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The map label for this gene is yhcA [H]

Identifier: 114800362

GI number: 114800362

Start: 2510876

End: 2512444

Strand: Direct

Name: yhcA [H]

Synonym: HNE_2405

Alternate gene names: 114800362

Gene position: 2510876-2512444 (Clockwise)

Preceding gene: 114797985

Following gene: 114797748

Centisome position: 67.77

GC content: 61.89

Gene sequence:

>1569_bases
ATGGCCGGCCCATCCGTCCGGGCTCAGTTCGAGCGATTTGGCGGCATCTATCGCTGGATATTGCTGTTCACAATGCTGAC
CGGCTCAATGGCCACCATGCTGGCCGCGACGACGATCAATGTCGCCCTGCCCGCGATTATCGGCGCCTTTGGCCTGGGGC
AGGATCAGGCGCAGTGGATGTCCACAGCGTTCCTCGCCTCGTCCACCATCGCCATGCTGGCGAACGCCTGGGCGATGACC
ACCTTCGGGCCGCGGGCGACGTATACGTTCGGCATGGTTGTGTTCGTGTTCGGCTCCCTGCTGGGGGCGGTGAGCAACAC
GCTGGAATTGCTGATCGTGTCGCGCGGATTGCAGGGTATTTCGGCGGGCCTGCTGCAGCCGATGTCGATGTTCCTGATTT
TTCAGACCTTTCCGGATAGCCGGCGCGGCACAGCGATGGGTGTGTTCTCGATCGGTGTGGTGCTGGCGCCTGCATTCGGG
CCTGCGCTGGGCGGGATTGCGGTGGATCTGGCTAGCTGGCGGCTGGTGTTTGTGGCGACCCTGCCTTTGGCGCTGGTCGC
GCTGGGGATCGCGCCTTTCCTGATGCCGAAGGGGGACCGCAACCGGAGCACCCCGCGCCCGCCGCTCGACTGGGTGGGGC
TGAGCCTGCTGGCGGTTGCCGTGATCGGCCTGCTGGCCGCCTTTGCCGGGGGGAACCGGGATGGGTGGGATTCGGATCAG
ACCTATCTGCGCTTTGCCATCGCCATTCTTGCGGCCATTGCCTTCTTCTTCTGGGAATTGCGCCATCCCTTTCCGGCATT
GAACCCGAAAGTGTTCACCTATCGGCAGTTCTGGTCGGCCGGGCTGATCATCTCGGCGACGGGGATTGCGATTTACGCGT
CGACCTATCTCATCCCACTTTTCGTGCAGCTGGTGCAGGGCTATTCGCCCACGGCGGCAGGGGTGATGATGATCCCTGCC
GGGATTGCCATGATGATCGGCTTTCCGATTGCCGGACGGCTTACCGACAGGGTTGATCCACGCTGGCTACTCGGCTTTGG
CATCACCACCTTTGCCGCCTCTGCCTGGTTGCTGTCGCATGTTTCGGCCATGACCCCCTATTGGGTGCTGGTGGGCTGGA
TCTTGCTCAGCCGGATCGGGATCAGCTTCTGTATGCCGCCTTCCAATACGACCGCTGTGCGCGCAGTGCCCCCGCACCTG
CTGGCCTCGGCGACGGGGGGGGTGTCTTTCCTGATGCAGGTGGGCGGGGCGTTCGGGGTGAACATCCTGGCGATCATCCT
ACAGCGGCGGACAATCTTTCACGGCGAACATCTTTCGACGGCGATGAACGAGACCAATGCCGAGATGATGTACCAGCATG
CCTTGCAGGCACAGACGCTGGAGATGACCGGCATGACGCAGGTTCAGGCGTTTCAGTCTGCCTTCGGTCTGCTCAATCAG
AAGGTGGCCATGGAAGCGTCCGTATATGCGTTCAGGGACTGTTTCTTCATTATCTTTGTCTGGTTCGTCATCGTCCTGGG
CGCGCTTGCCTTGATGCCCAAGCCAAAGATGATACAGCCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CGGAGGCCGGCAGGACACCGGCGTGACCGTCGCCCCCGGCATCCCGTCCCAGAGCGGCCCCGGCACTGCCCGCAAACCCC
TGCCCGACGACATTCCCGCC

Downstream 100 bases:

>100_bases
GCATTTTCACAGATAGGCTGGCCCTTTGGCACCCCAGGACACTCTTGCGCGCAACCGCGCGTTCATTGTCGCCAATACGC
GGCTGGCGCCGGTGGACGGG

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MAGPSVRAQFERFGGIYRWILLFTMLTGSMATMLAATTINVALPAIIGAFGLGQDQAQWMSTAFLASSTIAMLANAWAMT
TFGPRATYTFGMVVFVFGSLLGAVSNTLELLIVSRGLQGISAGLLQPMSMFLIFQTFPDSRRGTAMGVFSIGVVLAPAFG
PALGGIAVDLASWRLVFVATLPLALVALGIAPFLMPKGDRNRSTPRPPLDWVGLSLLAVAVIGLLAAFAGGNRDGWDSDQ
TYLRFAIAILAAIAFFFWELRHPFPALNPKVFTYRQFWSAGLIISATGIAIYASTYLIPLFVQLVQGYSPTAAGVMMIPA
GIAMMIGFPIAGRLTDRVDPRWLLGFGITTFAASAWLLSHVSAMTPYWVLVGWILLSRIGISFCMPPSNTTAVRAVPPHL
LASATGGVSFLMQVGGAFGVNILAIILQRRTIFHGEHLSTAMNETNAEMMYQHALQAQTLEMTGMTQVQAFQSAFGLLNQ
KVAMEASVYAFRDCFFIIFVWFVIVLGALALMPKPKMIQPAR

Sequences:

>Translated_522_residues
MAGPSVRAQFERFGGIYRWILLFTMLTGSMATMLAATTINVALPAIIGAFGLGQDQAQWMSTAFLASSTIAMLANAWAMT
TFGPRATYTFGMVVFVFGSLLGAVSNTLELLIVSRGLQGISAGLLQPMSMFLIFQTFPDSRRGTAMGVFSIGVVLAPAFG
PALGGIAVDLASWRLVFVATLPLALVALGIAPFLMPKGDRNRSTPRPPLDWVGLSLLAVAVIGLLAAFAGGNRDGWDSDQ
TYLRFAIAILAAIAFFFWELRHPFPALNPKVFTYRQFWSAGLIISATGIAIYASTYLIPLFVQLVQGYSPTAAGVMMIPA
GIAMMIGFPIAGRLTDRVDPRWLLGFGITTFAASAWLLSHVSAMTPYWVLVGWILLSRIGISFCMPPSNTTAVRAVPPHL
LASATGGVSFLMQVGGAFGVNILAIILQRRTIFHGEHLSTAMNETNAEMMYQHALQAQTLEMTGMTQVQAFQSAFGLLNQ
KVAMEASVYAFRDCFFIIFVWFVIVLGALALMPKPKMIQPAR
>Mature_521_residues
AGPSVRAQFERFGGIYRWILLFTMLTGSMATMLAATTINVALPAIIGAFGLGQDQAQWMSTAFLASSTIAMLANAWAMTT
FGPRATYTFGMVVFVFGSLLGAVSNTLELLIVSRGLQGISAGLLQPMSMFLIFQTFPDSRRGTAMGVFSIGVVLAPAFGP
ALGGIAVDLASWRLVFVATLPLALVALGIAPFLMPKGDRNRSTPRPPLDWVGLSLLAVAVIGLLAAFAGGNRDGWDSDQT
YLRFAIAILAAIAFFFWELRHPFPALNPKVFTYRQFWSAGLIISATGIAIYASTYLIPLFVQLVQGYSPTAAGVMMIPAG
IAMMIGFPIAGRLTDRVDPRWLLGFGITTFAASAWLLSHVSAMTPYWVLVGWILLSRIGISFCMPPSNTTAVRAVPPHLL
ASATGGVSFLMQVGGAFGVNILAIILQRRTIFHGEHLSTAMNETNAEMMYQHALQAQTLEMTGMTQVQAFQSAFGLLNQK
VAMEASVYAFRDCFFIIFVWFVIVLGALALMPKPKMIQPAR

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=490, Percent_Identity=28.3673469387755, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788710, Length=432, Percent_Identity=26.1574074074074, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87081983, Length=431, Percent_Identity=26.6821345707657, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1790195, Length=420, Percent_Identity=25.2380952380952, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788392, Length=435, Percent_Identity=26.8965517241379, Blast_Score=99, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56285; Mature: 56154

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AGPSVRAQFERFGGIYRWILLFTMLTGSMATMLAATTINVALPAIIGAFGLGQDQAQWM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]