues
MNKNRIRLAIQKSGRLSYDSQNLLKSCGVKVNLQKSSLIAFAENMPIDVMLVRDDDIPGLIMDGVVELGIIGLNVLEEKR
LTRLFSEETVSYAILQNLDFGICRLSLSVPFDMKYSGILCLKNSRIATSYPNLLKRYFDKKNIPFKPFVLNGSVEVAYNS
GLSDAICDLVSTGATLEANGLREVETIYNSRACLISREEKYMIPEKRHFIKKLLNRIQGVIKARESKYIMLHIEKSKLNK
VTDLLKGAERPTILELFGNPDKVALHMVSSEIIFWETMEQLKSLGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=298, Percent_Identity=65.7718120805369, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320896, Length=297, Percent_Identity=28.2828282828283, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 33782; Mature: 33782

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNRIRLAIQKSGRLSYDSQNLLKSCGVKVNLQKSSLIAFAENMPIDVMLVRDDDIPGL
CCCCEEEEEEEECCCCCCCHHHHHHHCCCEEEEEHHHEEEEECCCCEEEEEEECCCCCCH
IMDGVVELGIIGLNVLEEKRLTRLFSEETVSYAILQNLDFGICRLSLSVPFDMKYSGILC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEE
LKNSRIATSYPNLLKRYFDKKNIPFKPFVLNGSVEVAYNSGLSDAICDLVSTGATLEANG
EECCCCCCCCHHHHHHHHCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCEEECCC
LREVETIYNSRACLISREEKYMIPEKRHFIKKLLNRIQGVIKARESKYIMLHIEKSKLNK
CHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHH
VTDLLKGAERPTILELFGNPDKVALHMVSSEIIFWETMEQLKSLGASSILVLPIEKMME
HHHHHHCCCCCEEEEECCCCCCEEEEEHHCCEEHHHHHHHHHHCCCCEEEEEEHHHHCC
>Mature Secondary Structure
MNKNRIRLAIQKSGRLSYDSQNLLKSCGVKVNLQKSSLIAFAENMPIDVMLVRDDDIPGL
CCCCEEEEEEEECCCCCCCHHHHHHHCCCEEEEEHHHEEEEECCCCEEEEEEECCCCCCH
IMDGVVELGIIGLNVLEEKRLTRLFSEETVSYAILQNLDFGICRLSLSVPFDMKYSGILC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEE
LKNSRIATSYPNLLKRYFDKKNIPFKPFVLNGSVEVAYNSGLSDAICDLVSTGATLEANG
EECCCCCCCCHHHHHHHHCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHHCCCEEECCC
LREVETIYNSRACLISREEKYMIPEKRHFIKKLLNRIQGVIKARESKYIMLHIEKSKLNK
CHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHH
VTDLLKGAERPTILELFGNPDKVALHMVSSEIIFWETMEQLKSLGASSILVLPIEKMME
HHHHHHCCCCCEEEEECCCCCCEEEEEHHCCEEHHHHHHHHHHCCCCEEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]