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The map label for this gene is emrA [H]

Identifier: 114797985

GI number: 114797985

Start: 2509623

End: 2510801

Strand: Direct

Name: emrA [H]

Synonym: HNE_2404

Alternate gene names: 114797985

Gene position: 2509623-2510801 (Clockwise)

Preceding gene: 114800498

Following gene: 114800362

Centisome position: 67.74

GC content: 62.77

Gene sequence:

>1179_bases
ATGGAAGGCGATTCACAATCCTTTGCCGTTGAAACGGAGCCGACCGCCCGCCAGCGCGCCGTGGCTTTCGCACGGTCCAG
GCGCGGCAGAATGGTTATCGCGGCAGCCGCCGCCTTGATCCTGATGGTACTGGCGGCGCGCTTCCTGATGGATCGCAATG
CTTATGTCTCCACCTCTGACGCGCGGGTTGCGGCGGAGATGATTGCCCTCTCCACCGACATTTCCGGGCGCATCACCAGC
GTTCAGGTGAATGAAGGCGACCGGGTTTCAGCTGGCGACATTCTCTACACGATAGATGACCGGGAGGCCGTGTTCACGCT
GGCGCAGCTGGAAGCCGAGGCAACGCGGCTGCGGGCGGAGATGGCGCGGGAAGAAACCCGTGCCGGACTGGCAACGTCGA
AGGCAGGCAGTCAGGTGGCGGCGCGGCGTGCAGGTACGCTGTCGGCGTCGGCCAGTGTCGAGGCAGCCAGGTCCAATCTC
GAGATTGCCCAGCGTGATTATGACCGCACGAAAGACCTGTTCGAGCGAGGCCTGATGCCACAGTCCAATCTCGACCAGGC
CAAGAACGTGCTTGATACACGTGCACAGGCGCTGCGCCGGGCAGAGGCTGAACGGGAAACCGCCGCCGCCGACCAGCGCA
CCGCCAGCATCACGGGTCAGGAAGTGCGCCTGATCGACTATGAACTCACCGTTCTGGGCGCCGCGCTGGATCAGGCAGAA
GCCCGCGTTGAGGCGCAAAAAGTGGTGGTTGAACAACACACGATCCGCAGCCCGATTGACGGCGTGGTCGATGAGCTGTT
CTTCGATAATGGCGAGCATTCGCTGCGCGGCTATCGCATGGCGCTGGTTCATGACCCTGATGCGGTGTGGATTTCGGCGA
ATATCAAAGAGACCGACATTCGCCATGTGCGCCCGTCGGCAAGCGCCCTGGTTCGGGCTGACAGTGACCCTTCCCACGAG
ATTTCCGGGCGGGTGGTACGCATTCATGACGCCACACTCGGGGAAGCGGCGATGATGCCAAACCCCAATGCCAATGGTGT
TTTCACCAAGATCACGCAGCGGATCGGCGTGCGCATTGCCCTTGATCCGACAGATGTTGATCTGCGGCCCGGCACGATGG
TGCGTGTCCGCATCCGGAAGATCGAAGGCGGCGCGGAGGCCGGCAGGACACCGGCGTGA

Upstream 100 bases:

>100_bases
CGCTCAAATAGAGTCAGCGGCAGATGAGGGTGGCCAACGCCCCGCGAAGAAACCGCGCCAGGGAGGAGTAATCCGGCCGA
TCATGCGCCGGGCAGAGGCC

Downstream 100 bases:

>100_bases
CCGTCGCCCCCGGCATCCCGTCCCAGAGCGGCCCCGGCACTGCCCGCAAACCCCTGCCCGACGACATTCCCGCCATGGCC
GGCCCATCCGTCCGGGCTCA

Product: membrane fusion protein family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MEGDSQSFAVETEPTARQRAVAFARSRRGRMVIAAAAALILMVLAARFLMDRNAYVSTSDARVAAEMIALSTDISGRITS
VQVNEGDRVSAGDILYTIDDREAVFTLAQLEAEATRLRAEMAREETRAGLATSKAGSQVAARRAGTLSASASVEAARSNL
EIAQRDYDRTKDLFERGLMPQSNLDQAKNVLDTRAQALRRAEAERETAAADQRTASITGQEVRLIDYELTVLGAALDQAE
ARVEAQKVVVEQHTIRSPIDGVVDELFFDNGEHSLRGYRMALVHDPDAVWISANIKETDIRHVRPSASALVRADSDPSHE
ISGRVVRIHDATLGEAAMMPNPNANGVFTKITQRIGVRIALDPTDVDLRPGTMVRVRIRKIEGGAEAGRTPA

Sequences:

>Translated_392_residues
MEGDSQSFAVETEPTARQRAVAFARSRRGRMVIAAAAALILMVLAARFLMDRNAYVSTSDARVAAEMIALSTDISGRITS
VQVNEGDRVSAGDILYTIDDREAVFTLAQLEAEATRLRAEMAREETRAGLATSKAGSQVAARRAGTLSASASVEAARSNL
EIAQRDYDRTKDLFERGLMPQSNLDQAKNVLDTRAQALRRAEAERETAAADQRTASITGQEVRLIDYELTVLGAALDQAE
ARVEAQKVVVEQHTIRSPIDGVVDELFFDNGEHSLRGYRMALVHDPDAVWISANIKETDIRHVRPSASALVRADSDPSHE
ISGRVVRIHDATLGEAAMMPNPNANGVFTKITQRIGVRIALDPTDVDLRPGTMVRVRIRKIEGGAEAGRTPA
>Mature_392_residues
MEGDSQSFAVETEPTARQRAVAFARSRRGRMVIAAAAALILMVLAARFLMDRNAYVSTSDARVAAEMIALSTDISGRITS
VQVNEGDRVSAGDILYTIDDREAVFTLAQLEAEATRLRAEMAREETRAGLATSKAGSQVAARRAGTLSASASVEAARSNL
EIAQRDYDRTKDLFERGLMPQSNLDQAKNVLDTRAQALRRAEAERETAAADQRTASITGQEVRLIDYELTVLGAALDQAE
ARVEAQKVVVEQHTIRSPIDGVVDELFFDNGEHSLRGYRMALVHDPDAVWISANIKETDIRHVRPSASALVRADSDPSHE
ISGRVVRIHDATLGEAAMMPNPNANGVFTKITQRIGVRIALDPTDVDLRPGTMVRVRIRKIEGGAEAGRTPA

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=326, Percent_Identity=24.5398773006135, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790519, Length=319, Percent_Identity=26.0188087774295, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789041, Length=348, Percent_Identity=26.1494252873563, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1789637, Length=349, Percent_Identity=24.6418338108883, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87081951, Length=169, Percent_Identity=26.0355029585799, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42599; Mature: 42599

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGDSQSFAVETEPTARQRAVAFARSRRGRMVIAAAAALILMVLAARFLMDRNAYVSTSD
CCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEECCC
ARVAAEMIALSTDISGRITSVQVNEGDRVSAGDILYTIDDREAVFTLAQLEAEATRLRAE
HHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHH
MAREETRAGLATSKAGSQVAARRAGTLSASASVEAARSNLEIAQRDYDRTKDLFERGLMP
HHHHHHHCCCHHCCCCHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
QSNLDQAKNVLDTRAQALRRAEAERETAAADQRTASITGQEVRLIDYELTVLGAALDQAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEEEHHHHHHHHHHHH
ARVEAQKVVVEQHTIRSPIDGVVDELFFDNGEHSLRGYRMALVHDPDAVWISANIKETDI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEEECCCCCCCH
RHVRPSASALVRADSDPSHEISGRVVRIHDATLGEAAMMPNPNANGVFTKITQRIGVRIA
HHCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCEEECCCCCCCCHHHHHHHHHCEEEE
LDPTDVDLRPGTMVRVRIRKIEGGAEAGRTPA
ECCCCCCCCCCCEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MEGDSQSFAVETEPTARQRAVAFARSRRGRMVIAAAAALILMVLAARFLMDRNAYVSTSD
CCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEECCC
ARVAAEMIALSTDISGRITSVQVNEGDRVSAGDILYTIDDREAVFTLAQLEAEATRLRAE
HHHHHHHHHHCCCCCCEEEEEEECCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHH
MAREETRAGLATSKAGSQVAARRAGTLSASASVEAARSNLEIAQRDYDRTKDLFERGLMP
HHHHHHHCCCHHCCCCHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
QSNLDQAKNVLDTRAQALRRAEAERETAAADQRTASITGQEVRLIDYELTVLGAALDQAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEEEEHHHHHHHHHHHH
ARVEAQKVVVEQHTIRSPIDGVVDELFFDNGEHSLRGYRMALVHDPDAVWISANIKETDI
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEEECCCCCCCH
RHVRPSASALVRADSDPSHEISGRVVRIHDATLGEAAMMPNPNANGVFTKITQRIGVRIA
HHCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCEEECCCCCCCCHHHHHHHHHCEEEE
LDPTDVDLRPGTMVRVRIRKIEGGAEAGRTPA
ECCCCCCCCCCCEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]