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The map label for this gene is fabH [H]

Identifier: 114800475

GI number: 114800475

Start: 2482007

End: 2483002

Strand: Direct

Name: fabH [H]

Synonym: HNE_2380

Alternate gene names: 114800475

Gene position: 2482007-2483002 (Clockwise)

Preceding gene: 114798897

Following gene: 114799097

Centisome position: 66.99

GC content: 69.08

Gene sequence:

>996_bases
ATGTTGAACGCAGCTCTCCTTGGTACAGGCGCCCGCGCAGGTGGCAGAGCCTTGCCCTCCGCCGAGATCGACGCGCGCCT
CGGCAAACCGTCCGGCTGGCTGGAAAGCGCCAGCGGCGTCATCACCCGCCCGGTGATCGCCGAGGGCGAAACGCAGGAAA
GCCTCGCCGTGGACGCCGCCCGCCTGGCGCTGGCAGATGCCGGACTTGAGGCGGCTGACATCGATCTCCTCCTCTTCGCC
TCCGCGGTGGGCCGCCAGCCGATCCCCTCCACCGCGACGCTGATCAAGCGCGAGCTGGGCCTCAGCCACTGCGCCGCGCC
TGCCTTTGACATCAACGCAACCTGCCTCAGCGCCGTTGCCGCCATGGAAGTCGCCGCGCTTTACATCGCCGCCGGGCGCG
CGCGCCATGTGCTGATCGTCGCCAGCGAGATCGCCACCCGCGCCCTGCCCTGGGCGGATGACCCAGCCACCGCCGCGCTG
TTCGGCGATGGCGCCGCCGCCCTCATCCTCGGCCCGGCGCAAGCCACCGGCCTGCACCTGCGCGATATCTCCCTCGAAAC
CTGGGCGGAGGGTTACGATTTCTGCGCCCTGCCCGCGGGCGGCACCCGCTATGATCTGCATACCAACCGCGACGCCTTCG
AGGCCAACGCCTTCTTCCGCATGGACGGCCACGCCCTGTTCAAGCTGACCCGCACCAAACTGCCCGCCTTCATTGATCGC
CTGCTCGCCCGTGCGGGCTGGCGCCAGGAGGAGGTTGACCTCGTCATCCCCCATCAGGCGAGCCCTCTGGCGCTGGAACA
CATGATCCGCAAATGCGGCTTTGCCCGCGACCGCGTTGTCTCCACCGTTCAGAAAACCGGCAACCTCGTCGCCGCCTCCA
TCCCCATGACGCTCGACACCGCCCGCCGCGAGGGCCGCATCACGCGCGGAAGCAAGGTGCTGCTGATCGGCACCTCGGCC
GGCGTCTCCATTGGCGGGGCAACCCTCGAAGCATGA

Upstream 100 bases:

>100_bases
CCTCACAATGCAGAAAGCTGAAATCTTCCCGCTTGACGGCCTTTGCATTTGTGAGTAAACACTCACTTATTGAAGCAACG
GGAAAGCAACGAGGCCCGGA

Downstream 100 bases:

>100_bases
GCGGCACAGTCATCACCGGCGCCACGGGCTTTCTCGGCGGCGCAATTGCCCACCGCCTGCTGGCTGAAGGCGAACGCGTC
ATCGCGCTCGGCCGCGACCG

Product: putative 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MLNAALLGTGARAGGRALPSAEIDARLGKPSGWLESASGVITRPVIAEGETQESLAVDAARLALADAGLEAADIDLLLFA
SAVGRQPIPSTATLIKRELGLSHCAAPAFDINATCLSAVAAMEVAALYIAAGRARHVLIVASEIATRALPWADDPATAAL
FGDGAAALILGPAQATGLHLRDISLETWAEGYDFCALPAGGTRYDLHTNRDAFEANAFFRMDGHALFKLTRTKLPAFIDR
LLARAGWRQEEVDLVIPHQASPLALEHMIRKCGFARDRVVSTVQKTGNLVAASIPMTLDTARREGRITRGSKVLLIGTSA
GVSIGGATLEA

