| Definition | Hyphomonas neptunium ATCC 15444 chromosome, complete genome. |
|---|---|
| Accession | NC_008358 |
| Length | 3,705,021 |
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The map label for this gene is topA [H]
Identifier: 114799315
GI number: 114799315
Start: 2377254
End: 2379833
Strand: Direct
Name: topA [H]
Synonym: HNE_2276
Alternate gene names: 114799315
Gene position: 2377254-2379833 (Clockwise)
Preceding gene: 114797396
Following gene: 114797090
Centisome position: 64.16
GC content: 62.52
Gene sequence:
>2580_bases ATGAAACTTGTCGTCGTAGAGTCTCCGGCAAAGGCCAAAACGATCAACAAGTACCTGGGGAAGGACTATAAGGTCCTCGC CTCCTACGGTCACATCCGCGATCTGCCCTCGAAAAATGGCTCGGTTGACCCGGAAAACGACTTCGAAATGGTCTGGGAGG CCGATTCCAAGTCTGCCAAGCGCATCTCCGACATCGCCAACGCCCTGAAGGACGCCGACACGCTGATCCTGGCGACTGAC CCTGATCGCGAGGGCGAGGCCATCTCCTGGCACCTGGTCGAGGCGCTGAGAAAGCGCCGGGCGCTCAAGAAAGATGTCGC CATCGAGCGCGTCGTGTTCAACGCCATCACCAAGAGCGCCGTGACCCAGGCAATGGAGCATCCGCGCGCCATCGACGCCG AACTGGTCGACGCCTATCTGGCGCGCCGGGCGCTGGACTATCTGGTCGGCTTCAACCTCTCCCCGGTCCTCTGGCGCAAG CTGCCGGGCTCGCGCTCGGCGGGCCGCGTTCAGTCTGTGGCGCTGCGGATCGTGTGCGACCGCGAAAACGAGATCGAGAG CTTCCGGGCGCAGGAATACTGGAACATCGTGGCAGAGCTGCGCGCGCCCGACGGCACCGCCTTTGAAGCCCGCCTGCACA GCCTCGACGGCGAAACGCTGAAGAAGTTCACCCTCGGCAATCAGGGCGACGCAAACCGCGCGCTGGAGATCGTCAAGGTC GGCGGCTATTCGGTCGTCAGCGTTGAGGCCAAGCCCGTCAAGCGCAATCCGCCTCCGCCGTTCATCACTTCGACACTGCA ACAGGAAGCCAGCCGCAAGCTCGGATTCAACGCCAAGCGCACGATGCAGGCCGCTCAGAAGCTCTACGAAGAAGGCCGCA TCACCTATATGCGTACCGACGGCGTGAACATGGCCGAGGAAGCCTATGTCGCCGCCCGCACGATGATCCAGTCCAACTAT GGCGCGCGGTATCTGCCGGAAAATACGCGGCGCTATTCCTCCAAGGCGAAGAATGCGCAGGAGGCCCACGAGGCCATCCG CCCGACCGACTTCAATCTGCGCCCGGAAGATTACCACGGCGACGGCGACCTGAAGAAACTCTACACGCTCGTCTGGCGCC GGGCTGTCGCCTCGCAGATGGAAACGGCGCTGTTCGAGCGCACAACCATCGACCTTGCCTCCAAGGACAAGCGCGCGGGC CTGCGCGCCACCGGCCAGGTGCTGGTGTTTGATGGCTTCATCAAGCTCTACACCGAAGGTCATGACGCCGGGGATGATGA TGACGACGCCGAAGGCCGCCTGCCGAAGATGGCCGAAGGTCAGCATGCTGACCTCCTGAAGGCGGACGCCAACCAGTCCT TCACCCAGCCGCCCCCGCGCTATACCGAAGCCTCGCTCGTCAAGCGCCTTGAAGAACTCGGAATTGGCCGCCCGTCCACC TATGCCTCCACCATGTCGACGCTGGAAGATCGCGGCTATGTCCGCATCGAGGGCAAGGCGCTGGTGCCGGAAGACAAAGG CCGGCTTGTCACCGCCTTCCTCGAAAACTTCTTCAGCCGCTATGTGGAATATGACTTCACGGCCGGCCTGGAAGAAAAGC TCGACGTCATCTCCGATGGCAAGCTCGACTGGAAAGCCTTCCTGCGCGAATTCTGGCAGCAGTTTGCCGCTGACATTGAC GGCACGAAAGACCTGCGCGTTTCTGCCGTGCTCGACGCGCTGAACGAGGCGCTGGGCGCCTATGTGTTCCCGCGCCAGGA CGCCGAAGGCAACCCCATCGAAAACCCGCGCCAGTGCCCGCTCTGCAAAGAGGGCGAGCTGTCGATGAAGCTCGGCAAGT TCGGCGCCTTCGTTGGCTGCTCGCGCCATCCCGAGTGCAAATACACCCGCCAGTTTTCCTCCGAGGGCGGAGATGCCGCG ATCAATCCCGATGGCAACGAGATCGGCATCCACCCCGATACCGGCGCCATGATCCTGCTGAAATCAGGCCGGTTTGGCCC CTATGTGGAAATGGCCAATGGCGAAAAGCCAAAGCGCGCCAGCCTCGCCAAGGCAGACAATGCTGCCGAGCTGACCCTTG AACGCGCCGTGGAGCTGCTCAGCCTGCCGCGCGAAGTTGGTCCGCACCCGGAAGATGGCGAAATGATCCTCGCCAATTTC GGCCGCTTCGGGCCGTATGTTCAGCATGGCAAAACCTACGCCAACCTGAAAGACCCGCGCGACGTGTTCACCATCGGCGT CAACCACGCCGTCTCGCTGATCGAAGACAAGAAAGCCCGCGGCTCAGCCCGCGGGGGCGCCGCAGCGCTCAAAGCCCTCG GCGATCACCCGGACGGCGGCGCCATCGAGGTGTTCGAAGGCCGCTACGGGCCTTACGTGAAATGGGGCAAGGTCAACGCC ACCCTGCCCAAGGAGATCACGCCCGACGTGGTGACGCTGGAACAGGCCATCGAACTCGTAAACGCTAAAGGCGGCAGCGC GAAGAAAAAGGCCCCGGCCAAGAAAGCAGCCGCGAAAAAGCCGGCGGCAAAGAAAGCTGCGCCGAAGAAAAAAGCGCCGG CGAAGAAGGCTGAGGAATAG
Upstream 100 bases:
>100_bases GCCTTTATCGCCTACCGGGAAGATGGCTGAACCGTAGCGGCCTTGACAGCCCCTGCCGCTACAGACCATCTCTGCCGCCC TTGAAGAGGTGGACCCCTGC
Downstream 100 bases:
>100_bases CCATTCACCCTCCTTTCAGCTTCCCTCTGCCCGTATGCGGAGGAAGCTGACCGGAGGCCTATGCCATGCTCTTGCCTGCC CTGTTTTCGTCGATTGCCCT
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 859; Mature: 859
Protein sequence:
>859_residues MKLVVVESPAKAKTINKYLGKDYKVLASYGHIRDLPSKNGSVDPENDFEMVWEADSKSAKRISDIANALKDADTLILATD PDREGEAISWHLVEALRKRRALKKDVAIERVVFNAITKSAVTQAMEHPRAIDAELVDAYLARRALDYLVGFNLSPVLWRK LPGSRSAGRVQSVALRIVCDRENEIESFRAQEYWNIVAELRAPDGTAFEARLHSLDGETLKKFTLGNQGDANRALEIVKV GGYSVVSVEAKPVKRNPPPPFITSTLQQEASRKLGFNAKRTMQAAQKLYEEGRITYMRTDGVNMAEEAYVAARTMIQSNY GARYLPENTRRYSSKAKNAQEAHEAIRPTDFNLRPEDYHGDGDLKKLYTLVWRRAVASQMETALFERTTIDLASKDKRAG LRATGQVLVFDGFIKLYTEGHDAGDDDDDAEGRLPKMAEGQHADLLKADANQSFTQPPPRYTEASLVKRLEELGIGRPST YASTMSTLEDRGYVRIEGKALVPEDKGRLVTAFLENFFSRYVEYDFTAGLEEKLDVISDGKLDWKAFLREFWQQFAADID GTKDLRVSAVLDALNEALGAYVFPRQDAEGNPIENPRQCPLCKEGELSMKLGKFGAFVGCSRHPECKYTRQFSSEGGDAA INPDGNEIGIHPDTGAMILLKSGRFGPYVEMANGEKPKRASLAKADNAAELTLERAVELLSLPREVGPHPEDGEMILANF GRFGPYVQHGKTYANLKDPRDVFTIGVNHAVSLIEDKKARGSARGGAAALKALGDHPDGGAIEVFEGRYGPYVKWGKVNA TLPKEITPDVVTLEQAIELVNAKGGSAKKKAPAKKAAAKKPAAKKAAPKKKAPAKKAEE
Sequences:
>Translated_859_residues MKLVVVESPAKAKTINKYLGKDYKVLASYGHIRDLPSKNGSVDPENDFEMVWEADSKSAKRISDIANALKDADTLILATD PDREGEAISWHLVEALRKRRALKKDVAIERVVFNAITKSAVTQAMEHPRAIDAELVDAYLARRALDYLVGFNLSPVLWRK LPGSRSAGRVQSVALRIVCDRENEIESFRAQEYWNIVAELRAPDGTAFEARLHSLDGETLKKFTLGNQGDANRALEIVKV GGYSVVSVEAKPVKRNPPPPFITSTLQQEASRKLGFNAKRTMQAAQKLYEEGRITYMRTDGVNMAEEAYVAARTMIQSNY GARYLPENTRRYSSKAKNAQEAHEAIRPTDFNLRPEDYHGDGDLKKLYTLVWRRAVASQMETALFERTTIDLASKDKRAG LRATGQVLVFDGFIKLYTEGHDAGDDDDDAEGRLPKMAEGQHADLLKADANQSFTQPPPRYTEASLVKRLEELGIGRPST YASTMSTLEDRGYVRIEGKALVPEDKGRLVTAFLENFFSRYVEYDFTAGLEEKLDVISDGKLDWKAFLREFWQQFAADID GTKDLRVSAVLDALNEALGAYVFPRQDAEGNPIENPRQCPLCKEGELSMKLGKFGAFVGCSRHPECKYTRQFSSEGGDAA INPDGNEIGIHPDTGAMILLKSGRFGPYVEMANGEKPKRASLAKADNAAELTLERAVELLSLPREVGPHPEDGEMILANF GRFGPYVQHGKTYANLKDPRDVFTIGVNHAVSLIEDKKARGSARGGAAALKALGDHPDGGAIEVFEGRYGPYVKWGKVNA TLPKEITPDVVTLEQAIELVNAKGGSAKKKAPAKKAAAKKPAAKKAAPKKKAPAKKAEE >Mature_859_residues MKLVVVESPAKAKTINKYLGKDYKVLASYGHIRDLPSKNGSVDPENDFEMVWEADSKSAKRISDIANALKDADTLILATD PDREGEAISWHLVEALRKRRALKKDVAIERVVFNAITKSAVTQAMEHPRAIDAELVDAYLARRALDYLVGFNLSPVLWRK LPGSRSAGRVQSVALRIVCDRENEIESFRAQEYWNIVAELRAPDGTAFEARLHSLDGETLKKFTLGNQGDANRALEIVKV GGYSVVSVEAKPVKRNPPPPFITSTLQQEASRKLGFNAKRTMQAAQKLYEEGRITYMRTDGVNMAEEAYVAARTMIQSNY GARYLPENTRRYSSKAKNAQEAHEAIRPTDFNLRPEDYHGDGDLKKLYTLVWRRAVASQMETALFERTTIDLASKDKRAG LRATGQVLVFDGFIKLYTEGHDAGDDDDDAEGRLPKMAEGQHADLLKADANQSFTQPPPRYTEASLVKRLEELGIGRPST YASTMSTLEDRGYVRIEGKALVPEDKGRLVTAFLENFFSRYVEYDFTAGLEEKLDVISDGKLDWKAFLREFWQQFAADID GTKDLRVSAVLDALNEALGAYVFPRQDAEGNPIENPRQCPLCKEGELSMKLGKFGAFVGCSRHPECKYTRQFSSEGGDAA INPDGNEIGIHPDTGAMILLKSGRFGPYVEMANGEKPKRASLAKADNAAELTLERAVELLSLPREVGPHPEDGEMILANF GRFGPYVQHGKTYANLKDPRDVFTIGVNHAVSLIEDKKARGSARGGAAALKALGDHPDGGAIEVFEGRYGPYVKWGKVNA TLPKEITPDVVTLEQAIELVNAKGGSAKKKAPAKKAAAKKPAAKKAAPKKKAPAKKAEE
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=631, Percent_Identity=27.4167987321712, Blast_Score=148, Evalue=3e-35, Organism=Homo sapiens, GI4507635, Length=601, Percent_Identity=22.9617304492512, Blast_Score=104, Evalue=3e-22, Organism=Escherichia coli, GI1787529, Length=751, Percent_Identity=38.0825565912117, Blast_Score=460, Evalue=1e-130, Organism=Escherichia coli, GI1788061, Length=629, Percent_Identity=25.1192368839428, Blast_Score=126, Evalue=5e-30, Organism=Caenorhabditis elegans, GI32563869, Length=573, Percent_Identity=26.3525305410122, Blast_Score=140, Evalue=3e-33, Organism=Caenorhabditis elegans, GI17555378, Length=497, Percent_Identity=27.9678068410463, Blast_Score=125, Evalue=1e-28, Organism=Saccharomyces cerevisiae, GI6323263, Length=556, Percent_Identity=26.2589928057554, Blast_Score=122, Evalue=2e-28, Organism=Drosophila melanogaster, GI24585251, Length=652, Percent_Identity=27.3006134969325, Blast_Score=162, Evalue=1e-39, Organism=Drosophila melanogaster, GI24640096, Length=562, Percent_Identity=24.7330960854093, Blast_Score=108, Evalue=1e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 94720; Mature: 94720
Theoretical pI: Translated: 8.53; Mature: 8.53
Prosite motif: PS00396 TOPOISOMERASE_I_PROK ; PS00223 ANNEXIN
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLVVVESPAKAKTINKYLGKDYKVLASYGHIRDLPSKNGSVDPENDFEMVWEADSKSAK CEEEEECCCCHHHHHHHHHCCCHHHHHHHCHHHCCCCCCCCCCCCCCCEEEEECCCHHHH RISDIANALKDADTLILATDPDREGEAISWHLVEALRKRRALKKDVAIERVVFNAITKSA HHHHHHHHHHCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH VTQAMEHPRAIDAELVDAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRIVCD HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHEEEEEEEEEC RENEIESFRAQEYWNIVAELRAPDGTAFEARLHSLDGETLKKFTLGNQGDANRALEIVKV CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEEE GGYSVVSVEAKPVKRNPPPPFITSTLQQEASRKLGFNAKRTMQAAQKLYEEGRITYMRTD CCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECC GVNMAEEAYVAARTMIQSNYGARYLPENTRRYSSKAKNAQEAHEAIRPTDFNLRPEDYHG CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCC DGDLKKLYTLVWRRAVASQMETALFERTTIDLASKDKRAGLRATGQVLVFDGFIKLYTEG CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEECEEEEEECC HDAGDDDDDAEGRLPKMAEGQHADLLKADANQSFTQPPPRYTEASLVKRLEELGIGRPST CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCH YASTMSTLEDRGYVRIEGKALVPEDKGRLVTAFLENFFSRYVEYDFTAGLEEKLDVISDG HHHHHHHHHHCCEEEECCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC KLDWKAFLREFWQQFAADIDGTKDLRVSAVLDALNEALGAYVFPRQDAEGNPIENPRQCP CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCC LCKEGELSMKLGKFGAFVGCSRHPECKYTRQFSSEGGDAAINPDGNEIGIHPDTGAMILL CCCCCCCEEEHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEECCCCCEECCCCCCCCEEEE KSGRFGPYVEMANGEKPKRASLAKADNAAELTLERAVELLSLPREVGPHPEDGEMILANF ECCCCCCEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCEEEECC GRFGPYVQHGKTYANLKDPRDVFTIGVNHAVSLIEDKKARGSARGGAAALKALGDHPDGG CCCCCHHHCCCEECCCCCCHHEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCC AIEVFEGRYGPYVKWGKVNATLPKEITPDVVTLEQAIELVNAKGGSAKKKAPAKKAAAKK EEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCC PAAKKAAPKKKAPAKKAEE CCHHHCCCCCCCCCCCCCC >Mature Secondary Structure MKLVVVESPAKAKTINKYLGKDYKVLASYGHIRDLPSKNGSVDPENDFEMVWEADSKSAK CEEEEECCCCHHHHHHHHHCCCHHHHHHHCHHHCCCCCCCCCCCCCCCEEEEECCCHHHH RISDIANALKDADTLILATDPDREGEAISWHLVEALRKRRALKKDVAIERVVFNAITKSA HHHHHHHHHHCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH VTQAMEHPRAIDAELVDAYLARRALDYLVGFNLSPVLWRKLPGSRSAGRVQSVALRIVCD HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHEEEEEEEEEC RENEIESFRAQEYWNIVAELRAPDGTAFEARLHSLDGETLKKFTLGNQGDANRALEIVKV CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCCCCCCCEEEEEEE GGYSVVSVEAKPVKRNPPPPFITSTLQQEASRKLGFNAKRTMQAAQKLYEEGRITYMRTD CCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECC GVNMAEEAYVAARTMIQSNYGARYLPENTRRYSSKAKNAQEAHEAIRPTDFNLRPEDYHG CCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCC DGDLKKLYTLVWRRAVASQMETALFERTTIDLASKDKRAGLRATGQVLVFDGFIKLYTEG CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEECEEEEEECC HDAGDDDDDAEGRLPKMAEGQHADLLKADANQSFTQPPPRYTEASLVKRLEELGIGRPST CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCH YASTMSTLEDRGYVRIEGKALVPEDKGRLVTAFLENFFSRYVEYDFTAGLEEKLDVISDG HHHHHHHHHHCCEEEECCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC KLDWKAFLREFWQQFAADIDGTKDLRVSAVLDALNEALGAYVFPRQDAEGNPIENPRQCP CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCCCC LCKEGELSMKLGKFGAFVGCSRHPECKYTRQFSSEGGDAAINPDGNEIGIHPDTGAMILL CCCCCCCEEEHHHHHHHCCCCCCCCCHHHHHHCCCCCCEEECCCCCEECCCCCCCCEEEE KSGRFGPYVEMANGEKPKRASLAKADNAAELTLERAVELLSLPREVGPHPEDGEMILANF ECCCCCCEEECCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCEEEECC GRFGPYVQHGKTYANLKDPRDVFTIGVNHAVSLIEDKKARGSARGGAAALKALGDHPDGG CCCCCHHHCCCEECCCCCCHHEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCC AIEVFEGRYGPYVKWGKVNATLPKEITPDVVTLEQAIELVNAKGGSAKKKAPAKKAAAKK EEEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCC PAAKKAAPKKKAPAKKAEE CCHHHCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA