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The map label for this gene is accC [H]

Identifier: 114798573

GI number: 114798573

Start: 2351222

End: 2352595

Strand: Direct

Name: accC [H]

Synonym: HNE_2250

Alternate gene names: 114798573

Gene position: 2351222-2352595 (Clockwise)

Preceding gene: 114797700

Following gene: 114797414

Centisome position: 63.46

GC content: 62.08

Gene sequence:

>1374_bases
ATGACGGCCCCACGTCCCATCCAGAAGGTCCTGATCGCCAATCGTGGTGAAATCGCTCTGCGAATCCACCGCGCCTGCAA
GGAAATGGGCCTCTCCACCGTCGTCGTTCACTCCGAGGCGGACCGTGATGCCATGGCGGTGCGCCTGGCTGACGAAAGCG
TCTGCATCGGCCCGGCGCCCTCTTCAGAGAGCTATCTGAAGAAGTCGCGCATCCTGGCCGCTGCCGAAATCACCGGCGCC
GACGCGATCCATCCCGGCTACGGCTTCCTCTCGGAAAACGCCCAGTTCGCCGAAATGGTCGAAGCCCACGGCATCGCTTT
TATCGGCCCCACGGCCGAGCATATCCGCGTCATGGGCGACAAGATCGCCGCCAAACAGGCCATGATCGAAGCTGGCGTGC
CCTGCGTTCCCGGCTCTGATGGCGCGGTCGAATCAATCGCCGACGCCAAGAAGGCTGCCAAAAAGATCGGGTTCCCGATC
CTTGTTAAGGCCTCCGCAGGCGGCGGCGGACGCGGCATGAAACTCGCGATGACCGAGGCAGACCTCGAAAACGCGATAAA
AACGGCAAAGACCGAGTCCAAGGCCGCATTTGGCGATGACGCCGTCTATCTGGAAAAATATCTTCAGGGTCCGCGCCATA
TCGAGATCCAGGTGATCGCCGACACGCACGGAAACGTCGCCCACCTCTGGGAACGGGACTGTTCCCTGCAGCGCCGCAAC
CAGAAAGTCTTCGAAGAGGCGCCCTCGCCCGCGCTCAACCAGGTGCAGCGCGAGGAAATCGGCGGCATCGTCGCCCGCGC
CATGCAGAAATTGGGGTATCGCGGCGCCGGAACGATCGAGTTCCTCTATGAAGACGGCCGCTTCTATTTCATCGAAATGA
ACACCCGTCTTCAGGTCGAACACCCGGTCACCGAGATGATCACGGGGATCGACCTTGTGCGCGAACAGATCCGCATTGCC
GATGGCAAGGCGCTCTCCTTCCGCCAGGAAGATGTGATGCTGGTCGGCCACGCCATCGAATGCCGCATCAATGCCGAGCA
TCCGGAAACCTTCGTGCCATCGCCGGGTCTCATCACCGAGTTCCATGCGCCGGGCGGCCCGGATGTGCGCCTCGATAGCG
CCGCCTATGCCGGATACCGCATCCCGCCGCATTACGACTCGCTGATCGGCAAGCTGATCGTCCACGGGCGCACCCGCCGC
GAATGCCTGATGCGCCTGAAGCGCGCCCTACAGGAAATGGTGGTGGGCGGCGTCCACACGACGCTCGATCTGCATCGCCG
CCTTGTGGAAAACGATGACGTTCAGGCCGGGGATTACAACATCCACTGGCTCGAAAAGTTCCTGGCCGAGAACAAGCTGC
CGGCGGGCGAATAG

Upstream 100 bases:

>100_bases
AATCCCGTCGAAGCCGACCGCGCAGGCACTGTGAAGGCGATCTATGTCGATAACGCTCAGCCGGTCGAATACGGCGAAGC
GCTGGTCCTGATCGAGTAAC

Downstream 100 bases:

>100_bases
CCCGCCCGGCATCCCGCCACATTTACAGCCTGCGCGGCGCAACCCATATCTTTGGTCATGTCAGCCCGCTTCGGACCAGA
AGACCTGCTCGCCTGCTATC

Product: acetyl-CoA carboxylase biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTAPRPIQKVLIANRGEIALRIHRACKEMGLSTVVVHSEADRDAMAVRLADESVCIGPAPSSESYLKKSRILAAAEITGA
DAIHPGYGFLSENAQFAEMVEAHGIAFIGPTAEHIRVMGDKIAAKQAMIEAGVPCVPGSDGAVESIADAKKAAKKIGFPI
LVKASAGGGGRGMKLAMTEADLENAIKTAKTESKAAFGDDAVYLEKYLQGPRHIEIQVIADTHGNVAHLWERDCSLQRRN
QKVFEEAPSPALNQVQREEIGGIVARAMQKLGYRGAGTIEFLYEDGRFYFIEMNTRLQVEHPVTEMITGIDLVREQIRIA
DGKALSFRQEDVMLVGHAIECRINAEHPETFVPSPGLITEFHAPGGPDVRLDSAAYAGYRIPPHYDSLIGKLIVHGRTRR
ECLMRLKRALQEMVVGGVHTTLDLHRRLVENDDVQAGDYNIHWLEKFLAENKLPAGE

Sequences:

>Translated_457_residues
MTAPRPIQKVLIANRGEIALRIHRACKEMGLSTVVVHSEADRDAMAVRLADESVCIGPAPSSESYLKKSRILAAAEITGA
DAIHPGYGFLSENAQFAEMVEAHGIAFIGPTAEHIRVMGDKIAAKQAMIEAGVPCVPGSDGAVESIADAKKAAKKIGFPI
LVKASAGGGGRGMKLAMTEADLENAIKTAKTESKAAFGDDAVYLEKYLQGPRHIEIQVIADTHGNVAHLWERDCSLQRRN
QKVFEEAPSPALNQVQREEIGGIVARAMQKLGYRGAGTIEFLYEDGRFYFIEMNTRLQVEHPVTEMITGIDLVREQIRIA
DGKALSFRQEDVMLVGHAIECRINAEHPETFVPSPGLITEFHAPGGPDVRLDSAAYAGYRIPPHYDSLIGKLIVHGRTRR
ECLMRLKRALQEMVVGGVHTTLDLHRRLVENDDVQAGDYNIHWLEKFLAENKLPAGE
>Mature_456_residues
TAPRPIQKVLIANRGEIALRIHRACKEMGLSTVVVHSEADRDAMAVRLADESVCIGPAPSSESYLKKSRILAAAEITGAD
AIHPGYGFLSENAQFAEMVEAHGIAFIGPTAEHIRVMGDKIAAKQAMIEAGVPCVPGSDGAVESIADAKKAAKKIGFPIL
VKASAGGGGRGMKLAMTEADLENAIKTAKTESKAAFGDDAVYLEKYLQGPRHIEIQVIADTHGNVAHLWERDCSLQRRNQ
KVFEEAPSPALNQVQREEIGGIVARAMQKLGYRGAGTIEFLYEDGRFYFIEMNTRLQVEHPVTEMITGIDLVREQIRIAD
GKALSFRQEDVMLVGHAIECRINAEHPETFVPSPGLITEFHAPGGPDVRLDSAAYAGYRIPPHYDSLIGKLIVHGRTRRE
CLMRLKRALQEMVVGGVHTTLDLHRRLVENDDVQAGDYNIHWLEKFLAENKLPAGE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=46.2585034013605, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=46.1711711711712, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=46.1711711711712, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=46.1711711711712, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=43.8752783964365, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=43.8752783964365, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=43.8752783964365, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI38679977, Length=507, Percent_Identity=30.5719921104536, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI38679967, Length=507, Percent_Identity=30.5719921104536, Blast_Score=243, Evalue=4e-64,
Organism=Homo sapiens, GI38679974, Length=507, Percent_Identity=30.5719921104536, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI38679960, Length=507, Percent_Identity=30.5719921104536, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI38679971, Length=507, Percent_Identity=30.5719921104536, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=31.5686274509804, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI18105007, Length=231, Percent_Identity=25.5411255411255, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=61.1738148984199, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI1786216, Length=250, Percent_Identity=26.4, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71987519, Length=463, Percent_Identity=45.5723542116631, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=45.7399103139013, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17562816, Length=426, Percent_Identity=46.4788732394366, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=29.9412915851272, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=29.9412915851272, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI133931226, Length=500, Percent_Identity=29, Blast_Score=201, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=426, Percent_Identity=43.1924882629108, Blast_Score=354, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=41.834451901566, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=42.2818791946309, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=29.4346978557505, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=458, Percent_Identity=31.6593886462882, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=46.8325791855204, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=45.8797327394209, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24651759, Length=402, Percent_Identity=46.5174129353234, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=30.3571428571429, Blast_Score=225, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=30.3571428571429, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=30.3571428571429, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=30.3571428571429, Blast_Score=225, Evalue=6e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50005; Mature: 49874

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPRPIQKVLIANRGEIALRIHRACKEMGLSTVVVHSEADRDAMAVRLADESVCIGPAP
CCCCHHHHHHHHCCCCCEEHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEECCCC
SSESYLKKSRILAAAEITGADAIHPGYGFLSENAQFAEMVEAHGIAFIGPTAEHIRVMGD
CCHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHH
KIAAKQAMIEAGVPCVPGSDGAVESIADAKKAAKKIGFPILVKASAGGGGRGMKLAMTEA
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEHH
DLENAIKTAKTESKAAFGDDAVYLEKYLQGPRHIEIQVIADTHGNVAHLWERDCSLQRRN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
QKVFEEAPSPALNQVQREEIGGIVARAMQKLGYRGAGTIEFLYEDGRFYFIEMNTRLQVE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEEECCEEEEC
HPVTEMITGIDLVREQIRIADGKALSFRQEDVMLVGHAIECRINAEHPETFVPSPGLITE
CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCEEE
FHAPGGPDVRLDSAAYAGYRIPPHYDSLIGKLIVHGRTRRECLMRLKRALQEMVVGGVHT
ECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHH
TLDLHRRLVENDDVQAGDYNIHWLEKFLAENKLPAGE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAPRPIQKVLIANRGEIALRIHRACKEMGLSTVVVHSEADRDAMAVRLADESVCIGPAP
CCCHHHHHHHHCCCCCEEHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEECCCC
SSESYLKKSRILAAAEITGADAIHPGYGFLSENAQFAEMVEAHGIAFIGPTAEHIRVMGD
CCHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHH
KIAAKQAMIEAGVPCVPGSDGAVESIADAKKAAKKIGFPILVKASAGGGGRGMKLAMTEA
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEHH
DLENAIKTAKTESKAAFGDDAVYLEKYLQGPRHIEIQVIADTHGNVAHLWERDCSLQRRN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH
QKVFEEAPSPALNQVQREEIGGIVARAMQKLGYRGAGTIEFLYEDGRFYFIEMNTRLQVE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEEECCEEEEC
HPVTEMITGIDLVREQIRIADGKALSFRQEDVMLVGHAIECRINAEHPETFVPSPGLITE
CCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCEEE
FHAPGGPDVRLDSAAYAGYRIPPHYDSLIGKLIVHGRTRRECLMRLKRALQEMVVGGVHT
ECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHH
TLDLHRRLVENDDVQAGDYNIHWLEKFLAENKLPAGE
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]