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The map label for this gene is lldD [H]

Identifier: 114797920

GI number: 114797920

Start: 2200075

End: 2201172

Strand: Direct

Name: lldD [H]

Synonym: HNE_2118

Alternate gene names: 114797920

Gene position: 2200075-2201172 (Clockwise)

Preceding gene: 114798632

Following gene: 114797887

Centisome position: 59.38

GC content: 67.3

Gene sequence:

>1098_bases
ATGAGCGCGCCGGGTTATCCGTTTGCGGTCATTCCGGCCGATGTGGTAAGCGCGGGCGATTATGCCCGTCATGCCGAGGC
GATGCTTGATCCGCGCGTCTGGGCCTATCTGGATGGTGGTGCGGGCGACGAGATTACCCTGCGCGAGAATTTGGCCGCGT
TTGAAGCCCTGAAGATGACGCCGCGCGTTCTGGCCGATGTGTCGGGTGGGCATACGCGCCTGACGCTGGCCGGAGAGGCG
CTGGCGCATCCGTTCATTCTGGCACCGGTGGGCTGGCAGAAACTGTTTCATCCGCAGGGGGAGCTTGCGAGCGCGCAGGC
GGCGGGCGTGATGCAAGCGCCCTTGGCGGTTTCCTGCATGGCGACGGAGACGGTCGAAGCGATTGCCGGGCAAGGCGGGC
CGGTCTGGTTCCAGATTTACATGCAGGCAACGCGCGCAGCGACGGAGGCGCTGGTGCGCCGGGCCGAAGCAGCAGGCTGC
CGCGCGCTGCTGGTGACGGTGGACGCCCCGATTGGCGGCATACGCAACCGGGCGCAACGGGTGGGATTTTCCCTGCCACT
GGGCATGGTGGCGGCGAACCTGCCAGCTGAAGGGGCGCCGCCACCTCTGAAGGCGGGCGCAAGCGCGGTGTTCGACGGCA
TGATGCGCGCGGCGCCCGGATGGGCCGATATTGAATGGCTGACCCGCCTGACGCGGCTGCCCGTCTTCGTGAAAGGTATT
CTGCATGCCGATGATGCCGAACGCGCGCTTTCGGCTGGGGCGGCGGGCATTGTGGTTTCCAATCATGGCGGGCGGGTGCT
CGATACCGCGCCTGCCGCAATCAATGCCCTCCCCGCGATTGCCGCGCGGCTCAATGGGGCGGCGCCAATCCTGTTTGACA
GCGGCGTGCGGCGCGGCAGCGATGCGTTCAAGGCAATCGCACTGGGGGCGGACGCCGTGATGATCGGGCGGCCCTATATC
TGGGCGCTGAGCGTGGCGGGCGCGCTGGGCGTGGCGCACCTCCTCCGCACACTGCGCGAGGAGCTGGAGATCACCATGGC
GCTGATGGGCTGCCGGACACTGACGGACATTCGCCAGGCCAGCATCTGCCACGCTTAA

Upstream 100 bases:

>100_bases
ATATGACCATTCTTTCCCTGCGCGGGAAGTTGGCCGACGCGCCCGAAGTGGTCGCTTTGACGGGACATTATCACAACCTT
TTGCGCCAATGGGCGGACGC

Downstream 100 bases:

>100_bases
GGGATCAGCACTGCCTTGACGCAGTCGCCATGATGCTGGGCGGCGATGGCCTCGTTGATTTCGCTGAGGCGGTAGGTCTT
CACCAGCCTGTCGAACGGGA

Product: FMN-dependent alpha-hydroxy acid dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSAPGYPFAVIPADVVSAGDYARHAEAMLDPRVWAYLDGGAGDEITLRENLAAFEALKMTPRVLADVSGGHTRLTLAGEA
LAHPFILAPVGWQKLFHPQGELASAQAAGVMQAPLAVSCMATETVEAIAGQGGPVWFQIYMQATRAATEALVRRAEAAGC
RALLVTVDAPIGGIRNRAQRVGFSLPLGMVAANLPAEGAPPPLKAGASAVFDGMMRAAPGWADIEWLTRLTRLPVFVKGI
LHADDAERALSAGAAGIVVSNHGGRVLDTAPAAINALPAIAARLNGAAPILFDSGVRRGSDAFKAIALGADAVMIGRPYI
WALSVAGALGVAHLLRTLREELEITMALMGCRTLTDIRQASICHA

Sequences:

>Translated_365_residues
MSAPGYPFAVIPADVVSAGDYARHAEAMLDPRVWAYLDGGAGDEITLRENLAAFEALKMTPRVLADVSGGHTRLTLAGEA
LAHPFILAPVGWQKLFHPQGELASAQAAGVMQAPLAVSCMATETVEAIAGQGGPVWFQIYMQATRAATEALVRRAEAAGC
RALLVTVDAPIGGIRNRAQRVGFSLPLGMVAANLPAEGAPPPLKAGASAVFDGMMRAAPGWADIEWLTRLTRLPVFVKGI
LHADDAERALSAGAAGIVVSNHGGRVLDTAPAAINALPAIAARLNGAAPILFDSGVRRGSDAFKAIALGADAVMIGRPYI
WALSVAGALGVAHLLRTLREELEITMALMGCRTLTDIRQASICHA
>Mature_364_residues
SAPGYPFAVIPADVVSAGDYARHAEAMLDPRVWAYLDGGAGDEITLRENLAAFEALKMTPRVLADVSGGHTRLTLAGEAL
AHPFILAPVGWQKLFHPQGELASAQAAGVMQAPLAVSCMATETVEAIAGQGGPVWFQIYMQATRAATEALVRRAEAAGCR
ALLVTVDAPIGGIRNRAQRVGFSLPLGMVAANLPAEGAPPPLKAGASAVFDGMMRAAPGWADIEWLTRLTRLPVFVKGIL
HADDAERALSAGAAGIVVSNHGGRVLDTAPAAINALPAIAARLNGAAPILFDSGVRRGSDAFKAIALGADAVMIGRPYIW
ALSVAGALGVAHLLRTLREELEITMALMGCRTLTDIRQASICHA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=359, Percent_Identity=37.0473537604457, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI54234014, Length=348, Percent_Identity=36.4942528735632, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI7705393, Length=348, Percent_Identity=36.4942528735632, Blast_Score=237, Evalue=2e-62,
Organism=Escherichia coli, GI1790033, Length=375, Percent_Identity=35.4666666666667, Blast_Score=215, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI193208036, Length=358, Percent_Identity=35.4748603351955, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566217, Length=273, Percent_Identity=35.1648351648352, Blast_Score=160, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6323587, Length=361, Percent_Identity=32.6869806094183, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281363140, Length=369, Percent_Identity=39.8373983739837, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI78707190, Length=369, Percent_Identity=39.8373983739837, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI78707188, Length=358, Percent_Identity=40.5027932960894, Blast_Score=245, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 37954; Mature: 37823

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPGYPFAVIPADVVSAGDYARHAEAMLDPRVWAYLDGGAGDEITLRENLAAFEALKMT
CCCCCCCEEECCHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHHCC
PRVLADVSGGHTRLTLAGEALAHPFILAPVGWQKLFHPQGELASAQAAGVMQAPLAVSCM
HHHHHCCCCCCEEEEEECHHHCCCEEEECCCHHHHHCCCCCCCHHHHCCHHHCCCEEEHH
ATETVEAIAGQGGPVWFQIYMQATRAATEALVRRAEAAGCRALLVTVDAPIGGIRNRAQR
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHH
VGFSLPLGMVAANLPAEGAPPPLKAGASAVFDGMMRAAPGWADIEWLTRLTRLPVFVKGI
CCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHH
LHADDAERALSAGAAGIVVSNHGGRVLDTAPAAINALPAIAARLNGAAPILFDSGVRRGS
HCCCHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCCCCC
DAFKAIALGADAVMIGRPYIWALSVAGALGVAHLLRTLREELEITMALMGCRTLTDIRQA
HHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SICHA
HHCCC
>Mature Secondary Structure 
SAPGYPFAVIPADVVSAGDYARHAEAMLDPRVWAYLDGGAGDEITLRENLAAFEALKMT
CCCCCCEEECCHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHHCC
PRVLADVSGGHTRLTLAGEALAHPFILAPVGWQKLFHPQGELASAQAAGVMQAPLAVSCM
HHHHHCCCCCCEEEEEECHHHCCCEEEECCCHHHHHCCCCCCCHHHHCCHHHCCCEEEHH
ATETVEAIAGQGGPVWFQIYMQATRAATEALVRRAEAAGCRALLVTVDAPIGGIRNRAQR
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHH
VGFSLPLGMVAANLPAEGAPPPLKAGASAVFDGMMRAAPGWADIEWLTRLTRLPVFVKGI
CCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCHHHHHHH
LHADDAERALSAGAAGIVVSNHGGRVLDTAPAAINALPAIAARLNGAAPILFDSGVRRGS
HCCCHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCCCCC
DAFKAIALGADAVMIGRPYIWALSVAGALGVAHLLRTLREELEITMALMGCRTLTDIRQA
HHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SICHA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA