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The map label for this gene is ubiB [H]

Identifier: 114798427

GI number: 114798427

Start: 3433142

End: 3434665

Strand: Reverse

Name: ubiB [H]

Synonym: HNE_3271

Alternate gene names: 114798427

Gene position: 3434665-3433142 (Counterclockwise)

Preceding gene: 114800122

Following gene: 114799461

Centisome position: 92.7

GC content: 65.49

Gene sequence:

>1524_bases
ATGGGCATGTTCGCTGACTATCGGCGGCTCATCCGTGCGGGCACATCCCTGGCCCGCCACGACGTCGTGCTGCCTGGCGA
ATATCAGTCCCGCCTGCCGCTTCCCGCCCGCATTGCCGGCGGCGTTCTGCGCATTTTCGGCGGCGGCGCGAAAGGGCGTC
CGGGCGAACGCCTCGCCCATGCGCTTGAGCGCCTTGGCCCGGCCTATATCAAGCTCGGCCAGTTCCTTGCTACCCGGCCG
GATGTATTCGGTTCCGAAGTCGCCGGGGATCTTGCCCGCCTGAAAGACAAGCTGCCGCCTTTCCCCATGAAGCAGGCGCG
CGCCGCGCTGGCGGCCGAATTCGGCGCCGCCGAGGCCGCGCGCCTTTTCCCCGGACTGGGCGAGCCCGTGGCGGCCGCCT
CCCTCGCGCAGGTCCACCGCATGGCGCTTCCCGATGGTGACCGCGCGGTCAAAATACTCCGCCCAGGGATCGAGCGTCAG
CTGACGCTGGAGCTGTCAGCCATGCGCCGCGCGGCGCGCACCATCGAAGGGGTGTCCACCGAAAGCCGCCGCCTGAAGCC
CGTCGCCTTCACCGAAACCATCGCAAACGCCATGCTGCGCGAGACAGACCTCCGCCTGGAAGCGGGCGGGGCGGATGAAA
TGCGCGAGATTTACGAGAAGACCGGCTTCTTCCGTGTGCCGAAGGTCGACTGGGAGCGCACCGGCAAGCGGGTAATGACC
GCCGAATGGATCGAGGGCATTCCGTTGACGGCCCCCGGCGTTCTCGACCAGCCGGGCATTGACCGCAAGCGCCTCGCCAA
CGACATCACGCAAGGCTTCCTCGCCAGCGCCATCCATCACGGCGTCTTTCATGCCGATATGCATGAAGGCAACGCCATCC
TGACGCCCGAAGGCACGATTGCGCTGGTTGATTTCGGCATCATCGGCCGCATCGGCATCATCGAGCGGCGCTTCCTCGCA
GAAATCCTCTGGGGCTTCCTGAAGCGCGATTACATGCGCATCGCGCAGGTCCACTTCGAGGCAGGCTATGTCCCGCCCAG
CCAGTCTGTGGGCGACTTTGCCCAGGCCCTGCGCTCCATCGGGGAGCCGCTGTTTGGCCGTCCCGCCGAGGAAGTCTCGA
TGGGCCGCGTTTTGCTGCAACTCTTCGATTACACCCACACATTCGGCATGGCGCTGCGCCCCGAACTTGTCCTCCTGCAA
AAAACCATGGTGCAGGTCGAAGGCGTTGCCCGCACGATTGACCCCTCCCACAATATCTGGAACGCGTCAGAGCCCGTCAT
TGAAGGCTGGATGCGCCGGAATTTCGGCCCCGAGGGCGCCGCGCGCTTCATCAGCGAGAATGTCCGTGAAGTGACAAACC
GGTTGAAACGCCTGCCCGAAGTGATGGACCGGTTCGAGAAAAGCCTTGAGGCCGAGCCCGCCCCGCCGCCACCCCGCGAA
CGCTTTGCCCCCTGGTGGGGCTGGTTCGGTCTGGTTATTGCGCTCGCCGCGACCGCCGCCTGGATTGTTCAGGAACTCGC
CTGA

Upstream 100 bases:

>100_bases
GGGGGATGTAGACATGATTATTCTTCGCCTCCTGACGATATTCCTTTCCGGACAACGCGCTGCAATGCCGATTGGTTCCA
CAGAACCGGGCGCGCGCTAG

Downstream 100 bases:

>100_bases
CCTGACCTGCCTTGCCTGTCCCGTGCCGATTGTGCATTTTCCGGCGCAAGGAGGGATGGAATGATGGCTTACACCGGCGG
CTGCCAATGCGGAAAATATC

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MGMFADYRRLIRAGTSLARHDVVLPGEYQSRLPLPARIAGGVLRIFGGGAKGRPGERLAHALERLGPAYIKLGQFLATRP
DVFGSEVAGDLARLKDKLPPFPMKQARAALAAEFGAAEAARLFPGLGEPVAAASLAQVHRMALPDGDRAVKILRPGIERQ
LTLELSAMRRAARTIEGVSTESRRLKPVAFTETIANAMLRETDLRLEAGGADEMREIYEKTGFFRVPKVDWERTGKRVMT
AEWIEGIPLTAPGVLDQPGIDRKRLANDITQGFLASAIHHGVFHADMHEGNAILTPEGTIALVDFGIIGRIGIIERRFLA
EILWGFLKRDYMRIAQVHFEAGYVPPSQSVGDFAQALRSIGEPLFGRPAEEVSMGRVLLQLFDYTHTFGMALRPELVLLQ
KTMVQVEGVARTIDPSHNIWNASEPVIEGWMRRNFGPEGAARFISENVREVTNRLKRLPEVMDRFEKSLEAEPAPPPPRE
RFAPWWGWFGLVIALAATAAWIVQELA

Sequences:

>Translated_507_residues
MGMFADYRRLIRAGTSLARHDVVLPGEYQSRLPLPARIAGGVLRIFGGGAKGRPGERLAHALERLGPAYIKLGQFLATRP
DVFGSEVAGDLARLKDKLPPFPMKQARAALAAEFGAAEAARLFPGLGEPVAAASLAQVHRMALPDGDRAVKILRPGIERQ
LTLELSAMRRAARTIEGVSTESRRLKPVAFTETIANAMLRETDLRLEAGGADEMREIYEKTGFFRVPKVDWERTGKRVMT
AEWIEGIPLTAPGVLDQPGIDRKRLANDITQGFLASAIHHGVFHADMHEGNAILTPEGTIALVDFGIIGRIGIIERRFLA
EILWGFLKRDYMRIAQVHFEAGYVPPSQSVGDFAQALRSIGEPLFGRPAEEVSMGRVLLQLFDYTHTFGMALRPELVLLQ
KTMVQVEGVARTIDPSHNIWNASEPVIEGWMRRNFGPEGAARFISENVREVTNRLKRLPEVMDRFEKSLEAEPAPPPPRE
RFAPWWGWFGLVIALAATAAWIVQELA
>Mature_506_residues
GMFADYRRLIRAGTSLARHDVVLPGEYQSRLPLPARIAGGVLRIFGGGAKGRPGERLAHALERLGPAYIKLGQFLATRPD
VFGSEVAGDLARLKDKLPPFPMKQARAALAAEFGAAEAARLFPGLGEPVAAASLAQVHRMALPDGDRAVKILRPGIERQL
TLELSAMRRAARTIEGVSTESRRLKPVAFTETIANAMLRETDLRLEAGGADEMREIYEKTGFFRVPKVDWERTGKRVMTA
EWIEGIPLTAPGVLDQPGIDRKRLANDITQGFLASAIHHGVFHADMHEGNAILTPEGTIALVDFGIIGRIGIIERRFLAE
ILWGFLKRDYMRIAQVHFEAGYVPPSQSVGDFAQALRSIGEPLFGRPAEEVSMGRVLLQLFDYTHTFGMALRPELVLLQK
TMVQVEGVARTIDPSHNIWNASEPVIEGWMRRNFGPEGAARFISENVREVTNRLKRLPEVMDRFEKSLEAEPAPPPPRER
FAPWWGWFGLVIALAATAAWIVQELA

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=262, Percent_Identity=24.8091603053435, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI41393593, Length=274, Percent_Identity=24.0875912408759, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI34147522, Length=258, Percent_Identity=26.7441860465116, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI2367309, Length=415, Percent_Identity=34.6987951807229, Blast_Score=260, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17559152, Length=297, Percent_Identity=26.2626262626263, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325148, Length=259, Percent_Identity=25.0965250965251, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=327, Percent_Identity=23.8532110091743, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24662575, Length=312, Percent_Identity=25.3205128205128, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI22024280, Length=277, Percent_Identity=24.9097472924188, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 56107; Mature: 55975

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMFADYRRLIRAGTSLARHDVVLPGEYQSRLPLPARIAGGVLRIFGGGAKGRPGERLAH
CCCHHHHHHHHHHCCHHHHCCCCCCCCHHCCCCCCHHHHCCHHHEECCCCCCCCHHHHHH
ALERLGPAYIKLGQFLATRPDVFGSEVAGDLARLKDKLPPFPMKQARAALAAEFGAAEAA
HHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHH
RLFPGLGEPVAAASLAQVHRMALPDGDRAVKILRPGIERQLTLELSAMRRAARTIEGVST
HHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
ESRRLKPVAFTETIANAMLRETDLRLEAGGADEMREIYEKTGFFRVPKVDWERTGKRVMT
CCCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCEECCCCCHHHCCCEEEH
AEWIEGIPLTAPGVLDQPGIDRKRLANDITQGFLASAIHHGVFHADMHEGNAILTPEGTI
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCE
ALVDFGIIGRIGIIERRFLAEILWGFLKRDYMRIAQVHFEAGYVPPSQSVGDFAQALRSI
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
GEPLFGRPAEEVSMGRVLLQLFDYTHTFGMALRPELVLLQKTMVQVEGVARTIDPSHNIW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
NASEPVIEGWMRRNFGPEGAARFISENVREVTNRLKRLPEVMDRFEKSLEAEPAPPPPRE
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
RFAPWWGWFGLVIALAATAAWIVQELA
HCCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
GMFADYRRLIRAGTSLARHDVVLPGEYQSRLPLPARIAGGVLRIFGGGAKGRPGERLAH
CCHHHHHHHHHHCCHHHHCCCCCCCCHHCCCCCCHHHHCCHHHEECCCCCCCCHHHHHH
ALERLGPAYIKLGQFLATRPDVFGSEVAGDLARLKDKLPPFPMKQARAALAAEFGAAEAA
HHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHH
RLFPGLGEPVAAASLAQVHRMALPDGDRAVKILRPGIERQLTLELSAMRRAARTIEGVST
HHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCC
ESRRLKPVAFTETIANAMLRETDLRLEAGGADEMREIYEKTGFFRVPKVDWERTGKRVMT
CCCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCEECCCCCHHHCCCEEEH
AEWIEGIPLTAPGVLDQPGIDRKRLANDITQGFLASAIHHGVFHADMHEGNAILTPEGTI
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCE
ALVDFGIIGRIGIIERRFLAEILWGFLKRDYMRIAQVHFEAGYVPPSQSVGDFAQALRSI
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
GEPLFGRPAEEVSMGRVLLQLFDYTHTFGMALRPELVLLQKTMVQVEGVARTIDPSHNIW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
NASEPVIEGWMRRNFGPEGAARFISENVREVTNRLKRLPEVMDRFEKSLEAEPAPPPPRE
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
RFAPWWGWFGLVIALAATAAWIVQELA
HCCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA