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The map label for this gene is zraR [H]

Identifier: 114797505

GI number: 114797505

Start: 3208917

End: 3210392

Strand: Reverse

Name: zraR [H]

Synonym: HNE_3039

Alternate gene names: 114797505

Gene position: 3210392-3208917 (Counterclockwise)

Preceding gene: 114797702

Following gene: 114797286

Centisome position: 86.65

GC content: 64.02

Gene sequence:

>1476_bases
ATGGCCAAAACGATCCTCGTGGTCGATGACGATCCGACACAGCGCCGCCTGCTTCAAGCTGCCGTGGAGAAGGCCGGCTT
TGCCTGCCGCACGGCGCCCGATGGCGAGACGGGGCTGCAGATGGCGTCCGATGCGCGCGAAGGCGTGGATGTCGTGCTGC
TGGATCTGACGATGCCGGGCCTTTCGGGGATGGACACGCTGGAGCGGCTGAACGGCAAGCGCCCGGACCTGCCGGTGATC
ATGCTGACGGCGACGAGCGGCATCGACACGATCGTGCAGACGATGCGGCGCGGGGCGGTGGACTTTATCGTGAAGCCGGC
CAATCCGGAGCGCGTGGTTGTCTCGATCCGCAATGCCCTGAAGATGCAGAGCCTGACGGGGGAGGTGAAACGCCTGTCGC
GCAAGGTGGAAGGGGGCATGAAGTTCGAGGACATGATCGCCTCGGCCCCGGCGATGCGCAGCGTGATCCGCATGGCAGAG
CGCGGAGCGGCGTCGGACATTCCGGTGCTGATCCTGGGCGAAAGCGGTGTGGGTAAAGAAGTTGTGGCGCGCTGTATTCA
GGGCGCCAGCCAGCGGGCGGGCAAACCGTTCGTGACGGTCAACTGCGGGGCGATCCCGGAGAACCTCGTGGAGTCGATCC
TGTTCGGCCATGAGAAGGGCGCGTTTACGGGCGCGGTTTCCAAGGCGCCGGGCAAGTTTGTCGAAGCCGATGGCGGCACG
CTGTTCCTCGATGAGGTGGGCGAGTTGCCGCTGGACGCGCAGGTGAAACTGCTCCGTGCGCTGCAGGAAGGGGAGGTCGA
TGCCGTTGGCTCGCGCCGCCCGACCAAGGTGGACGTGCGCATCATCTCGGCGACGAACCGTGATCTGGCCGGCCAGGTGA
AGGCGGGCACGTTCCGCGAAGACCTGTTCTACCGTCTCAACGTGTTCCCCATCGACATGCCGTCGCTGAACGAGCGGCGC
GAAGATATTCCGGCGCTGGTGGATCATTTCATTGCGCGCTTCAATGCCAGCGAAGGCACCAAGGTGGCCGGGGCGAGCGA
AGACACGCTGAAGATGCTGTATTCCTATGACTGGCCGGGTAACGTGCGCCAGCTGGAGAATGCGGTATTCCGCGCGGTTG
TGCTGTGTGACGGCGATGAGCTGCGCCCGCAGGACTTCCCGCAGATTTCCGGCCAGATGGCGGACGTTATGATGATGCCG
GCGATCCCGGCGCAGCGCCCGCCTGAAGCGCCGCCGGTGCCTGCAAATGATGTGAAGCGCGGTTTTGTCGGGGATGTGCC
GGTGGCCATCAAGGACGAGGACGGCGAAATCCGCAGCCTGCAGGATATCGAGCGCGATCTTCTTCAGTATGCGATTGAAT
TCTATGACGGCCATATGAGCGAAGTTTCGCGCCGTCTCGGGATTGGCCGCTCGACGCTTTACCGCAAGGTGCGTGAATAC
GACCTGGAAGTGCGCGGCGACCGCGAGACGGGTTGA

Upstream 100 bases:

>100_bases
GTAACTCCATGCGTCTGTGTCAGAACGGGGCGTAACGAAACGGCACGGGGCGCCCTCAGTGAGGCGCGCTGGCCGCAACC
GGAATGATGAGGGCACACCC

Downstream 100 bases:

>100_bases
TCTTCCCTTTGAAGCCGCGCCGGATCAGATCCGGGGCGGCTTCGAGAGATCATAGGACATCGCCACATTGCAGCGGGCAT
AGCTGGCGCCGTAACGCGCC

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MAKTILVVDDDPTQRRLLQAAVEKAGFACRTAPDGETGLQMASDAREGVDVVLLDLTMPGLSGMDTLERLNGKRPDLPVI
MLTATSGIDTIVQTMRRGAVDFIVKPANPERVVVSIRNALKMQSLTGEVKRLSRKVEGGMKFEDMIASAPAMRSVIRMAE
RGAASDIPVLILGESGVGKEVVARCIQGASQRAGKPFVTVNCGAIPENLVESILFGHEKGAFTGAVSKAPGKFVEADGGT
LFLDEVGELPLDAQVKLLRALQEGEVDAVGSRRPTKVDVRIISATNRDLAGQVKAGTFREDLFYRLNVFPIDMPSLNERR
EDIPALVDHFIARFNASEGTKVAGASEDTLKMLYSYDWPGNVRQLENAVFRAVVLCDGDELRPQDFPQISGQMADVMMMP
AIPAQRPPEAPPVPANDVKRGFVGDVPVAIKDEDGEIRSLQDIERDLLQYAIEFYDGHMSEVSRRLGIGRSTLYRKVREY
DLEVRGDRETG

Sequences:

>Translated_491_residues
MAKTILVVDDDPTQRRLLQAAVEKAGFACRTAPDGETGLQMASDAREGVDVVLLDLTMPGLSGMDTLERLNGKRPDLPVI
MLTATSGIDTIVQTMRRGAVDFIVKPANPERVVVSIRNALKMQSLTGEVKRLSRKVEGGMKFEDMIASAPAMRSVIRMAE
RGAASDIPVLILGESGVGKEVVARCIQGASQRAGKPFVTVNCGAIPENLVESILFGHEKGAFTGAVSKAPGKFVEADGGT
LFLDEVGELPLDAQVKLLRALQEGEVDAVGSRRPTKVDVRIISATNRDLAGQVKAGTFREDLFYRLNVFPIDMPSLNERR
EDIPALVDHFIARFNASEGTKVAGASEDTLKMLYSYDWPGNVRQLENAVFRAVVLCDGDELRPQDFPQISGQMADVMMMP
AIPAQRPPEAPPVPANDVKRGFVGDVPVAIKDEDGEIRSLQDIERDLLQYAIEFYDGHMSEVSRRLGIGRSTLYRKVREY
DLEVRGDRETG
>Mature_490_residues
AKTILVVDDDPTQRRLLQAAVEKAGFACRTAPDGETGLQMASDAREGVDVVLLDLTMPGLSGMDTLERLNGKRPDLPVIM
LTATSGIDTIVQTMRRGAVDFIVKPANPERVVVSIRNALKMQSLTGEVKRLSRKVEGGMKFEDMIASAPAMRSVIRMAER
GAASDIPVLILGESGVGKEVVARCIQGASQRAGKPFVTVNCGAIPENLVESILFGHEKGAFTGAVSKAPGKFVEADGGTL
FLDEVGELPLDAQVKLLRALQEGEVDAVGSRRPTKVDVRIISATNRDLAGQVKAGTFREDLFYRLNVFPIDMPSLNERRE
DIPALVDHFIARFNASEGTKVAGASEDTLKMLYSYDWPGNVRQLENAVFRAVVLCDGDELRPQDFPQISGQMADVMMMPA
IPAQRPPEAPPVPANDVKRGFVGDVPVAIKDEDGEIRSLQDIERDLLQYAIEFYDGHMSEVSRRLGIGRSTLYRKVREYD
LEVRGDRETG

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=479, Percent_Identity=38.6221294363257, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI1790437, Length=475, Percent_Identity=40.8421052631579, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1790299, Length=479, Percent_Identity=40.0835073068894, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788905, Length=374, Percent_Identity=43.048128342246, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87082117, Length=279, Percent_Identity=46.9534050179211, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789087, Length=285, Percent_Identity=46.3157894736842, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI1789233, Length=343, Percent_Identity=39.3586005830904, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI87082152, Length=272, Percent_Identity=47.7941176470588, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1787583, Length=354, Percent_Identity=36.7231638418079, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI87081872, Length=268, Percent_Identity=40.2985074626866, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1786524, Length=348, Percent_Identity=36.4942528735632, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87081858, Length=364, Percent_Identity=28.021978021978, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=232, Percent_Identity=38.3620689655172, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1789809, Length=121, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786599, Length=123, Percent_Identity=31.7073170731707, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53565; Mature: 53434

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTILVVDDDPTQRRLLQAAVEKAGFACRTAPDGETGLQMASDAREGVDVVLLDLTMPG
CCCEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCC
LSGMDTLERLNGKRPDLPVIMLTATSGIDTIVQTMRRGAVDFIVKPANPERVVVSIRNAL
CCCHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHH
KMQSLTGEVKRLSRKVEGGMKFEDMIASAPAMRSVIRMAERGAASDIPVLILGESGVGKE
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
VVARCIQGASQRAGKPFVTVNCGAIPENLVESILFGHEKGAFTGAVSKAPGKFVEADGGT
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCE
LFLDEVGELPLDAQVKLLRALQEGEVDAVGSRRPTKVDVRIISATNRDLAGQVKAGTFRE
EEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHH
DLFYRLNVFPIDMPSLNERREDIPALVDHFIARFNASEGTKVAGASEDTLKMLYSYDWPG
HHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHEECCCCC
NVRQLENAVFRAVVLCDGDELRPQDFPQISGQMADVMMMPAIPAQRPPEAPPVPANDVKR
CHHHHHHHHHEEEEEECCCCCCCCCCHHHCCHHHHEEECCCCCCCCCCCCCCCCHHHHCC
GFVGDVPVAIKDEDGEIRSLQDIERDLLQYAIEFYDGHMSEVSRRLGIGRSTLYRKVREY
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHC
DLEVRGDRETG
CCEECCCCCCC
>Mature Secondary Structure 
AKTILVVDDDPTQRRLLQAAVEKAGFACRTAPDGETGLQMASDAREGVDVVLLDLTMPG
CCEEEEECCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCC
LSGMDTLERLNGKRPDLPVIMLTATSGIDTIVQTMRRGAVDFIVKPANPERVVVSIRNAL
CCCHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCEEHHHHHHHH
KMQSLTGEVKRLSRKVEGGMKFEDMIASAPAMRSVIRMAERGAASDIPVLILGESGVGKE
HHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHH
VVARCIQGASQRAGKPFVTVNCGAIPENLVESILFGHEKGAFTGAVSKAPGKFVEADGGT
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCE
LFLDEVGELPLDAQVKLLRALQEGEVDAVGSRRPTKVDVRIISATNRDLAGQVKAGTFRE
EEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHH
DLFYRLNVFPIDMPSLNERREDIPALVDHFIARFNASEGTKVAGASEDTLKMLYSYDWPG
HHEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHEECCCCC
NVRQLENAVFRAVVLCDGDELRPQDFPQISGQMADVMMMPAIPAQRPPEAPPVPANDVKR
CHHHHHHHHHEEEEEECCCCCCCCCCHHHCCHHHHEEECCCCCCCCCCCCCCCCHHHHCC
GFVGDVPVAIKDEDGEIRSLQDIERDLLQYAIEFYDGHMSEVSRRLGIGRSTLYRKVREY
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHC
DLEVRGDRETG
CCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]