Click here to switch to the map view.

The map label for this gene is msrA1 [H]

Identifier: 114798944

GI number: 114798944

Start: 3165359

End: 3166006

Strand: Reverse

Name: msrA1 [H]

Synonym: HNE_3001

Alternate gene names: 114798944

Gene position: 3166006-3165359 (Counterclockwise)

Preceding gene: 114797739

Following gene: 114797805

Centisome position: 85.45

GC content: 60.34

Gene sequence:

>648_bases
GTGCTTACCAATCGCCCAGCCGTCCTTATCGCCGTTGTCTCCGGGGCACTCGCCTCGAGCGTCGCTTTCATGTCTGACGC
AGGCGCCGAAGACCGCCGCGCCGAAGTGGCACCGATTCGCGTTGCAACGGCCGTTTTTGCGGGCGGAGACTTCCGCGGCG
TTGAGGCTGATTTCGATGGAATGAACGGCGTTATCGAAACCGTTTCGGGATATACGGGTGGCACGATTGAGCGCCCGACC
CACAAGCAGGTCGCTGCCGGACAGTCGGGACATTACGAGGCTGTAAAGGTCACCTACGACCCGTCGCAGGTTACTTATCT
CGAGCTTGCTGCCCACTTCATTCGCGGCATTGATCCTACCGACGATGCTGGCCAGTTCTGTGACAAGGGCGAAAGCTACC
GCAGCGCAATTTTCGTGTCCGGCCAGAGCGAACGGAATGTGGCGGTCGAGACCCTGTCCGGTGCCCAGCGCACGCTTGGC
AAGGATGTTGTCACAGAGATCCGTCCACTGACGGCCTTCTGGCCGGCCGAGGCCCAGTATCAGGACTATTACCTCAAGAA
CGCGTCAAAGTATTCCAGCGAGCGTGAAGCCTGCGGCCGCGATCAGCGTCTTGTGGAAGTCTGGGGCAATGACACGCCAG
CGCTCTGA

Upstream 100 bases:

>100_bases
CATTTGATGCCTTTTTTGTGCCGCCTGTAGCAACTACTTCGGGCTTGCCGTGTACAAGTGCCCCCTCGGGTACCGGCAAA
CCAAGAGTTAATAATCCAGC

Downstream 100 bases:

>100_bases
GCGCTGGCCCCTTAGCCGTCATATGCCGCCGTCGGGCAGGGCGGCTCGGGAAACTCCATTTCCCCTATGAACTGGTTTTC
CCATTCCTGGGTCCGCTCGG

Product: methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MLTNRPAVLIAVVSGALASSVAFMSDAGAEDRRAEVAPIRVATAVFAGGDFRGVEADFDGMNGVIETVSGYTGGTIERPT
HKQVAAGQSGHYEAVKVTYDPSQVTYLELAAHFIRGIDPTDDAGQFCDKGESYRSAIFVSGQSERNVAVETLSGAQRTLG
KDVVTEIRPLTAFWPAEAQYQDYYLKNASKYSSEREACGRDQRLVEVWGNDTPAL

Sequences:

>Translated_215_residues
MLTNRPAVLIAVVSGALASSVAFMSDAGAEDRRAEVAPIRVATAVFAGGDFRGVEADFDGMNGVIETVSGYTGGTIERPT
HKQVAAGQSGHYEAVKVTYDPSQVTYLELAAHFIRGIDPTDDAGQFCDKGESYRSAIFVSGQSERNVAVETLSGAQRTLG
KDVVTEIRPLTAFWPAEAQYQDYYLKNASKYSSEREACGRDQRLVEVWGNDTPAL
>Mature_215_residues
MLTNRPAVLIAVVSGALASSVAFMSDAGAEDRRAEVAPIRVATAVFAGGDFRGVEADFDGMNGVIETVSGYTGGTIERPT
HKQVAAGQSGHYEAVKVTYDPSQVTYLELAAHFIRGIDPTDDAGQFCDKGESYRSAIFVSGQSERNVAVETLSGAQRTLG
KDVVTEIRPLTAFWPAEAQYQDYYLKNASKYSSEREACGRDQRLVEVWGNDTPAL

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=165, Percent_Identity=33.9393939393939, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI208609995, Length=165, Percent_Identity=33.9393939393939, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1790665, Length=155, Percent_Identity=37.4193548387097, Blast_Score=96, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=31.4685314685315, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320881, Length=163, Percent_Identity=27.6073619631902, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664627, Length=183, Percent_Identity=26.2295081967213, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664631, Length=183, Percent_Identity=26.2295081967213, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 23137; Mature: 23137

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNRPAVLIAVVSGALASSVAFMSDAGAEDRRAEVAPIRVATAVFAGGDFRGVEADFDG
CCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEHEEECCCCCCCCCCCCC
MNGVIETVSGYTGGTIERPTHKQVAAGQSGHYEAVKVTYDPSQVTYLELAAHFIRGIDPT
CCHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCC
DDAGQFCDKGESYRSAIFVSGQSERNVAVETLSGAQRTLGKDVVTEIRPLTAFWPAEAQY
CCHHHHHHCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEECCCCCCH
QDYYLKNASKYSSEREACGRDQRLVEVWGNDTPAL
HHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MLTNRPAVLIAVVSGALASSVAFMSDAGAEDRRAEVAPIRVATAVFAGGDFRGVEADFDG
CCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEHEEECCCCCCCCCCCCC
MNGVIETVSGYTGGTIERPTHKQVAAGQSGHYEAVKVTYDPSQVTYLELAAHFIRGIDPT
CCHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCC
DDAGQFCDKGESYRSAIFVSGQSERNVAVETLSGAQRTLGKDVVTEIRPLTAFWPAEAQY
CCHHHHHHCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEECCCCCCH
QDYYLKNASKYSSEREACGRDQRLVEVWGNDTPAL
HHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]