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The map label for this gene is mrdA [H]

Identifier: 114331576

GI number: 114331576

Start: 1669627

End: 1671504

Strand: Reverse

Name: mrdA [H]

Synonym: Neut_1589

Alternate gene names: 114331576

Gene position: 1671504-1669627 (Counterclockwise)

Preceding gene: 114331577

Following gene: 114331575

Centisome position: 62.81

GC content: 47.18

Gene sequence:

>1878_bases
ATGAGTGATATTGTAGAGTTACGTAATCATATACGTGAAACTCGGCATTTTCGCATCAGGTTGGTGATCAGTGCGATTGG
TGTCGTGGTTTTGTTCAGTTTGCTCTTTGGTCGTTTTTTTTATCTGCAGGTATTGCAAGAAGAGCACTACACGACTCTCG
CGGAGGCGAATCGCATTGCTATCCAGCCGCTGACCCCTAACCGGGGGCTCATATTTGATCGTAATGGAGATATTCTGGCT
CAAAATTACACGGCCTACACTTTGGAGATAATCCCCGATCAAGTTAAAAATCTTGATGCAGCTATCAATGAACTGGCAAC
GATCATTGAGATTACTCCCGAGGATCGGAGACGCTTTAACAAGCTGAAACTTGAAAATACAAGATTTAAGAGCCTGCCCA
TACGTTCCCGTCTGACAGATTTTGAAGTAGCTCGTTTTGCGGAAAATCAGTATCGCTTTCCCGGGATGGATATCAAGGCG
CATCCCCTCAGGCATTACCCGAAAGGAGAGCTGGTTTCTCATGTGATAGGCTACATTGGACGTATCAGCGACAAGGATCT
GGAACAGCTCGAAGCGGATAAGCGGCTAAAGAATTACTACGGCTCCACGCATATCGGGCGGATTGGTATCGAAAAAAGCT
ACGAAAGTGTGCTGCATGGGCAGACTGGCTTTGAGCAGGTTGAGACTGATGCTGTTGGTCGTCCTGTACGTACTTTGTCC
CGTGTTGCGCCAACTGCCGGGAACGATCTTACGCTTTCTCTCGATATTGGGTTGCAGCAGGCAGCTGTACAGGCTTTTGG
GGATTATCGCGGTGCTTTGGTTGCGCTGGATCCATCTAATGGAGAAATTTTGGCTTTTGTCAGTAAACCGGGTTTTGATC
CCAATTTGTTTGTGGACGGCATTGACCACCTTAATTGGCGTCTGCTTAATGAATCCATAGACAGACCCTTGAACAATCGT
GCTTTACGGGGTGTATACCCTCCTGGTTCCACCTTTAAGCCATTTATGGCGCTGGCCGGGTTGGAGCTGGGTAAACGCTC
TCTTCATTATGCATTTAATGATCCGGGTTTTTTCAGTTTACCTGGAAGTTCACACCGTTTTCGTGACTGGAAGCCGGGAG
GGCATGGCTGGGTCGATTTGCGCAAATCTCTGGTAATTTCGTGTGACACTTACTATTACATGCTCGCACATGATTTGGGT
ATTACCAACATTCATGATTTCATCGGGCAGTTTGGTTTTGGTAAAGAAACTGGAATAGATATTCCAGGAGAAGCTGCTGG
ATTATTGCCTTCTCCAGAGTGGAAAAAGAGGCGATTTAATCAAAACTGGCTGCCAGGGGATACCATTTCGGTTGGTATCG
GGCAGGGGTTTAATTTGTCCACGCCACTTCAGCTGACGTTTGCAATGATGTTACTGGCTAACGATGGTAGGGCCTACAGG
CCGCATTTTGTTAGACAGCAGGTGGATCATTATAAGAATTTTGTGAAAGATAATTTTGTAGAGGAAATTTACAGACTGAA
TCTGAGGCAGGAATATCTGGATTCTGTCAGACAGGCATTAGCAGATGTTACCCGCCCTGGTGGTACAGCATCCCGTGCCG
GTGCTAATACTGCTTATACCTTTGCCGGGAAAACCGGTACTTCTCAGGTAATCAATATCAAGCAGGGTGAACGCTACAAT
GCCAGTAAAATTGACGAGCGGCATCGCGACCATGCGCTGTTTACAGCTTTTGCGCCTGTAGAAAATCCCAGGATAGTGCT
AACAGTACTGATCGAGAACGGTGGCTCGGGCGGATCAACCGCTGCCCCTATCGCTCGCAAAGTACTGGATTATTTTTTCC
TGGGAACAATGCCAGAACCGGCTGAGAAAGCAGGGTAG

Upstream 100 bases:

>100_bases
GGTATATTTTCCTGGCGAGTGTAACCGGGGCGTTATGTTGGCCCTTATTGGTTTTTCTGCTGGGAATATTTCGTAAGCAG
CGAATTGATCGCGATGAAGT

Downstream 100 bases:

>100_bases
CGGATGAATTCCTGATCGCGAGATGATTACTCCGGATATCAAGCAAGCATGGCATTATTGTACGCGCTATATTGATAATT
TTCTGCTTGCCGGGATTTTT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MSDIVELRNHIRETRHFRIRLVISAIGVVVLFSLLFGRFFYLQVLQEEHYTTLAEANRIAIQPLTPNRGLIFDRNGDILA
QNYTAYTLEIIPDQVKNLDAAINELATIIEITPEDRRRFNKLKLENTRFKSLPIRSRLTDFEVARFAENQYRFPGMDIKA
HPLRHYPKGELVSHVIGYIGRISDKDLEQLEADKRLKNYYGSTHIGRIGIEKSYESVLHGQTGFEQVETDAVGRPVRTLS
RVAPTAGNDLTLSLDIGLQQAAVQAFGDYRGALVALDPSNGEILAFVSKPGFDPNLFVDGIDHLNWRLLNESIDRPLNNR
ALRGVYPPGSTFKPFMALAGLELGKRSLHYAFNDPGFFSLPGSSHRFRDWKPGGHGWVDLRKSLVISCDTYYYMLAHDLG
ITNIHDFIGQFGFGKETGIDIPGEAAGLLPSPEWKKRRFNQNWLPGDTISVGIGQGFNLSTPLQLTFAMMLLANDGRAYR
PHFVRQQVDHYKNFVKDNFVEEIYRLNLRQEYLDSVRQALADVTRPGGTASRAGANTAYTFAGKTGTSQVINIKQGERYN
ASKIDERHRDHALFTAFAPVENPRIVLTVLIENGGSGGSTAAPIARKVLDYFFLGTMPEPAEKAG

Sequences:

>Translated_625_residues
MSDIVELRNHIRETRHFRIRLVISAIGVVVLFSLLFGRFFYLQVLQEEHYTTLAEANRIAIQPLTPNRGLIFDRNGDILA
QNYTAYTLEIIPDQVKNLDAAINELATIIEITPEDRRRFNKLKLENTRFKSLPIRSRLTDFEVARFAENQYRFPGMDIKA
HPLRHYPKGELVSHVIGYIGRISDKDLEQLEADKRLKNYYGSTHIGRIGIEKSYESVLHGQTGFEQVETDAVGRPVRTLS
RVAPTAGNDLTLSLDIGLQQAAVQAFGDYRGALVALDPSNGEILAFVSKPGFDPNLFVDGIDHLNWRLLNESIDRPLNNR
ALRGVYPPGSTFKPFMALAGLELGKRSLHYAFNDPGFFSLPGSSHRFRDWKPGGHGWVDLRKSLVISCDTYYYMLAHDLG
ITNIHDFIGQFGFGKETGIDIPGEAAGLLPSPEWKKRRFNQNWLPGDTISVGIGQGFNLSTPLQLTFAMMLLANDGRAYR
PHFVRQQVDHYKNFVKDNFVEEIYRLNLRQEYLDSVRQALADVTRPGGTASRAGANTAYTFAGKTGTSQVINIKQGERYN
ASKIDERHRDHALFTAFAPVENPRIVLTVLIENGGSGGSTAAPIARKVLDYFFLGTMPEPAEKAG
>Mature_624_residues
SDIVELRNHIRETRHFRIRLVISAIGVVVLFSLLFGRFFYLQVLQEEHYTTLAEANRIAIQPLTPNRGLIFDRNGDILAQ
NYTAYTLEIIPDQVKNLDAAINELATIIEITPEDRRRFNKLKLENTRFKSLPIRSRLTDFEVARFAENQYRFPGMDIKAH
PLRHYPKGELVSHVIGYIGRISDKDLEQLEADKRLKNYYGSTHIGRIGIEKSYESVLHGQTGFEQVETDAVGRPVRTLSR
VAPTAGNDLTLSLDIGLQQAAVQAFGDYRGALVALDPSNGEILAFVSKPGFDPNLFVDGIDHLNWRLLNESIDRPLNNRA
LRGVYPPGSTFKPFMALAGLELGKRSLHYAFNDPGFFSLPGSSHRFRDWKPGGHGWVDLRKSLVISCDTYYYMLAHDLGI
TNIHDFIGQFGFGKETGIDIPGEAAGLLPSPEWKKRRFNQNWLPGDTISVGIGQGFNLSTPLQLTFAMMLLANDGRAYRP
HFVRQQVDHYKNFVKDNFVEEIYRLNLRQEYLDSVRQALADVTRPGGTASRAGANTAYTFAGKTGTSQVINIKQGERYNA
SKIDERHRDHALFTAFAPVENPRIVLTVLIENGGSGGSTAAPIARKVLDYFFLGTMPEPAEKAG

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=612, Percent_Identity=41.8300653594771, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1786272, Length=593, Percent_Identity=24.4519392917369, Blast_Score=129, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70198; Mature: 70066

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIVELRNHIRETRHFRIRLVISAIGVVVLFSLLFGRFFYLQVLQEEHYTTLAEANRIA
CCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
IQPLTPNRGLIFDRNGDILAQNYTAYTLEIIPDQVKNLDAAINELATIIEITPEDRRRFN
EEECCCCCCEEEECCCCEEEECCEEEEEEECCHHHHHHHHHHHHHHHHEEECCHHHHHHH
KLKLENTRFKSLPIRSRLTDFEVARFAENQYRFPGMDIKAHPLRHYPKGELVSHVIGYIG
HHCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RISDKDLEQLEADKRLKNYYGSTHIGRIGIEKSYESVLHGQTGFEQVETDAVGRPVRTLS
CCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
RVAPTAGNDLTLSLDIGLQQAAVQAFGDYRGALVALDPSNGEILAFVSKPGFDPNLFVDG
HHCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCEEECC
IDHLNWRLLNESIDRPLNNRALRGVYPPGSTFKPFMALAGLELGKRSLHYAFNDPGFFSL
CCCCHHEEHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEC
PGSSHRFRDWKPGGHGWVDLRKSLVISCDTYYYMLAHDLGITNIHDFIGQFGFGKETGID
CCCCCCCCCCCCCCCCHHHCCCCEEEEECHHEEEHHHHCCCCHHHHHHHHCCCCCCCCCC
IPGEAAGLLPSPEWKKRRFNQNWLPGDTISVGIGQGFNLSTPLQLTFAMMLLANDGRAYR
CCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCC
PHFVRQQVDHYKNFVKDNFVEEIYRLNLRQEYLDSVRQALADVTRPGGTASRAGANTAYT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
FAGKTGTSQVINIKQGERYNASKIDERHRDHALFTAFAPVENPRIVLTVLIENGGSGGST
EECCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCCCH
AAPIARKVLDYFFLGTMPEPAEKAG
HHHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure 
SDIVELRNHIRETRHFRIRLVISAIGVVVLFSLLFGRFFYLQVLQEEHYTTLAEANRIA
CHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
IQPLTPNRGLIFDRNGDILAQNYTAYTLEIIPDQVKNLDAAINELATIIEITPEDRRRFN
EEECCCCCCEEEECCCCEEEECCEEEEEEECCHHHHHHHHHHHHHHHHEEECCHHHHHHH
KLKLENTRFKSLPIRSRLTDFEVARFAENQYRFPGMDIKAHPLRHYPKGELVSHVIGYIG
HHCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RISDKDLEQLEADKRLKNYYGSTHIGRIGIEKSYESVLHGQTGFEQVETDAVGRPVRTLS
CCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
RVAPTAGNDLTLSLDIGLQQAAVQAFGDYRGALVALDPSNGEILAFVSKPGFDPNLFVDG
HHCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCEEECC
IDHLNWRLLNESIDRPLNNRALRGVYPPGSTFKPFMALAGLELGKRSLHYAFNDPGFFSL
CCCCHHEEHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEC
PGSSHRFRDWKPGGHGWVDLRKSLVISCDTYYYMLAHDLGITNIHDFIGQFGFGKETGID
CCCCCCCCCCCCCCCCHHHCCCCEEEEECHHEEEHHHHCCCCHHHHHHHHCCCCCCCCCC
IPGEAAGLLPSPEWKKRRFNQNWLPGDTISVGIGQGFNLSTPLQLTFAMMLLANDGRAYR
CCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCC
PHFVRQQVDHYKNFVKDNFVEEIYRLNLRQEYLDSVRQALADVTRPGGTASRAGANTAYT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
FAGKTGTSQVINIKQGERYNASKIDERHRDHALFTAFAPVENPRIVLTVLIENGGSGGST
EECCCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCCCH
AAPIARKVLDYFFLGTMPEPAEKAG
HHHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]