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The map label for this gene is cysM [H]

Identifier: 114331714

GI number: 114331714

Start: 1831074

End: 1833017

Strand: Direct

Name: cysM [H]

Synonym: Neut_1734

Alternate gene names: 114331714

Gene position: 1831074-1833017 (Clockwise)

Preceding gene: 114331713

Following gene: 114331715

Centisome position: 68.81

GC content: 55.09

Gene sequence:

>1944_bases
ATGAAAAACATTTATCTATCTGACAGCATCGTCGATCTGAAACGGCACATCCTGGAAGCTGGAGAACGCATACTCGCATT
CGGTGCTTGTGGCCCGGAGAATGCGCAGTTTCATCAAGCCCGCTACAAGTTGTACTCCATCGCTAGCTCCGACGTGTCGG
TTAGCGACGCGAGCGTGATCGCCGCTGATGCGGACGTTCTTGCTCTAGCCCGCGACGTCTTTCCTATCTCCTGCGACGCC
GGTGTTCTCGAAGAATGTCGGATTGCAGAAAATTTATTAGGGGAATCTAACCTGACCTTCGGCAAGATCTATCGCGCCTA
CCATGGACAGATCTATCAGGGCCTGATGGAGGACGAGCTGACCTGGCTCGAACGTGAAGGTCAGCTGCGCTCCTGTACTG
AATCTACTTATCCGTCCGCTGCCACTCAATGCTGTCGCATCGGCTACATAGGCGGTGGCGCGCTGCCGCTTCCGGCCATG
CTGTTGGCGCAGCGACTCGGCTATCAGGTCGTGGTGTTGGATCCTCACACCAGATCCGCCGCCTTTGCCACGGAGTTGAT
TGCCAAGGTGGGGTTGGACCATCTGGTCCGTGTGATTTGTGTCGATGGCAGTAAGTACGATTTCAGTGATTGCGACTTGG
TATTCGTGTCGAACTGGATCGCCAACAAGCAACCTTTGTTACGCCATCTGCGGAAGTTCACCAATATCCAGTACTTCATA
TTCCGCAGCGCGCCCCGTAATAGCTTGGGTTTCATTATCAATGACATGATTGATCCCAATCGTGTGTGCGAACATGGTTT
CAGGTTCCGATATCAGACAGAGAAACGACCAGGCCTCTCCCTGATCTCGCTGATATTCAGCCTGCTGAGTCAATCGGAAG
CTACCGAATCGACAGAGACCATCCGTCGTGCCGATGACGAGCCAGCCAAGATGGCCACTAGCAGGAAACGACTGGTGGTC
GATTCGATCACCGATCTGATCGGTAATACGCCGATCTTGAAATTGAATCCAGCCAAGACTAGCCTGACGAATATCGACTT
GTATGCCAAGCTCGAGCACCTCAACCCGTTTGGCTCGATCAAGGATCGGACGGCATGGGCAATGCTACGCCCGCACTTGG
GTACTCTGCAGTCCAGTAACAAGCAGTTGTTGGAGCTATCGAGCGGCAATGCAGCGCGTGCACTTCAGGCAGTGGCATCT
ATCTATGGCAGCGCCCTTGAGACCATTACCAACCGTATCCGTATTCAGGAGATGCGCCGCATGCTGGTAGTACAGGGCGC
CAAGGTTTCACCGATGGCGGGAGACGTCGACCCCACCGATGCCATGGCAGCCTTGCTGTACGTCGATGCGCGCGCATACG
AGCAGCGCGATCGTTATCTCTATACCGATCAATACCGCAATCCCAACAATGACTGCACCCACTACGCCACCACGGCGCAG
GAGATCCTGGAGGATCTCGGGCCGGTCGACTACTTTTTTGCACCAGTCGGCACTGCGGGTTCCAGTATCGGTATCGGCCG
GCGCCTTCGGGAAGCGAACGAGAAATTGAAAGTGTCCGGTATCGTTTCGACCAAGGACAGCGCCATTCCCGGCATCCGTC
ACATGGATGAGATGTTCTACGTCGGCCCCTTTGAGGAACAAAAGTATGACCAGTTAGTTGGCATCACGGCGAGCGAGGCA
CTTGATGGCATGCTCGCCCTAATCCGTGACTATGGAGTGATGGCAGGCCCTTCCAGTGGCGCCACCTATCTAGCTGCACT
GCGCTACCTGCGAGCCATTGATGCCAAACAGACAGAGCGCAAGAGCGCTGTAATCATCGTCTGTGATCGGGTGGAACTGT
ATCTGAGTTGGATCGAGCAGATGCGTCCCGCGCTGTTCGAGGATTATGAGACACCCGAGGCAGAGCACGCCACCGTTGCA
ACCTCTGCGACACTGGGGGCTTGA

Upstream 100 bases:

>100_bases
GAGAAGGTACGATGAAAGAGACTGCGGAGGTCTTTAGTGACCACCTTCTTGTGCCATTTTCACTCCCATCATCTTAAACA
AGATTAGAGAGTTTCCGACT

Downstream 100 bases:

>100_bases
GATGAGCGGAATCGCTGGGTTCGTTGGGCGCGAGACTCCGGCGGCCTTGCGCATTAGGGTAGTCGAGGACATGGTGCGAA
CCGATGCCATGCAACGGCGC

Product: pyridoxal-5'-phosphate-dependent enzyme, beta subunit

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MKNIYLSDSIVDLKRHILEAGERILAFGACGPENAQFHQARYKLYSIASSDVSVSDASVIAADADVLALARDVFPISCDA
GVLEECRIAENLLGESNLTFGKIYRAYHGQIYQGLMEDELTWLEREGQLRSCTESTYPSAATQCCRIGYIGGGALPLPAM
LLAQRLGYQVVVLDPHTRSAAFATELIAKVGLDHLVRVICVDGSKYDFSDCDLVFVSNWIANKQPLLRHLRKFTNIQYFI
FRSAPRNSLGFIINDMIDPNRVCEHGFRFRYQTEKRPGLSLISLIFSLLSQSEATESTETIRRADDEPAKMATSRKRLVV
DSITDLIGNTPILKLNPAKTSLTNIDLYAKLEHLNPFGSIKDRTAWAMLRPHLGTLQSSNKQLLELSSGNAARALQAVAS
IYGSALETITNRIRIQEMRRMLVVQGAKVSPMAGDVDPTDAMAALLYVDARAYEQRDRYLYTDQYRNPNNDCTHYATTAQ
EILEDLGPVDYFFAPVGTAGSSIGIGRRLREANEKLKVSGIVSTKDSAIPGIRHMDEMFYVGPFEEQKYDQLVGITASEA
LDGMLALIRDYGVMAGPSSGATYLAALRYLRAIDAKQTERKSAVIIVCDRVELYLSWIEQMRPALFEDYETPEAEHATVA
TSATLGA

Sequences:

>Translated_647_residues
MKNIYLSDSIVDLKRHILEAGERILAFGACGPENAQFHQARYKLYSIASSDVSVSDASVIAADADVLALARDVFPISCDA
GVLEECRIAENLLGESNLTFGKIYRAYHGQIYQGLMEDELTWLEREGQLRSCTESTYPSAATQCCRIGYIGGGALPLPAM
LLAQRLGYQVVVLDPHTRSAAFATELIAKVGLDHLVRVICVDGSKYDFSDCDLVFVSNWIANKQPLLRHLRKFTNIQYFI
FRSAPRNSLGFIINDMIDPNRVCEHGFRFRYQTEKRPGLSLISLIFSLLSQSEATESTETIRRADDEPAKMATSRKRLVV
DSITDLIGNTPILKLNPAKTSLTNIDLYAKLEHLNPFGSIKDRTAWAMLRPHLGTLQSSNKQLLELSSGNAARALQAVAS
IYGSALETITNRIRIQEMRRMLVVQGAKVSPMAGDVDPTDAMAALLYVDARAYEQRDRYLYTDQYRNPNNDCTHYATTAQ
EILEDLGPVDYFFAPVGTAGSSIGIGRRLREANEKLKVSGIVSTKDSAIPGIRHMDEMFYVGPFEEQKYDQLVGITASEA
LDGMLALIRDYGVMAGPSSGATYLAALRYLRAIDAKQTERKSAVIIVCDRVELYLSWIEQMRPALFEDYETPEAEHATVA
TSATLGA
>Mature_647_residues
MKNIYLSDSIVDLKRHILEAGERILAFGACGPENAQFHQARYKLYSIASSDVSVSDASVIAADADVLALARDVFPISCDA
GVLEECRIAENLLGESNLTFGKIYRAYHGQIYQGLMEDELTWLEREGQLRSCTESTYPSAATQCCRIGYIGGGALPLPAM
LLAQRLGYQVVVLDPHTRSAAFATELIAKVGLDHLVRVICVDGSKYDFSDCDLVFVSNWIANKQPLLRHLRKFTNIQYFI
FRSAPRNSLGFIINDMIDPNRVCEHGFRFRYQTEKRPGLSLISLIFSLLSQSEATESTETIRRADDEPAKMATSRKRLVV
DSITDLIGNTPILKLNPAKTSLTNIDLYAKLEHLNPFGSIKDRTAWAMLRPHLGTLQSSNKQLLELSSGNAARALQAVAS
IYGSALETITNRIRIQEMRRMLVVQGAKVSPMAGDVDPTDAMAALLYVDARAYEQRDRYLYTDQYRNPNNDCTHYATTAQ
EILEDLGPVDYFFAPVGTAGSSIGIGRRLREANEKLKVSGIVSTKDSAIPGIRHMDEMFYVGPFEEQKYDQLVGITASEA
LDGMLALIRDYGVMAGPSSGATYLAALRYLRAIDAKQTERKSAVIIVCDRVELYLSWIEQMRPALFEDYETPEAEHATVA
TSATLGA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=334, Percent_Identity=25.1497005988024, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI295821200, Length=334, Percent_Identity=25.1497005988024, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI4557415, Length=334, Percent_Identity=25.1497005988024, Blast_Score=86, Evalue=8e-17,
Organism=Escherichia coli, GI2367138, Length=309, Percent_Identity=30.7443365695793, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1788754, Length=323, Percent_Identity=30.3405572755418, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17535051, Length=317, Percent_Identity=29.9684542586751, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=28.3828382838284, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17562970, Length=303, Percent_Identity=28.3828382838284, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17534315, Length=342, Percent_Identity=28.6549707602339, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115535073, Length=293, Percent_Identity=30.3754266211604, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25147552, Length=321, Percent_Identity=27.1028037383178, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17561720, Length=289, Percent_Identity=28.0276816608997, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=323, Percent_Identity=28.4829721362229, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321449, Length=200, Percent_Identity=30.5, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24643623, Length=215, Percent_Identity=31.1627906976744, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129101, Length=215, Percent_Identity=31.1627906976744, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 71713; Mature: 71713

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIYLSDSIVDLKRHILEAGERILAFGACGPENAQFHQARYKLYSIASSDVSVSDASVI
CCCEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEE
AADADVLALARDVFPISCDAGVLEECRIAENLLGESNLTFGKIYRAYHGQIYQGLMEDEL
ECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TWLEREGQLRSCTESTYPSAATQCCRIGYIGGGALPLPAMLLAQRLGYQVVVLDPHTRSA
HHHHCCCCHHHHHCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCHH
AFATELIAKVGLDHLVRVICVDGSKYDFSDCDLVFVSNWIANKQPLLRHLRKFTNIQYFI
HHHHHHHHHHCHHHHEEEEEECCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHCCCEEEE
FRSAPRNSLGFIINDMIDPNRVCEHGFRFRYQTEKRPGLSLISLIFSLLSQSEATESTET
EECCCCCCCCHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
IRRADDEPAKMATSRKRLVVDSITDLIGNTPILKLNPAKTSLTNIDLYAKLEHLNPFGSI
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEHHCCCCCCC
KDRTAWAMLRPHLGTLQSSNKQLLELSSGNAARALQAVASIYGSALETITNRIRIQEMRR
CCHHHHHHHCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVVQGAKVSPMAGDVDPTDAMAALLYVDARAYEQRDRYLYTDQYRNPNNDCTHYATTAQ
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHH
EILEDLGPVDYFFAPVGTAGSSIGIGRRLREANEKLKVSGIVSTKDSAIPGIRHMDEMFY
HHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHEE
VGPFEEQKYDQLVGITASEALDGMLALIRDYGVMAGPSSGATYLAALRYLRAIDAKQTER
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
KSAVIIVCDRVELYLSWIEQMRPALFEDYETPEAEHATVATSATLGA
CCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure
MKNIYLSDSIVDLKRHILEAGERILAFGACGPENAQFHQARYKLYSIASSDVSVSDASVI
CCCEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEE
AADADVLALARDVFPISCDAGVLEECRIAENLLGESNLTFGKIYRAYHGQIYQGLMEDEL
ECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TWLEREGQLRSCTESTYPSAATQCCRIGYIGGGALPLPAMLLAQRLGYQVVVLDPHTRSA
HHHHCCCCHHHHHCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCHH
AFATELIAKVGLDHLVRVICVDGSKYDFSDCDLVFVSNWIANKQPLLRHLRKFTNIQYFI
HHHHHHHHHHCHHHHEEEEEECCCCCCCCCCCEEEEHHHHCCCHHHHHHHHHHCCCEEEE
FRSAPRNSLGFIINDMIDPNRVCEHGFRFRYQTEKRPGLSLISLIFSLLSQSEATESTET
EECCCCCCCCHHHHCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
IRRADDEPAKMATSRKRLVVDSITDLIGNTPILKLNPAKTSLTNIDLYAKLEHLNPFGSI
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEHHCCCCCCC
KDRTAWAMLRPHLGTLQSSNKQLLELSSGNAARALQAVASIYGSALETITNRIRIQEMRR
CCHHHHHHHCCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVVQGAKVSPMAGDVDPTDAMAALLYVDARAYEQRDRYLYTDQYRNPNNDCTHYATTAQ
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHH
EILEDLGPVDYFFAPVGTAGSSIGIGRRLREANEKLKVSGIVSTKDSAIPGIRHMDEMFY
HHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHEE
VGPFEEQKYDQLVGITASEALDGMLALIRDYGVMAGPSSGATYLAALRYLRAIDAKQTER
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
KSAVIIVCDRVELYLSWIEQMRPALFEDYETPEAEHATVATSATLGA
CCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]