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The map label for this gene is prk [H]

Identifier: 113477129

GI number: 113477129

Start: 5611983

End: 5612993

Strand: Reverse

Name: prk [H]

Synonym: Tery_3654

Alternate gene names: 113477129

Gene position: 5612993-5611983 (Counterclockwise)

Preceding gene: 113477134

Following gene: 113477126

Centisome position: 72.42

GC content: 38.87

Gene sequence:

>1011_bases
GTGAAAAAACCAGATAAAGTAGTCTTAATTGGAGTTGCCGGAGATTCTGGATGCGGAAAATCTACTTTTTTGCGCCGAAT
TACAGATGTATTTGGACCAGAATTCGTTACAGTTATCTGCCTGGACGATTATCATAGTCTAGACCGTAAGCAACGTAAGG
AAACAGGAATTACTGCCCTGGATCCAAGAGCTAATAATTTTGACCTCATGTACGAGCAAATTAAAGCTCTTAAAAATCTT
GAGTCCATCGATAAGCCAATTTATAACCACGAAACTGGCATGATTGACCCACCAGAAAAAATTCATCCTAATCATATTAT
AGTAATTGAGGGCCTTCATCCTCTCTATGATGAGCGTGTACGAGAGCTCATTGATTTTAGTGTCTATCTAGATATTGGTG
ATGAAGTTAAAATTGCTTGGAAAATCAAGCGCGATCTAGCAGAAAGAGGCCACCGTTACGAAGATGTTCTAGCTTCTATT
AATGCCCGTCGTCCCGACTTTGAATCCTATATTGATCCACAAAAAGTTCATGCAGATGTGGTCATTCAAGTTTTGCCCAC
TAAGCTGATTCCTAATGACCAGGAACATAAGGTTCTACGGGTACGCTTGATTCAACGTGAAGGAGTCAAAAATTTCGATC
CAGTTTATCTGTTTGATGAAGGATCTACTATTAACTGGATTCCTTGTGGACGAAAACTTACTTGCTCTTATCCTGGAATT
AAGATGTTCTATGGGCCAGACTCCTATGATGGCAATGAAGTTTCTATATTAGAAGTAGATGGTAACTTTGATAACCTCGA
AGAGATGATCTACGTTGAAGGACATCTCAGCAATACTTCTACTAAATACTATGGTGAAATGACTCATGCAATGATGAAAC
ATCAAGACTATCCAGGTTCTAATAATGGTAGTGGGCTATTCCAAGTTTTAGTTGGTCTGAAAATGCGTGCAACTTATGAA
AGCTTGACTGCTACAACTTTAGATGAAAAGGTAGTAGCAGCAGTTTCCTAA

Upstream 100 bases:

>100_bases
TGAGGAATTTGTCCTGGACTAACTAATAAGCCTAGACTCATCCAGAAAGAAACCATTGAATATGTCAGTAAACTTTGTTT
TGTCTTAAAGGGAAATTATT

Downstream 100 bases:

>100_bases
ATATCTTGGAGTAAATTTTTGATTTCTTGGCTCTAGATCGGATATCTAGTATCAGTTACCGAAGAATTGGGTTTAAAGCT
TCCCCCATAAGCCGGCGACT

Product: phosphoribulokinase

Products: NA

Alternate protein names: PRK; PRKase; Phosphopentokinase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKKPDKVVLIGVAGDSGCGKSTFLRRITDVFGPEFVTVICLDDYHSLDRKQRKETGITALDPRANNFDLMYEQIKALKNL
ESIDKPIYNHETGMIDPPEKIHPNHIIVIEGLHPLYDERVRELIDFSVYLDIGDEVKIAWKIKRDLAERGHRYEDVLASI
NARRPDFESYIDPQKVHADVVIQVLPTKLIPNDQEHKVLRVRLIQREGVKNFDPVYLFDEGSTINWIPCGRKLTCSYPGI
KMFYGPDSYDGNEVSILEVDGNFDNLEEMIYVEGHLSNTSTKYYGEMTHAMMKHQDYPGSNNGSGLFQVLVGLKMRATYE
SLTATTLDEKVVAAVS

Sequences:

>Translated_336_residues
MKKPDKVVLIGVAGDSGCGKSTFLRRITDVFGPEFVTVICLDDYHSLDRKQRKETGITALDPRANNFDLMYEQIKALKNL
ESIDKPIYNHETGMIDPPEKIHPNHIIVIEGLHPLYDERVRELIDFSVYLDIGDEVKIAWKIKRDLAERGHRYEDVLASI
NARRPDFESYIDPQKVHADVVIQVLPTKLIPNDQEHKVLRVRLIQREGVKNFDPVYLFDEGSTINWIPCGRKLTCSYPGI
KMFYGPDSYDGNEVSILEVDGNFDNLEEMIYVEGHLSNTSTKYYGEMTHAMMKHQDYPGSNNGSGLFQVLVGLKMRATYE
SLTATTLDEKVVAAVS
>Mature_336_residues
MKKPDKVVLIGVAGDSGCGKSTFLRRITDVFGPEFVTVICLDDYHSLDRKQRKETGITALDPRANNFDLMYEQIKALKNL
ESIDKPIYNHETGMIDPPEKIHPNHIIVIEGLHPLYDERVRELIDFSVYLDIGDEVKIAWKIKRDLAERGHRYEDVLASI
NARRPDFESYIDPQKVHADVVIQVLPTKLIPNDQEHKVLRVRLIQREGVKNFDPVYLFDEGSTINWIPCGRKLTCSYPGI
KMFYGPDSYDGNEVSILEVDGNFDNLEEMIYVEGHLSNTSTKYYGEMTHAMMKHQDYPGSNNGSGLFQVLVGLKMRATYE
SLTATTLDEKVVAAVS

Specific function: Pyrimidine salvage pathway. [C]

COG id: COG0572

COG function: function code F; Uridine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoribulokinase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=179, Percent_Identity=28.4916201117318, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI57863312, Length=179, Percent_Identity=28.4916201117318, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI18699734, Length=187, Percent_Identity=24.5989304812834, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI13899253, Length=187, Percent_Identity=25.668449197861, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082034, Length=187, Percent_Identity=32.0855614973262, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17539892, Length=180, Percent_Identity=30, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17539894, Length=180, Percent_Identity=30, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71981181, Length=193, Percent_Identity=29.5336787564767, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324339, Length=170, Percent_Identity=25.8823529411765, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28573516, Length=180, Percent_Identity=26.1111111111111, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573514, Length=180, Percent_Identity=26.1111111111111, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573512, Length=180, Percent_Identity=26.1111111111111, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550449, Length=180, Percent_Identity=26.1111111111111, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221458995, Length=188, Percent_Identity=28.7234042553192, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24649624, Length=188, Percent_Identity=28.7234042553192, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006082
- InterPro:   IPR006083 [H]

Pfam domain/function: PF00485 PRK [H]

EC number: =2.7.1.19 [H]

Molecular weight: Translated: 38227; Mature: 38227

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPDKVVLIGVAGDSGCGKSTFLRRITDVFGPEFVTVICLDDYHSLDRKQRKETGITAL
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCEEE
DPRANNFDLMYEQIKALKNLESIDKPIYNHETGMIDPPEKIHPNHIIVIEGLHPLYDERV
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEEECCCCHHHHHHH
RELIDFSVYLDIGDEVKIAWKIKRDLAERGHRYEDVLASINARRPDFESYIDPQKVHADV
HHHHCEEEEEECCCCEEEEEEEHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHHH
VIQVLPTKLIPNDQEHKVLRVRLIQREGVKNFDPVYLFDEGSTINWIPCGRKLTCSYPGI
HEEEECHHCCCCCCCCCEEEEEEHHHCCCCCCCCEEEEECCCEEEEEECCCEEEECCCCE
KMFYGPDSYDGNEVSILEVDGNFDNLEEMIYVEGHLSNTSTKYYGEMTHAMMKHQDYPGS
EEEECCCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
NNGSGLFQVLVGLKMRATYESLTATTLDEKVVAAVS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MKKPDKVVLIGVAGDSGCGKSTFLRRITDVFGPEFVTVICLDDYHSLDRKQRKETGITAL
CCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHCCCEEE
DPRANNFDLMYEQIKALKNLESIDKPIYNHETGMIDPPEKIHPNHIIVIEGLHPLYDERV
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCEEEEECCCCHHHHHHH
RELIDFSVYLDIGDEVKIAWKIKRDLAERGHRYEDVLASINARRPDFESYIDPQKVHADV
HHHHCEEEEEECCCCEEEEEEEHHHHHHCCCHHHHHHHHHCCCCCCHHHHCCHHHHHHHH
VIQVLPTKLIPNDQEHKVLRVRLIQREGVKNFDPVYLFDEGSTINWIPCGRKLTCSYPGI
HEEEECHHCCCCCCCCCEEEEEEHHHCCCCCCCCEEEEECCCEEEEEECCCEEEECCCCE
KMFYGPDSYDGNEVSILEVDGNFDNLEEMIYVEGHLSNTSTKYYGEMTHAMMKHQDYPGS
EEEECCCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
NNGSGLFQVLVGLKMRATYESLTATTLDEKVVAAVS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1660882; 8905231 [H]