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The map label for this gene is hisC2 [H]

Identifier: 114331556

GI number: 114331556

Start: 1644596

End: 1645714

Strand: Reverse

Name: hisC2 [H]

Synonym: Neut_1569

Alternate gene names: 114331556

Gene position: 1645714-1644596 (Counterclockwise)

Preceding gene: 114331557

Following gene: 114331555

Centisome position: 61.84

GC content: 47.27

Gene sequence:

>1119_bases
ATGAACCTTTTTGAACTGGCACCGGAATATATCCGGGCAATCCAACCCTATCAGCCGGGTAAACCGATATCGGAACTGGT
CAGAGACCTTGGTCTGGATAAAAATGAAGTCATTAAACTGGCTTCCAACGAGAATCCATTGGGAACCAGTCCGTTGGCAA
GAGAAGCGATGATTCAGGCGCTTAGTGAGTCTGCACGGTATCCAGATGGGAGTGGTTTTGAACTAAAAGTGGCTTTATCT
GATCGTCTGGGTGTATCTGCCGAGCAAATCGTGCTGGGCAACGGCTCCAATGATGTACTTGAGCTTGCTTCCCGCATCTT
TCTGCGGCCCGGTACAAGTGCAATTTATTCCCAGTATGCTTTTGCCATATATCCGCTCTTGGTTCAGGCAGCAGGTGCCA
GAGGCATTACTGTTCCTGCCAGAAATTATGGGCACGACCTGGAAGCCATGCTGGATGCTATTACACCAGAAACACGCATC
ATATTTATTGCGAATCCTAATAATCCGACCGGCACCTTGTGCGATGCCAGAGATCTATTGCGTTTTATAGAACGTGTTTC
GCCGGATGTACTTGTTATTCTGGATCAAGCTTATGATGAATATCTGCCAGAAGCGAACAAGACCAACAGTGTCGCATGGT
TGAAAAATTTCCAGAATCTGGTTATCACGCATACTTTCTCCAAGGCTTATGGTCTGGCCAGCGTACGTGTTGGTTTTGCA
CTGGCGCATGCTGATATTGCCAATCTGATGAACCGTATCCGACAGCCTTTCAATGTCAACAGCATTGGTTTGGCGGCTGC
TCAGGCAGCACTCGACGATGTTGAATTTGTCAAACTTTCCTACATGACAAACCGGACCGGTATGCAGCGGATGATCGCTG
GTTTGGATCGACTGGGTGTCGGCTTTATCCCTTCTTTTGGTAATTTTGTCAGTATCCAGATTGACGGTCATCAGGCCGAT
ACCCTGAAAATTTATAAAAGTCTGTTGCAGCAAGGGGTCATTGTGCGTCCATTGGGTAATTACGGCATGCCCAATCATTT
GCGGGTGACTATCGGGATTGAGGAAGAAAACAAGAGATTCCTGTATGCGCTGGAACAAGCGTTGAAAGAATCCGACTAA

Upstream 100 bases:

>100_bases
AAACGTAGCCAGGGCACTTCAGATGCTGCGCGACAATGCAACCTTTCTGAAGGTTTTCGGCTCTTATCCTGCAGCGTAAA
TTAATTAATTCCTGAATGTT

Downstream 100 bases:

>100_bases
TCACCCACCAACCCATACACACCGATCATGGCTTCATCCAGCATCTCAAAACTGGTTATTATCGGTGTGGGATTAATTGG
TGGTTCATTTGCGCAAGCGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNLFELAPEYIRAIQPYQPGKPISELVRDLGLDKNEVIKLASNENPLGTSPLAREAMIQALSESARYPDGSGFELKVALS
DRLGVSAEQIVLGNGSNDVLELASRIFLRPGTSAIYSQYAFAIYPLLVQAAGARGITVPARNYGHDLEAMLDAITPETRI
IFIANPNNPTGTLCDARDLLRFIERVSPDVLVILDQAYDEYLPEANKTNSVAWLKNFQNLVITHTFSKAYGLASVRVGFA
LAHADIANLMNRIRQPFNVNSIGLAAAQAALDDVEFVKLSYMTNRTGMQRMIAGLDRLGVGFIPSFGNFVSIQIDGHQAD
TLKIYKSLLQQGVIVRPLGNYGMPNHLRVTIGIEEENKRFLYALEQALKESD

Sequences:

>Translated_372_residues
MNLFELAPEYIRAIQPYQPGKPISELVRDLGLDKNEVIKLASNENPLGTSPLAREAMIQALSESARYPDGSGFELKVALS
DRLGVSAEQIVLGNGSNDVLELASRIFLRPGTSAIYSQYAFAIYPLLVQAAGARGITVPARNYGHDLEAMLDAITPETRI
IFIANPNNPTGTLCDARDLLRFIERVSPDVLVILDQAYDEYLPEANKTNSVAWLKNFQNLVITHTFSKAYGLASVRVGFA
LAHADIANLMNRIRQPFNVNSIGLAAAQAALDDVEFVKLSYMTNRTGMQRMIAGLDRLGVGFIPSFGNFVSIQIDGHQAD
TLKIYKSLLQQGVIVRPLGNYGMPNHLRVTIGIEEENKRFLYALEQALKESD
>Mature_372_residues
MNLFELAPEYIRAIQPYQPGKPISELVRDLGLDKNEVIKLASNENPLGTSPLAREAMIQALSESARYPDGSGFELKVALS
DRLGVSAEQIVLGNGSNDVLELASRIFLRPGTSAIYSQYAFAIYPLLVQAAGARGITVPARNYGHDLEAMLDAITPETRI
IFIANPNNPTGTLCDARDLLRFIERVSPDVLVILDQAYDEYLPEANKTNSVAWLKNFQNLVITHTFSKAYGLASVRVGFA
LAHADIANLMNRIRQPFNVNSIGLAAAQAALDDVEFVKLSYMTNRTGMQRMIAGLDRLGVGFIPSFGNFVSIQIDGHQAD
TLKIYKSLLQQGVIVRPLGNYGMPNHLRVTIGIEEENKRFLYALEQALKESD

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=371, Percent_Identity=28.0323450134771, Blast_Score=135, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322075, Length=393, Percent_Identity=27.2264631043257, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40941; Mature: 40941

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFELAPEYIRAIQPYQPGKPISELVRDLGLDKNEVIKLASNENPLGTSPLAREAMIQA
CCHHHHCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHEEEEECCCCCCCCCHHHHHHHHHH
LSESARYPDGSGFELKVALSDRLGVSAEQIVLGNGSNDVLELASRIFLRPGTSAIYSQYA
HHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHH
FAIYPLLVQAAGARGITVPARNYGHDLEAMLDAITPETRIIFIANPNNPTGTLCDARDLL
HHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHH
RFIERVSPDVLVILDQAYDEYLPEANKTNSVAWLKNFQNLVITHTFSKAYGLASVRVGFA
HHHHHCCCCEEEEEEHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEHHHHHCHHHHHHHHH
LAHADIANLMNRIRQPFNVNSIGLAAAQAALDDVEFVKLSYMTNRTGMQRMIAGLDRLGV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHEEEEHHHCHHHHHHHHHHHHHCCC
GFIPSFGNFVSIQIDGHQADTLKIYKSLLQQGVIVRPLGNYGMPNHLRVTIGIEEENKRF
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEEEECCCCHH
LYALEQALKESD
HHHHHHHHHCCC
>Mature Secondary Structure
MNLFELAPEYIRAIQPYQPGKPISELVRDLGLDKNEVIKLASNENPLGTSPLAREAMIQA
CCHHHHCHHHHHHCCCCCCCCCHHHHHHHHCCCHHHEEEEECCCCCCCCCHHHHHHHHHH
LSESARYPDGSGFELKVALSDRLGVSAEQIVLGNGSNDVLELASRIFLRPGTSAIYSQYA
HHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHH
FAIYPLLVQAAGARGITVPARNYGHDLEAMLDAITPETRIIFIANPNNPTGTLCDARDLL
HHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHH
RFIERVSPDVLVILDQAYDEYLPEANKTNSVAWLKNFQNLVITHTFSKAYGLASVRVGFA
HHHHHCCCCEEEEEEHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEHHHHHCHHHHHHHHH
LAHADIANLMNRIRQPFNVNSIGLAAAQAALDDVEFVKLSYMTNRTGMQRMIAGLDRLGV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHEEEEHHHCHHHHHHHHHHHHHCCC
GFIPSFGNFVSIQIDGHQADTLKIYKSLLQQGVIVRPLGNYGMPNHLRVTIGIEEENKRF
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEEEECCCCHH
LYALEQALKESD
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]