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The map label for this gene is adk

Identifier: 113476560

GI number: 113476560

Start: 4646985

End: 4647560

Strand: Reverse

Name: adk

Synonym: Tery_2993

Alternate gene names: 113476560

Gene position: 4647560-4646985 (Counterclockwise)

Preceding gene: 113476561

Following gene: 113476559

Centisome position: 59.97

GC content: 36.28

Gene sequence:

>576_bases
GTGGTAAAACTGGTATTTTTAGGTCCACCAGGAGCGGGGAAAGGAACACAAGCATCTCTCATAGCAGATTTTTATAAAGT
TCCCCATATTTCTACTGGTGATATTCTGCGCAGTAACGTAGCAGAAAGATCTCCTTTGGGTATTAAAGCCAAAGACTATA
TGGATAAGGGAGATTTAGTCCCTGACCAACTCATTCTTGATATGGTTAAGGAAAGACTGGAAAACCCTAATGCTCAAAAT
GGTTGGATTCTAGATGGCTTTCCCCGGACTGTAACTCAGGCAGAAGAGTTTTTCAAAAAATATGAGAGTGAAGGAGAAGA
AGCTAAGAGTAGTAGTTCTTTTCACGTAATTAATTTACAAGTACCGGATGATGTTTTAGTAGCTCGTTTGTTATCAAGAA
AACGTGAAGATGATCAGGAAGAAACTATTAGAAATCGTTTACAAGTTTATTATCAACAAACGCAACCTTTGATTGAGTTT
TATCAAGCACGTGAACAGTTAATTATTATAGATGGAAATAATCCTATTGAAACTGTGACTAATGCTATAAAACAAGAGGT
TGATAAAATTACCTGA

Upstream 100 bases:

>100_bases
CTACTTCTCTATTAATTCTAGTAGGTGTAGCAATAGATACAGCCAAACAAATTCAAACTTATGTTATCTCTCAAAGATAC
GAAGGAATGGTTAAGCAATA

Downstream 100 bases:

>100_bases
AGTAACTTGGAATAAAATTTTGAAGGTGGAAAAATTAAACTTTTTATACCTCCAACTAGAATTATTGAAGCTACTTATTT
CAGATAAATATTTGTAGAGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MVKLVFLGPPGAGKGTQASLIADFYKVPHISTGDILRSNVAERSPLGIKAKDYMDKGDLVPDQLILDMVKERLENPNAQN
GWILDGFPRTVTQAEEFFKKYESEGEEAKSSSSFHVINLQVPDDVLVARLLSRKREDDQEETIRNRLQVYYQQTQPLIEF
YQAREQLIIIDGNNPIETVTNAIKQEVDKIT

Sequences:

>Translated_191_residues
MVKLVFLGPPGAGKGTQASLIADFYKVPHISTGDILRSNVAERSPLGIKAKDYMDKGDLVPDQLILDMVKERLENPNAQN
GWILDGFPRTVTQAEEFFKKYESEGEEAKSSSSFHVINLQVPDDVLVARLLSRKREDDQEETIRNRLQVYYQQTQPLIEF
YQAREQLIIIDGNNPIETVTNAIKQEVDKIT
>Mature_191_residues
MVKLVFLGPPGAGKGTQASLIADFYKVPHISTGDILRSNVAERSPLGIKAKDYMDKGDLVPDQLILDMVKERLENPNAQN
GWILDGFPRTVTQAEEFFKKYESEGEEAKSSSSFHVINLQVPDDVLVARLLSRKREDDQEETIRNRLQVYYQQTQPLIEF
YQAREQLIIIDGNNPIETVTNAIKQEVDKIT

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=221, Percent_Identity=37.10407239819, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI7524346, Length=221, Percent_Identity=37.10407239819, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI4502011, Length=195, Percent_Identity=34.8717948717949, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI19923437, Length=204, Percent_Identity=32.843137254902, Blast_Score=118, Evalue=3e-27,
Organism=Homo sapiens, GI28144897, Length=195, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI28144899, Length=195, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI310110345, Length=214, Percent_Identity=33.1775700934579, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI53832003, Length=214, Percent_Identity=33.1775700934579, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI8051579, Length=214, Percent_Identity=33.1775700934579, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI53832001, Length=214, Percent_Identity=33.1775700934579, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI7706497, Length=195, Percent_Identity=31.2820512820513, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI22749187, Length=180, Percent_Identity=27.2222222222222, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=214, Percent_Identity=37.3831775700935, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17552384, Length=221, Percent_Identity=34.3891402714932, Blast_Score=136, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17567503, Length=192, Percent_Identity=34.8958333333333, Blast_Score=123, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17533833, Length=192, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=31.1827956989247, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=220, Percent_Identity=34.0909090909091, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=194, Percent_Identity=28.8659793814433, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=31.7948717948718, Blast_Score=89, Evalue=6e-19,
Organism=Drosophila melanogaster, GI22026816, Length=194, Percent_Identity=36.0824742268041, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24663208, Length=192, Percent_Identity=29.6875, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17647141, Length=192, Percent_Identity=29.6875, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221459597, Length=195, Percent_Identity=31.2820512820513, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356893, Length=195, Percent_Identity=31.2820512820513, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24582962, Length=192, Percent_Identity=25.5208333333333, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_TRIEI (Q110C6)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_722621.1
- ProteinModelPortal:   Q110C6
- SMR:   Q110C6
- STRING:   Q110C6
- GeneID:   4245109
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_2993
- NMPDR:   fig|203124.1.peg.5487
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- BioCyc:   TERY203124:TERY_2993-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21650; Mature: 21650

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLVFLGPPGAGKGTQASLIADFYKVPHISTGDILRSNVAERSPLGIKAKDYMDKGDLV
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCC
PDQLILDMVKERLENPNAQNGWILDGFPRTVTQAEEFFKKYESEGEEAKSSSSFHVINLQ
HHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEE
VPDDVLVARLLSRKREDDQEETIRNRLQVYYQQTQPLIEFYQAREQLIIIDGNNPIETVT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
NAIKQEVDKIT
HHHHHHHHHCC
>Mature Secondary Structure
MVKLVFLGPPGAGKGTQASLIADFYKVPHISTGDILRSNVAERSPLGIKAKDYMDKGDLV
CEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCC
PDQLILDMVKERLENPNAQNGWILDGFPRTVTQAEEFFKKYESEGEEAKSSSSFHVINLQ
HHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEE
VPDDVLVARLLSRKREDDQEETIRNRLQVYYQQTQPLIEFYQAREQLIIIDGNNPIETVT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
NAIKQEVDKIT
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA