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The map label for this gene is sucD [H]

Identifier: 114798328

GI number: 114798328

Start: 305272

End: 306174

Strand: Direct

Name: sucD [H]

Synonym: HNE_0311

Alternate gene names: 114798328

Gene position: 305272-306174 (Clockwise)

Preceding gene: 114799396

Following gene: 114800323

Centisome position: 8.24

GC content: 60.69

Gene sequence:

>903_bases
ATGTCCATTCTGATCGACAAGAACACGAAAGTCCTGACGCAAGGCATGACCGGTAACACCGGCTCGTTCCACACCAATCA
GGCGCTGGCTTATTACGGCACCCAGATGGTGGGCGGCATTCACCCCAAGAAGGGTGGCGAGATGTGGAAGGCCGATAACG
GCCAGGAACTCCCCATCTTTGCGTCTGTCGCCGAAGGCAAGGAAAAGACCGGCGCCACCGCGTCTGTGGTCTATGTTCCA
CCTGCTGGCGCAGCGGCTGCCATCGAGGAAGCAATCGATGCGGAAATCCCGCTGATCGTCTGCATCACCGAAGGCGTGCC
GGTCATGGACATGGTTCGCGTCAAGGCGAAGCTGGCCAAGTCCAAATCGCGCCTCATCGGCCCGAACTGCCCCGGCATCA
TCACGGCCAACGCCTGCAAGATCGGCATCATGCCGGGCTCCATCTTCAAAAAGGGCTCGGTCGGTATCGTCTCGCGCTCG
GGCACGCTGACCTATGAAGCCGTGTTCCAGACCACGAATGCGGGCCTCGGCCAGACCACCGCTGTCGGTATCGGCGGCGA
CCCGGTTAAGGGCACCGAATTCATCGACATCCTGGAAATGTTCCTGGCTGACGACGAAACCCAATCGATCATCATGATCG
GCGAAATCGGCGGCTCTGCCGAAGAAGAAGCCGCTCAGTTCCTGATGGACGAAGCCAAAAAAGGCCGCAAGAAACCGATG
GCAGGTTTCATTGCAGGCCGCACAGCGCCTCCTGGCCGGACGATGGGCCATGCTGGCGCGATCGTTTCCGGTGGCAAGGG
GGATGCCGAGTCGAAGATTGCCGCCATGGAGGCCGCGGGCATCCGCGTCAGCCCCAGCCCGGCACGTCTCGGTACGACAC
TTGTCGAGGTGCTAAAGGGTTAG

Upstream 100 bases:

>100_bases
GGCAAGAAGATCATCCGCGAGAGCGGCCTGAACGTCATTCCGGCCGACGATCTCGACGATGCAGCCCAGAAAATTGTTAA
AGCGGTGCGGGGATAGTTCC

Downstream 100 bases:

>100_bases
AAAGACCCTATAGTTGAGATAGGCGGCGCCCGCTCCCGGCGATTCGGGGGCGGGCGTTGCAACATAACCTGCTTCACGTA
GGGGCAGGGGGTATCGTCCG

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSILIDKNTKVLTQGMTGNTGSFHTNQALAYYGTQMVGGIHPKKGGEMWKADNGQELPIFASVAEGKEKTGATASVVYVP
PAGAAAAIEEAIDAEIPLIVCITEGVPVMDMVRVKAKLAKSKSRLIGPNCPGIITANACKIGIMPGSIFKKGSVGIVSRS
GTLTYEAVFQTTNAGLGQTTAVGIGGDPVKGTEFIDILEMFLADDETQSIIMIGEIGGSAEEEAAQFLMDEAKKGRKKPM
AGFIAGRTAPPGRTMGHAGAIVSGGKGDAESKIAAMEAAGIRVSPSPARLGTTLVEVLKG

Sequences:

>Translated_300_residues
MSILIDKNTKVLTQGMTGNTGSFHTNQALAYYGTQMVGGIHPKKGGEMWKADNGQELPIFASVAEGKEKTGATASVVYVP
PAGAAAAIEEAIDAEIPLIVCITEGVPVMDMVRVKAKLAKSKSRLIGPNCPGIITANACKIGIMPGSIFKKGSVGIVSRS
GTLTYEAVFQTTNAGLGQTTAVGIGGDPVKGTEFIDILEMFLADDETQSIIMIGEIGGSAEEEAAQFLMDEAKKGRKKPM
AGFIAGRTAPPGRTMGHAGAIVSGGKGDAESKIAAMEAAGIRVSPSPARLGTTLVEVLKG
>Mature_299_residues
SILIDKNTKVLTQGMTGNTGSFHTNQALAYYGTQMVGGIHPKKGGEMWKADNGQELPIFASVAEGKEKTGATASVVYVPP
AGAAAAIEEAIDAEIPLIVCITEGVPVMDMVRVKAKLAKSKSRLIGPNCPGIITANACKIGIMPGSIFKKGSVGIVSRSG
TLTYEAVFQTTNAGLGQTTAVGIGGDPVKGTEFIDILEMFLADDETQSIIMIGEIGGSAEEEAAQFLMDEAKKGRKKPMA
GFIAGRTAPPGRTMGHAGAIVSGGKGDAESKIAAMEAAGIRVSPSPARLGTTLVEVLKG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=295, Percent_Identity=63.0508474576271, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI38569423, Length=317, Percent_Identity=25.2365930599369, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI38569421, Length=317, Percent_Identity=25.2365930599369, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1786949, Length=299, Percent_Identity=59.866220735786, Blast_Score=336, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17550194, Length=300, Percent_Identity=59.6666666666667, Blast_Score=338, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17553126, Length=300, Percent_Identity=60, Blast_Score=334, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17557344, Length=318, Percent_Identity=27.6729559748428, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17551266, Length=315, Percent_Identity=27.9365079365079, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324716, Length=301, Percent_Identity=53.4883720930233, Blast_Score=282, Evalue=4e-77,
Organism=Drosophila melanogaster, GI21356559, Length=296, Percent_Identity=58.1081081081081, Blast_Score=338, Evalue=2e-93,
Organism=Drosophila melanogaster, GI28574296, Length=299, Percent_Identity=61.2040133779264, Blast_Score=317, Evalue=6e-87,
Organism=Drosophila melanogaster, GI281363477, Length=281, Percent_Identity=26.6903914590747, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281363475, Length=281, Percent_Identity=26.6903914590747, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363473, Length=281, Percent_Identity=26.6903914590747, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30866; Mature: 30735

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILIDKNTKVLTQGMTGNTGSFHTNQALAYYGTQMVGGIHPKKGGEMWKADNGQELPIF
CEEEEECCCEEEEECCCCCCCCCCCCCCHHHHCHHHHCCCCCCCCCCCEECCCCCCCCEE
ASVAEGKEKTGATASVVYVPPAGAAAAIEEAIDAEIPLIVCITEGVPVMDMVRVKAKLAK
EECCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
SKSRLIGPNCPGIITANACKIGIMPGSIFKKGSVGIVSRSGTLTYEAVFQTTNAGLGQTT
HHCCCCCCCCCCEEEECCEEEEECCCHHCCCCCEEEEECCCCEEEEEEEEECCCCCCCEE
AVGIGGDPVKGTEFIDILEMFLADDETQSIIMIGEIGGSAEEEAAQFLMDEAKKGRKKPM
EEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
AGFIAGRTAPPGRTMGHAGAIVSGGKGDAESKIAAMEAAGIRVSPSPARLGTTLVEVLKG
CCEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SILIDKNTKVLTQGMTGNTGSFHTNQALAYYGTQMVGGIHPKKGGEMWKADNGQELPIF
EEEEECCCEEEEECCCCCCCCCCCCCCHHHHCHHHHCCCCCCCCCCCEECCCCCCCCEE
ASVAEGKEKTGATASVVYVPPAGAAAAIEEAIDAEIPLIVCITEGVPVMDMVRVKAKLAK
EECCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHH
SKSRLIGPNCPGIITANACKIGIMPGSIFKKGSVGIVSRSGTLTYEAVFQTTNAGLGQTT
HHCCCCCCCCCCEEEECCEEEEECCCHHCCCCCEEEEECCCCEEEEEEEEECCCCCCCEE
AVGIGGDPVKGTEFIDILEMFLADDETQSIIMIGEIGGSAEEEAAQFLMDEAKKGRKKPM
EEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
AGFIAGRTAPPGRTMGHAGAIVSGGKGDAESKIAAMEAAGIRVSPSPARLGTTLVEVLKG
CCEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]