Sequences:

>Translated_331_residues
MLNAALLGTGARAGGRALPSAEIDARLGKPSGWLESASGVITRPVIAEGETQESLAVDAARLALADAGLEAADIDLLLFA
SAVGRQPIPSTATLIKRELGLSHCAAPAFDINATCLSAVAAMEVAALYIAAGRARHVLIVASEIATRALPWADDPATAAL
FGDGAAALILGPAQATGLHLRDISLETWAEGYDFCALPAGGTRYDLHTNRDAFEANAFFRMDGHALFKLTRTKLPAFIDR
LLARAGWRQEEVDLVIPHQASPLALEHMIRKCGFARDRVVSTVQKTGNLVAASIPMTLDTARREGRITRGSKVLLIGTSA
GVSIGGATLEA
>Mature_331_residues
MLNAALLGTGARAGGRALPSAEIDARLGKPSGWLESASGVITRPVIAEGETQESLAVDAARLALADAGLEAADIDLLLFA
SAVGRQPIPSTATLIKRELGLSHCAAPAFDINATCLSAVAAMEVAALYIAAGRARHVLIVASEIATRALPWADDPATAAL
FGDGAAALILGPAQATGLHLRDISLETWAEGYDFCALPAGGTRYDLHTNRDAFEANAFFRMDGHALFKLTRTKLPAFIDR
LLARAGWRQEEVDLVIPHQASPLALEHMIRKCGFARDRVVSTVQKTGNLVAASIPMTLDTARREGRITRGSKVLLIGTSA
GVSIGGATLEA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=324, Percent_Identity=30.5555555555556, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 34632; Mature: 34632

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00098 THIOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNAALLGTGARAGGRALPSAEIDARLGKPSGWLESASGVITRPVIAEGETQESLAVDAA
CCCCEEEECCCCCCCCCCCCCHHHHCCCCCCCCHHCCCCCEECCEECCCCCHHHHHHHHH
RLALADAGLEAADIDLLLFASAVGRQPIPSTATLIKRELGLSHCAAPAFDINATCLSAVA
HHHHHHCCCCHHCHHHHEEHHHHCCCCCCHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHH
AMEVAALYIAAGRARHVLIVASEIATRALPWADDPATAALFGDGAAALILGPAQATGLHL
HHHHHHHHHCCCCCEEEEEEECHHHHHCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEE
RDISLETWAEGYDFCALPAGGTRYDLHTNRDAFEANAFFRMDGHALFKLTRTKLPAFIDR
EECCHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHH
LLARAGWRQEEVDLVIPHQASPLALEHMIRKCGFARDRVVSTVQKTGNLVAASIPMTLDT
HHHHCCCCCCCCCEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCEEHH
ARREGRITRGSKVLLIGTSAGVSIGGATLEA
HHHCCCEECCCEEEEEECCCCCEECCEEECC
>Mature Secondary Structure
MLNAALLGTGARAGGRALPSAEIDARLGKPSGWLESASGVITRPVIAEGETQESLAVDAA
CCCCEEEECCCCCCCCCCCCCHHHHCCCCCCCCHHCCCCCEECCEECCCCCHHHHHHHHH
RLALADAGLEAADIDLLLFASAVGRQPIPSTATLIKRELGLSHCAAPAFDINATCLSAVA
HHHHHHCCCCHHCHHHHEEHHHHCCCCCCHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHH
AMEVAALYIAAGRARHVLIVASEIATRALPWADDPATAALFGDGAAALILGPAQATGLHL
HHHHHHHHHCCCCCEEEEEEECHHHHHCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEE
RDISLETWAEGYDFCALPAGGTRYDLHTNRDAFEANAFFRMDGHALFKLTRTKLPAFIDR
EECCHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHH
LLARAGWRQEEVDLVIPHQASPLALEHMIRKCGFARDRVVSTVQKTGNLVAASIPMTLDT
HHHHCCCCCCCCCEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCEEHH
ARREGRITRGSKVLLIGTSAGVSIGGATLEA
HHHCCCEECCCEEEEEECCCCCEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA