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The map label for this gene is hflK [H]

Identifier: 114799007

GI number: 114799007

Start: 462082

End: 463248

Strand: Direct

Name: hflK [H]

Synonym: HNE_0469

Alternate gene names: 114799007

Gene position: 462082-463248 (Clockwise)

Preceding gene: 114799910

Following gene: 114799745

Centisome position: 12.47

GC content: 63.07

Gene sequence:

>1167_bases
ATGCCCTGGGACGATAAGACAAAAGGCTCTGGCCCTTGGGGCGGAGGCGGCTCGGGCAACGGTGGCGGCGAGGGGGGCTC
CCCGTGGAACCGTCCCGGCAAACCCGATGCCGGCAAGGAAAAAGACCAGCCTGCAGACCTTGAAGAGCAGATGCGCCGCA
TGCAGGAGCGCTTTCGTCAGCGCCGGGGCGGCGGTGGCGGACGCAAGGGCGGCGGCAGCGGTGGTGGTGGCGGCGGTCTC
GGCCGCGGCGCTGGCCCGCTCGGTGTCCTTGTCATTGTTGGCGTCGCGCTTCTGGCCTGGCTCTCGACCAGCGTTGTCGT
CGTTGACCCGACCCAGCAGGCAGCGGTCTTCCGGTTTGGCAAATGGCAGGCAAATTACGGCCCAGGCCTCCACTTCCACC
TGCCCGCGCCGTTGGAAAACCACCGCCTTATCCAGGTGGAAACCCGCAACGAAACCCGCATCGGCGCGACGGAAGACGAA
AGCCTGATGCTGACGCAGGACGAAAACATCGTCGACATCCATTTTTCGATCATCTGGAAAGTCGATACCCAGAACCCTGA
GAACTACGTGCTCAATGTTCGCGATCCCGACAGCACGGTCGCCATGGTCGGCGAGTCCGTGATGCGTGAAGTGGTCGGCA
AGACCCGCCTTCAGGACATCATCACCACCCAGCGTGACGAGGTCCAGTTGCAGGTGGTCGAGCAGACCCAGGCACTGCTC
AACGAGTATCGCGCCGGCGTGCAGATTCTGCAGGTCCAGATCGGCAAGGCAGACCCGCCTCAGCCGGTCATCGAGGCGTT
CAACGACGTTAACGTTGCCGAGCAGGACGCCGAAACCCTGACCAACCGTGCCACGCAGTTCGCCAACGAAATCGTTCCGC
AGGCTCGCGGTACCGCTTCGCGCCTGCAACAGGAATCGGAAGCCTACCGCGACCAGATTGTGGCCGACGCAAACGGTGAA
GCCGCCCGCTTTGACCAGATCTATGCGGAATACATCAAGGCGCCCCGCGTCACGCGGGAACGCATGTATCTTGAAACCAT
GGAACGTGTTCTGGAGCGGTCGGACAAATTGCTGATCGATCAGGATTCCGGCGCGGTGCCCTATCTGCCGATTGAACGAA
CGCGGCCCCAGCCCGCGGCTCCGGCGAGCAATGGAGGAGACCGCTAA

Upstream 100 bases:

>100_bases
GCCCGAATGCGTCATTTTTGCTGCGCCTGAAAGGCGATTTAGCGTGCACAGCGCATTAGACGCTCTATATAGGCGGGAAA
CGCAAATTTCAGGAGGGTGA

Downstream 100 bases:

>100_bases
TGCGTGCTTTTGGTTGGCTCATTCTGATCCTGTCCATCGTTGGACTGATCATCGCTTCAAACGTATTCTTCATCGTCCGC
CAGTCGGAACAGGCCATCGT

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPWDDKTKGSGPWGGGGSGNGGGEGGSPWNRPGKPDAGKEKDQPADLEEQMRRMQERFRQRRGGGGGRKGGGSGGGGGGL
GRGAGPLGVLVIVGVALLAWLSTSVVVVDPTQQAAVFRFGKWQANYGPGLHFHLPAPLENHRLIQVETRNETRIGATEDE
SLMLTQDENIVDIHFSIIWKVDTQNPENYVLNVRDPDSTVAMVGESVMREVVGKTRLQDIITTQRDEVQLQVVEQTQALL
NEYRAGVQILQVQIGKADPPQPVIEAFNDVNVAEQDAETLTNRATQFANEIVPQARGTASRLQQESEAYRDQIVADANGE
AARFDQIYAEYIKAPRVTRERMYLETMERVLERSDKLLIDQDSGAVPYLPIERTRPQPAAPASNGGDR

Sequences:

>Translated_388_residues
MPWDDKTKGSGPWGGGGSGNGGGEGGSPWNRPGKPDAGKEKDQPADLEEQMRRMQERFRQRRGGGGGRKGGGSGGGGGGL
GRGAGPLGVLVIVGVALLAWLSTSVVVVDPTQQAAVFRFGKWQANYGPGLHFHLPAPLENHRLIQVETRNETRIGATEDE
SLMLTQDENIVDIHFSIIWKVDTQNPENYVLNVRDPDSTVAMVGESVMREVVGKTRLQDIITTQRDEVQLQVVEQTQALL
NEYRAGVQILQVQIGKADPPQPVIEAFNDVNVAEQDAETLTNRATQFANEIVPQARGTASRLQQESEAYRDQIVADANGE
AARFDQIYAEYIKAPRVTRERMYLETMERVLERSDKLLIDQDSGAVPYLPIERTRPQPAAPASNGGDR
>Mature_387_residues
PWDDKTKGSGPWGGGGSGNGGGEGGSPWNRPGKPDAGKEKDQPADLEEQMRRMQERFRQRRGGGGGRKGGGSGGGGGGLG
RGAGPLGVLVIVGVALLAWLSTSVVVVDPTQQAAVFRFGKWQANYGPGLHFHLPAPLENHRLIQVETRNETRIGATEDES
LMLTQDENIVDIHFSIIWKVDTQNPENYVLNVRDPDSTVAMVGESVMREVVGKTRLQDIITTQRDEVQLQVVEQTQALLN
EYRAGVQILQVQIGKADPPQPVIEAFNDVNVAEQDAETLTNRATQFANEIVPQARGTASRLQQESEAYRDQIVADANGEA
ARFDQIYAEYIKAPRVTRERMYLETMERVLERSDKLLIDQDSGAVPYLPIERTRPQPAAPASNGGDR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=287, Percent_Identity=31.7073170731707, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 42386; Mature: 42255

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWDDKTKGSGPWGGGGSGNGGGEGGSPWNRPGKPDAGKEKDQPADLEEQMRRMQERFRQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RRGGGGGRKGGGSGGGGGGLGRGAGPLGVLVIVGVALLAWLSTSVVVVDPTQQAAVFRFG
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHC
KWQANYGPGLHFHLPAPLENHRLIQVETRNETRIGATEDESLMLTQDENIVDIHFSIIWK
CEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEEEEE
VDTQNPENYVLNVRDPDSTVAMVGESVMREVVGKTRLQDIITTQRDEVQLQVVEQTQALL
EECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NEYRAGVQILQVQIGKADPPQPVIEAFNDVNVAEQDAETLTNRATQFANEIVPQARGTAS
HHHHHCEEEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RLQQESEAYRDQIVADANGEAARFDQIYAEYIKAPRVTRERMYLETMERVLERSDKLLID
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEE
QDSGAVPYLPIERTRPQPAAPASNGGDR
CCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PWDDKTKGSGPWGGGGSGNGGGEGGSPWNRPGKPDAGKEKDQPADLEEQMRRMQERFRQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RRGGGGGRKGGGSGGGGGGLGRGAGPLGVLVIVGVALLAWLSTSVVVVDPTQQAAVFRFG
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHC
KWQANYGPGLHFHLPAPLENHRLIQVETRNETRIGATEDESLMLTQDENIVDIHFSIIWK
CEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEEEEE
VDTQNPENYVLNVRDPDSTVAMVGESVMREVVGKTRLQDIITTQRDEVQLQVVEQTQALL
EECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NEYRAGVQILQVQIGKADPPQPVIEAFNDVNVAEQDAETLTNRATQFANEIVPQARGTAS
HHHHHCEEEEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
RLQQESEAYRDQIVADANGEAARFDQIYAEYIKAPRVTRERMYLETMERVLERSDKLLID
HHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEE
QDSGAVPYLPIERTRPQPAAPASNGGDR
CCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]