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The map label for this gene is pbpC [H]

Identifier: 114797739

GI number: 114797739

Start: 3166169

End: 3168223

Strand: Reverse

Name: pbpC [H]

Synonym: HNE_3002

Alternate gene names: 114797739

Gene position: 3168223-3166169 (Counterclockwise)

Preceding gene: 114800482

Following gene: 114798944

Centisome position: 85.51

GC content: 67.1

Gene sequence:

>2055_bases
GTGCCGAAACGCCTCCTTGCGGGACTGGCCGCACTGATTGCGGCTGTCCTGCTGATCGATGTGATCTTCCCCCCGCCGCT
GGAGCGTGCGGGGGGCGTATCTGTCCTGGTCACTGACCGTGCCGGTAAGCCGCTCCGCGCGTTTCCAACGCCCGATGGCC
GCTGGCGGTTCGGCGTGGACCTGGAAGAGATTGACCCCGAATTTGTCGACGCGCTGGTGCGGGTCGAAGACAAGCGCTTC
TGGGATCATCACGGCACGGACTGGCTCGGTCTCACCCGCGCGGCGTTTGACAGCCTGCTGGCCGGAGAGATCGTCTCGGG
CGGCTCTACCCTCACCATGCAGACGGCGCGCATGCTGGAACCGCGCCCGCGCAATCCCGGCTCCAAGCTGATCGAGATCT
GGCGCGCCAACCAGCTCGAACGCCGGCTCTCCAAGCGCGAAATCATCGAGCTGTATCTTTCGCTGACCCCCTATGGCGGA
AACCTGGAAGGCGTCCGCGCCGCCAGTTGGAGCTATTTCGGCCATGAGGCTGACCGTCTCTCGACCGATGAGATCGCGTT
GCTCATCGCGCTGCCCCAATCGCCCGAAGTGCGACGGCCTGACCGGCGGCCGGAATTTGCCGCCCGCTCGCGCGACTGGG
TGGCCGAAAAGCTCGCGCGCTATGGCGTGTTCTCGGAGAATGATGTGCTGGAGGTCGCGGCAACCTCCGTGCCCGCCCGC
CGCCTCGATTTTCCAGACCGTGCCTGGCACGGAGCGGACGCGGTGCTGGCCAGTGGCCCGCGCGAAGACGTTCGCTCTAC
ACTGGACGCGGCCCTTCAGGCGGAACTGGAACGGATCGCCCTCACGCGGGCGGAGCTTGAAGGCACGGACGTGCAGGTCT
CCGTTATTGTCGTTCATGTGCCCACCCGCGCTGTACGCGCGCTCGTGGGGTCTGCATCGCGGCAGCGGGCCGGCGGCTGG
CTCGACCTGACAGATCGCCCGAGGTCTCCCGGCTCGACGCTCAAACCCTTCATCTATGGCCTTGCTTTTGACGATGGCAC
GGCCTCGCCCGATACGCGCATCCAGGACCTTCCCAGCCAGTTTGCTGGATATCAGCCAGAGAATTTCGACCGGATGTTTC
ATGGCGATGTGCGCGTGTCAGACGCGCTCCAGCATTCGCTGAACGTGCCCGCGGTGCTGATGCTGGACCGGATCGGAGCC
GAACGCTTCTCGGCGCAGCTGGCGATCGCAGGCGCGCGGCCGCGTGTCTCGGGCGCCACCGGCCAGTCTGCGGGCCTTGC
CATCGCGCTCGGCGGGGCAGGGCTGACAGGCCGTGAACTCGCCGTGCTCTATTCTGCGCTGGGAGATGGCGGGGTGGCCA
AGCCGCTGGTCTGGCGCGCCGAAGAAGAAGCGGCGAGCGCCGCCGATCCCGGCCACCGCCTGATGGGCGAAGCCAGCGCG
GGTGAAATCCTCCGTATCCTGCAGGGCTCTCCCTCGCCTGCGGGCCGGATGCCGGGACAGCTGACACGCGACGCGCCCCA
GATCGCCTTCAAGACCGGCACCTCCTATGGCTATAGGGACGCCTGGGCGGCGGCCGTCTCCGGGCAGCATGTCATTGTCG
TCTGGGTTGGCCGTGCAGACGGCGCCCCGCGCACCGGCGTCACGGGCCGTGACATTGCGCTGCCCATCCTGTTCGAGATG
GCAGACCGCGCCGCCCACCATCTGCGCGATGACGGCGACAGCGAATTACGCCTCAGCGCGGCGCCGTTAACCCCTGCGAA
AGGGGCGTTGCGTGCCTTTTCAACCGACCGGCCACCTGAAATCCTGTTTCCGCCTCAGGGCGCGGAGCTTTGGGCGGGCA
CTGTGGATGGGCGCGCGCCGCGGCCATTTGTCCTCGCGGGCCGGGGGGCGGGGGCACTTAACTGGTTCATTGATGGCGAT
CCTGCATCCCTGGATGATGCGGGCGCGCCAGTCTGGCGTCCGGACCGGCCGGGCTTTTATCTCGTAATGGCTGTAGATGA
TGCGGGACGGTCCAGCCGGGTACGGGTCCGTGTGCTGACAGAAGACCCCGCCTGA

Upstream 100 bases:

>100_bases
GTTCGGCGCCCGGCCGCGTGACCGTGCAGGCCGTGCAGGGCGCAGCGGGCGGACGCTGATCAAGGGGGAGGGCAGTTTGG
GCCAATCTTTGGGCCAGTCC

Downstream 100 bases:

>100_bases
CGCCCGGTCTGATCATTTTGTGTGCATCAGGTCACATAGGCGTGAGAAAATACATTCTAACGCATTTGATGCCTTTTTTG
TGCCGCCTGTAGCAACTACT

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MPKRLLAGLAALIAAVLLIDVIFPPPLERAGGVSVLVTDRAGKPLRAFPTPDGRWRFGVDLEEIDPEFVDALVRVEDKRF
WDHHGTDWLGLTRAAFDSLLAGEIVSGGSTLTMQTARMLEPRPRNPGSKLIEIWRANQLERRLSKREIIELYLSLTPYGG
NLEGVRAASWSYFGHEADRLSTDEIALLIALPQSPEVRRPDRRPEFAARSRDWVAEKLARYGVFSENDVLEVAATSVPAR
RLDFPDRAWHGADAVLASGPREDVRSTLDAALQAELERIALTRAELEGTDVQVSVIVVHVPTRAVRALVGSASRQRAGGW
LDLTDRPRSPGSTLKPFIYGLAFDDGTASPDTRIQDLPSQFAGYQPENFDRMFHGDVRVSDALQHSLNVPAVLMLDRIGA
ERFSAQLAIAGARPRVSGATGQSAGLAIALGGAGLTGRELAVLYSALGDGGVAKPLVWRAEEEAASAADPGHRLMGEASA
GEILRILQGSPSPAGRMPGQLTRDAPQIAFKTGTSYGYRDAWAAAVSGQHVIVVWVGRADGAPRTGVTGRDIALPILFEM
ADRAAHHLRDDGDSELRLSAAPLTPAKGALRAFSTDRPPEILFPPQGAELWAGTVDGRAPRPFVLAGRGAGALNWFIDGD
PASLDDAGAPVWRPDRPGFYLVMAVDDAGRSSRVRVRVLTEDPA

Sequences:

>Translated_684_residues
MPKRLLAGLAALIAAVLLIDVIFPPPLERAGGVSVLVTDRAGKPLRAFPTPDGRWRFGVDLEEIDPEFVDALVRVEDKRF
WDHHGTDWLGLTRAAFDSLLAGEIVSGGSTLTMQTARMLEPRPRNPGSKLIEIWRANQLERRLSKREIIELYLSLTPYGG
NLEGVRAASWSYFGHEADRLSTDEIALLIALPQSPEVRRPDRRPEFAARSRDWVAEKLARYGVFSENDVLEVAATSVPAR
RLDFPDRAWHGADAVLASGPREDVRSTLDAALQAELERIALTRAELEGTDVQVSVIVVHVPTRAVRALVGSASRQRAGGW
LDLTDRPRSPGSTLKPFIYGLAFDDGTASPDTRIQDLPSQFAGYQPENFDRMFHGDVRVSDALQHSLNVPAVLMLDRIGA
ERFSAQLAIAGARPRVSGATGQSAGLAIALGGAGLTGRELAVLYSALGDGGVAKPLVWRAEEEAASAADPGHRLMGEASA
GEILRILQGSPSPAGRMPGQLTRDAPQIAFKTGTSYGYRDAWAAAVSGQHVIVVWVGRADGAPRTGVTGRDIALPILFEM
ADRAAHHLRDDGDSELRLSAAPLTPAKGALRAFSTDRPPEILFPPQGAELWAGTVDGRAPRPFVLAGRGAGALNWFIDGD
PASLDDAGAPVWRPDRPGFYLVMAVDDAGRSSRVRVRVLTEDPA
>Mature_683_residues
PKRLLAGLAALIAAVLLIDVIFPPPLERAGGVSVLVTDRAGKPLRAFPTPDGRWRFGVDLEEIDPEFVDALVRVEDKRFW
DHHGTDWLGLTRAAFDSLLAGEIVSGGSTLTMQTARMLEPRPRNPGSKLIEIWRANQLERRLSKREIIELYLSLTPYGGN
LEGVRAASWSYFGHEADRLSTDEIALLIALPQSPEVRRPDRRPEFAARSRDWVAEKLARYGVFSENDVLEVAATSVPARR
LDFPDRAWHGADAVLASGPREDVRSTLDAALQAELERIALTRAELEGTDVQVSVIVVHVPTRAVRALVGSASRQRAGGWL
DLTDRPRSPGSTLKPFIYGLAFDDGTASPDTRIQDLPSQFAGYQPENFDRMFHGDVRVSDALQHSLNVPAVLMLDRIGAE
RFSAQLAIAGARPRVSGATGQSAGLAIALGGAGLTGRELAVLYSALGDGGVAKPLVWRAEEEAASAADPGHRLMGEASAG
EILRILQGSPSPAGRMPGQLTRDAPQIAFKTGTSYGYRDAWAAAVSGQHVIVVWVGRADGAPRTGVTGRDIALPILFEMA
DRAAHHLRDDGDSELRLSAAPLTPAKGALRAFSTDRPPEILFPPQGAELWAGTVDGRAPRPFVLAGRGAGALNWFIDGDP
ASLDDAGAPVWRPDRPGFYLVMAVDDAGRSSRVRVRVLTEDPA

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=548, Percent_Identity=39.7810218978102, Blast_Score=352, Evalue=5e-98,
Organism=Escherichia coli, GI1786343, Length=561, Percent_Identity=27.0944741532977, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI87082258, Length=186, Percent_Identity=34.4086021505376, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 73725; Mature: 73594

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKRLLAGLAALIAAVLLIDVIFPPPLERAGGVSVLVTDRAGKPLRAFPTPDGRWRFGVD
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCC
LEEIDPEFVDALVRVEDKRFWDHHGTDWLGLTRAAFDSLLAGEIVSGGSTLTMQTARMLE
HHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCC
PRPRNPGSKLIEIWRANQLERRLSKREIIELYLSLTPYGGNLEGVRAASWSYFGHEADRL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEECCCHHCCCCCCCC
STDEIALLIALPQSPEVRRPDRRPEFAARSRDWVAEKLARYGVFSENDVLEVAATSVPAR
CCCCEEEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCEEEEHHCCCCHH
RLDFPDRAWHGADAVLASGPREDVRSTLDAALQAELERIALTRAELEGTDVQVSVIVVHV
HCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
PTRAVRALVGSASRQRAGGWLDLTDRPRSPGSTLKPFIYGLAFDDGTASPDTRIQDLPSQ
CHHHHHHHHCCCCHHHCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
FAGYQPENFDRMFHGDVRVSDALQHSLNVPAVLMLDRIGAERFSAQLAIAGARPRVSGAT
HCCCCCCCCCHHCCCCEEHHHHHHHHCCCCCEEEHHHHCHHHHCCEEEEECCCCCCCCCC
GQSAGLAIALGGAGLTGRELAVLYSALGDGGVAKPLVWRAEEEAASAADPGHRLMGEASA
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHHHCCCCCCHHHHCCCCH
GEILRILQGSPSPAGRMPGQLTRDAPQIAFKTGTSYGYRDAWAAAVSGQHVIVVWVGRAD
HHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCEEEEEEEECCC
GAPRTGVTGRDIALPILFEMADRAAHHLRDDGDSELRLSAAPLTPAKGALRAFSTDRPPE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCC
ILFPPQGAELWAGTVDGRAPRPFVLAGRGAGALNWFIDGDPASLDDAGAPVWRPDRPGFY
EEECCCCCCEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEE
LVMAVDDAGRSSRVRVRVLTEDPA
EEEEECCCCCCCEEEEEEEECCCC
>Mature Secondary Structure 
PKRLLAGLAALIAAVLLIDVIFPPPLERAGGVSVLVTDRAGKPLRAFPTPDGRWRFGVD
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCC
LEEIDPEFVDALVRVEDKRFWDHHGTDWLGLTRAAFDSLLAGEIVSGGSTLTMQTARMLE
HHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCC
PRPRNPGSKLIEIWRANQLERRLSKREIIELYLSLTPYGGNLEGVRAASWSYFGHEADRL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEECCCHHCCCCCCCC
STDEIALLIALPQSPEVRRPDRRPEFAARSRDWVAEKLARYGVFSENDVLEVAATSVPAR
CCCCEEEEEECCCCCCCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCEEEEHHCCCCHH
RLDFPDRAWHGADAVLASGPREDVRSTLDAALQAELERIALTRAELEGTDVQVSVIVVHV
HCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEC
PTRAVRALVGSASRQRAGGWLDLTDRPRSPGSTLKPFIYGLAFDDGTASPDTRIQDLPSQ
CHHHHHHHHCCCCHHHCCCEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHH
FAGYQPENFDRMFHGDVRVSDALQHSLNVPAVLMLDRIGAERFSAQLAIAGARPRVSGAT
HCCCCCCCCCHHCCCCEEHHHHHHHHCCCCCEEEHHHHCHHHHCCEEEEECCCCCCCCCC
GQSAGLAIALGGAGLTGRELAVLYSALGDGGVAKPLVWRAEEEAASAADPGHRLMGEASA
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHHHCCCCCCHHHHCCCCH
GEILRILQGSPSPAGRMPGQLTRDAPQIAFKTGTSYGYRDAWAAAVSGQHVIVVWVGRAD
HHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCEEEEEEEECCC
GAPRTGVTGRDIALPILFEMADRAAHHLRDDGDSELRLSAAPLTPAKGALRAFSTDRPPE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCC
ILFPPQGAELWAGTVDGRAPRPFVLAGRGAGALNWFIDGDPASLDDAGAPVWRPDRPGFY
EEECCCCCCEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEE
LVMAVDDAGRSSRVRVRVLTEDPA
EEEEECCCCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]