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The map label for this gene is coaBC [H]

Identifier: 114799868

GI number: 114799868

Start: 3430830

End: 3432056

Strand: Reverse

Name: coaBC [H]

Synonym: HNE_3268

Alternate gene names: 114799868

Gene position: 3432056-3430830 (Counterclockwise)

Preceding gene: 114800496

Following gene: 114798633

Centisome position: 92.63

GC content: 64.96

Gene sequence:

>1227_bases
ATGAGCGCCAAACGCATCCTACTCGTCATCGGTGGCGGCATTGCCGCCTATAAAAGCCTTGAGCTCATCCGTGAGCTCGG
CCGGCGCGGCATTGGCGCGCGCGTCATCCTCACAAAGGCGGGCACAGAGTTTGTCACGCCGCTCTCCGTCGCCGCGCTTT
CCGGCGAAAAAGTGTATACGGAACTCTTCAGCCTGACCGACGAGACCGAGATGGGCCATATCGAGCTTTCCCGCTCGGCC
GACCTCGTCGTCGTCTGCCCCGCCACCGCAGACCTGATGGCCAAGGCCGTTCACGGCCACGCCAACGACCTTGCGTCCAC
CACGCTGCTCGCCACTGACAAGCCGGTCCTCATGGTGCCCGCCATGAATGTGCGCATGTGGCAGCATGGCGCCACCCAGC
GCAACATTGCCCAGCTCCGCGCGGATGGCGTTACAGTCATGGAGCCTGATGTTGGCCCGATGGCCTGCGGCGAGTTCGGC
CCCGGCCGCCTGCCGGATGTGCCGCGTATCGTGGCGCAGATCGAGGCGATGCTCCGCCCCCGGCAGAAACGCCTCGCCGG
CCGCCACGCCCTCGTCACCGCCGGGCCGACACGCGAGCCCCTTGATCCGGTGCGCTACATCTCCAATCATTCCTCCGGCA
AGCAGGGCTATTCCATTGCTGCGGCCCTCGCCGCCGAAGGCGCCAGGGTTACGCTCGTCTCCGGCCCTGTTTCTCTCCCA
GCCCCTGAAGGCGTCACGCTGGTAAAGGTCGAAACCGCCCGCGAGATGCTCAAGGCCTGCGAAGATGCTCTGCCAGCGGA
TATCTTTATCTCGGTCGCCGCCGTCGCAGACTGGCGCCCGGTGAAAGCGGCCGACAAGAAGCTCAAGCTGAAAGGGGAGG
GCAAATCCCCCGCCATCGAGCTTGCCGAAAATCCGGACATCCTGCGCACGATCAGCCACAAGAAGAAAAAGCGCCCGGCA
CTCGTCATCGGCTTTGCCGCCGAGACCCACGACCTGGAGCGCCATGCGAGCGAAAAACTCGCCCGCAAGGGCTGCGACTG
GATCGTTGCCAATGATGTCTCCGGCGACGTCATGGGCGGCCTCGAAAACGAGATCGCCCTGATTACCCAGGCCGGTATCG
ACCGCTGGCCCCGCATGCCCAAGGAAGCCGTCAGCGCCCGCCTCGCCGAAAAGATTGCCGAGGCCTTTGCTGGCGATGCA
GACGGCCTGTCCCTCGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
GGAAAGTTGAGGCCGCGCGCGCATTCGCGGGGTTTTGATGGCGTCCCGGCAATGTTTTTGCGCTAGAAACGCGGCCAGTC
ACACCCGATATAGCGGATAT

Downstream 100 bases:

>100_bases
GCTCCCCGCTTGACTCCTCCCCAGAGTCTCCCCACCCGTCGCGTCATGACCGATGTGACCGTTCAAGTGCTTCCGCTGCC
CCATTTTGCCGGGCTTGATC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSAKRILLVIGGGIAAYKSLELIRELGRRGIGARVILTKAGTEFVTPLSVAALSGEKVYTELFSLTDETEMGHIELSRSA
DLVVVCPATADLMAKAVHGHANDLASTTLLATDKPVLMVPAMNVRMWQHGATQRNIAQLRADGVTVMEPDVGPMACGEFG
PGRLPDVPRIVAQIEAMLRPRQKRLAGRHALVTAGPTREPLDPVRYISNHSSGKQGYSIAAALAAEGARVTLVSGPVSLP
APEGVTLVKVETAREMLKACEDALPADIFISVAAVADWRPVKAADKKLKLKGEGKSPAIELAENPDILRTISHKKKKRPA
LVIGFAAETHDLERHASEKLARKGCDWIVANDVSGDVMGGLENEIALITQAGIDRWPRMPKEAVSARLAEKIAEAFAGDA
DGLSLAAE

Sequences:

>Translated_408_residues
MSAKRILLVIGGGIAAYKSLELIRELGRRGIGARVILTKAGTEFVTPLSVAALSGEKVYTELFSLTDETEMGHIELSRSA
DLVVVCPATADLMAKAVHGHANDLASTTLLATDKPVLMVPAMNVRMWQHGATQRNIAQLRADGVTVMEPDVGPMACGEFG
PGRLPDVPRIVAQIEAMLRPRQKRLAGRHALVTAGPTREPLDPVRYISNHSSGKQGYSIAAALAAEGARVTLVSGPVSLP
APEGVTLVKVETAREMLKACEDALPADIFISVAAVADWRPVKAADKKLKLKGEGKSPAIELAENPDILRTISHKKKKRPA
LVIGFAAETHDLERHASEKLARKGCDWIVANDVSGDVMGGLENEIALITQAGIDRWPRMPKEAVSARLAEKIAEAFAGDA
DGLSLAAE
>Mature_407_residues
SAKRILLVIGGGIAAYKSLELIRELGRRGIGARVILTKAGTEFVTPLSVAALSGEKVYTELFSLTDETEMGHIELSRSAD
LVVVCPATADLMAKAVHGHANDLASTTLLATDKPVLMVPAMNVRMWQHGATQRNIAQLRADGVTVMEPDVGPMACGEFGP
GRLPDVPRIVAQIEAMLRPRQKRLAGRHALVTAGPTREPLDPVRYISNHSSGKQGYSIAAALAAEGARVTLVSGPVSLPA
PEGVTLVKVETAREMLKACEDALPADIFISVAAVADWRPVKAADKKLKLKGEGKSPAIELAENPDILRTISHKKKKRPAL
VIGFAAETHDLERHASEKLARKGCDWIVANDVSGDVMGGLENEIALITQAGIDRWPRMPKEAVSARLAEKIAEAFAGDAD
GLSLAAE

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=29.7297297297297, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87082301, Length=400, Percent_Identity=46.75, Blast_Score=303, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17560194, Length=189, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43416; Mature: 43285

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKRILLVIGGGIAAYKSLELIRELGRRGIGARVILTKAGTEFVTPLSVAALSGEKVYT
CCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHCCCCHHHH
ELFSLTDETEMGHIELSRSADLVVVCPATADLMAKAVHGHANDLASTTLLATDKPVLMVP
HHHHHCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHCCCCHHHHHEEEEECCCCEEEEC
AMNVRMWQHGATQRNIAQLRADGVTVMEPDVGPMACGEFGPGRLPDVPRIVAQIEAMLRP
CCCEEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RQKRLAGRHALVTAGPTREPLDPVRYISNHSSGKQGYSIAAALAAEGARVTLVSGPVSLP
HHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCC
APEGVTLVKVETAREMLKACEDALPADIFISVAAVADWRPVKAADKKLKLKGEGKSPAIE
CCCCEEEEEEHHHHHHHHHHHHCCCHHHEEEEHHHCCCCCCCCCCCEEEEECCCCCCEEE
LAENPDILRTISHKKKKRPALVIGFAAETHDLERHASEKLARKGCDWIVANDVSGDVMGG
ECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCC
LENEIALITQAGIDRWPRMPKEAVSARLAEKIAEAFAGDADGLSLAAE
CCCCEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCC
>Mature Secondary Structure 
SAKRILLVIGGGIAAYKSLELIRELGRRGIGARVILTKAGTEFVTPLSVAALSGEKVYT
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHCCCCHHHH
ELFSLTDETEMGHIELSRSADLVVVCPATADLMAKAVHGHANDLASTTLLATDKPVLMVP
HHHHHCCCCCCCEEEECCCCCEEEECCCCHHHHHHHHCCCCHHHHHEEEEECCCCEEEEC
AMNVRMWQHGATQRNIAQLRADGVTVMEPDVGPMACGEFGPGRLPDVPRIVAQIEAMLRP
CCCEEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RQKRLAGRHALVTAGPTREPLDPVRYISNHSSGKQGYSIAAALAAEGARVTLVSGPVSLP
HHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCC
APEGVTLVKVETAREMLKACEDALPADIFISVAAVADWRPVKAADKKLKLKGEGKSPAIE
CCCCEEEEEEHHHHHHHHHHHHCCCHHHEEEEHHHCCCCCCCCCCCEEEEECCCCCCEEE
LAENPDILRTISHKKKKRPALVIGFAAETHDLERHASEKLARKGCDWIVANDVSGDVMGG
ECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHCC
LENEIALITQAGIDRWPRMPKEAVSARLAEKIAEAFAGDADGLSLAAE
CCCCEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]