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The map label for this gene is aqpZ [H]

Identifier: 114798833

GI number: 114798833

Start: 455843

End: 456523

Strand: Direct

Name: aqpZ [H]

Synonym: HNE_0461

Alternate gene names: 114798833

Gene position: 455843-456523 (Clockwise)

Preceding gene: 114798205

Following gene: 114797071

Centisome position: 12.3

GC content: 64.17

Gene sequence:

>681_bases
ATGAAACCCCTGATCGCTGAACTTATCGGCACATTCGCCCTGGTCCTGTTTGGCTGTGGTTCTGCTGTCCTCGCCGGAGG
CGAGGTTGGCCAGTTAGGTATCGCGTTCGCTTTCGGCCTGGCCATCGTCGCCATGGCCTATGGCATCGGCCCCATCTCGG
GCTGCCACGTCAATCCGGCGGTCAGCTTCGGCGCCTTCATCGCCGGGCGTATGACGCTCAACTCCATGTTCCAGTACTGG
ATCGCCCAGTTCATCGGGGCCGTGCTCGGCGCCGCCGTCCTCTATCTCATCGCCTCAGGCAAGGCAGGCTATGACCTGGC
CGCAAACGGGCTTGGCCAGAATGGCTGGGGCGCAGGGTATCTGGGCGAATACAGCCTCGTCTCGGCGCTGGTCTTCGAGA
TTGTCGCCACCTTCCTGTTCCTCGTCGTGATCCTGGGCGCCACCCAGAAATCCGCGCCCGGAATGGTCGCTGGCCTCGCC
ATCGGCCTCACGCTCGCGGTCATCCACATTGTCGGCATCCAGGTCACCGGCGTCTCGGTAAACCCCGCCCGCAGCTTCGG
CCCCGCCGTCATCGTGGGCGGCGCGGCAATCTCCCAGCTCTGGCTGTTCTTCGTCGCCCCGCTTATCGGCGCAGCGCTCG
CCGGCATCCTCTTCCGCCAGAAACTCCTGGAAACGGAATAG

Upstream 100 bases:

>100_bases
GGCAGGCCAGAATCCTGCTTGCCGCAGATTGAAAAGCTCTGCATCCTGACAGTGGCTTGAGGCGGCAATAAGACCGCCTG
GGCCCATCAAGGAGACATCC

Downstream 100 bases:

>100_bases
GCCTGTTGTCTATCGGCCTCGTCCTGAAAGGGACGGGGCCTCCAACCTCCCGGCTGCCACCCCCACAAGCAACGCGCAGG
CGCAGGTGCCGCGAGCCTTG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKPLIAELIGTFALVLFGCGSAVLAGGEVGQLGIAFAFGLAIVAMAYGIGPISGCHVNPAVSFGAFIAGRMTLNSMFQYW
IAQFIGAVLGAAVLYLIASGKAGYDLAANGLGQNGWGAGYLGEYSLVSALVFEIVATFLFLVVILGATQKSAPGMVAGLA
IGLTLAVIHIVGIQVTGVSVNPARSFGPAVIVGGAAISQLWLFFVAPLIGAALAGILFRQKLLETE

Sequences:

>Translated_226_residues
MKPLIAELIGTFALVLFGCGSAVLAGGEVGQLGIAFAFGLAIVAMAYGIGPISGCHVNPAVSFGAFIAGRMTLNSMFQYW
IAQFIGAVLGAAVLYLIASGKAGYDLAANGLGQNGWGAGYLGEYSLVSALVFEIVATFLFLVVILGATQKSAPGMVAGLA
IGLTLAVIHIVGIQVTGVSVNPARSFGPAVIVGGAAISQLWLFFVAPLIGAALAGILFRQKLLETE
>Mature_226_residues
MKPLIAELIGTFALVLFGCGSAVLAGGEVGQLGIAFAFGLAIVAMAYGIGPISGCHVNPAVSFGAFIAGRMTLNSMFQYW
IAQFIGAVLGAAVLYLIASGKAGYDLAANGLGQNGWGAGYLGEYSLVSALVFEIVATFLFLVVILGATQKSAPGMVAGLA
IGLTLAVIHIVGIQVTGVSVNPARSFGPAVIVGGAAISQLWLFFVAPLIGAALAGILFRQKLLETE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=222, Percent_Identity=36.9369369369369, Blast_Score=120, Evalue=8e-28,
Organism=Homo sapiens, GI6912506, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI37694062, Length=227, Percent_Identity=34.3612334801762, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI4502179, Length=222, Percent_Identity=36.036036036036, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI4502181, Length=227, Percent_Identity=35.6828193832599, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI4755125, Length=227, Percent_Identity=35.6828193832599, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI45446752, Length=195, Percent_Identity=34.3589743589744, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI86792455, Length=220, Percent_Identity=33.1818181818182, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI157266307, Length=245, Percent_Identity=32.6530612244898, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI4826645, Length=247, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4502187, Length=239, Percent_Identity=27.6150627615063, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI297307120, Length=88, Percent_Identity=40.9090909090909, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787101, Length=230, Percent_Identity=48.695652173913, Blast_Score=180, Evalue=5e-47,
Organism=Escherichia coli, GI1790362, Length=242, Percent_Identity=27.6859504132231, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558372, Length=226, Percent_Identity=31.4159292035398, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17531429, Length=230, Percent_Identity=31.304347826087, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17531431, Length=228, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71993722, Length=239, Percent_Identity=32.2175732217573, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71992966, Length=231, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24652747, Length=220, Percent_Identity=37.2727272727273, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45551084, Length=220, Percent_Identity=37.2727272727273, Blast_Score=126, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24652751, Length=223, Percent_Identity=32.7354260089686, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922038, Length=223, Percent_Identity=33.1838565022422, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550503, Length=233, Percent_Identity=26.6094420600858, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24762344, Length=229, Percent_Identity=31.0043668122271, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24762346, Length=232, Percent_Identity=30.6034482758621, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24762348, Length=232, Percent_Identity=30.6034482758621, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130305, Length=232, Percent_Identity=30.6034482758621, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 22937; Mature: 22937

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLIAELIGTFALVLFGCGSAVLAGGEVGQLGIAFAFGLAIVAMAYGIGPISGCHVNPA
CCHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VSFGAFIAGRMTLNSMFQYWIAQFIGAVLGAAVLYLIASGKAGYDLAANGLGQNGWGAGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCC
LGEYSLVSALVFEIVATFLFLVVILGATQKSAPGMVAGLAIGLTLAVIHIVGIQVTGVSV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCC
NPARSFGPAVIVGGAAISQLWLFFVAPLIGAALAGILFRQKLLETE
CCCHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPLIAELIGTFALVLFGCGSAVLAGGEVGQLGIAFAFGLAIVAMAYGIGPISGCHVNPA
CCHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VSFGAFIAGRMTLNSMFQYWIAQFIGAVLGAAVLYLIASGKAGYDLAANGLGQNGWGAGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCC
LGEYSLVSALVFEIVATFLFLVVILGATQKSAPGMVAGLAIGLTLAVIHIVGIQVTGVSV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCC
NPARSFGPAVIVGGAAISQLWLFFVAPLIGAALAGILFRQKLLETE
CCCHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]