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The map label for this gene is phoQ [H]

Identifier: 114798979

GI number: 114798979

Start: 2461577

End: 2462899

Strand: Direct

Name: phoQ [H]

Synonym: HNE_2362

Alternate gene names: 114798979

Gene position: 2461577-2462899 (Clockwise)

Preceding gene: 114797742

Following gene: 114798628

Centisome position: 66.44

GC content: 68.41

Gene sequence:

>1323_bases
GTGAGGCCCCTGCGATCCATCCGGCTTCGCCTGCTAGCAGGCGGCGCGCTGGCCATTGCGGCCGCCCTGCTGGTTTCATG
GTTCACGCTTGTGCTGCTGTTCGACAGTCACATCCGGCGCAACACCGAGGACGATCTGATCCGCCACGGCCGCGCCATCG
TCAGCGCCATCACCTTCACGCCCGGTGGCTTCGCCACCGACACTTACGAGCCAACAGACCTGCGCTTCGACCGGCCCGCC
AGCGGTCTCTACTGGCAGGTATCGCGCAACGGTGATGTGCACCGCTCCCGTTCGCTCTGGGATAATGCGCTGGACCTGCC
CGCTGGCGTAGACGGCGCCAAATGGCACCGCGACACCGCCGCCGGCCCCTTCGGCCAGGATCTTGTCCGCGTAGCGCGCA
CCATCCGGCAAACCCAAACCTCGGCGCCTGTGATGCTGATTATTGCGGAAGACCGGGCGAGCCTGATCAATGCGCGGGAG
GAATTTGCCCGCGAACTGGCGATCTTCCTGACCCTGCTCTGGGCAACACTGAGCCTGGCCGCCTGGTTGCAGGTGACGAT
CGGCCTCCTGCCCCTGCGCGCCGTGCAATCTTCCATCAGCGAGCTTAAATCCTCGCCTGTCTCGCGCCTCGATCCGGCCC
GGTTTGCCACCGAAGTGACCCCGCTGGTCGACCAGATCAACGAACTGGCGGACGCCCGGGAAGCCGATGTGCACGCCGCG
CGCGACCGCGCCGCCAATCTCGCCCACGGCCTGAAGACGCCGCTCTCTGCCCTGCGCGCCATTGCCCGGCGGGTGCGCGA
TGGCGGACAGGCCGACATGGCCGAAGGGCTGGAACACTCCATCCGCGCCGCCTCTGACGCGGTGGATCGTGAACTCGCCC
GCGCCCGCACGGCGGCGAGCCTGGACCGGGGCCCCACAGAGCCCGGCCCGCTGATCGAGCGGCTGGTGACGGTCCTCTCC
CGCACCGAGCGGGGCGCAAGGGTGGACTTCGAGATCGACTGCCCGGCTGGCGAGACGCTGCCTGTCTCCGCCGATCAGCT
CATGGAAATGGCCGGGCCGCTGATGGAGAACGCCGCGCGATACGCCGCCGCCCGTGTCCGCATTACCGCGCGCGCCCGCG
CGTTGCGGATTGAGGATGATGGCCCCGGCCTCGACACCGCTGATCGGGATCAGGTCATCCTGCGCGGTCAGCGCGCCGAC
GAACGCCCCGGCGGCCACGGGCTCGGCCTCTCCATCGCGCATGATCTGGCAGAGGCCACCGATGGCCATCTGGAGCTGGG
CACATCGGAACTGGGCGGGCTCAAGGCAAGCCTGATCTGGTAA

Upstream 100 bases:

>100_bases
CCAACGCCATCGAGGCCATTGTCTCACGCCTGCGCCGCAAGCTTGGCCCGGGCGTGATCAGCACCCGGCGCGGTTTCGGC
TACGTCATCGAAGCGGGCGC

Downstream 100 bases:

>100_bases
CCAACCGTCTTCCGGCGACCAGCGCCGCAAATAGTAGGCAGGCAACGCCAACGGCCGCTGGAAACAGCGCCGTGGTCCAG
GAATAATGCTCCAGCGCCAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MRPLRSIRLRLLAGGALAIAAALLVSWFTLVLLFDSHIRRNTEDDLIRHGRAIVSAITFTPGGFATDTYEPTDLRFDRPA
SGLYWQVSRNGDVHRSRSLWDNALDLPAGVDGAKWHRDTAAGPFGQDLVRVARTIRQTQTSAPVMLIIAEDRASLINARE
EFARELAIFLTLLWATLSLAAWLQVTIGLLPLRAVQSSISELKSSPVSRLDPARFATEVTPLVDQINELADAREADVHAA
RDRAANLAHGLKTPLSALRAIARRVRDGGQADMAEGLEHSIRAASDAVDRELARARTAASLDRGPTEPGPLIERLVTVLS
RTERGARVDFEIDCPAGETLPVSADQLMEMAGPLMENAARYAAARVRITARARALRIEDDGPGLDTADRDQVILRGQRAD
ERPGGHGLGLSIAHDLAEATDGHLELGTSELGGLKASLIW

Sequences:

>Translated_440_residues
MRPLRSIRLRLLAGGALAIAAALLVSWFTLVLLFDSHIRRNTEDDLIRHGRAIVSAITFTPGGFATDTYEPTDLRFDRPA
SGLYWQVSRNGDVHRSRSLWDNALDLPAGVDGAKWHRDTAAGPFGQDLVRVARTIRQTQTSAPVMLIIAEDRASLINARE
EFARELAIFLTLLWATLSLAAWLQVTIGLLPLRAVQSSISELKSSPVSRLDPARFATEVTPLVDQINELADAREADVHAA
RDRAANLAHGLKTPLSALRAIARRVRDGGQADMAEGLEHSIRAASDAVDRELARARTAASLDRGPTEPGPLIERLVTVLS
RTERGARVDFEIDCPAGETLPVSADQLMEMAGPLMENAARYAAARVRITARARALRIEDDGPGLDTADRDQVILRGQRAD
ERPGGHGLGLSIAHDLAEATDGHLELGTSELGGLKASLIW
>Mature_440_residues
MRPLRSIRLRLLAGGALAIAAALLVSWFTLVLLFDSHIRRNTEDDLIRHGRAIVSAITFTPGGFATDTYEPTDLRFDRPA
SGLYWQVSRNGDVHRSRSLWDNALDLPAGVDGAKWHRDTAAGPFGQDLVRVARTIRQTQTSAPVMLIIAEDRASLINARE
EFARELAIFLTLLWATLSLAAWLQVTIGLLPLRAVQSSISELKSSPVSRLDPARFATEVTPLVDQINELADAREADVHAA
RDRAANLAHGLKTPLSALRAIARRVRDGGQADMAEGLEHSIRAASDAVDRELARARTAASLDRGPTEPGPLIERLVTVLS
RTERGARVDFEIDCPAGETLPVSADQLMEMAGPLMENAARYAAARVRITARARALRIEDDGPGLDTADRDQVILRGQRAD
ERPGGHGLGLSIAHDLAEATDGHLELGTSELGGLKASLIW

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=283, Percent_Identity=28.6219081272085, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788393, Length=256, Percent_Identity=26.5625, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=239, Percent_Identity=27.1966527196653, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789808, Length=229, Percent_Identity=26.6375545851528, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47745; Mature: 47745

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLRSIRLRLLAGGALAIAAALLVSWFTLVLLFDSHIRRNTEDDLIRHGRAIVSAITFT
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEC
PGGFATDTYEPTDLRFDRPASGLYWQVSRNGDVHRSRSLWDNALDLPAGVDGAKWHRDTA
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCC
AGPFGQDLVRVARTIRQTQTSAPVMLIIAEDRASLINAREEFARELAIFLTLLWATLSLA
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWLQVTIGLLPLRAVQSSISELKSSPVSRLDPARFATEVTPLVDQINELADAREADVHAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDRAANLAHGLKTPLSALRAIARRVRDGGQADMAEGLEHSIRAASDAVDRELARARTAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDRGPTEPGPLIERLVTVLSRTERGARVDFEIDCPAGETLPVSADQLMEMAGPLMENAAR
HCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
YAAARVRITARARALRIEDDGPGLDTADRDQVILRGQRADERPGGHGLGLSIAHDLAEAT
HHHHHHEEEEHEEEEEECCCCCCCCCCCCCHHEEECCCCCCCCCCCCCCHHHHHHHHHHC
DGHLELGTSELGGLKASLIW
CCCEEECCHHHCCCCCCCCC
>Mature Secondary Structure
MRPLRSIRLRLLAGGALAIAAALLVSWFTLVLLFDSHIRRNTEDDLIRHGRAIVSAITFT
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEC
PGGFATDTYEPTDLRFDRPASGLYWQVSRNGDVHRSRSLWDNALDLPAGVDGAKWHRDTA
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCC
AGPFGQDLVRVARTIRQTQTSAPVMLIIAEDRASLINAREEFARELAIFLTLLWATLSLA
CCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWLQVTIGLLPLRAVQSSISELKSSPVSRLDPARFATEVTPLVDQINELADAREADVHAA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDRAANLAHGLKTPLSALRAIARRVRDGGQADMAEGLEHSIRAASDAVDRELARARTAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDRGPTEPGPLIERLVTVLSRTERGARVDFEIDCPAGETLPVSADQLMEMAGPLMENAAR
HCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
YAAARVRITARARALRIEDDGPGLDTADRDQVILRGQRADERPGGHGLGLSIAHDLAEAT
HHHHHHEEEEHEEEEEECCCCCCCCCCCCCHHEEECCCCCCCCCCCCCCHHHHHHHHHHC
DGHLELGTSELGGLKASLIW
CCCEEECCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA