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The map label for this gene is ahpC [H]

Identifier: 114797286

GI number: 114797286

Start: 3204895

End: 3205452

Strand: Reverse

Name: ahpC [H]

Synonym: HNE_3035

Alternate gene names: 114797286

Gene position: 3205452-3204895 (Counterclockwise)

Preceding gene: 114797505

Following gene: 114799646

Centisome position: 86.52

GC content: 59.32

Gene sequence:

>558_bases
ATGCTTGGCATTGGCCAGAAACTGCCTGACTTCCAGATCACCGGCGTGAAGCCGAAATTCATGCAACACGAACAGAATGG
TGAAAGCGCTTTCGAGCCGCTGAACCAGGACAGCTTCCCCGGTCTCTGGAAGGTCATCTTCTTCTATCCGAAGGACTTCA
CTTTCGTTTGCCCGACCGAGATCGCAGAGTTTGCGCGCCTTGCGCCTGAGTTTGCTGATCGCGACGCGGTTATCCTTGGC
GGCTCGACCGACAATGAGTTCGTGAAGCTCGCCTGGCGCCGGGAACACGCCGACCTGCGCGAACTGCCGATCTGGCAATT
TGCAGACACCAACGGCTCGCTCGTTGATGGCCTCGGCGTGCGTGAAGAAGGCGCCGGCGTTGCCTATCGCGCGACCTACA
TCGTCGACCCGCACAATGTCATCCAGCACGTTTACGTCACCAACCTGAACGTTGGCCGTAACCCGCAGGACACCCTGCGC
GTGCTCGACGCTCTGCAGACCGACGAGCTTTGCCCTTGCAACCGCCCTGTCGGCGGCAAGACGCTTGAGCTTGCTTAA

Upstream 100 bases:

>100_bases
AATCGGAATTATCAATTTTATTTATTGCGTGCAGTGCACCAATTCGGTACGGCCTGCAGCCACCGACGTAGGCTACAAAT
CCCGTTTTAGGAGACCTCCC

Downstream 100 bases:

>100_bases
GCACGACTGAATGCCAGCCGGTTCCGGGCCCTGCGCCCGCCCCGCGTCCCCCCACTCATGGTGGGCGCGGCCTGGGACCG
GCTGGTTATTCCCTTATTTC

Product: alkylhydroperoxide reductase C

Products: NA

Alternate protein names: MtAhpC; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MLGIGQKLPDFQITGVKPKFMQHEQNGESAFEPLNQDSFPGLWKVIFFYPKDFTFVCPTEIAEFARLAPEFADRDAVILG
GSTDNEFVKLAWRREHADLRELPIWQFADTNGSLVDGLGVREEGAGVAYRATYIVDPHNVIQHVYVTNLNVGRNPQDTLR
VLDALQTDELCPCNRPVGGKTLELA

Sequences:

>Translated_185_residues
MLGIGQKLPDFQITGVKPKFMQHEQNGESAFEPLNQDSFPGLWKVIFFYPKDFTFVCPTEIAEFARLAPEFADRDAVILG
GSTDNEFVKLAWRREHADLRELPIWQFADTNGSLVDGLGVREEGAGVAYRATYIVDPHNVIQHVYVTNLNVGRNPQDTLR
VLDALQTDELCPCNRPVGGKTLELA
>Mature_185_residues
MLGIGQKLPDFQITGVKPKFMQHEQNGESAFEPLNQDSFPGLWKVIFFYPKDFTFVCPTEIAEFARLAPEFADRDAVILG
GSTDNEFVKLAWRREHADLRELPIWQFADTNGSLVDGLGVREEGAGVAYRATYIVDPHNVIQHVYVTNLNVGRNPQDTLR
VLDALQTDELCPCNRPVGGKTLELA

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=179, Percent_Identity=39.1061452513966, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI32483377, Length=156, Percent_Identity=41.6666666666667, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI32189392, Length=187, Percent_Identity=36.3636363636364, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI4505591, Length=187, Percent_Identity=32.620320855615, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI32455266, Length=187, Percent_Identity=32.620320855615, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI32455264, Length=187, Percent_Identity=32.620320855615, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI5453549, Length=162, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI4758638, Length=163, Percent_Identity=30.6748466257669, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI33188454, Length=99, Percent_Identity=39.3939393939394, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786822, Length=174, Percent_Identity=35.0574712643678, Blast_Score=103, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI193204376, Length=187, Percent_Identity=36.8983957219251, Blast_Score=116, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI32565831, Length=187, Percent_Identity=36.8983957219251, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17554494, Length=180, Percent_Identity=35, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25153706, Length=147, Percent_Identity=30.6122448979592, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=163, Percent_Identity=39.8773006134969, Blast_Score=112, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320661, Length=160, Percent_Identity=37.5, Blast_Score=109, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319407, Length=169, Percent_Identity=30.7692307692308, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17157991, Length=159, Percent_Identity=37.7358490566038, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641739, Length=159, Percent_Identity=37.7358490566038, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=33.6842105263158, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17738015, Length=154, Percent_Identity=32.4675324675325, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24656348, Length=156, Percent_Identity=34.6153846153846, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17864676, Length=156, Percent_Identity=34.6153846153846, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17975518, Length=199, Percent_Identity=29.1457286432161, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24652436, Length=199, Percent_Identity=29.1457286432161, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24652434, Length=199, Percent_Identity=29.1457286432161, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24581278, Length=180, Percent_Identity=28.3333333333333, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20735; Mature: 20735

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIGQKLPDFQITGVKPKFMQHEQNGESAFEPLNQDSFPGLWKVIFFYPKDFTFVCPTE
CCCCCCCCCCEEEECCCHHHHHCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCEEECHHH
IAEFARLAPEFADRDAVILGGSTDNEFVKLAWRREHADLRELPIWQFADTNGSLVDGLGV
HHHHHHHCHHHCCCCEEEEECCCCCCEEEEEEHHCCCCHHHCCEEEEECCCCCEECCCCC
REEGAGVAYRATYIVDPHNVIQHVYVTNLNVGRNPQDTLRVLDALQTDELCPCNRPVGGK
CCCCCCEEEEEEEEECHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCE
TLELA
EEEEC
>Mature Secondary Structure
MLGIGQKLPDFQITGVKPKFMQHEQNGESAFEPLNQDSFPGLWKVIFFYPKDFTFVCPTE
CCCCCCCCCCEEEECCCHHHHHCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCEEECHHH
IAEFARLAPEFADRDAVILGGSTDNEFVKLAWRREHADLRELPIWQFADTNGSLVDGLGV
HHHHHHHCHHHCCCCEEEEECCCCCCEEEEEEHHCCCCHHHCCEEEEECCCCCEECCCCC
REEGAGVAYRATYIVDPHNVIQHVYVTNLNVGRNPQDTLRVLDALQTDELCPCNRPVGGK
CCCCCCEEEEEEEEECHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCE
TLELA
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604044; 8596438; 9634230; 12218036 [H]