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The map label for this gene is ubiE [H]

Identifier: 114800122

GI number: 114800122

Start: 3434927

End: 3435715

Strand: Reverse

Name: ubiE [H]

Synonym: HNE_3273

Alternate gene names: 114800122

Gene position: 3435715-3434927 (Counterclockwise)

Preceding gene: 114798759

Following gene: 114798427

Centisome position: 92.73

GC content: 62.61

Gene sequence:

>789_bases
ATGACCGGTCAGGACAGCAAAGAACGCATCGTCTCCTTCGGCTTCGAAGATGTGACGGAAACCGAGAAGGTGGCGCGCGT
GAAGGGCGTCTTCCGCTCGGTGGCGTCCCGCTATGACCTGATGAACGATCTGATGAGCGCCGGGGTCCACCGCCTCTGGA
AGCATGATGCGATGAACCGCATCAACCCTCAGCCGGGCGAGCGCCATCTCGATGTCGCCGGCGGCACAGGCGAACTCGGC
CGCGCTTTCCTCGATCTGGCGGACAAGGCCGGCAAGCGCCGCGGCGACACGCGCCAGGCCACCGCCATCGTGTCAGACAT
CAACGACGCCATGCTCGAAGCGGGCAAAGCGCGCAGCGACAACGCCCGATGGGGCGACCGGCTGAGCTGGGTCTGCGCCG
ATGGACAGAAACTGCCCTATCCCGACAAGAGCTTTGATGTGGTGACTGTGTCCTTCGGCATCCGCAACTTTGCAGACCGT
GTTGCGGGCCTGAAGGAATTCCGCCGCGTGCTGAAAACCGGTGGGCGCCTCGCGGTGCTCGAATTCAGCCATATGACCGC
GCCGATCCTGCAGGACGCGTATGACCGCTACAGTTTCGCCGTCATCCCGCGCCTCGGCGAACTCATCACCAGCGACCGGG
ACAGCTATCAATACCTGATTGAATCTATCCGGAAATTCCCGGACCAGCAGACGTTCAAATCCGAGATCGAAGACGCGGGC
TTCTCCCAGGTCTCCGTCACAAACTACTCCGGCGGCATCGCCGCCCTGCACTTTGGCTGGGCGGTCTGA

Upstream 100 bases:

>100_bases
CATGACAGGGGCAAGTCCGCGGCGAACTGTCTCGACTTCAGGTAATTCAGGCATCGTTATCGCATATACGCTAAGGCATT
CGCAGGTAAGATAGGTTCCC

Downstream 100 bases:

>100_bases
TGCGCGCGGGGTCAGTTCCCGTCGATGTCGATGCCATCTTCGCCGATGGAAATCTCGACCTTGTCTTCGCCGCCCGGCCC
TTCGGTGAAGTAGTAGATGC

Product: ubiquinone/menaquinone biosynthesis methyltransferase UbiE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTGQDSKERIVSFGFEDVTETEKVARVKGVFRSVASRYDLMNDLMSAGVHRLWKHDAMNRINPQPGERHLDVAGGTGELG
RAFLDLADKAGKRRGDTRQATAIVSDINDAMLEAGKARSDNARWGDRLSWVCADGQKLPYPDKSFDVVTVSFGIRNFADR
VAGLKEFRRVLKTGGRLAVLEFSHMTAPILQDAYDRYSFAVIPRLGELITSDRDSYQYLIESIRKFPDQQTFKSEIEDAG
FSQVSVTNYSGGIAALHFGWAV

Sequences:

>Translated_262_residues
MTGQDSKERIVSFGFEDVTETEKVARVKGVFRSVASRYDLMNDLMSAGVHRLWKHDAMNRINPQPGERHLDVAGGTGELG
RAFLDLADKAGKRRGDTRQATAIVSDINDAMLEAGKARSDNARWGDRLSWVCADGQKLPYPDKSFDVVTVSFGIRNFADR
VAGLKEFRRVLKTGGRLAVLEFSHMTAPILQDAYDRYSFAVIPRLGELITSDRDSYQYLIESIRKFPDQQTFKSEIEDAG
FSQVSVTNYSGGIAALHFGWAV
>Mature_261_residues
TGQDSKERIVSFGFEDVTETEKVARVKGVFRSVASRYDLMNDLMSAGVHRLWKHDAMNRINPQPGERHLDVAGGTGELGR
AFLDLADKAGKRRGDTRQATAIVSDINDAMLEAGKARSDNARWGDRLSWVCADGQKLPYPDKSFDVVTVSFGIRNFADRV
AGLKEFRRVLKTGGRLAVLEFSHMTAPILQDAYDRYSFAVIPRLGELITSDRDSYQYLIESIRKFPDQQTFKSEIEDAGF
SQVSVTNYSGGIAALHFGWAV

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=287, Percent_Identity=41.8118466898955, Blast_Score=230, Evalue=8e-61,
Organism=Escherichia coli, GI48994983, Length=256, Percent_Identity=44.53125, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17557039, Length=249, Percent_Identity=46.1847389558233, Blast_Score=213, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6323526, Length=270, Percent_Identity=42.5925925925926, Blast_Score=193, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24641702, Length=264, Percent_Identity=45.4545454545455, Blast_Score=230, Evalue=8e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 29205; Mature: 29074

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQDSKERIVSFGFEDVTETEKVARVKGVFRSVASRYDLMNDLMSAGVHRLWKHDAMNR
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INPQPGERHLDVAGGTGELGRAFLDLADKAGKRRGDTRQATAIVSDINDAMLEAGKARSD
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
NARWGDRLSWVCADGQKLPYPDKSFDVVTVSFGIRNFADRVAGLKEFRRVLKTGGRLAVL
CCCCCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
EFSHMTAPILQDAYDRYSFAVIPRLGELITSDRDSYQYLIESIRKFPDQQTFKSEIEDAG
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCC
FSQVSVTNYSGGIAALHFGWAV
CCEEEEECCCCCEEEEECCCCC
>Mature Secondary Structure 
TGQDSKERIVSFGFEDVTETEKVARVKGVFRSVASRYDLMNDLMSAGVHRLWKHDAMNR
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INPQPGERHLDVAGGTGELGRAFLDLADKAGKRRGDTRQATAIVSDINDAMLEAGKARSD
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
NARWGDRLSWVCADGQKLPYPDKSFDVVTVSFGIRNFADRVAGLKEFRRVLKTGGRLAVL
CCCCCCCEEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
EFSHMTAPILQDAYDRYSFAVIPRLGELITSDRDSYQYLIESIRKFPDQQTFKSEIEDAG
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCC
FSQVSVTNYSGGIAALHFGWAV
CCEEEEECCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA