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The map label for this gene is rppH [H]

Identifier: 114800548

GI number: 114800548

Start: 3379671

End: 3380186

Strand: Reverse

Name: rppH [H]

Synonym: HNE_3207

Alternate gene names: 114800548

Gene position: 3380186-3379671 (Counterclockwise)

Preceding gene: 114799786

Following gene: 114798796

Centisome position: 91.23

GC content: 62.4

Gene sequence:

>516_bases
GTGACCCAGCCAAAACTCGACCCTCAACTGTATCGCGCCAATGTTGGCCTCGCCATGTTCTCGAAGGCGGGGCATGTTTT
CATTGGCCGGCGTATCAACGGGCGCGGCCCGTTCCAGTGGCAGATGCCACAGGGCGGAGTTGATCCGGGAGAGGACCCGC
TGACCGGCGCGCTGCGCGAGCTGGAAGAAGAGATCGGGGTGCCGGCCAAGCTGGTGGACGTTCTCGAAGAGACCAGCGAT
TGGCTCTATTACGACTTTCCGCCAGACCTGAAGAAGCGGATGCCTGGCCCCTATCTTGGCCAGCGGCAGAAATGGTTCGC
TTTCCGCTTCAAGGGCTCTGACAGCGATGTGCGCCTCGACCGGCATACGCCCGAGTTTGACGCCTGGCGCTGGGCAAGGC
TGGACGAGACCCCGGACCTGATCGTACCGTTCAAACGGCCCGTCTATCAGGATGTGGCCGAGCGTTTTGCCAAATGGACC
GATCCGGTACTGCCGGGCCGTGTGCCGCAAGGCTGA

Upstream 100 bases:

>100_bases
CGTTTCTTGTGCCCGACGCAGCCCCCGTTCCGGTGCCCATGGCCGAACGCCGCGAGCTTCGCACTGGTAGCCCAGACAAG
GCTGGTCTAAAAACCGGCGG

Downstream 100 bases:

>100_bases
ACTGGAAAAGGGGGTAGGAAATTGGGCGATCTTCTGATGATTCACGGCGTCGGCTGTGACGGTTCGGCCTGGGACAGGAT
GAAGCCGCTGTTTGAGGCCG

Product: NUDIX family hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTQPKLDPQLYRANVGLAMFSKAGHVFIGRRINGRGPFQWQMPQGGVDPGEDPLTGALRELEEEIGVPAKLVDVLEETSD
WLYYDFPPDLKKRMPGPYLGQRQKWFAFRFKGSDSDVRLDRHTPEFDAWRWARLDETPDLIVPFKRPVYQDVAERFAKWT
DPVLPGRVPQG

Sequences:

>Translated_171_residues
MTQPKLDPQLYRANVGLAMFSKAGHVFIGRRINGRGPFQWQMPQGGVDPGEDPLTGALRELEEEIGVPAKLVDVLEETSD
WLYYDFPPDLKKRMPGPYLGQRQKWFAFRFKGSDSDVRLDRHTPEFDAWRWARLDETPDLIVPFKRPVYQDVAERFAKWT
DPVLPGRVPQG
>Mature_170_residues
TQPKLDPQLYRANVGLAMFSKAGHVFIGRRINGRGPFQWQMPQGGVDPGEDPLTGALRELEEEIGVPAKLVDVLEETSDW
LYYDFPPDLKKRMPGPYLGQRQKWFAFRFKGSDSDVRLDRHTPEFDAWRWARLDETPDLIVPFKRPVYQDVAERFAKWTD
PVLPGRVPQG

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=154, Percent_Identity=38.961038961039, Blast_Score=109, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19727; Mature: 19595

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPKLDPQLYRANVGLAMFSKAGHVFIGRRINGRGPFQWQMPQGGVDPGEDPLTGALRE
CCCCCCCHHHHHHHCCHHHHCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHH
LEEEIGVPAKLVDVLEETSDWLYYDFPPDLKKRMPGPYLGQRQKWFAFRFKGSDSDVRLD
HHHHHCCCHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEC
RHTPEFDAWRWARLDETPDLIVPFKRPVYQDVAERFAKWTDPVLPGRVPQG
CCCCCCCCEEECCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TQPKLDPQLYRANVGLAMFSKAGHVFIGRRINGRGPFQWQMPQGGVDPGEDPLTGALRE
CCCCCCHHHHHHHCCHHHHCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHH
LEEEIGVPAKLVDVLEETSDWLYYDFPPDLKKRMPGPYLGQRQKWFAFRFKGSDSDVRLD
HHHHHCCCHHHHHHHHHCCCEEEECCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEC
RHTPEFDAWRWARLDETPDLIVPFKRPVYQDVAERFAKWTDPVLPGRVPQG
CCCCCCCCEEECCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA