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The map label for this gene is hapE [H]

Identifier: 114798584

GI number: 114798584

Start: 3141405

End: 3142736

Strand: Reverse

Name: hapE [H]

Synonym: HNE_2983

Alternate gene names: 114798584

Gene position: 3142736-3141405 (Counterclockwise)

Preceding gene: 114798761

Following gene: 114798883

Centisome position: 84.82

GC content: 61.19

Gene sequence:

>1332_bases
ATGGCATTTGACGCAGCGGCAAAGCCCAAGACATGCATCATCGGCGCCGGTTGTTCCGGTTTCACCATGGCAAAACGGCT
GAAAGACGCCAGCCTGCCGTATGACTGTTTCGAGAAGTCCGACAATATCGGCGGCAACTGGTATTACATGAACCCCAACG
GGGTCTCCTCCTGCTACCAGTCCCTCCACATCGACACGTCCAAATGGCGCCTGGCCTTCGAGGATTATCCCGTCCCCGGC
GATTGGCCAGACTTCCCCCACCACGCCCAGCTGCTGCAATATTTCCACGACTATGTGGACCATTTCGGCCTGCGCGAGAC
GATCACCTTCAACACCTCCGTGGAAGATGTCGCCGACCTCCCCAATGGGCGCTACCGCGTCACGCTCTCGACCGGCGAAA
CCCGCGACTATGACGCCGTCTGCGTCGCCAACGGCCACCATTGGGACGCCCGCACGCCCACCTATCCGGGCACTTTCACC
GGCTACCAGGTCCACTCCCACCATTACCGCGACCCGTTCGAGCCGTTCGACTTCCGCGGCAAGCGCATCATGATCGTCGG
CGCCGGCAATTCGGCGATGGACATCTCCTCCGAGCTTTCCCAGCGCCCGATTGCCGAGAAACTCTTCATCTCCATGCGCC
GCGGCGTCTGGGTCATGCCCAAATACATGGACGGGCGCCCCGCCGATAAAGCCGTGCTGCCTGCCTGGATGCCCACCAGC
CTCGGCCGCTCGCTCGCCAAGAAGAAGATCAAGAAAACCATCGGCAATATGGAAGACTACGGCCTGCCAAAGCCAGACCA
TGAGCCGCTGGAAGGCCACCCCTCCGTCTCCGGAGAATTCCTCACCCGCGTCGGTTGCGGCGACATTCTTCCCAAGCCCG
GCATTGACCGGTTCGACGGCAAAACCGTCCACTTCACCGATGGCACCTCTGAGGAGATTGACGCCATCGTCTGGGCCACC
GGCTACAATACCAGCTTCCCCTTCTTCAAGCAGGATGAGCTGACCCCCAAAGACAACGTCTTCTCCCTCTATAAGCGCAT
GGTGAAGCCCGGCCGCGAAACGCTGTTCTTCCTCGGCCTCGCCCAGCCGCTGCCGACTTTGGTTAACTTTGCAGAACAAC
AGTCAAAGCTGGTGGCGGCCGCGCTTCAGGGGCGCTACGCTTTCCCATCGCACGAGGAGATGGACCGCGTGACCGTTGCC
GATGAACAGGCCCATCTGGGCCACTTCTATGACAGCCCGCGCCACCGGATGCAGGTGGACTTCAACCTCTATGTGCGCGA
TCTGCACAAGGAGCTCGAGCGCGGCGCGAAACGGGCACAGGTCGGCGCATGA

Upstream 100 bases:

>100_bases
CGCGTCCGGATTTGACGCCTTATCCCAGCCGGATAACATCGCAGCAATTCCAAAGAAACGGCAAACGTGACCCGCCCTAG
CGGAAGAGGAGACGCCCAAA

Downstream 100 bases:

>100_bases
GGGCCGACGCATGAGGGTACGGGCGATTGCTCTTGCGCTCGCGGCCCTTGCCGTGTCTGCCTGCGCCTCATCGCCCGCGC
CTGTTTCCAATCGCCCGTCC

Product: monooxygenase flavin-binding family protein

Products: NA

Alternate protein names: HAPMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAFDAAAKPKTCIIGAGCSGFTMAKRLKDASLPYDCFEKSDNIGGNWYYMNPNGVSSCYQSLHIDTSKWRLAFEDYPVPG
DWPDFPHHAQLLQYFHDYVDHFGLRETITFNTSVEDVADLPNGRYRVTLSTGETRDYDAVCVANGHHWDARTPTYPGTFT
GYQVHSHHYRDPFEPFDFRGKRIMIVGAGNSAMDISSELSQRPIAEKLFISMRRGVWVMPKYMDGRPADKAVLPAWMPTS
LGRSLAKKKIKKTIGNMEDYGLPKPDHEPLEGHPSVSGEFLTRVGCGDILPKPGIDRFDGKTVHFTDGTSEEIDAIVWAT
GYNTSFPFFKQDELTPKDNVFSLYKRMVKPGRETLFFLGLAQPLPTLVNFAEQQSKLVAAALQGRYAFPSHEEMDRVTVA
DEQAHLGHFYDSPRHRMQVDFNLYVRDLHKELERGAKRAQVGA

Sequences:

>Translated_443_residues
MAFDAAAKPKTCIIGAGCSGFTMAKRLKDASLPYDCFEKSDNIGGNWYYMNPNGVSSCYQSLHIDTSKWRLAFEDYPVPG
DWPDFPHHAQLLQYFHDYVDHFGLRETITFNTSVEDVADLPNGRYRVTLSTGETRDYDAVCVANGHHWDARTPTYPGTFT
GYQVHSHHYRDPFEPFDFRGKRIMIVGAGNSAMDISSELSQRPIAEKLFISMRRGVWVMPKYMDGRPADKAVLPAWMPTS
LGRSLAKKKIKKTIGNMEDYGLPKPDHEPLEGHPSVSGEFLTRVGCGDILPKPGIDRFDGKTVHFTDGTSEEIDAIVWAT
GYNTSFPFFKQDELTPKDNVFSLYKRMVKPGRETLFFLGLAQPLPTLVNFAEQQSKLVAAALQGRYAFPSHEEMDRVTVA
DEQAHLGHFYDSPRHRMQVDFNLYVRDLHKELERGAKRAQVGA
>Mature_442_residues
AFDAAAKPKTCIIGAGCSGFTMAKRLKDASLPYDCFEKSDNIGGNWYYMNPNGVSSCYQSLHIDTSKWRLAFEDYPVPGD
WPDFPHHAQLLQYFHDYVDHFGLRETITFNTSVEDVADLPNGRYRVTLSTGETRDYDAVCVANGHHWDARTPTYPGTFTG
YQVHSHHYRDPFEPFDFRGKRIMIVGAGNSAMDISSELSQRPIAEKLFISMRRGVWVMPKYMDGRPADKAVLPAWMPTSL
GRSLAKKKIKKTIGNMEDYGLPKPDHEPLEGHPSVSGEFLTRVGCGDILPKPGIDRFDGKTVHFTDGTSEEIDAIVWATG
YNTSFPFFKQDELTPKDNVFSLYKRMVKPGRETLFFLGLAQPLPTLVNFAEQQSKLVAAALQGRYAFPSHEEMDRVTVAD
EQAHLGHFYDSPRHRMQVDFNLYVRDLHKELERGAKRAQVGA

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Can oxidize a wide range of acetophenone derivatives. Highest activity occurs with co

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=451, Percent_Identity=34.589800443459, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI221316672, Length=439, Percent_Identity=36.2186788154898, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI221316674, Length=411, Percent_Identity=36.9829683698297, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI4503759, Length=444, Percent_Identity=29.954954954955, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI50541965, Length=443, Percent_Identity=31.6027088036117, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI50541961, Length=443, Percent_Identity=31.6027088036117, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4503755, Length=443, Percent_Identity=29.7968397291196, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI221316678, Length=281, Percent_Identity=38.7900355871886, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25145785, Length=434, Percent_Identity=29.0322580645161, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17541300, Length=444, Percent_Identity=31.3063063063063, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI25150462, Length=456, Percent_Identity=29.8245614035088, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17555726, Length=448, Percent_Identity=30.1339285714286, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17561948, Length=449, Percent_Identity=29.1759465478842, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI193202226, Length=196, Percent_Identity=33.6734693877551, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17506045, Length=212, Percent_Identity=31.1320754716981, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19922866, Length=406, Percent_Identity=25.1231527093596, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI19921694, Length=225, Percent_Identity=30.6666666666667, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.84 [H]

Molecular weight: Translated: 50066; Mature: 49935

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDAAAKPKTCIIGAGCSGFTMAKRLKDASLPYDCFEKSDNIGGNWYYMNPNGVSSCYQ
CCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCHHHHHHH
SLHIDTSKWRLAFEDYPVPGDWPDFPHHAQLLQYFHDYVDHFGLRETITFNTSVEDVADL
HHCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHC
PNGRYRVTLSTGETRDYDAVCVANGHHWDARTPTYPGTFTGYQVHSHHYRDPFEPFDFRG
CCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCC
KRIMIVGAGNSAMDISSELSQRPIAEKLFISMRRGVWVMPKYMDGRPADKAVLPAWMPTS
CEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHH
LGRSLAKKKIKKTIGNMEDYGLPKPDHEPLEGHPSVSGEFLTRVGCGDILPKPGIDRFDG
HHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
KTVHFTDGTSEEIDAIVWATGYNTSFPFFKQDELTPKDNVFSLYKRMVKPGRETLFFLGL
CEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEH
AQPLPTLVNFAEQQSKLVAAALQGRYAFPSHEEMDRVTVADEQAHLGHFYDSPRHRMQVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCEEECCCHHHHHHHHCCCCCEEEEE
FNLYVRDLHKELERGAKRAQVGA
HHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AFDAAAKPKTCIIGAGCSGFTMAKRLKDASLPYDCFEKSDNIGGNWYYMNPNGVSSCYQ
CCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCHHHHHHH
SLHIDTSKWRLAFEDYPVPGDWPDFPHHAQLLQYFHDYVDHFGLRETITFNTSVEDVADL
HHCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHC
PNGRYRVTLSTGETRDYDAVCVANGHHWDARTPTYPGTFTGYQVHSHHYRDPFEPFDFRG
CCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCC
KRIMIVGAGNSAMDISSELSQRPIAEKLFISMRRGVWVMPKYMDGRPADKAVLPAWMPTS
CEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCHH
LGRSLAKKKIKKTIGNMEDYGLPKPDHEPLEGHPSVSGEFLTRVGCGDILPKPGIDRFDG
HHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCC
KTVHFTDGTSEEIDAIVWATGYNTSFPFFKQDELTPKDNVFSLYKRMVKPGRETLFFLGL
CEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEH
AQPLPTLVNFAEQQSKLVAAALQGRYAFPSHEEMDRVTVADEQAHLGHFYDSPRHRMQVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCEEECCCHHHHHHHHCCCCCEEEEE
FNLYVRDLHKELERGAKRAQVGA
HHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11322873 [H]