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The map label for this gene is fabG [C]

Identifier: 116328424

GI number: 116328424

Start: 2055852

End: 2056592

Strand: Direct

Name: fabG [C]

Synonym: LBL_1765

Alternate gene names: 116328424

Gene position: 2055852-2056592 (Clockwise)

Preceding gene: 116328423

Following gene: 116328425

Centisome position: 56.88

GC content: 45.48

Gene sequence:

>741_bases
ATGGCAAAAAAAATCGTCGTCGTCGGTGCATCTAGCGGTATCGGAAAAGAATTAGCGATTCTCCTTTTGGAACAAGGACA
TACGGTCACTCTCGTAGCCCGTCGTGATAAGGAATTGAAGGCAATCGCAGCTCCGTTTAATTCTCCCGGTAAAACAAACG
CATTCGTTATCAAACAAGACGTCACCAACTTTGATCAAGTCGACTCCGCGTTTCAAAAAGCGGTCAAATCCATGAAAGGT
GTCGACGAGATTTATTACGCTTCCGGAATTATGTACGACGTGAAACCGGATGAGTTCGATGTTACAAAAGACATCGCCAT
GTTAAATACAAATCTTCTGGGTTGTGTGGCATGGCTCAATCTCGCAGCAGTCCTTTTTCAAAAACAAAAAAGCGGAAAGA
TCATCGGGATCTCTTCGATCGCAGGAGATCGTGGAAGAAGAGGCAATCCCGTTTATAATACTTCCAAAGCGGGAATGAAC
ACGTATCTCGAAGCTCTTCGAAATCGTCTTTCGACGTTAGGTGTTCAAGTTCTCACCGTAAAACCCGGCTTTATCGATAC
TGCCATGACCCGAGGTATGAAAGGTCTTTTCTGGCTTATCTCGGCCAAAGAAGCGGCGACTATCATCGTCAAGGCGGCAG
ACTCCGGCAAAGAATGTGTCTACGTTCCGGCCCGCTGGGGACTCGTGGGTTTGATTATCCGTTTGATTCCATCTTTTCTT
TTTAAACGTCTTTCTATTTGA

Upstream 100 bases:

>100_bases
GCTAGTAGTTCCTGCAACTCTAAAGTTTTGGGGTAAGTTCATTCTATCTTCCTTCAAATCATACTTGTCAGTTCCGTTTC
TTTCCATAGAACGGATGAAT

Downstream 100 bases:

>100_bases
ACGAACCTGAATCGATCAAAGGTAATACTATGGCAAAGGCATCCAAAGTTTCTCCGAAAAAGAAAACTTCCGCAAAAACT
TCGAAAACGGCAAAAGTAAA

Product: Short chain dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MAKKIVVVGASSGIGKELAILLLEQGHTVTLVARRDKELKAIAAPFNSPGKTNAFVIKQDVTNFDQVDSAFQKAVKSMKG
VDEIYYASGIMYDVKPDEFDVTKDIAMLNTNLLGCVAWLNLAAVLFQKQKSGKIIGISSIAGDRGRRGNPVYNTSKAGMN
TYLEALRNRLSTLGVQVLTVKPGFIDTAMTRGMKGLFWLISAKEAATIIVKAADSGKECVYVPARWGLVGLIIRLIPSFL
FKRLSI

Sequences:

>Translated_246_residues
MAKKIVVVGASSGIGKELAILLLEQGHTVTLVARRDKELKAIAAPFNSPGKTNAFVIKQDVTNFDQVDSAFQKAVKSMKG
VDEIYYASGIMYDVKPDEFDVTKDIAMLNTNLLGCVAWLNLAAVLFQKQKSGKIIGISSIAGDRGRRGNPVYNTSKAGMN
TYLEALRNRLSTLGVQVLTVKPGFIDTAMTRGMKGLFWLISAKEAATIIVKAADSGKECVYVPARWGLVGLIIRLIPSFL
FKRLSI
>Mature_245_residues
AKKIVVVGASSGIGKELAILLLEQGHTVTLVARRDKELKAIAAPFNSPGKTNAFVIKQDVTNFDQVDSAFQKAVKSMKGV
DEIYYASGIMYDVKPDEFDVTKDIAMLNTNLLGCVAWLNLAAVLFQKQKSGKIIGISSIAGDRGRRGNPVYNTSKAGMNT
YLEALRNRLSTLGVQVLTVKPGFIDTAMTRGMKGLFWLISAKEAATIIVKAADSGKECVYVPARWGLVGLIIRLIPSFLF
KRLSI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=197, Percent_Identity=31.4720812182741, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503817, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI20149619, Length=191, Percent_Identity=26.1780104712042, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI32455239, Length=247, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI5031765, Length=247, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1787335, Length=196, Percent_Identity=29.5918367346939, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=196, Percent_Identity=31.1224489795918, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571387, Length=194, Percent_Identity=31.4432989690722, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571526, Length=185, Percent_Identity=28.6486486486486, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=194, Percent_Identity=28.3505154639175, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358495, Length=193, Percent_Identity=27.4611398963731, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24649181, Length=247, Percent_Identity=26.7206477732794, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26715; Mature: 26584

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKIVVVGASSGIGKELAILLLEQGHTVTLVARRDKELKAIAAPFNSPGKTNAFVIKQD
CCCEEEEEECCCCCCHHEEEEEEECCCEEEEEEECCCCHHEEECCCCCCCCCCEEEEECC
VTNFDQVDSAFQKAVKSMKGVDEIYYASGIMYDVKPDEFDVTKDIAMLNTNLLGCVAWLN
CCCHHHHHHHHHHHHHHHCCHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LAAVLFQKQKSGKIIGISSIAGDRGRRGNPVYNTSKAGMNTYLEALRNRLSTLGVQVLTV
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEE
KPGFIDTAMTRGMKGLFWLISAKEAATIIVKAADSGKECVYVPARWGLVGLIIRLIPSFL
CCCCHHHHHHCCCCCEEEEEECCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHH
FKRLSI
HHHHCC
>Mature Secondary Structure 
AKKIVVVGASSGIGKELAILLLEQGHTVTLVARRDKELKAIAAPFNSPGKTNAFVIKQD
CCEEEEEECCCCCCHHEEEEEEECCCEEEEEEECCCCHHEEECCCCCCCCCCEEEEECC
VTNFDQVDSAFQKAVKSMKGVDEIYYASGIMYDVKPDEFDVTKDIAMLNTNLLGCVAWLN
CCCHHHHHHHHHHHHHHHCCHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LAAVLFQKQKSGKIIGISSIAGDRGRRGNPVYNTSKAGMNTYLEALRNRLSTLGVQVLTV
HHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEE
KPGFIDTAMTRGMKGLFWLISAKEAATIIVKAADSGKECVYVPARWGLVGLIIRLIPSFL
CCCCHHHHHHCCCCCEEEEEECCCEEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHH
FKRLSI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]