| Definition | Hyphomonas neptunium ATCC 15444 chromosome, complete genome. |
|---|---|
| Accession | NC_008358 |
| Length | 3,705,021 |
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The map label for this gene is gra-orf6 [H]
Identifier: 114799895
GI number: 114799895
Start: 987352
End: 988164
Strand: Reverse
Name: gra-orf6 [H]
Synonym: HNE_0974
Alternate gene names: 114799895
Gene position: 988164-987352 (Counterclockwise)
Preceding gene: 114798323
Following gene: 114799574
Centisome position: 26.67
GC content: 63.71
Gene sequence:
>813_bases ATGACCCCTCGTGACCTTGAAGGCCGCACCGCCCTCGTAACCGGCTCCGCCAACGGCCTTGGCCGCTCGATCGCCCTGAA ACTCGCAGAACGCGGCGCCAGCGTGATTATCAACTGCACAAAATCCATCGCCGATGGCGAAGCCACCGTTGCAGACTGCC AGAAGGCTGGCGCTCAGGCCCGTCTCGTCGTCGCCGATGTCTCCACCGATGAGGGCTGTTCAAAGCTGGCCGAAGCCGCC GCCCAGGCTGGCCGCCTCGATATTCTCGTCAACAATGCCGGCATCACCAAACATGCCCGCGACCATTCCGATCTCGACGC GCTCAGCCGCGACGATTTCCTCAACCTCTATTCGGTCAACGTCGCCGGCCCCTTCATCATGATGCAGAAAACCAGATCCC TGCTGGTGGAGGCACATAAACAGACCGGCCGGGCCTCGACGGTCCTCAACGTCTCCTCGATTGCCGGAGTTGCCGGCGTC GGCTCCTCAGTGGCCTATGCCGCCTCCAAGGGCGCCTTCAACACCATGACGATCAGCCTCGCCCGCGCCCTCGCCCCGGC CATCCGCGTCAACGCCATCTGCCCCGGCTTCATCGGCACCCGCTGGTTCAAGGACACGATGAGCGAGGAGCAATACATGA AGATGGAGGCCGGGGTCGCCGCCTCCGTACCCCTGAACGTCGCCTCGGGGCCTGACGACATCGCGGATTCGGCGCTGTTC CTGCTCAGTGACGCGTCCCGTCATATAACTGGCGAAACCCTGCTCGTGGATGCCGGCATGCACCTTGGCTATGCCCCGCT GAAGGCACGCTGA
Upstream 100 bases:
>100_bases ACCCGCTCGCGCGTCACGGGCGGCGCCATGGCTTGACTTACCTTCCCGCCCCCAGACCATTGAAGCCGCAGGTAAAAAAT CCAGAAAAGGGAGACCCCGG
Downstream 100 bases:
>100_bases CTCGGCCTCTGCCTGTTTTCTGGACGCTGCGGCGCACAATTGAGAGGCAGAGGCCCGCCCATCTGCCTAAAACAGGTGCG TTCGCACCGGTCTCCCGGCA
Product: short chain dehydrogenase/reductase family oxidoreductase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: ORF6 [H]
Number of amino acids: Translated: 270; Mature: 269
Protein sequence:
>270_residues MTPRDLEGRTALVTGSANGLGRSIALKLAERGASVIINCTKSIADGEATVADCQKAGAQARLVVADVSTDEGCSKLAEAA AQAGRLDILVNNAGITKHARDHSDLDALSRDDFLNLYSVNVAGPFIMMQKTRSLLVEAHKQTGRASTVLNVSSIAGVAGV GSSVAYAASKGAFNTMTISLARALAPAIRVNAICPGFIGTRWFKDTMSEEQYMKMEAGVAASVPLNVASGPDDIADSALF LLSDASRHITGETLLVDAGMHLGYAPLKAR
Sequences:
>Translated_270_residues MTPRDLEGRTALVTGSANGLGRSIALKLAERGASVIINCTKSIADGEATVADCQKAGAQARLVVADVSTDEGCSKLAEAA AQAGRLDILVNNAGITKHARDHSDLDALSRDDFLNLYSVNVAGPFIMMQKTRSLLVEAHKQTGRASTVLNVSSIAGVAGV GSSVAYAASKGAFNTMTISLARALAPAIRVNAICPGFIGTRWFKDTMSEEQYMKMEAGVAASVPLNVASGPDDIADSALF LLSDASRHITGETLLVDAGMHLGYAPLKAR >Mature_269_residues TPRDLEGRTALVTGSANGLGRSIALKLAERGASVIINCTKSIADGEATVADCQKAGAQARLVVADVSTDEGCSKLAEAAA QAGRLDILVNNAGITKHARDHSDLDALSRDDFLNLYSVNVAGPFIMMQKTRSLLVEAHKQTGRASTVLNVSSIAGVAGVG SSVAYAASKGAFNTMTISLARALAPAIRVNAICPGFIGTRWFKDTMSEEQYMKMEAGVAASVPLNVASGPDDIADSALFL LSDASRHITGETLLVDAGMHLGYAPLKAR
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=264, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=30.9160305343511, Blast_Score=89, Evalue=3e-18, Organism=Homo sapiens, GI4758504, Length=203, Percent_Identity=32.512315270936, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=32.0675105485232, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI31542939, Length=247, Percent_Identity=29.1497975708502, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=27.7777777777778, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI4504505, Length=219, Percent_Identity=32.4200913242009, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI19923817, Length=274, Percent_Identity=26.2773722627737, Blast_Score=76, Evalue=2e-14, Organism=Homo sapiens, GI7705925, Length=258, Percent_Identity=29.8449612403101, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI83715985, Length=188, Percent_Identity=30.8510638297872, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI109715829, Length=244, Percent_Identity=28.2786885245902, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=30.8300395256917, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI210032110, Length=207, Percent_Identity=27.536231884058, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI142976729, Length=208, Percent_Identity=29.3269230769231, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=34.8258706467662, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI7706318, Length=201, Percent_Identity=29.3532338308458, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI146231950, Length=124, Percent_Identity=38.7096774193548, Blast_Score=65, Evalue=7e-11, Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=35.632183908046, Blast_Score=120, Evalue=1e-28, Organism=Escherichia coli, GI1786812, Length=266, Percent_Identity=31.5789473684211, Blast_Score=97, Evalue=8e-22, Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=31.5573770491803, Blast_Score=97, Evalue=1e-21, Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=30.7392996108949, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI87082100, Length=267, Percent_Identity=34.0823970037453, Blast_Score=94, Evalue=9e-21, Organism=Escherichia coli, GI1789208, Length=257, Percent_Identity=30.7392996108949, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=29.296875, Blast_Score=92, Evalue=4e-20, Organism=Escherichia coli, GI1788459, Length=256, Percent_Identity=28.125, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=32.03125, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=29.1666666666667, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1787526, Length=261, Percent_Identity=29.8850574712644, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1787891, Length=252, Percent_Identity=25.3968253968254, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI2367365, Length=200, Percent_Identity=32, Blast_Score=61, Evalue=9e-11, Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=35.0194552529183, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI25147288, Length=259, Percent_Identity=32.8185328185328, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17563726, Length=275, Percent_Identity=30.9090909090909, Blast_Score=101, Evalue=5e-22, Organism=Caenorhabditis elegans, GI17560676, Length=262, Percent_Identity=30.5343511450382, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI72000259, Length=269, Percent_Identity=30.4832713754647, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17562904, Length=276, Percent_Identity=31.1594202898551, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI193204405, Length=270, Percent_Identity=32.2222222222222, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI115534694, Length=262, Percent_Identity=30.9160305343511, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17562906, Length=274, Percent_Identity=33.5766423357664, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17560220, Length=272, Percent_Identity=31.25, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17562908, Length=273, Percent_Identity=31.8681318681319, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=30.4182509505703, Blast_Score=91, Evalue=7e-19, Organism=Caenorhabditis elegans, GI17531453, Length=277, Percent_Identity=31.4079422382672, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=29.6992481203008, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17544670, Length=273, Percent_Identity=26.7399267399267, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17551412, Length=273, Percent_Identity=27.4725274725275, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17538480, Length=275, Percent_Identity=29.4545454545455, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17562990, Length=270, Percent_Identity=30.3703703703704, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17561402, Length=266, Percent_Identity=30.0751879699248, Blast_Score=85, Evalue=5e-17, Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=30.1115241635688, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI17560332, Length=272, Percent_Identity=30.5147058823529, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17538182, Length=270, Percent_Identity=30.3703703703704, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17559104, Length=273, Percent_Identity=31.8681318681319, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI71994600, Length=261, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI32563809, Length=270, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17507613, Length=270, Percent_Identity=29.6296296296296, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17562910, Length=268, Percent_Identity=28.3582089552239, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI193203115, Length=204, Percent_Identity=29.9019607843137, Blast_Score=80, Evalue=2e-15, Organism=Caenorhabditis elegans, GI71994604, Length=260, Percent_Identity=31.5384615384615, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI193203117, Length=200, Percent_Identity=30, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17564282, Length=208, Percent_Identity=31.7307692307692, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI71982365, Length=255, Percent_Identity=28.2352941176471, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17568967, Length=202, Percent_Identity=32.6732673267327, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI86565303, Length=220, Percent_Identity=27.7272727272727, Blast_Score=65, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=197, Percent_Identity=29.4416243654822, Blast_Score=65, Evalue=1e-11, Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=32.5581395348837, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI21355319, Length=261, Percent_Identity=30.6513409961686, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI24643142, Length=257, Percent_Identity=30.3501945525292, Blast_Score=91, Evalue=6e-19, Organism=Drosophila melanogaster, GI24644339, Length=261, Percent_Identity=27.5862068965517, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=31.2741312741313, Blast_Score=89, Evalue=3e-18, Organism=Drosophila melanogaster, GI21357041, Length=259, Percent_Identity=30.5019305019305, Blast_Score=84, Evalue=9e-17, Organism=Drosophila melanogaster, GI24639444, Length=265, Percent_Identity=32.4528301886792, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI17737361, Length=258, Percent_Identity=29.0697674418605, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI18859837, Length=202, Percent_Identity=35.6435643564356, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24644337, Length=214, Percent_Identity=28.9719626168224, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24649181, Length=204, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI24580925, Length=214, Percent_Identity=27.1028037383178, Blast_Score=65, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 28047; Mature: 27916
Theoretical pI: Translated: 7.03; Mature: 7.03
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTPRDLEGRTALVTGSANGLGRSIALKLAERGASVIINCTKSIADGEATVADCQKAGAQA CCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECHHHCCCCHHHHHHHHCCCCE RLVVADVSTDEGCSKLAEAAAQAGRLDILVNNAGITKHARDHSDLDALSRDDFLNLYSVN EEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCEEEEEEC VAGPFIMMQKTRSLLVEAHKQTGRASTVLNVSSIAGVAGVGSSVAYAASKGAFNTMTISL CCCCEEHHHHHHHHHHHHHHHCCCHHEEEEHHHHCCHHCCCCHHHHHHCCCCCHHHHHHH ARALAPAIRVNAICPGFIGTRWFKDTMSEEQYMKMEAGVAASVPLNVASGPDDIADSALF HHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCEEECCEECCCCCCHHHHHHEE LLSDASRHITGETLLVDAGMHLGYAPLKAR EEECCCCCCCCCEEEEECCCCCCCCCCCCC >Mature Secondary Structure TPRDLEGRTALVTGSANGLGRSIALKLAERGASVIINCTKSIADGEATVADCQKAGAQA CCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECHHHCCCCHHHHHHHHCCCCE RLVVADVSTDEGCSKLAEAAAQAGRLDILVNNAGITKHARDHSDLDALSRDDFLNLYSVN EEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCEEEEEEC VAGPFIMMQKTRSLLVEAHKQTGRASTVLNVSSIAGVAGVGSSVAYAASKGAFNTMTISL CCCCEEHHHHHHHHHHHHHHHCCCHHEEEEHHHHCCHHCCCCHHHHHHCCCCCHHHHHHH ARALAPAIRVNAICPGFIGTRWFKDTMSEEQYMKMEAGVAASVPLNVASGPDDIADSALF HHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCEEECCEECCCCCCHHHHHHEE LLSDASRHITGETLLVDAGMHLGYAPLKAR EEECCCCCCCCCEEEEECCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2583128; 9831526 [H]