Click here to switch to the map view.

The map label for this gene is qacA [H]

Identifier: 114331716

GI number: 114331716

Start: 1835009

End: 1836505

Strand: Direct

Name: qacA [H]

Synonym: Neut_1736

Alternate gene names: 114331716

Gene position: 1835009-1836505 (Clockwise)

Preceding gene: 114331715

Following gene: 114331717

Centisome position: 68.96

GC content: 57.31

Gene sequence:

>1497_bases
GTGATCAGCATAGCGGCCAAGGCCACGCGGCGCGAATGGATCGGCTTAGCAGTAATCGCCCTGCCATGTCTGCTGTACTC
CATGGATCTGACGATCATGACCTTGGCACTACCGACCATCAATGCAGCGCTGAACGCCACTAACGCACAGATGTTATGGA
TGGTGGATATCTATGGCTTCATGGTTGCCGGCTTCCTGATCACCATGGGTACTATCGGCGACCGCATCGGGCGACGGCGA
CTGTTATTGATTGGTGCAGCGGCTTTTGGCATTGTCTCGGTCCTCGCTGCACTGGTCAAAAGTGCCGGCACCTTGATTCT
TCTTCGCGCCTTGCTCGGAGTGGCCGGCGCAACGTTGGCGCCGTCCACGCTCTCACTGATTCGCAATATGTTTCACAACA
AGAACGAACGGACGACAGCTATCGGCATCTGGATGGCTAGCTTCTCGGCCGGAGCAGTAGTCGGCCCCTTGCTGGGCGGG
ATACTGATTACGCATTTTCATTGGAGCTCGATATTTCTCATCTCCGTACCTGCAATGTTGCTGTTGTTGGCACTGGGTCC
CTGGCTGCTGCCTGAATATCGCGATCCGGCCCCGGGCCGTGTCGACCTGTGTAGCGTACTGTTATCGCTAGGCGCCGTAT
TGGCTGTTGTGTACGGTATAAAAGAGGGGGCAGGACAAGGGCTGAGTTGGTGGCCTGTTTTATCGCTGCTCGTTGGTGTG
GCGCTGGCCGGAGTATTTCTGCATCGTCAGACGCGACTGGCCTATCCCATGGTGGATCTGCAGCTGTTCAGCAGGCCAGG
CTTTTCCGCGGCCATGCTCAGCTACGCATTCGGCTTCTTTGTGTTGTTCGGACTCTCAATCCTTCTGACCCAGTATCTGC
AACTAGTGCTCGATCTTTCGCCATTCAAGGCCGCCTGCTGGCTTGCGCCCTGGGGGGGTGCCTTCATGATTGGCTCCGCC
ACGGCACCGCGCATCGCACGCTATTGGCATCCCTGCCGCATCACCACCTGTGGCCTGTTGTTGTCGGCATTGGGATTTGC
CCTGTTGACGCAAGTAGGTGGTTCGTCTGACAAGGAAGTAATTATTACCGGGACAGTGATGCTGGCGCTGGGGCTGACAC
CGCTGTTCACCTTCAGCGTCGAGCTAATCATCGCTCAAGCCCCTTCGGAGCGGGCGGGGGCTGCGGCAGCATTGTCCGAG
ACAGGCTCCGAACTCAGTGGTGCGCTGGGCATCGCCCTGTTGGGCAGCCTCGCTAGCCTGATCTACCGCATGGAGTTTTC
TCCTGAATCATTATCGGGCGTGCCCGAAGATGCTCTCACATATGCAAATGGTTCCCTGAGCGCGGCGGTCGCCATCGCTG
ACAAATTACTGGAACCTGCAAGGATCGAGTTGCTTACTGCCTCACGGCACGCATTTACCGCCAGCATGCAATTCATTTCC
GCAACGTCGATGCTGATCGTACTGGCGGCGGCGCTGATTTCCTGCCGCACATCTTGA

Upstream 100 bases:

>100_bases
CTACGTTATCCCTATGCGGATTACGACACCGACGGCAGGTCGAGGCTGAACCTCTGGCGATCCAACTTTACCAGAGACGG
CTGCCTAGGCTGGCTATTCC

Downstream 100 bases:

>100_bases
GTCGCGGCAGACGAGCTTAGCACAATCACATTCTGACCAACATGGTCACGAACCTGTTCAACCATTGGGATAGTTAAATT
CGCTTTAACAAAGATTTTCT

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MISIAAKATRREWIGLAVIALPCLLYSMDLTIMTLALPTINAALNATNAQMLWMVDIYGFMVAGFLITMGTIGDRIGRRR
LLLIGAAAFGIVSVLAALVKSAGTLILLRALLGVAGATLAPSTLSLIRNMFHNKNERTTAIGIWMASFSAGAVVGPLLGG
ILITHFHWSSIFLISVPAMLLLLALGPWLLPEYRDPAPGRVDLCSVLLSLGAVLAVVYGIKEGAGQGLSWWPVLSLLVGV
ALAGVFLHRQTRLAYPMVDLQLFSRPGFSAAMLSYAFGFFVLFGLSILLTQYLQLVLDLSPFKAACWLAPWGGAFMIGSA
TAPRIARYWHPCRITTCGLLLSALGFALLTQVGGSSDKEVIITGTVMLALGLTPLFTFSVELIIAQAPSERAGAAAALSE
TGSELSGALGIALLGSLASLIYRMEFSPESLSGVPEDALTYANGSLSAAVAIADKLLEPARIELLTASRHAFTASMQFIS
ATSMLIVLAAALISCRTS

Sequences:

>Translated_498_residues
MISIAAKATRREWIGLAVIALPCLLYSMDLTIMTLALPTINAALNATNAQMLWMVDIYGFMVAGFLITMGTIGDRIGRRR
LLLIGAAAFGIVSVLAALVKSAGTLILLRALLGVAGATLAPSTLSLIRNMFHNKNERTTAIGIWMASFSAGAVVGPLLGG
ILITHFHWSSIFLISVPAMLLLLALGPWLLPEYRDPAPGRVDLCSVLLSLGAVLAVVYGIKEGAGQGLSWWPVLSLLVGV
ALAGVFLHRQTRLAYPMVDLQLFSRPGFSAAMLSYAFGFFVLFGLSILLTQYLQLVLDLSPFKAACWLAPWGGAFMIGSA
TAPRIARYWHPCRITTCGLLLSALGFALLTQVGGSSDKEVIITGTVMLALGLTPLFTFSVELIIAQAPSERAGAAAALSE
TGSELSGALGIALLGSLASLIYRMEFSPESLSGVPEDALTYANGSLSAAVAIADKLLEPARIELLTASRHAFTASMQFIS
ATSMLIVLAAALISCRTS
>Mature_498_residues
MISIAAKATRREWIGLAVIALPCLLYSMDLTIMTLALPTINAALNATNAQMLWMVDIYGFMVAGFLITMGTIGDRIGRRR
LLLIGAAAFGIVSVLAALVKSAGTLILLRALLGVAGATLAPSTLSLIRNMFHNKNERTTAIGIWMASFSAGAVVGPLLGG
ILITHFHWSSIFLISVPAMLLLLALGPWLLPEYRDPAPGRVDLCSVLLSLGAVLAVVYGIKEGAGQGLSWWPVLSLLVGV
ALAGVFLHRQTRLAYPMVDLQLFSRPGFSAAMLSYAFGFFVLFGLSILLTQYLQLVLDLSPFKAACWLAPWGGAFMIGSA
TAPRIARYWHPCRITTCGLLLSALGFALLTQVGGSSDKEVIITGTVMLALGLTPLFTFSVELIIAQAPSERAGAAAALSE
TGSELSGALGIALLGSLASLIYRMEFSPESLSGVPEDALTYANGSLSAAVAIADKLLEPARIELLTASRHAFTASMQFIS
ATSMLIVLAAALISCRTS

Specific function: Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=395, Percent_Identity=28.6075949367089, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789042, Length=413, Percent_Identity=26.3922518159806, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788710, Length=323, Percent_Identity=26.625386996904, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1790195, Length=426, Percent_Identity=23.943661971831, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790146, Length=179, Percent_Identity=26.8156424581006, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52532; Mature: 52532

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISIAAKATRREWIGLAVIALPCLLYSMDLTIMTLALPTINAALNATNAQMLWMVDIYGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHH
MVAGFLITMGTIGDRIGRRRLLLIGAAAFGIVSVLAALVKSAGTLILLRALLGVAGATLA
HHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
PSTLSLIRNMFHNKNERTTAIGIWMASFSAGAVVGPLLGGILITHFHWSSIFLISVPAML
HHHHHHHHHHHHCCCCCEEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLALGPWLLPEYRDPAPGRVDLCSVLLSLGAVLAVVYGIKEGAGQGLSWWPVLSLLVGV
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ALAGVFLHRQTRLAYPMVDLQLFSRPGFSAAMLSYAFGFFVLFGLSILLTQYLQLVLDLS
HHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFKAACWLAPWGGAFMIGSATAPRIARYWHPCRITTCGLLLSALGFALLTQVGGSSDKEV
CCHHEEEECCCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IITGTVMLALGLTPLFTFSVELIIAQAPSERAGAAAALSETGSELSGALGIALLGSLASL
EEEHHHHHHHCCHHHHHHHHHEEEEECCCCHHCHHHHHHHCCHHHHHHHHHHHHHHHHHH
IYRMEFSPESLSGVPEDALTYANGSLSAAVAIADKLLEPARIELLTASRHAFTASMQFIS
HHHHCCCCHHCCCCCHHHHHCCCCCHHHHHHHHHHHCCCHHEEEEECCCHHHHHHHHHHH
ATSMLIVLAAALISCRTS
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MISIAAKATRREWIGLAVIALPCLLYSMDLTIMTLALPTINAALNATNAQMLWMVDIYGF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHH
MVAGFLITMGTIGDRIGRRRLLLIGAAAFGIVSVLAALVKSAGTLILLRALLGVAGATLA
HHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
PSTLSLIRNMFHNKNERTTAIGIWMASFSAGAVVGPLLGGILITHFHWSSIFLISVPAML
HHHHHHHHHHHHCCCCCEEEEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLALGPWLLPEYRDPAPGRVDLCSVLLSLGAVLAVVYGIKEGAGQGLSWWPVLSLLVGV
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ALAGVFLHRQTRLAYPMVDLQLFSRPGFSAAMLSYAFGFFVLFGLSILLTQYLQLVLDLS
HHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFKAACWLAPWGGAFMIGSATAPRIARYWHPCRITTCGLLLSALGFALLTQVGGSSDKEV
CCHHEEEECCCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEE
IITGTVMLALGLTPLFTFSVELIIAQAPSERAGAAAALSETGSELSGALGIALLGSLASL
EEEHHHHHHHCCHHHHHHHHHEEEEECCCCHHCHHHHHHHCCHHHHHHHHHHHHHHHHHH
IYRMEFSPESLSGVPEDALTYANGSLSAAVAIADKLLEPARIELLTASRHAFTASMQFIS
HHHHCCCCHHCCCCCHHHHHCCCCCHHHHHHHHHHHCCCHHEEEEECCCHHHHHHHHHHH
ATSMLIVLAAALISCRTS
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]