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The map label for this gene is mdmC [H]

Identifier: 113476546

GI number: 113476546

Start: 4629834

End: 4630664

Strand: Reverse

Name: mdmC [H]

Synonym: Tery_2976

Alternate gene names: 113476546

Gene position: 4630664-4629834 (Counterclockwise)

Preceding gene: 113476547

Following gene: 113476545

Centisome position: 59.75

GC content: 38.39

Gene sequence:

>831_bases
ATGACAACCGTTGTGAAAACAGAAACTGCCAGACCAGTTACACCATTAGGTATTTTGGTAGAGCAACTTGAAAGAATTGT
CAAGATGGCAGAAACTGCAGAAATACCACCAGAATTATCTAATGCTATTAAGCAAGCGTATCAATTAGGGGCAGGTCTTG
ACCCCTATTTAGAAGAAAATACCACTCAAGAATCTCCTGCTTTGACAGCATTAGCAGAAAAGACTCGTCAAGAACCATGG
AGTTCAAGATTTTCCAATAGCGAGACTGTGCGTCAATTAGAGCAGGAAATGTTATCTGGGCATATTGAGGGACAAACCTT
AAAAATGTTTGTTCATATGATTGGGGCTAAAAGTATCCTGGAAATAGGGATGTTTACTGGGTATTCAGCATTGGCAATGG
CGGAAGCTTTACCACAAAATGGGCGGATGGTTGCTTGTGAAGTGGATGAATATGTATCTAACTTTGCTAAATCTTGTTTT
GATGGGTCTCCACATGGAAGCAAAATCTCGGTGGAAGTTGCACCTGCTCTAGAAACCATTAAGAAGTTGGCAGATGCAGG
AGAAACTTTTGATTTAGTCTTTATTGATGCTGATAAAAAAGAGTATATAGAGTACTTCAAAATACTTTTGGATACAAGTT
TGTTAGCAACAAATGGATTTATTTGTGTCGATAATACTTTACTTCAAGGGGAACCCTATCTACCGAAAGAAAAACGTAAT
CTTAATGGAGAAGCGATCGCTCAATTTAATCGCTTTGTTGCAGAAGATCCTAGAGTAGAACAAGTTTTACTACCTTTACG
AGATGGGTTAACTATTATTAGGCGAAAGTAG

Upstream 100 bases:

>100_bases
ATCAGGGAAAATTTTAGTGATTTGAGGCTTAGATTTTACCTATAATTTTTGTCTAGATGCTCTACTGCTCTGCTGTTATT
AAGTAGTAAGGGATAAAAAT

Downstream 100 bases:

>100_bases
TTATGATTTGAGGAAAATATTATGACATGAGGAATTAGTAAAAGTTTACAACCTTTTGTCAGCTCATTTTAACTTTTTAC
CTTTTGCCTGATCCGTAGAA

Product: caffeoyl-CoA O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTTVVKTETARPVTPLGILVEQLERIVKMAETAEIPPELSNAIKQAYQLGAGLDPYLEENTTQESPALTALAEKTRQEPW
SSRFSNSETVRQLEQEMLSGHIEGQTLKMFVHMIGAKSILEIGMFTGYSALAMAEALPQNGRMVACEVDEYVSNFAKSCF
DGSPHGSKISVEVAPALETIKKLADAGETFDLVFIDADKKEYIEYFKILLDTSLLATNGFICVDNTLLQGEPYLPKEKRN
LNGEAIAQFNRFVAEDPRVEQVLLPLRDGLTIIRRK

Sequences:

>Translated_276_residues
MTTVVKTETARPVTPLGILVEQLERIVKMAETAEIPPELSNAIKQAYQLGAGLDPYLEENTTQESPALTALAEKTRQEPW
SSRFSNSETVRQLEQEMLSGHIEGQTLKMFVHMIGAKSILEIGMFTGYSALAMAEALPQNGRMVACEVDEYVSNFAKSCF
DGSPHGSKISVEVAPALETIKKLADAGETFDLVFIDADKKEYIEYFKILLDTSLLATNGFICVDNTLLQGEPYLPKEKRN
LNGEAIAQFNRFVAEDPRVEQVLLPLRDGLTIIRRK
>Mature_275_residues
TTVVKTETARPVTPLGILVEQLERIVKMAETAEIPPELSNAIKQAYQLGAGLDPYLEENTTQESPALTALAEKTRQEPWS
SRFSNSETVRQLEQEMLSGHIEGQTLKMFVHMIGAKSILEIGMFTGYSALAMAEALPQNGRMVACEVDEYVSNFAKSCFD
GSPHGSKISVEVAPALETIKKLADAGETFDLVFIDADKKEYIEYFKILLDTSLLATNGFICVDNTLLQGEPYLPKEKRNL
NGEAIAQFNRFVAEDPRVEQVLLPLRDGLTIIRRK

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=219, Percent_Identity=35.1598173515982, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17565612, Length=176, Percent_Identity=35.7954545454545, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25148771, Length=176, Percent_Identity=35.2272727272727, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI72001127, Length=248, Percent_Identity=30.241935483871, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI72001028, Length=235, Percent_Identity=31.063829787234, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 30630; Mature: 30499

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVVKTETARPVTPLGILVEQLERIVKMAETAEIPPELSNAIKQAYQLGAGLDPYLEEN
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHCC
TTQESPALTALAEKTRQEPWSSRFSNSETVRQLEQEMLSGHIEGQTLKMFVHMIGAKSIL
CCCCCHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
EIGMFTGYSALAMAEALPQNGRMVACEVDEYVSNFAKSCFDGSPHGSKISVEVAPALETI
HHHHHCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHH
KKLADAGETFDLVFIDADKKEYIEYFKILLDTSLLATNGFICVDNTLLQGEPYLPKEKRN
HHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEECCEEECCCCCCCHHHCC
LNGEAIAQFNRFVAEDPRVEQVLLPLRDGLTIIRRK
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
TTVVKTETARPVTPLGILVEQLERIVKMAETAEIPPELSNAIKQAYQLGAGLDPYLEEN
CCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHCC
TTQESPALTALAEKTRQEPWSSRFSNSETVRQLEQEMLSGHIEGQTLKMFVHMIGAKSIL
CCCCCHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
EIGMFTGYSALAMAEALPQNGRMVACEVDEYVSNFAKSCFDGSPHGSKISVEVAPALETI
HHHHHCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHH
KKLADAGETFDLVFIDADKKEYIEYFKILLDTSLLATNGFICVDNTLLQGEPYLPKEKRN
HHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEECCEEECCCCCCCHHHCC
LNGEAIAQFNRFVAEDPRVEQVLLPLRDGLTIIRRK
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]