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The map label for this gene is mrdB [H]

Identifier: 114331575

GI number: 114331575

Start: 1668495

End: 1669604

Strand: Reverse

Name: mrdB [H]

Synonym: Neut_1588

Alternate gene names: 114331575

Gene position: 1669604-1668495 (Counterclockwise)

Preceding gene: 114331576

Following gene: 114331574

Centisome position: 62.74

GC content: 45.5

Gene sequence:

>1110_bases
ATGATTACTCCGGATATCAAGCAAGCATGGCATTATTGTACGCGCTATATTGATAATTTTCTGCTTGCCGGGATTTTTCT
GCTAATGCTGACCGGGTTGATCGTGCTATACAGCGCTACCGGTGGGAGCTCTGCCCGGGTAATCAGTCAGTTAATTAACA
TGGTTGTTGCATATGTAGTGATGTGGGTAGTTGCGAACATTCCTCCGCAAAGGATTATGCGCATGGCCTTTCCGCTGTAT
GTACTGGGTATTGTCTTGCTGATTGCTGTAGCGTTATTTGGTGAAGTGCAGAATGGTGCCCGCCGCTGGTTAAATCTGGG
AATTGTTCATATCCAGCCTTCAGAACTGCTGAAAATTGCTGTTCCTCTTATGATGGCGTGGTATTTTGACAAAGCTCACA
TTACTCTGCGTTGGCGGGATTATGTTATTGCTGCGCTTATTCTGCTGCTGCCGGTTGCGCTTATCGTGCGACAACCTGAT
CTTGGGACTGCCTTGCTGATCCTGATTAGCGGATTTTATGTTATTTTTTTGGCAGGTCTGTCATGGCGTCTCATGACTGG
CTTGGCTGTGGCAGTGACAGTGAGTCTGCCTTTACTCTGGTCTTTTGGTATGCATGATTACCAGCGCAAGCGAATTATGA
CTATGCTTGATCCTTCACAAGACGCACTAGGCGCCGGGTATCATACGATACAATCCAGTATTGCTATTGGATCTGGCGGA
ATTGCAGGAAAGGGGTGGTTAAAAGGTACCCAGTCTCAACTTGATTTCTTGCCTGAACCGAGTACAGATTTTATTTTTTC
AGTATTCTCAGAAGAATTCGGGCTGATTGGTAACAGTTTGTTATTATCGCTGTATCTGATCGTAATCGGGCGCTGCATGG
TTATTACGGCCAGTGCGCCGACACGGTTTGCACGGCTGGTTGCGGGATCAATCACCTTAACTTTTTTTACTTATGTGTTC
GTCAATATGGGTATGGTAAGTGGTATCTTGCCCGTTGTCGGCATACCTCTTCCACTCATCAGTTATGGAGGCACTTCTAT
GGTCACCATACTGCTGGGATTTGGAATTTTAATGAGCATACATACTCATCCAAAACTTGTTAAGACTTAA

Upstream 100 bases:

>100_bases
GCTGCCCCTATCGCTCGCAAAGTACTGGATTATTTTTTCCTGGGAACAATGCCAGAACCGGCTGAGAAAGCAGGGTAGCG
GATGAATTCCTGATCGCGAG

Downstream 100 bases:

>100_bases
AAATATGAAACCAAATTCTTATTTCCATTCTGATATTCCAAGCAGAAGTGCACTATTTGTTTTTTCTGCTGTTGTCATAT
TATTTATGCTCTCAGCTTGC

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MITPDIKQAWHYCTRYIDNFLLAGIFLLMLTGLIVLYSATGGSSARVISQLINMVVAYVVMWVVANIPPQRIMRMAFPLY
VLGIVLLIAVALFGEVQNGARRWLNLGIVHIQPSELLKIAVPLMMAWYFDKAHITLRWRDYVIAALILLLPVALIVRQPD
LGTALLILISGFYVIFLAGLSWRLMTGLAVAVTVSLPLLWSFGMHDYQRKRIMTMLDPSQDALGAGYHTIQSSIAIGSGG
IAGKGWLKGTQSQLDFLPEPSTDFIFSVFSEEFGLIGNSLLLSLYLIVIGRCMVITASAPTRFARLVAGSITLTFFTYVF
VNMGMVSGILPVVGIPLPLISYGGTSMVTILLGFGILMSIHTHPKLVKT

Sequences:

>Translated_369_residues
MITPDIKQAWHYCTRYIDNFLLAGIFLLMLTGLIVLYSATGGSSARVISQLINMVVAYVVMWVVANIPPQRIMRMAFPLY
VLGIVLLIAVALFGEVQNGARRWLNLGIVHIQPSELLKIAVPLMMAWYFDKAHITLRWRDYVIAALILLLPVALIVRQPD
LGTALLILISGFYVIFLAGLSWRLMTGLAVAVTVSLPLLWSFGMHDYQRKRIMTMLDPSQDALGAGYHTIQSSIAIGSGG
IAGKGWLKGTQSQLDFLPEPSTDFIFSVFSEEFGLIGNSLLLSLYLIVIGRCMVITASAPTRFARLVAGSITLTFFTYVF
VNMGMVSGILPVVGIPLPLISYGGTSMVTILLGFGILMSIHTHPKLVKT
>Mature_369_residues
MITPDIKQAWHYCTRYIDNFLLAGIFLLMLTGLIVLYSATGGSSARVISQLINMVVAYVVMWVVANIPPQRIMRMAFPLY
VLGIVLLIAVALFGEVQNGARRWLNLGIVHIQPSELLKIAVPLMMAWYFDKAHITLRWRDYVIAALILLLPVALIVRQPD
LGTALLILISGFYVIFLAGLSWRLMTGLAVAVTVSLPLLWSFGMHDYQRKRIMTMLDPSQDALGAGYHTIQSSIAIGSGG
IAGKGWLKGTQSQLDFLPEPSTDFIFSVFSEEFGLIGNSLLLSLYLIVIGRCMVITASAPTRFARLVAGSITLTFFTYVF
VNMGMVSGILPVVGIPLPLISYGGTSMVTILLGFGILMSIHTHPKLVKT

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=367, Percent_Identity=49.3188010899183, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1786277, Length=326, Percent_Identity=31.2883435582822, Blast_Score=150, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40511; Mature: 40511

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITPDIKQAWHYCTRYIDNFLLAGIFLLMLTGLIVLYSATGGSSARVISQLINMVVAYVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
MWVVANIPPQRIMRMAFPLYVLGIVLLIAVALFGEVQNGARRWLNLGIVHIQPSELLKIA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHH
VPLMMAWYFDKAHITLRWRDYVIAALILLLPVALIVRQPDLGTALLILISGFYVIFLAGL
HHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SWRLMTGLAVAVTVSLPLLWSFGMHDYQRKRIMTMLDPSQDALGAGYHTIQSSIAIGSGG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCHHHHHHHHEECCCC
IAGKGWLKGTQSQLDFLPEPSTDFIFSVFSEEFGLIGNSLLLSLYLIVIGRCMVITASAP
CCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCH
TRFARLVAGSITLTFFTYVFVNMGMVSGILPVVGIPLPLISYGGTSMVTILLGFGILMSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHH
HTHPKLVKT
CCCCCCCCC
>Mature Secondary Structure
MITPDIKQAWHYCTRYIDNFLLAGIFLLMLTGLIVLYSATGGSSARVISQLINMVVAYVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
MWVVANIPPQRIMRMAFPLYVLGIVLLIAVALFGEVQNGARRWLNLGIVHIQPSELLKIA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHH
VPLMMAWYFDKAHITLRWRDYVIAALILLLPVALIVRQPDLGTALLILISGFYVIFLAGL
HHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SWRLMTGLAVAVTVSLPLLWSFGMHDYQRKRIMTMLDPSQDALGAGYHTIQSSIAIGSGG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCHHHHHHHHEECCCC
IAGKGWLKGTQSQLDFLPEPSTDFIFSVFSEEFGLIGNSLLLSLYLIVIGRCMVITASAP
CCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCH
TRFARLVAGSITLTFFTYVFVNMGMVSGILPVVGIPLPLISYGGTSMVTILLGFGILMSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHH
HTHPKLVKT
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]