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The map label for this gene is nirB [H]

Identifier: 114800413

GI number: 114800413

Start: 2336181

End: 2338652

Strand: Direct

Name: nirB [H]

Synonym: HNE_2234

Alternate gene names: 114800413

Gene position: 2336181-2338652 (Clockwise)

Preceding gene: 114799172

Following gene: 114797238

Centisome position: 63.05

GC content: 62.99

Gene sequence:

>2472_bases
ATGCCTGAAGTCCCTTATCCCTTACCAAAGCGACATCGCCTGGTCATCGTCGGCAATGGCATGGCGCCCGGCCGCATGCT
CGAACATCTGTTCGAGCACGGAGGGAAAGACTTCGACGTCAAGATCTTCAATGCCGAACCGCGCGTCAATTATGACCGCA
TCATGCTTTCCCCCGTATTGTCCGGCGAGAAGACATTCGACGACATCGTGATCCATGGCGATGGCTGGTACATCGAGCAC
GGGATCACTCTCTATAAGGGCCACCGCGTCGTAGCAATTGACCGGCAGTTAAAAACCGTGACGTCCGATCAGGGTGAGGT
CGCCCGCTACGATACGCTCGTCCTGGCGACGGGCTCCGACCCCCTGATCCTGCCGGTTCCGGGCGCCAGCCTCAGCGGCG
TCCTCTCCTACCGCGACCTGGATGACGTCACCGCGATGATGCTGGCCGCGCAGCCCGGTCACAAGGCCGTGGTCATCGGC
GGCGGCCTGCTCGGGCTGGAAGCGGCGGCCGGGCTTCAGGCTCGCGGCATGGAGGTGACGGTCGTTCACCTGATGCCGAC
CCTGATGGAGCGTCAGCTTGATGCGTCCGCCGGCTACCTCCTGCAGAAGGAACTGGAGGCGCGCGGCATCCGGGTCCTCT
GCGGCGCAAAAACCCGGGCCGTGCTCGGGGAAACCCGCGCCGAAGGCCTTGAACTTGAAGACGGAACAACACTCGACGCC
TCCCTGGTCGTCATGGCCGTCGGCATCCGGCCGAATGCGGCGCTGGCGCGGGGCGCCGGGCTGAACGTGGGCCGCGGCAT
CCGCGTTGATGCGCAGATGGGCACCTCTGACCCCGATATTCTCGCCCTCGGGGAATGCGCCGAAGTGGACGGGCGGGTCT
ATGGCCTCGTCGCGCCGCTCTACGAGATGGCAAAAGCCGCCGCGGCGCGGCTGGCCGGAGATGAAACGATTACATTCCGG
CATGCCGACACCGCCACCAAACTGAAAGTGACAGGGATCAATCTCTATTCGCTCGGCGACTTTGCCTCCGAAAGCGATCG
CGAAGACATCGTGCTGCGCGACGCGGCCCGCGGCATCTACAAGCGTGTCGTGCTCAGGGAGAACCGCGTCATCGGCGCGG
TTCTTTATGGCGACACGCGGGATGGTCCCTGGCTGAGCGACCTCAAGAAGCGGGACGTCGACATCGGGGACATAAGGGAA
ACCCTGATCTTCGGGCAAAACGCGCAAGGGGCTGCCCTCGATCCCCTGGCGACGGTCGCTGCCCTGCCCGACGACGCGGA
AATCTGCGGGTGTAACGGGGTCTGCAAGGGAAAGATCGTCACGACGATCCGGACAAAGAACCTCACCACCCTCGACGCGG
TCCGGGCCCATACCAAGGCATCCGCCTCGTGCGGCAGCTGCACCGGGCTCGTCGAAAATCTGATGTCGCTGGTCCTGGGC
GACGGCTACCAGGCCGGCGCGGCCAAAACGATGTGCCCCTGCACGCCCCTGGGTCACGGAGAGGTTCGCCGGCTGATCAA
GGTCAAAACCCTGACATCGATTCCGGCGGTGATGCAGGAACTTGGCTGGTCGACCCCGGACGGCTGCGCCAAGTGCCGGC
CCGCCCTCAACTATTATCTTCTGTGCGACTGGCCCGATACGTATACGGACGATCCTCAGTCCCGGTTCATCAATGAGCGG
GCGCATGCAAATATCCAGAAGGACGGGACATTCTCCGTCGTGCCCCGCGCCTGGGGCGGGGTGACGTCGTCGAAGGAATT
ACGGGCCATTGCGGACGTTGTCGACAGGTTCGAGATACCGATGGTCAAATATACCGGCGGCCAGCGGATTGACCTGCTGG
GCGTGAAAAAAGAAGACTTGCCGGCTGTCTGGGCGGATCTGAATGCCGCCGGCATGGTGTCGGGGCATGCCTATGCCAAG
GGACTGCGCACGGTGAAGACCTGCGTCGGGTCAGAATGGTGCCGCTTCGGCACGCAGGATTCGACCGGGCTTGGCATTCG
TCTGGAGAAATTCCTCTGGGGGTCATGGACCCCCGCCAAGGTGAAACTCGCCGTCTCCGGCTGCCCCCGTAACTGCGCGG
AAGCCACGTGCAAGGACATTGGCGTCATTTGTGTGGACAGCGGCTATGAGATCCACTTCGCCGGCGCCGCGGGCCTCGAA
ATCAGGGGCACGGAAAAACTCGGCCTGGTCCGCACCGAAGACGAAGCGGTCGAAGTGATCGCCGCCCTGCTCCAGATGTA
CCGCGAACAGGGTTTCTATCTCGAACGGATCTACAAATGGGCGGCCCGGATCGGCACGCCGGTCATTTCTGAGCAGATCC
TCGCAGATCCAGAACGGCGCCGCGACTATTTCGAGCGATTTATCGTGTCCCAGAAAAAGGCGCAGATCGATCCCTGGGCG
GAGCGGGTCGCCGGACTCGAAAGACAGGAATTTGTATCCCTGACGCCCCAACTGCCAGGAGGGGTGTCATGA

Upstream 100 bases:

>100_bases
CTCCCTTCCAACGGGGAGAGCCGGAGCGCGGTCTGTGGCCGGGTTCCGGGAAAAGAACCCGGCGAAGGCAAGATGCTTCG
CCGTTTAAAGCGGAGTATCC

Downstream 100 bases:

>100_bases
GCCACGCGCCGCTCACCGACCTCGCCGCCCTGGAGGACATCCCCCGGCCAGGTGCCCTCAGGATTATGGCTGGCGGGATC
AGGATCGCCGTTTTCCGGAC

Product: nitrite reductase [NAD(P)H] large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 823; Mature: 822

Protein sequence:

>823_residues
MPEVPYPLPKRHRLVIVGNGMAPGRMLEHLFEHGGKDFDVKIFNAEPRVNYDRIMLSPVLSGEKTFDDIVIHGDGWYIEH
GITLYKGHRVVAIDRQLKTVTSDQGEVARYDTLVLATGSDPLILPVPGASLSGVLSYRDLDDVTAMMLAAQPGHKAVVIG
GGLLGLEAAAGLQARGMEVTVVHLMPTLMERQLDASAGYLLQKELEARGIRVLCGAKTRAVLGETRAEGLELEDGTTLDA
SLVVMAVGIRPNAALARGAGLNVGRGIRVDAQMGTSDPDILALGECAEVDGRVYGLVAPLYEMAKAAAARLAGDETITFR
HADTATKLKVTGINLYSLGDFASESDREDIVLRDAARGIYKRVVLRENRVIGAVLYGDTRDGPWLSDLKKRDVDIGDIRE
TLIFGQNAQGAALDPLATVAALPDDAEICGCNGVCKGKIVTTIRTKNLTTLDAVRAHTKASASCGSCTGLVENLMSLVLG
DGYQAGAAKTMCPCTPLGHGEVRRLIKVKTLTSIPAVMQELGWSTPDGCAKCRPALNYYLLCDWPDTYTDDPQSRFINER
AHANIQKDGTFSVVPRAWGGVTSSKELRAIADVVDRFEIPMVKYTGGQRIDLLGVKKEDLPAVWADLNAAGMVSGHAYAK
GLRTVKTCVGSEWCRFGTQDSTGLGIRLEKFLWGSWTPAKVKLAVSGCPRNCAEATCKDIGVICVDSGYEIHFAGAAGLE
IRGTEKLGLVRTEDEAVEVIAALLQMYREQGFYLERIYKWAARIGTPVISEQILADPERRRDYFERFIVSQKKAQIDPWA
ERVAGLERQEFVSLTPQLPGGVS

Sequences:

>Translated_823_residues
MPEVPYPLPKRHRLVIVGNGMAPGRMLEHLFEHGGKDFDVKIFNAEPRVNYDRIMLSPVLSGEKTFDDIVIHGDGWYIEH
GITLYKGHRVVAIDRQLKTVTSDQGEVARYDTLVLATGSDPLILPVPGASLSGVLSYRDLDDVTAMMLAAQPGHKAVVIG
GGLLGLEAAAGLQARGMEVTVVHLMPTLMERQLDASAGYLLQKELEARGIRVLCGAKTRAVLGETRAEGLELEDGTTLDA
SLVVMAVGIRPNAALARGAGLNVGRGIRVDAQMGTSDPDILALGECAEVDGRVYGLVAPLYEMAKAAAARLAGDETITFR
HADTATKLKVTGINLYSLGDFASESDREDIVLRDAARGIYKRVVLRENRVIGAVLYGDTRDGPWLSDLKKRDVDIGDIRE
TLIFGQNAQGAALDPLATVAALPDDAEICGCNGVCKGKIVTTIRTKNLTTLDAVRAHTKASASCGSCTGLVENLMSLVLG
DGYQAGAAKTMCPCTPLGHGEVRRLIKVKTLTSIPAVMQELGWSTPDGCAKCRPALNYYLLCDWPDTYTDDPQSRFINER
AHANIQKDGTFSVVPRAWGGVTSSKELRAIADVVDRFEIPMVKYTGGQRIDLLGVKKEDLPAVWADLNAAGMVSGHAYAK
GLRTVKTCVGSEWCRFGTQDSTGLGIRLEKFLWGSWTPAKVKLAVSGCPRNCAEATCKDIGVICVDSGYEIHFAGAAGLE
IRGTEKLGLVRTEDEAVEVIAALLQMYREQGFYLERIYKWAARIGTPVISEQILADPERRRDYFERFIVSQKKAQIDPWA
ERVAGLERQEFVSLTPQLPGGVS
>Mature_822_residues
PEVPYPLPKRHRLVIVGNGMAPGRMLEHLFEHGGKDFDVKIFNAEPRVNYDRIMLSPVLSGEKTFDDIVIHGDGWYIEHG
ITLYKGHRVVAIDRQLKTVTSDQGEVARYDTLVLATGSDPLILPVPGASLSGVLSYRDLDDVTAMMLAAQPGHKAVVIGG
GLLGLEAAAGLQARGMEVTVVHLMPTLMERQLDASAGYLLQKELEARGIRVLCGAKTRAVLGETRAEGLELEDGTTLDAS
LVVMAVGIRPNAALARGAGLNVGRGIRVDAQMGTSDPDILALGECAEVDGRVYGLVAPLYEMAKAAAARLAGDETITFRH
ADTATKLKVTGINLYSLGDFASESDREDIVLRDAARGIYKRVVLRENRVIGAVLYGDTRDGPWLSDLKKRDVDIGDIRET
LIFGQNAQGAALDPLATVAALPDDAEICGCNGVCKGKIVTTIRTKNLTTLDAVRAHTKASASCGSCTGLVENLMSLVLGD
GYQAGAAKTMCPCTPLGHGEVRRLIKVKTLTSIPAVMQELGWSTPDGCAKCRPALNYYLLCDWPDTYTDDPQSRFINERA
HANIQKDGTFSVVPRAWGGVTSSKELRAIADVVDRFEIPMVKYTGGQRIDLLGVKKEDLPAVWADLNAAGMVSGHAYAKG
LRTVKTCVGSEWCRFGTQDSTGLGIRLEKFLWGSWTPAKVKLAVSGCPRNCAEATCKDIGVICVDSGYEIHFAGAAGLEI
RGTEKLGLVRTEDEAVEVIAALLQMYREQGFYLERIYKWAARIGTPVISEQILADPERRRDYFERFIVSQKKAQIDPWAE
RVAGLERQEFVSLTPQLPGGVS

Specific function: Required for nitrite assimilation [H]

COG id: COG1251

COG function: function code C; NAD(P)H-nitrite reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=275, Percent_Identity=27.6363636363636, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI21389617, Length=275, Percent_Identity=27.6363636363636, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI65787454, Length=275, Percent_Identity=27.6363636363636, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI4757732, Length=209, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI22202629, Length=209, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=4e-11,
Organism=Escherichia coli, GI1789765, Length=805, Percent_Identity=34.9068322981366, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1789065, Length=340, Percent_Identity=28.2352941176471, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788892, Length=279, Percent_Identity=30.8243727598566, Blast_Score=113, Evalue=5e-26,
Organism=Escherichia coli, GI1787352, Length=336, Percent_Identity=25.8928571428571, Blast_Score=63, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17559934, Length=278, Percent_Identity=27.3381294964029, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281359715, Length=292, Percent_Identity=25.3424657534247, Blast_Score=93, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281359713, Length=292, Percent_Identity=25.3424657534247, Blast_Score=93, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24639250, Length=292, Percent_Identity=25.3424657534247, Blast_Score=93, Evalue=9e-19,
Organism=Drosophila melanogaster, GI18543267, Length=292, Percent_Identity=25.3424657534247, Blast_Score=93, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24639252, Length=292, Percent_Identity=25.3424657534247, Blast_Score=93, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24639257, Length=292, Percent_Identity=25.3424657534247, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24581020, Length=205, Percent_Identity=30.2439024390244, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573993, Length=205, Percent_Identity=30.2439024390244, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585130, Length=265, Percent_Identity=22.6415094339623, Blast_Score=78, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR013027
- InterPro:   IPR005117
- InterPro:   IPR012744
- InterPro:   IPR017121
- InterPro:   IPR006067
- InterPro:   IPR006066
- InterPro:   IPR001327 [H]

Pfam domain/function: PF04324 Fer2_BFD; PF01077 NIR_SIR; PF03460 NIR_SIR_ferr; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.7.1.4 [H]

Molecular weight: Translated: 89078; Mature: 88947

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00365 NIR_SIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEVPYPLPKRHRLVIVGNGMAPGRMLEHLFEHGGKDFDVKIFNAEPRVNYDRIMLSPVL
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEHHC
SGEKTFDDIVIHGDGWYIEHGITLYKGHRVVAIDRQLKTVTSDQGEVARYDTLVLATGSD
CCCCCCCEEEEECCCEEEECCEEEEECCEEEEECCHHHHHCCCCCCEEEEEEEEEEECCC
PLILPVPGASLSGVLSYRDLDDVTAMMLAAQPGHKAVVIGGGLLGLEAAAGLQARGMEVT
CEEEECCCCCHHHEEECCCHHHHHHHHHCCCCCCEEEEEECCEEHHHHHCCCCCCCCEEE
VVHLMPTLMERQLDASAGYLLQKELEARGIRVLCGAKTRAVLGETRAEGLELEDGTTLDA
EHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCEECCCCCCCCC
SLVVMAVGIRPNAALARGAGLNVGRGIRVDAQMGTSDPDILALGECAEVDGRVYGLVAPL
EEEEEEECCCCCCHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCEEEEHHHHH
YEMAKAAAARLAGDETITFRHADTATKLKVTGINLYSLGDFASESDREDIVLRDAARGIY
HHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCEEHHHHHHHHH
KRVVLRENRVIGAVLYGDTRDGPWLSDLKKRDVDIGDIRETLIFGQNAQGAALDPLATVA
HHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHH
ALPDDAEICGCNGVCKGKIVTTIRTKNLTTLDAVRAHTKASASCGSCTGLVENLMSLVLG
CCCCCCCEECCCCEECCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
DGYQAGAAKTMCPCTPLGHGEVRRLIKVKTLTSIPAVMQELGWSTPDGCAKCRPALNYYL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEE
LCDWPDTYTDDPQSRFINERAHANIQKDGTFSVVPRAWGGVTSSKELRAIADVVDRFEIP
EECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
MVKYTGGQRIDLLGVKKEDLPAVWADLNAAGMVSGHAYAKGLRTVKTCVGSEWCRFGTQD
EEEECCCCEEEEEECCCCCCCHHHHCCCCCCEECCHHHHHHHHHHHHHHCCHHHHCCCCC
STGLGIRLEKFLWGSWTPAKVKLAVSGCPRNCAEATCKDIGVICVDSGYEIHFAGAAGLE
CCCCCEEEEEHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEECCCCEEEEECCCCEE
IRGTEKLGLVRTEDEAVEVIAALLQMYREQGFYLERIYKWAARIGTPVISEQILADPERR
EECCCCCCEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHH
RDYFERFIVSQKKAQIDPWAERVAGLERQEFVSLTPQLPGGVS
HHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHEECCCCCCCCC
>Mature Secondary Structure 
PEVPYPLPKRHRLVIVGNGMAPGRMLEHLFEHGGKDFDVKIFNAEPRVNYDRIMLSPVL
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEHHC
SGEKTFDDIVIHGDGWYIEHGITLYKGHRVVAIDRQLKTVTSDQGEVARYDTLVLATGSD
CCCCCCCEEEEECCCEEEECCEEEEECCEEEEECCHHHHHCCCCCCEEEEEEEEEEECCC
PLILPVPGASLSGVLSYRDLDDVTAMMLAAQPGHKAVVIGGGLLGLEAAAGLQARGMEVT
CEEEECCCCCHHHEEECCCHHHHHHHHHCCCCCCEEEEEECCEEHHHHHCCCCCCCCEEE
VVHLMPTLMERQLDASAGYLLQKELEARGIRVLCGAKTRAVLGETRAEGLELEDGTTLDA
EHHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCEECCCCCCCCC
SLVVMAVGIRPNAALARGAGLNVGRGIRVDAQMGTSDPDILALGECAEVDGRVYGLVAPL
EEEEEEECCCCCCHHHCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCEEEEHHHHH
YEMAKAAAARLAGDETITFRHADTATKLKVTGINLYSLGDFASESDREDIVLRDAARGIY
HHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCEEHHHHHHHHH
KRVVLRENRVIGAVLYGDTRDGPWLSDLKKRDVDIGDIRETLIFGQNAQGAALDPLATVA
HHHHHCCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHH
ALPDDAEICGCNGVCKGKIVTTIRTKNLTTLDAVRAHTKASASCGSCTGLVENLMSLVLG
CCCCCCCEECCCCEECCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
DGYQAGAAKTMCPCTPLGHGEVRRLIKVKTLTSIPAVMQELGWSTPDGCAKCRPALNYYL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEEE
LCDWPDTYTDDPQSRFINERAHANIQKDGTFSVVPRAWGGVTSSKELRAIADVVDRFEIP
EECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCC
MVKYTGGQRIDLLGVKKEDLPAVWADLNAAGMVSGHAYAKGLRTVKTCVGSEWCRFGTQD
EEEECCCCEEEEEECCCCCCCHHHHCCCCCCEECCHHHHHHHHHHHHHHCCHHHHCCCCC
STGLGIRLEKFLWGSWTPAKVKLAVSGCPRNCAEATCKDIGVICVDSGYEIHFAGAAGLE
CCCCCEEEEEHHCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEECCCCEEEEECCCCEE
IRGTEKLGLVRTEDEAVEVIAALLQMYREQGFYLERIYKWAARIGTPVISEQILADPERR
EECCCCCCEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHH
RDYFERFIVSQKKAQIDPWAERVAGLERQEFVSLTPQLPGGVS
HHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7868621; 8969502; 9384377 [H]