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The map label for this gene is phoQ [H]

Identifier: 114331352

GI number: 114331352

Start: 1431292

End: 1432629

Strand: Reverse

Name: phoQ [H]

Synonym: Neut_1361

Alternate gene names: 114331352

Gene position: 1432629-1431292 (Counterclockwise)

Preceding gene: 114331353

Following gene: 114331351

Centisome position: 53.84

GC content: 50.0

Gene sequence:

>1338_bases
ATGATGTCGCTCAATCAGCGTGTCCTGCTCAGTGCAACGCTGGTATTACTGGTTTTTATTGGCGGCATTACGTTTACATT
GGATCGCGCTTTCTACGACAGTGCACGCATAGGGGTGAAGGATCGCCTATTTGCAAAACTGTTAATGCTGATGGGTGATG
CCGAAGTGGAAGACGGCGAACTGGATGTGCCTGTCAATCAGCTGGATGTGGAATTTGAACACGTCAACTCGCATACTTAT
GCCTTCATCATCGGCCCTGCCAACACGATCATTTGGCGTTCCATCTCGTCATTGAATAAATCTATTCCGGCTATTGCCCC
ACTGGGACAGGGAGAAAAAATATTTGAGCAGATCCTGCTCAATGACGAACCACACTTTATCTATCGCTACGGCATCGCTT
GGGAAACCTCCTCTGGCGGTTACCCGCTGACTTTCAACGTCATAACCGATACCACGCTGCTTGATGCCCAGATAGAACGT
TATCGTGAAGATCTATGGGGTTGGTTGGGTGTCATGGCGGTAGTTCTGCTCGCTGCACAAATGCTGGTATTACGCTGGGG
GCTGCTGCCATTACGCAAAGTTTCCGTGGAGCTTGCCGCAATTGAATCCGGTCGACAGGAAAGCCTCAAGGGTATCTATC
CCAGAGAGCTTAAACTACTGACTGACAGCATTAATTCCCTGATTACCCATGAACACAAGCAGCAGAAGCGCTATCGCAAC
GGTCTTGCTGATCTGGCGCACAGTCTGAAAACACCACTTGCTATACTGCAAGGCGCGATTCATGGTGAGGACGAGGAGGT
CATCCGGCACAAAACAATTCAAGAGCAAATCGACCGCATGGATAACACCATCCAGTATCAATTACGCCGTGCCGCGACTG
CCGGCAGCTCACCAGGCATGGGGTTGATCTTGTTACGCCCGATGATCGACAGAATCATCAACACGGTGACCAAAGCCTAT
CGCCACAAGCATCCGGATATTACAGTGAACATTGATAACAGCATCCGTCTGCGCATTGACGAAGGCGATCTGATGGAACT
GCTTGGGAACTTGATCGACAATGCATTCAAGTGGTGCCGTTACAGCATTCATTTATCTGCCGGTTATCAGGGAAATCAAG
TGGAAATTCAAATCAGGGATGACGGCCCCGGTATCCCACCGCATGAAATCGCCCGCATTCTGGAACGTGGTGCGCGTGCC
GACCAATCCACCTCTGGCCACGGTATTGGCTTGGCCATAGTACGCGACATCATGCAGGTATATGGCGGTGAATTATTGAT
TGAAAACCATCCTGTTGGGGGACTCAGCGTCATACTGCACTTCGAAAGAAGCAAATAA

Upstream 100 bases:

>100_bases
GCAGGTTGCGGCGCAAACTTGATCCCGCTGGTACATTAAAGCCAATTGAAACCATGCGTGGGCGTGGCTACCGTTTCATA
CTGGAATGTAATAAATCGGC

Downstream 100 bases:

>100_bases
CAGCCTGCACTCCCAAGATTGGGTGGCATGATCGCATGGTGTGATAACATCATGATGCGTATACATCAGTCAAAGGAGTT
TATTGTGCGTACCACGATAG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MMSLNQRVLLSATLVLLVFIGGITFTLDRAFYDSARIGVKDRLFAKLLMLMGDAEVEDGELDVPVNQLDVEFEHVNSHTY
AFIIGPANTIIWRSISSLNKSIPAIAPLGQGEKIFEQILLNDEPHFIYRYGIAWETSSGGYPLTFNVITDTTLLDAQIER
YREDLWGWLGVMAVVLLAAQMLVLRWGLLPLRKVSVELAAIESGRQESLKGIYPRELKLLTDSINSLITHEHKQQKRYRN
GLADLAHSLKTPLAILQGAIHGEDEEVIRHKTIQEQIDRMDNTIQYQLRRAATAGSSPGMGLILLRPMIDRIINTVTKAY
RHKHPDITVNIDNSIRLRIDEGDLMELLGNLIDNAFKWCRYSIHLSAGYQGNQVEIQIRDDGPGIPPHEIARILERGARA
DQSTSGHGIGLAIVRDIMQVYGGELLIENHPVGGLSVILHFERSK

Sequences:

>Translated_445_residues
MMSLNQRVLLSATLVLLVFIGGITFTLDRAFYDSARIGVKDRLFAKLLMLMGDAEVEDGELDVPVNQLDVEFEHVNSHTY
AFIIGPANTIIWRSISSLNKSIPAIAPLGQGEKIFEQILLNDEPHFIYRYGIAWETSSGGYPLTFNVITDTTLLDAQIER
YREDLWGWLGVMAVVLLAAQMLVLRWGLLPLRKVSVELAAIESGRQESLKGIYPRELKLLTDSINSLITHEHKQQKRYRN
GLADLAHSLKTPLAILQGAIHGEDEEVIRHKTIQEQIDRMDNTIQYQLRRAATAGSSPGMGLILLRPMIDRIINTVTKAY
RHKHPDITVNIDNSIRLRIDEGDLMELLGNLIDNAFKWCRYSIHLSAGYQGNQVEIQIRDDGPGIPPHEIARILERGARA
DQSTSGHGIGLAIVRDIMQVYGGELLIENHPVGGLSVILHFERSK
>Mature_445_residues
MMSLNQRVLLSATLVLLVFIGGITFTLDRAFYDSARIGVKDRLFAKLLMLMGDAEVEDGELDVPVNQLDVEFEHVNSHTY
AFIIGPANTIIWRSISSLNKSIPAIAPLGQGEKIFEQILLNDEPHFIYRYGIAWETSSGGYPLTFNVITDTTLLDAQIER
YREDLWGWLGVMAVVLLAAQMLVLRWGLLPLRKVSVELAAIESGRQESLKGIYPRELKLLTDSINSLITHEHKQQKRYRN
GLADLAHSLKTPLAILQGAIHGEDEEVIRHKTIQEQIDRMDNTIQYQLRRAATAGSSPGMGLILLRPMIDRIINTVTKAY
RHKHPDITVNIDNSIRLRIDEGDLMELLGNLIDNAFKWCRYSIHLSAGYQGNQVEIQIRDDGPGIPPHEIARILERGARA
DQSTSGHGIGLAIVRDIMQVYGGELLIENHPVGGLSVILHFERSK

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=297, Percent_Identity=31.3131313131313, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=29.4930875576037, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=23.8493723849372, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=30.0448430493274, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789403, Length=348, Percent_Identity=27.2988505747126, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=24.3445692883895, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=26.3636363636364, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=29.5774647887324, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=280, Percent_Identity=25.3571428571429, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=25.089605734767, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49930; Mature: 49930

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSLNQRVLLSATLVLLVFIGGITFTLDRAFYDSARIGVKDRLFAKLLMLMGDAEVEDGE
CCCCCHHHHHHHHHHHHHHHCCHHEEEHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
LDVPVNQLDVEFEHVNSHTYAFIIGPANTIIWRSISSLNKSIPAIAPLGQGEKIFEQILL
CCCCHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHC
NDEPHFIYRYGIAWETSSGGYPLTFNVITDTTLLDAQIERYREDLWGWLGVMAVVLLAAQ
CCCCCEEEEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVLRWGLLPLRKVSVELAAIESGRQESLKGIYPRELKLLTDSINSLITHEHKQQKRYRN
HHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLADLAHSLKTPLAILQGAIHGEDEEVIRHKTIQEQIDRMDNTIQYQLRRAATAGSSPGM
HHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLILLRPMIDRIINTVTKAYRHKHPDITVNIDNSIRLRIDEGDLMELLGNLIDNAFKWCR
EEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHE
YSIHLSAGYQGNQVEIQIRDDGPGIPPHEIARILERGARADQSTSGHGIGLAIVRDIMQV
EEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
YGGELLIENHPVGGLSVILHFERSK
CCCEEEEECCCCCCEEEEEEEECCC
>Mature Secondary Structure
MMSLNQRVLLSATLVLLVFIGGITFTLDRAFYDSARIGVKDRLFAKLLMLMGDAEVEDGE
CCCCCHHHHHHHHHHHHHHHCCHHEEEHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
LDVPVNQLDVEFEHVNSHTYAFIIGPANTIIWRSISSLNKSIPAIAPLGQGEKIFEQILL
CCCCHHHHEEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHC
NDEPHFIYRYGIAWETSSGGYPLTFNVITDTTLLDAQIERYREDLWGWLGVMAVVLLAAQ
CCCCCEEEEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVLRWGLLPLRKVSVELAAIESGRQESLKGIYPRELKLLTDSINSLITHEHKQQKRYRN
HHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLADLAHSLKTPLAILQGAIHGEDEEVIRHKTIQEQIDRMDNTIQYQLRRAATAGSSPGM
HHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLILLRPMIDRIINTVTKAYRHKHPDITVNIDNSIRLRIDEGDLMELLGNLIDNAFKWCR
EEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHHHHE
YSIHLSAGYQGNQVEIQIRDDGPGIPPHEIARILERGARADQSTSGHGIGLAIVRDIMQV
EEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
YGGELLIENHPVGGLSVILHFERSK
CCCEEEEECCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA