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The map label for this gene is czcR [H]

Identifier: 113475941

GI number: 113475941

Start: 3571184

End: 3571870

Strand: Reverse

Name: czcR [H]

Synonym: Tery_2305

Alternate gene names: 113475941

Gene position: 3571870-3571184 (Counterclockwise)

Preceding gene: 113475945

Following gene: 113475939

Centisome position: 46.09

GC content: 39.01

Gene sequence:

>687_bases
ATGCAGATTCTTTTGGTGGATGATGAACCAGAGTTTACTTCTCCTCTAAGTTGTGCTTTGAATAGGGAGGGTTATAATGT
TGATGTTGCTGATCATGGAGAGGCGGGTTTTCAAATGGCTGTTGAGGGTAACTATGATTTATTGATTTTAGATTGGATGT
TACCCCAAAAGACAGGGCTGGAGATTTGTCAAAGGTTGCGATCGCGCCATGACTATACCCCTGTTTTATTTCTTACTGCT
AAAGATACATTAGATGAGCGTGTTAGGGGGTTAGATGCTGGTGCGGATGATTATTTAGTTAAGCCTTTTGAGTTACGAGA
GTTATTAGCAAGGGTTCGAGCTTTATTGCGTCGCCGTGTTATTATTGAAACATCTACAGCTGATCAAAATTTACGGGTAG
GAAATTTAGAGTTAGATATAGAAAATAAGGTTGCTTATCGTGGCGGGCAAGTGATTTTCTTATCTGAAAAAGAATGTAAG
CTGTTGGGATATTTTATGAACTATCCCGGGGAACTTTTAACTCACCAACAAATTTATGAATATTTGTGGGGAGAAGGGGG
ACAACCAAGTAGTAATGTTTTAGCAGCACAAGTACGGTTATTGCGAAGAAAAATAGAGGTGGCTGGGGACTCGCCATTAA
TTCATACTGTTTATGGGAAAGGTTATTGGTTTAGAATATTAAGCTAA

Upstream 100 bases:

>100_bases
TTTTGCTCTGATTTTTTGTTTTTTGCTGCTACTAAATTTTGTTTGGAAGTTTATTTTTTGGGTAAGTACTGGGTATATTT
ACAGTTATTTAATTGATCAA

Downstream 100 bases:

>100_bases
TTAAAGAAGAATGGTTTTATGGTTTATAGGTTATTCAGTTAAGCTGTATTGATGGCAAAATTATAAAGGTAGTTCGGTTC
TGAGCTAGTAGTAGTAGTAG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MQILLVDDEPEFTSPLSCALNREGYNVDVADHGEAGFQMAVEGNYDLLILDWMLPQKTGLEICQRLRSRHDYTPVLFLTA
KDTLDERVRGLDAGADDYLVKPFELRELLARVRALLRRRVIIETSTADQNLRVGNLELDIENKVAYRGGQVIFLSEKECK
LLGYFMNYPGELLTHQQIYEYLWGEGGQPSSNVLAAQVRLLRRKIEVAGDSPLIHTVYGKGYWFRILS

Sequences:

>Translated_228_residues
MQILLVDDEPEFTSPLSCALNREGYNVDVADHGEAGFQMAVEGNYDLLILDWMLPQKTGLEICQRLRSRHDYTPVLFLTA
KDTLDERVRGLDAGADDYLVKPFELRELLARVRALLRRRVIIETSTADQNLRVGNLELDIENKVAYRGGQVIFLSEKECK
LLGYFMNYPGELLTHQQIYEYLWGEGGQPSSNVLAAQVRLLRRKIEVAGDSPLIHTVYGKGYWFRILS
>Mature_228_residues
MQILLVDDEPEFTSPLSCALNREGYNVDVADHGEAGFQMAVEGNYDLLILDWMLPQKTGLEICQRLRSRHDYTPVLFLTA
KDTLDERVRGLDAGADDYLVKPFELRELLARVRALLRRRVIIETSTADQNLRVGNLELDIENKVAYRGGQVIFLSEKECK
LLGYFMNYPGELLTHQQIYEYLWGEGGQPSSNVLAAQVRLLRRKIEVAGDSPLIHTVYGKGYWFRILS

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=41.6666666666667, Blast_Score=166, Evalue=9e-43,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=37.9464285714286, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=38.3928571428571, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=38.2882882882883, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=31.858407079646, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=33.9285714285714, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=36.7256637168142, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=34.0807174887892, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=30.5676855895196, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=31.7180616740088, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=31.0810810810811, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=28.3185840707965, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=28.755364806867, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=116, Percent_Identity=37.0689655172414, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790437, Length=126, Percent_Identity=29.3650793650794, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=34.7826086956522, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=32.1428571428571, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26037; Mature: 26037

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILLVDDEPEFTSPLSCALNREGYNVDVADHGEAGFQMAVEGNYDLLILDWMLPQKTGL
CEEEEECCCCCCCCCHHEEECCCCCEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCHH
EICQRLRSRHDYTPVLFLTAKDTLDERVRGLDAGADDYLVKPFELRELLARVRALLRRRV
HHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCE
IIETSTADQNLRVGNLELDIENKVAYRGGQVIFLSEKECKLLGYFMNYPGELLTHQQIYE
EEEECCCCCCEEECEEEEEECCCEEECCCEEEEEECCCCEEEHHHHCCCHHHHHHHHHHH
YLWGEGGQPSSNVLAAQVRLLRRKIEVAGDSPLIHTVYGKGYWFRILS
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEC
>Mature Secondary Structure
MQILLVDDEPEFTSPLSCALNREGYNVDVADHGEAGFQMAVEGNYDLLILDWMLPQKTGL
CEEEEECCCCCCCCCHHEEECCCCCEEEECCCCCCCEEEEEECCCCEEEEEECCCCCCHH
EICQRLRSRHDYTPVLFLTAKDTLDERVRGLDAGADDYLVKPFELRELLARVRALLRRRV
HHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCE
IIETSTADQNLRVGNLELDIENKVAYRGGQVIFLSEKECKLLGYFMNYPGELLTHQQIYE
EEEECCCCCCEEECEEEEEECCCEEECCCEEEEEECCCCEEEHHHHCCCHHHHHHHHHHH
YLWGEGGQPSSNVLAAQVRLLRRKIEVAGDSPLIHTVYGKGYWFRILS
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]