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The map label for this gene is dut [H]

Identifier: 114798633

GI number: 114798633

Start: 3430329

End: 3430784

Strand: Reverse

Name: dut [H]

Synonym: HNE_3267

Alternate gene names: 114798633

Gene position: 3430784-3430329 (Counterclockwise)

Preceding gene: 114799868

Following gene: 114797838

Centisome position: 92.6

GC content: 66.67

Gene sequence:

>456_bases
ATGACCGATGTGACCGTTCAAGTGCTTCCGCTGCCCCATTTTGCCGGGCTTGATCTTCCCGCTTACGAGACGGCGGGCTC
TGCCGGCATGGATGTCCGCGCGGCGGTGCCAGATCGCGAACCGGTTATTCTGGCCCCCGGCCAGCGCGCCATGGTGCCCA
CCGGTCTTTCGGTCGCGATTCCCGAAGGCTACGAAATCCAGGTCCGCCCGCGCTCTGGCCTTGCCGCCAAGCACGGCCTT
ACCTGCCTCAACACGCCCGGCACGATCGACAGCGATTATCGCGGCGAAATCAAGGTCATCCTGATCAACCTCGGCGCTGA
GCCCTTCACCATCCAGCGCGGCGAGCGGATTGCCCAGCTCGTGCTGGCCCCGGTCACGCGGCTTGCCTGGACTGAGGTTG
AGGCGCTCGGCGAGACCGCGCGCGGGGCAGGTGGCTTCGGCTCCACAGGCCGCTGA

Upstream 100 bases:

>100_bases
GATTGCCGAGGCCTTTGCTGGCGATGCAGACGGCCTGTCCCTCGCGGCGGAGTAAGCTCCCCGCTTGACTCCTCCCCAGA
GTCTCCCCACCCGTCGCGTC

Downstream 100 bases:

>100_bases
CGGACCGCTTATGGGGCGTCCTCTCCAAAAATAATGGCCCCCGCCGTTCAATTTTTCTTGAACGCGAGCCCATCTTCCCC
ACATATTGAATATCAATAAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MTDVTVQVLPLPHFAGLDLPAYETAGSAGMDVRAAVPDREPVILAPGQRAMVPTGLSVAIPEGYEIQVRPRSGLAAKHGL
TCLNTPGTIDSDYRGEIKVILINLGAEPFTIQRGERIAQLVLAPVTRLAWTEVEALGETARGAGGFGSTGR

Sequences:

>Translated_151_residues
MTDVTVQVLPLPHFAGLDLPAYETAGSAGMDVRAAVPDREPVILAPGQRAMVPTGLSVAIPEGYEIQVRPRSGLAAKHGL
TCLNTPGTIDSDYRGEIKVILINLGAEPFTIQRGERIAQLVLAPVTRLAWTEVEALGETARGAGGFGSTGR
>Mature_150_residues
TDVTVQVLPLPHFAGLDLPAYETAGSAGMDVRAAVPDREPVILAPGQRAMVPTGLSVAIPEGYEIQVRPRSGLAAKHGLT
CLNTPGTIDSDYRGEIKVILINLGAEPFTIQRGERIAQLVLAPVTRLAWTEVEALGETARGAGGFGSTGR

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=132, Percent_Identity=42.4242424242424, Blast_Score=103, Evalue=8e-23,
Organism=Homo sapiens, GI4503423, Length=132, Percent_Identity=42.4242424242424, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI70906441, Length=132, Percent_Identity=42.4242424242424, Blast_Score=100, Evalue=9e-22,
Organism=Escherichia coli, GI1790071, Length=134, Percent_Identity=47.7611940298507, Blast_Score=120, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71988561, Length=150, Percent_Identity=44.6666666666667, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319729, Length=153, Percent_Identity=40.5228758169935, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24583610, Length=131, Percent_Identity=38.1679389312977, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921126, Length=131, Percent_Identity=38.1679389312977, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15856; Mature: 15725

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVTVQVLPLPHFAGLDLPAYETAGSAGMDVRAAVPDREPVILAPGQRAMVPTGLSVAI
CCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCCCCEECCCCCEEEC
PEGYEIQVRPRSGLAAKHGLTCLNTPGTIDSDYRGEIKVILINLGAEPFTIQRGERIAQL
CCCCEEEEECCCCCCHHCCCEEECCCCCCCCCCCCEEEEEEEECCCCCEEECCHHHHHHH
VLAPVTRLAWTEVEALGETARGAGGFGSTGR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TDVTVQVLPLPHFAGLDLPAYETAGSAGMDVRAAVPDREPVILAPGQRAMVPTGLSVAI
CCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCCCCEECCCCCEEEC
PEGYEIQVRPRSGLAAKHGLTCLNTPGTIDSDYRGEIKVILINLGAEPFTIQRGERIAQL
CCCCEEEEECCCCCCHHCCCEEECCCCCCCCCCCCEEEEEEEECCCCCEEECCHHHHHHH
VLAPVTRLAWTEVEALGETARGAGGFGSTGR
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA