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The map label for this gene is dprE1 [H]

Identifier: 116328425

GI number: 116328425

Start: 2056622

End: 2058118

Strand: Direct

Name: dprE1 [H]

Synonym: LBL_1766

Alternate gene names: 116328425

Gene position: 2056622-2058118 (Clockwise)

Preceding gene: 116328424

Following gene: 116328426

Centisome position: 56.9

GC content: 41.75

Gene sequence:

>1497_bases
ATGGCAAAGGCATCCAAAGTTTCTCCGAAAAAGAAAACTTCCGCAAAAACTTCGAAAACGGCAAAAGTAAAAAAGTCTCC
AATTGAAATAACCCTTCCGCTTCCAAGTAAAGTGGAAACTTGGGGGATGAACCATTATTCGCTTTCTCCCGTCTTCTTTC
CGGAAAAGGAAGAAGACTTTAGGGATCTTTTCTCCTATGCAAACAATAAAGGACTGAAATTGACGCTTCGCGGAGGAGGT
TGCAGTTACGGAGACGCGGCCACAAATACGAAGGGCGTGGTGATCGATATTTCGAAGTATAATCGAATTTTGGAATTTAA
TTCAAAAACGGGGATCATCAAAGCGGAATCCGGAGTTACGATCAAACAACTTTGGGAATTCGGAATCGAAAAAGGTTACT
GGCCTCCGGTCGTAAGCGGAACGATGTTTCCTACTTTAGGCGGCGCCTTATCGATGAACATCCATGGAAAGAATAACTTT
GCGGTGGGTTCGATCGGCGATCACGTCCTTGAATTTACATTTATGACTCCGAACGGAAAAGTCTTCGTCTGTTCCCGTAA
AAAGAATCGGGAACTTTTTTTTGCCGCAATCTCCGGTTTTGGAATGCTCGGAGTTTTTTTGAACATAACGATCCAACTGA
AAGCTATCTACGCGGGAAAAATGAAGGTATGGCCCGTGGTCGGCAAAAATCTGCAGGATATGTTCGACTATTTTGAAAGG
GAATATAAAAGCGCGGACTATCTCGTAGGTTGGATCGATGCATTCGCATCCGGAAATTCTTTAGGAAGAGGACAGATCCA
CAAAGCGGTACATTTGAAAAAAGGAGAAGATCCGGACTTTCCTGAAAATTGTAAATTAGAAAGACAGAATTTACCAAGCA
CATTTCTCGGAATTATCCCTAAATCTTGGATGTGGTTATTCATGATTCCTTTCGCCAACAACTTGGGGATGAGGCTCGTC
AATTTTGCAAAATTCGTTTCCGGTTATTTGACGAATAACAAACCGTATTTTCAAGGTCACGCAGAATATGCGTTTTTATT
GGATTACGTTCCAAACTGGAAGCTCATGTATAAGCCCGGTTCCATGATTCAATACCAGAGTTTCATTCCCAAGGAGAATG
CGGTGGACGCTTTTTGTGAAATTCTAAAGATTTGCCAGAAAAGGAGAATCGTTACCTGGCTTGCCGTATTCAAAAAACAT
AAATCTGATCCTTTTCTTCTCACACACGCATTGGACGGCTATTCGATGGCTATGGATTTTCCAGTGACTTTCGGAAATAG
AAAAAGACTTTGGGAACTCGCGGGCGAGTTAGACGAAATCGTGTTGAAGTTCGGAGGAAAATTCTATTTTGCGAAAGACA
GCACTCTCAGACCGGAAACCGTTCAAAGAGCATTTCCGAAAAAAAATTTGGAGAAGTTTTATTCCTTAAAAAGGAAATTA
GATCCGAAAGGGATTTTAGAAACCGATCTCTACAGAAGAATTACAGGAACCTGGTGA

Upstream 100 bases:

>100_bases
CCCGCTGGGGACTCGTGGGTTTGATTATCCGTTTGATTCCATCTTTTCTTTTTAAACGTCTTTCTATTTGAACGAACCTG
AATCGATCAAAGGTAATACT

Downstream 100 bases:

>100_bases
TTTGTTTTATGAATCGGCTGAATGCGCTCTTGATAGAAATCAAAAAGGATAAGGTTTTCCTATTCCTTTTGGGATTAGGA
GCCTTCTTCCGATTTTTTCG

Product: FAD/FMN-containing dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MAKASKVSPKKKTSAKTSKTAKVKKSPIEITLPLPSKVETWGMNHYSLSPVFFPEKEEDFRDLFSYANNKGLKLTLRGGG
CSYGDAATNTKGVVIDISKYNRILEFNSKTGIIKAESGVTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNNF
AVGSIGDHVLEFTFMTPNGKVFVCSRKKNRELFFAAISGFGMLGVFLNITIQLKAIYAGKMKVWPVVGKNLQDMFDYFER
EYKSADYLVGWIDAFASGNSLGRGQIHKAVHLKKGEDPDFPENCKLERQNLPSTFLGIIPKSWMWLFMIPFANNLGMRLV
NFAKFVSGYLTNNKPYFQGHAEYAFLLDYVPNWKLMYKPGSMIQYQSFIPKENAVDAFCEILKICQKRRIVTWLAVFKKH
KSDPFLLTHALDGYSMAMDFPVTFGNRKRLWELAGELDEIVLKFGGKFYFAKDSTLRPETVQRAFPKKNLEKFYSLKRKL
DPKGILETDLYRRITGTW

Sequences:

>Translated_498_residues
MAKASKVSPKKKTSAKTSKTAKVKKSPIEITLPLPSKVETWGMNHYSLSPVFFPEKEEDFRDLFSYANNKGLKLTLRGGG
CSYGDAATNTKGVVIDISKYNRILEFNSKTGIIKAESGVTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNNF
AVGSIGDHVLEFTFMTPNGKVFVCSRKKNRELFFAAISGFGMLGVFLNITIQLKAIYAGKMKVWPVVGKNLQDMFDYFER
EYKSADYLVGWIDAFASGNSLGRGQIHKAVHLKKGEDPDFPENCKLERQNLPSTFLGIIPKSWMWLFMIPFANNLGMRLV
NFAKFVSGYLTNNKPYFQGHAEYAFLLDYVPNWKLMYKPGSMIQYQSFIPKENAVDAFCEILKICQKRRIVTWLAVFKKH
KSDPFLLTHALDGYSMAMDFPVTFGNRKRLWELAGELDEIVLKFGGKFYFAKDSTLRPETVQRAFPKKNLEKFYSLKRKL
DPKGILETDLYRRITGTW
>Mature_497_residues
AKASKVSPKKKTSAKTSKTAKVKKSPIEITLPLPSKVETWGMNHYSLSPVFFPEKEEDFRDLFSYANNKGLKLTLRGGGC
SYGDAATNTKGVVIDISKYNRILEFNSKTGIIKAESGVTIKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNNFA
VGSIGDHVLEFTFMTPNGKVFVCSRKKNRELFFAAISGFGMLGVFLNITIQLKAIYAGKMKVWPVVGKNLQDMFDYFERE
YKSADYLVGWIDAFASGNSLGRGQIHKAVHLKKGEDPDFPENCKLERQNLPSTFLGIIPKSWMWLFMIPFANNLGMRLVN
FAKFVSGYLTNNKPYFQGHAEYAFLLDYVPNWKLMYKPGSMIQYQSFIPKENAVDAFCEILKICQKRRIVTWLAVFKKHK
SDPFLLTHALDGYSMAMDFPVTFGNRKRLWELAGELDEIVLKFGGKFYFAKDSTLRPETVQRAFPKKNLEKFYSLKRKLD
PKGILETDLYRRITGTW

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 56609; Mature: 56477

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKASKVSPKKKTSAKTSKTAKVKKSPIEITLPLPSKVETWGMNHYSLSPVFFPEKEEDF
CCCCCCCCCCHHCCCCCCHHHEEECCCEEEEECCCCCHHHCCCCCEECCEEECCCCHHHH
RDLFSYANNKGLKLTLRGGGCSYGDAATNTKGVVIDISKYNRILEFNSKTGIIKAESGVT
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHCCEEEEECCCCCEEEECCCCC
IKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNNFAVGSIGDHVLEFTFMTPNGK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCEEEEEEECCCCE
VFVCSRKKNRELFFAAISGFGMLGVFLNITIQLKAIYAGKMKVWPVVGKNLQDMFDYFER
EEEEECCCCCEEEEEEHHCCHHEEEEEEEEEEEEEEEECCEEEEECCCCCHHHHHHHHHH
EYKSADYLVGWIDAFASGNSLGRGQIHKAVHLKKGEDPDFPENCKLERQNLPSTFLGIIP
HHCCCCCEEEHHHHHCCCCCCCCCHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCC
KSWMWLFMIPFANNLGMRLVNFAKFVSGYLTNNKPYFQGHAEYAFLLDYVPNWKLMYKPG
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCCEEEECCC
SMIQYQSFIPKENAVDAFCEILKICQKRRIVTWLAVFKKHKSDPFLLTHALDGYSMAMDF
CCEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEC
PVTFGNRKRLWELAGELDEIVLKFGGKFYFAKDSTLRPETVQRAFPKKNLEKFYSLKRKL
CEEECCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCC
DPKGILETDLYRRITGTW
CCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AKASKVSPKKKTSAKTSKTAKVKKSPIEITLPLPSKVETWGMNHYSLSPVFFPEKEEDF
CCCCCCCCCHHCCCCCCHHHEEECCCEEEEECCCCCHHHCCCCCEECCEEECCCCHHHH
RDLFSYANNKGLKLTLRGGGCSYGDAATNTKGVVIDISKYNRILEFNSKTGIIKAESGVT
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHCCEEEEECCCCCEEEECCCCC
IKQLWEFGIEKGYWPPVVSGTMFPTLGGALSMNIHGKNNFAVGSIGDHVLEFTFMTPNGK
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCEEEEEEECCCCE
VFVCSRKKNRELFFAAISGFGMLGVFLNITIQLKAIYAGKMKVWPVVGKNLQDMFDYFER
EEEEECCCCCEEEEEEHHCCHHEEEEEEEEEEEEEEEECCEEEEECCCCCHHHHHHHHHH
EYKSADYLVGWIDAFASGNSLGRGQIHKAVHLKKGEDPDFPENCKLERQNLPSTFLGIIP
HHCCCCCEEEHHHHHCCCCCCCCCHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCC
KSWMWLFMIPFANNLGMRLVNFAKFVSGYLTNNKPYFQGHAEYAFLLDYVPNWKLMYKPG
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEECCCCCEEEECCC
SMIQYQSFIPKENAVDAFCEILKICQKRRIVTWLAVFKKHKSDPFLLTHALDGYSMAMDF
CCEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEC
PVTFGNRKRLWELAGELDEIVLKFGGKFYFAKDSTLRPETVQRAFPKKNLEKFYSLKRKL
CEEECCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHCC
DPKGILETDLYRRITGTW
CCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]