Click here to switch to the map view.

The map label for this gene is phoP [H]

Identifier: 114331353

GI number: 114331353

Start: 1432626

End: 1433312

Strand: Reverse

Name: phoP [H]

Synonym: Neut_1362

Alternate gene names: 114331353

Gene position: 1433312-1432626 (Counterclockwise)

Preceding gene: 114331354

Following gene: 114331352

Centisome position: 53.86

GC content: 49.49

Gene sequence:

>687_bases
ATGCGCATTCTGGTTATCGAAGATGAATTCCTTTTGCAAAACCAGATTCGTCAGCAACTGGAAGCAGCAGGTTACATGGT
TGATACTTGCAACAATGGCGAAGAAGGGTTGTTTCTCGCTACGGAATACCGTTTGAATGCCGCCATTATCGATATTGGCC
TGTCCGGTAAATCCGGTCTGGATGTAATCAAGGCACTGCGACAGCGGGGCAGTCTCCTGCCAATTTTGATTCTGACCGCG
CGCAGCAGTTGGCAAGACAAGGTGCGCGGCCTGGAAACGGGTGCGGATGATTACCTGACCAAGCCATTTCAAATGGAAGA
ACTGCAAGCCCGGGTCAAAGCATTATTGCGCCGTGCCAACGGCATCCCGCAGACCTTGCTGGAATGCGGCCCTATCGCGG
TGGATATGACAGCACAACAGGTTTCCATCAATGGTGTAAATATCGAATTAACCTCATTTGAATACCGCTTGCTGGAAGAA
CTGGTGCGTCATCGTGGTGAAGTGCTTTCTAAACAAATACTTGCAGACGCCCTTTATCCACATGACGAAGATCGAGACAG
CAATGTGCTTGAGGTCATGATTGGCAGGTTGCGGCGCAAACTTGATCCCGCTGGTACATTAAAGCCAATTGAAACCATGC
GTGGGCGTGGCTACCGTTTCATACTGGAATGTAATAAATCGGCATGA

Upstream 100 bases:

>100_bases
CACAGAATGGCGCGGTTGTATCCACGCATTAATCTTCAAAGTAAATTTCATGATTCAATTCAACGCATTTTATTGTCACC
CTGTGAGACAAGAGGCTTGA

Downstream 100 bases:

>100_bases
TGTCGCTCAATCAGCGTGTCCTGCTCAGTGCAACGCTGGTATTACTGGTTTTTATTGGCGGCATTACGTTTACATTGGAT
CGCGCTTTCTACGACAGTGC

Product: two component transcriptional regulator, winged helix family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRILVIEDEFLLQNQIRQQLEAAGYMVDTCNNGEEGLFLATEYRLNAAIIDIGLSGKSGLDVIKALRQRGSLLPILILTA
RSSWQDKVRGLETGADDYLTKPFQMEELQARVKALLRRANGIPQTLLECGPIAVDMTAQQVSINGVNIELTSFEYRLLEE
LVRHRGEVLSKQILADALYPHDEDRDSNVLEVMIGRLRRKLDPAGTLKPIETMRGRGYRFILECNKSA

Sequences:

>Translated_228_residues
MRILVIEDEFLLQNQIRQQLEAAGYMVDTCNNGEEGLFLATEYRLNAAIIDIGLSGKSGLDVIKALRQRGSLLPILILTA
RSSWQDKVRGLETGADDYLTKPFQMEELQARVKALLRRANGIPQTLLECGPIAVDMTAQQVSINGVNIELTSFEYRLLEE
LVRHRGEVLSKQILADALYPHDEDRDSNVLEVMIGRLRRKLDPAGTLKPIETMRGRGYRFILECNKSA
>Mature_228_residues
MRILVIEDEFLLQNQIRQQLEAAGYMVDTCNNGEEGLFLATEYRLNAAIIDIGLSGKSGLDVIKALRQRGSLLPILILTA
RSSWQDKVRGLETGADDYLTKPFQMEELQARVKALLRRANGIPQTLLECGPIAVDMTAQQVSINGVNIELTSFEYRLLEE
LVRHRGEVLSKQILADALYPHDEDRDSNVLEVMIGRLRRKLDPAGTLKPIETMRGRGYRFILECNKSA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=43.6363636363636, Blast_Score=197, Evalue=4e-52,
Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=40.1826484018265, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=39.3665158371041, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=38.9908256880734, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=38.5650224215247, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=36.6071428571429, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=33.7837837837838, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=34.2465753424658, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367329, Length=236, Percent_Identity=36.0169491525424, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=31.9148936170213, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=32.0512820512821, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.9285714285714, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=33.0357142857143, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693140, Length=185, Percent_Identity=29.7297297297297, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=186, Percent_Identity=28.494623655914, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=30.8333333333333, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=27.5862068965517, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25669; Mature: 25669

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVIEDEFLLQNQIRQQLEAAGYMVDTCNNGEEGLFLATEYRLNAAIIDIGLSGKSGL
CEEEEECHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEEEEEEEEEEEEEECCCCCCH
DVIKALRQRGSLLPILILTARSSWQDKVRGLETGADDYLTKPFQMEELQARVKALLRRAN
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHCC
GIPQTLLECGPIAVDMTAQQVSINGVNIELTSFEYRLLEELVRHRGEVLSKQILADALYP
CCHHHHHHCCCEEEEEEHHEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HDEDRDSNVLEVMIGRLRRKLDPAGTLKPIETMRGRGYRFILECNKSA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCC
>Mature Secondary Structure
MRILVIEDEFLLQNQIRQQLEAAGYMVDTCNNGEEGLFLATEYRLNAAIIDIGLSGKSGL
CEEEEECHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEEEEEEEEEEEEEECCCCCCH
DVIKALRQRGSLLPILILTARSSWQDKVRGLETGADDYLTKPFQMEELQARVKALLRRAN
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHCC
GIPQTLLECGPIAVDMTAQQVSINGVNIELTSFEYRLLEELVRHRGEVLSKQILADALYP
CCHHHHHHCCCEEEEEEHHEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HDEDRDSNVLEVMIGRLRRKLDPAGTLKPIETMRGRGYRFILECNKSA
CCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA