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The map label for this gene is hflC [H]

Identifier: 114799745

GI number: 114799745

Start: 463248

End: 464144

Strand: Direct

Name: hflC [H]

Synonym: HNE_0470

Alternate gene names: 114799745

Gene position: 463248-464144 (Clockwise)

Preceding gene: 114799007

Following gene: 114800434

Centisome position: 12.5

GC content: 60.98

Gene sequence:

>897_bases
ATGCGTGCTTTTGGTTGGCTCATTCTGATCCTGTCCATCGTTGGACTGATCATCGCTTCAAACGTATTCTTCATCGTCCG
CCAGTCGGAACAGGCCATCGTGCTTGAAGTTGGCCGTCCGGTCAGCATCATCAACGCGCCGGGCACGGACCAGGCGGGTC
TTCACATGAAGATCCCGGTCTATCAGCAGGTCGAAATTCTCGACAAACGCAACCTTGGCCTCGACATCGAAGGCATTCAG
GTGATCGCATCCGACCAGCGCCGCCTGCAGGTCGACGCTTTCGTGCGGTGGCGGATCAGTGACCCACTGCGTTACTATCA
GAGCTTCCGCACCGAGCGTGTCGCGACCCAGCAGATCAACACCGTTGCTGTCGCTGCCATCCGCGCCGTGCTGGGGGATG
TGCCGGTTCCGGAAATCATCTCCGGCCAGCGCGTCGCTCTGATGGGAGAGATCCGCGATAATGTGAACACCGAACTCGCC
AAGGCGGGTGTGGACATCATCGACGTGCGTATCCGCCAGGCAGACCTTCCGCAGGAAGTGACCGAAGGCGTTTACAACCG
CATGCGGACGGCGCGTCTTCAGGAAGCTCAGCGTATCCGTTCGGAAGGGGAGGAGCGGGCCCGCCTGATCCGTGCCCAGG
CCGAGCGTGAGAAAACGGTTCTTGAAGCTCAGGCCCGTGAAACGGCCCAGAAGGTTCGTGGTGAGGGGGATGCCCGTGCT
ACCGAGATCTATGCGGCGGCCTACGGCAAGGACTCTGAATTCTTCCGCTTCCAGCGCGCACTCGTAGCGTGTGAAAAGGC
GATCCAGGAAGGTACGCAGATGGTTCTCAGCCCCGGCGCCATCGGCGTGTGCGACCAGTTCTTCGACAGCGCACGCGCTG
CCGGCGGCCCTCGCTAA

Upstream 100 bases:

>100_bases
AATTGCTGATCGATCAGGATTCCGGCGCGGTGCCCTATCTGCCGATTGAACGAACGCGGCCCCAGCCCGCGGCTCCGGCG
AGCAATGGAGGAGACCGCTA

Downstream 100 bases:

>100_bases
CCGGGCGGTGAGCGCGCGATGAGCGCAATCACGCTCGCTCTGGCCGGTTTCGGCGTCTGGCTCCTGGTGGAGGGCGCGCT
CTGCGCCATTGCCCCGGAAT

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MRAFGWLILILSIVGLIIASNVFFIVRQSEQAIVLEVGRPVSIINAPGTDQAGLHMKIPVYQQVEILDKRNLGLDIEGIQ
VIASDQRRLQVDAFVRWRISDPLRYYQSFRTERVATQQINTVAVAAIRAVLGDVPVPEIISGQRVALMGEIRDNVNTELA
KAGVDIIDVRIRQADLPQEVTEGVYNRMRTARLQEAQRIRSEGEERARLIRAQAEREKTVLEAQARETAQKVRGEGDARA
TEIYAAAYGKDSEFFRFQRALVACEKAIQEGTQMVLSPGAIGVCDQFFDSARAAGGPR

Sequences:

>Translated_298_residues
MRAFGWLILILSIVGLIIASNVFFIVRQSEQAIVLEVGRPVSIINAPGTDQAGLHMKIPVYQQVEILDKRNLGLDIEGIQ
VIASDQRRLQVDAFVRWRISDPLRYYQSFRTERVATQQINTVAVAAIRAVLGDVPVPEIISGQRVALMGEIRDNVNTELA
KAGVDIIDVRIRQADLPQEVTEGVYNRMRTARLQEAQRIRSEGEERARLIRAQAEREKTVLEAQARETAQKVRGEGDARA
TEIYAAAYGKDSEFFRFQRALVACEKAIQEGTQMVLSPGAIGVCDQFFDSARAAGGPR
>Mature_298_residues
MRAFGWLILILSIVGLIIASNVFFIVRQSEQAIVLEVGRPVSIINAPGTDQAGLHMKIPVYQQVEILDKRNLGLDIEGIQ
VIASDQRRLQVDAFVRWRISDPLRYYQSFRTERVATQQINTVAVAAIRAVLGDVPVPEIISGQRVALMGEIRDNVNTELA
KAGVDIIDVRIRQADLPQEVTEGVYNRMRTARLQEAQRIRSEGEERARLIRAQAEREKTVLEAQARETAQKVRGEGDARA
TEIYAAAYGKDSEFFRFQRALVACEKAIQEGTQMVLSPGAIGVCDQFFDSARAAGGPR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=301, Percent_Identity=31.5614617940199, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1786697, Length=324, Percent_Identity=24.0740740740741, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33174; Mature: 33174

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFGWLILILSIVGLIIASNVFFIVRQSEQAIVLEVGRPVSIINAPGTDQAGLHMKIPV
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCEEEEECCCCCCCCEEEECCC
YQQVEILDKRNLGLDIEGIQVIASDQRRLQVDAFVRWRISDPLRYYQSFRTERVATQQIN
HHHHHHHHCCCCCCCCCCCEEEECCCHHEEEEHEEEEECCCHHHHHHHHHHHHHHHHHHH
TVAVAAIRAVLGDVPVPEIISGQRVALMGEIRDNVNTELAKAGVDIIDVRIRQADLPQEV
HHHHHHHHHHHCCCCCCHHHCCCEEEEEHHHHHCCHHHHHHCCCCEEEEEECCCCCCHHH
TEGVYNRMRTARLQEAQRIRSEGEERARLIRAQAEREKTVLEAQARETAQKVRGEGDARA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
TEIYAAAYGKDSEFFRFQRALVACEKAIQEGTQMVLSPGAIGVCDQFFDSARAAGGPR
HHEEHHHCCCCHHHHHHHHHHHHHHHHHHHCHHEEECCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRAFGWLILILSIVGLIIASNVFFIVRQSEQAIVLEVGRPVSIINAPGTDQAGLHMKIPV
CCHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCEEEEECCCCCCCCEEEECCC
YQQVEILDKRNLGLDIEGIQVIASDQRRLQVDAFVRWRISDPLRYYQSFRTERVATQQIN
HHHHHHHHCCCCCCCCCCCEEEECCCHHEEEEHEEEEECCCHHHHHHHHHHHHHHHHHHH
TVAVAAIRAVLGDVPVPEIISGQRVALMGEIRDNVNTELAKAGVDIIDVRIRQADLPQEV
HHHHHHHHHHHCCCCCCHHHCCCEEEEEHHHHHCCHHHHHHCCCCEEEEEECCCCCCHHH
TEGVYNRMRTARLQEAQRIRSEGEERARLIRAQAEREKTVLEAQARETAQKVRGEGDARA
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
TEIYAAAYGKDSEFFRFQRALVACEKAIQEGTQMVLSPGAIGVCDQFFDSARAAGGPR
HHEEHHHCCCCHHHHHHHHHHHHHHHHHHHCHHEEECCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]