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The map label for this gene is lspA [H]

Identifier: 114331427

GI number: 114331427

Start: 1518993

End: 1519475

Strand: Reverse

Name: lspA [H]

Synonym: Neut_1438

Alternate gene names: 114331427

Gene position: 1519475-1518993 (Counterclockwise)

Preceding gene: 114331428

Following gene: 114331426

Centisome position: 57.1

GC content: 44.1

Gene sequence:

>483_bases
ATGAAACTGTATTTCAGTCTGAGTTTAGCCACAATCATCCTGATGCTGGATTTACTCAGCAAACGCTGGGTTGAGCTTAA
TTTATCGTATGGTCAGCAGATTGTCATCACTGAATTCTTCAATCTTGTACTTGCCTACAATGCAGGAGCAGCCTTCAGTT
TTCTGAGTAATGCTTCTGGCTGGCAGCGCTGGTTTTTGAGCGCAATTGCTCTTCTTGTATCAGCTCTGATTATTTATCTG
TTGTACAAGAACACAACAAACCGGCTGTTTTGTATTGCGTTGAGCTTTATTCTAGGGGGGGCATTGGGCAATCTCTGGGA
TCGGATTATGCTGGGGCATGTTGTCGATTTTCTGGATTTTCACGTGAGTGGTTATCATTGGCCAGCATTTAATCTTGCTG
ATTCAGCCATAGTCTGCGGAGCGTGCTTGTTGATTCTGGACGGGATCCTGAATAGACAGAACGATTCTATTCAGGAAGGG
TGA

Upstream 100 bases:

>100_bases
TGTGTAGTCGTTGTGTGAGCAATCTTTCGGGGCCTGGTGAACACCGGCGCTATGCCTGATTCCTGTGAAGAATCACTGGG
AAAATATATAGGGGTGCGTG

Downstream 100 bases:

>100_bases
GACAGAATCTTCAGGGATTTGTCTGTGATCAGCGCGAACTGATTTACCTTACCATATTAGGATCAATGGTCTATCCTGCC
TACTACCAGGATACCATCAT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MKLYFSLSLATIILMLDLLSKRWVELNLSYGQQIVITEFFNLVLAYNAGAAFSFLSNASGWQRWFLSAIALLVSALIIYL
LYKNTTNRLFCIALSFILGGALGNLWDRIMLGHVVDFLDFHVSGYHWPAFNLADSAIVCGACLLILDGILNRQNDSIQEG

Sequences:

>Translated_160_residues
MKLYFSLSLATIILMLDLLSKRWVELNLSYGQQIVITEFFNLVLAYNAGAAFSFLSNASGWQRWFLSAIALLVSALIIYL
LYKNTTNRLFCIALSFILGGALGNLWDRIMLGHVVDFLDFHVSGYHWPAFNLADSAIVCGACLLILDGILNRQNDSIQEG
>Mature_160_residues
MKLYFSLSLATIILMLDLLSKRWVELNLSYGQQIVITEFFNLVLAYNAGAAFSFLSNASGWQRWFLSAIALLVSALIIYL
LYKNTTNRLFCIALSFILGGALGNLWDRIMLGHVVDFLDFHVSGYHWPAFNLADSAIVCGACLLILDGILNRQNDSIQEG

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=146, Percent_Identity=43.8356164383562, Blast_Score=123, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 17901; Mature: 17901

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYFSLSLATIILMLDLLSKRWVELNLSYGQQIVITEFFNLVLAYNAGAAFSFLSNASG
CEEEEHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCH
WQRWFLSAIALLVSALIIYLLYKNTTNRLFCIALSFILGGALGNLWDRIMLGHVVDFLDF
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVSGYHWPAFNLADSAIVCGACLLILDGILNRQNDSIQEG
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLYFSLSLATIILMLDLLSKRWVELNLSYGQQIVITEFFNLVLAYNAGAAFSFLSNASG
CEEEEHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCH
WQRWFLSAIALLVSALIIYLLYKNTTNRLFCIALSFILGGALGNLWDRIMLGHVVDFLDF
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVSGYHWPAFNLADSAIVCGACLLILDGILNRQNDSIQEG
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA