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The map label for this gene is pyrC [H]

Identifier: 113475820

GI number: 113475820

Start: 3400076

End: 3401407

Strand: Reverse

Name: pyrC [H]

Synonym: Tery_2177

Alternate gene names: 113475820

Gene position: 3401407-3400076 (Counterclockwise)

Preceding gene: 113475822

Following gene: 113475819

Centisome position: 43.89

GC content: 39.86

Gene sequence:

>1332_bases
ATGGCTCCTATCTCTTCTTTGTTGATTCGTCGTGCCCGCATCCTTTTACCGGATGGGACATTTTTGATTGGTGATGTGCA
AACTCAAGGCCGAGAAATTATTCAGGTTGCTCCAGAGATTTCATCTTCTGAAGCTCCAGAAAAAATCATAGATGCTGAAG
GTTTAACTTTATTACCGGGAGTAATTGATCCTCAAGTACATTTTCGGGAACCTGGGTTGGAACATAAGGAGGACTTATTT
ACTGCTAGTCGGGCTTGTGTGAAGGGTGGTGTTACTTCTTTTCTAGAAATGCCTAATACTAAACCTTTGACTACAACTCA
AGGAGCATTGGATGATAAGTTACGACGGGCAGAGCAAAAATGCGTGGCTAATTTTGGTTTTTTTATTGGGGCAACGGCAG
AGAATTTACCTGATTTATTAACAGCTAATCCTACTCCTGGAATTAAAATTTTTATGGGTTCTATGCACGGACCTTTGTTG
GTGGATACTGAGGAAAAGTTAGAGCCAATTTTTGCTAGGGGAAAAAGATTAATTGCTGTTCATGCTGAAAATCAAGCTCG
AATTGATGAAAGGAAAAAACAGTTTGCTGGTATTTCTGATCCTGCTATTCATTCACAAATTCAGGATAATGAAGCTGCTT
TGTTGGCAACTAAGATGGCTTTGAAATTATCTAAGAAGTATGAGCGGAGGTTACATATTTTGCATACTTCGACTGGAGAT
GAGGCTGAATTGTTGCGTCAGGATAAGCCTAGTTGGGTAACTGCTGAAGTTACGCCTCAACATTTGTTCTTAAATACAAG
TGCTTATGAAAAAATTGGTACTTTAGCTCAGATGAATCCTCCTTTAAAATCTGCTGGTGATAATGATATTTTATGGCGAG
CTTTGTTGGATGGAGTAATTGATTTTATTGCAACGGATCATGCACCTCATACTTTGGCAGAAAAGGGTAAAGGTTATCCG
AATACTCCTTCGGGAATGCCTGGGGTGGAAACTTCTTTGCCTTTGATGTTGACTCAAGCTATTGAGGGAAGATGTTCTGT
TGCTCAGGTTTCGAATTGGATGTCTACTGCTGTGGCTAAGGGTTATGGAATTCTGAAAAAGGGTGCGATCGCTCCTGGTT
TTGATGCAGATTTAGTGTTAGTTGATTTAAATAATTATCGCCCTGTTTTAAGAGAGGAATTGATGACAAAATGTAGGTGG
AGTCCTTTTGAAGGATGGAGTTTAACTGGTTGGCCTGTTGTTACTATTGTTGGGGGAGAGGTTGCTTTTAATCGTGGTGA
ATTTAATTCTGAAGTTCGGGGTCGAGCTTTGATTTTTTCGGAAATTGCCTAA

Upstream 100 bases:

>100_bases
TGAATTACTAGCTCCTAGTCCTTTATCTTTAATTCCTAAAATAATATAATAAGTTTCAAACCAAATTTTCTTTCTCTAGT
TTTCAAACCAAATTTTTATT

Downstream 100 bases:

>100_bases
ACAATTTTGACAGTAATTTTCGGGATTTTTTTGCTGCTTTGTTGCACAAAAGATGAAAATGGACTAAAAATATAGTTATA
GTACAAAAAATCTGCACCTA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAPISSLLIRRARILLPDGTFLIGDVQTQGREIIQVAPEISSSEAPEKIIDAEGLTLLPGVIDPQVHFREPGLEHKEDLF
TASRACVKGGVTSFLEMPNTKPLTTTQGALDDKLRRAEQKCVANFGFFIGATAENLPDLLTANPTPGIKIFMGSMHGPLL
VDTEEKLEPIFARGKRLIAVHAENQARIDERKKQFAGISDPAIHSQIQDNEAALLATKMALKLSKKYERRLHILHTSTGD
EAELLRQDKPSWVTAEVTPQHLFLNTSAYEKIGTLAQMNPPLKSAGDNDILWRALLDGVIDFIATDHAPHTLAEKGKGYP
NTPSGMPGVETSLPLMLTQAIEGRCSVAQVSNWMSTAVAKGYGILKKGAIAPGFDADLVLVDLNNYRPVLREELMTKCRW
SPFEGWSLTGWPVVTIVGGEVAFNRGEFNSEVRGRALIFSEIA

Sequences:

>Translated_443_residues
MAPISSLLIRRARILLPDGTFLIGDVQTQGREIIQVAPEISSSEAPEKIIDAEGLTLLPGVIDPQVHFREPGLEHKEDLF
TASRACVKGGVTSFLEMPNTKPLTTTQGALDDKLRRAEQKCVANFGFFIGATAENLPDLLTANPTPGIKIFMGSMHGPLL
VDTEEKLEPIFARGKRLIAVHAENQARIDERKKQFAGISDPAIHSQIQDNEAALLATKMALKLSKKYERRLHILHTSTGD
EAELLRQDKPSWVTAEVTPQHLFLNTSAYEKIGTLAQMNPPLKSAGDNDILWRALLDGVIDFIATDHAPHTLAEKGKGYP
NTPSGMPGVETSLPLMLTQAIEGRCSVAQVSNWMSTAVAKGYGILKKGAIAPGFDADLVLVDLNNYRPVLREELMTKCRW
SPFEGWSLTGWPVVTIVGGEVAFNRGEFNSEVRGRALIFSEIA
>Mature_442_residues
APISSLLIRRARILLPDGTFLIGDVQTQGREIIQVAPEISSSEAPEKIIDAEGLTLLPGVIDPQVHFREPGLEHKEDLFT
ASRACVKGGVTSFLEMPNTKPLTTTQGALDDKLRRAEQKCVANFGFFIGATAENLPDLLTANPTPGIKIFMGSMHGPLLV
DTEEKLEPIFARGKRLIAVHAENQARIDERKKQFAGISDPAIHSQIQDNEAALLATKMALKLSKKYERRLHILHTSTGDE
AELLRQDKPSWVTAEVTPQHLFLNTSAYEKIGTLAQMNPPLKSAGDNDILWRALLDGVIDFIATDHAPHTLAEKGKGYPN
TPSGMPGVETSLPLMLTQAIEGRCSVAQVSNWMSTAVAKGYGILKKGAIAPGFDADLVLVDLNNYRPVLREELMTKCRWS
PFEGWSLTGWPVVTIVGGEVAFNRGEFNSEVRGRALIFSEIA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=384, Percent_Identity=31.25, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI4503051, Length=447, Percent_Identity=24.1610738255034, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI62422571, Length=447, Percent_Identity=24.1610738255034, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4503375, Length=458, Percent_Identity=24.6724890829694, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4503379, Length=446, Percent_Identity=24.2152466367713, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4503377, Length=456, Percent_Identity=24.1228070175439, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI190194363, Length=447, Percent_Identity=24.1610738255034, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=22.9074889867841, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=26.7734553775744, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI87082175, Length=453, Percent_Identity=28.2560706401766, Blast_Score=151, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI193204318, Length=420, Percent_Identity=30.7142857142857, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71989490, Length=452, Percent_Identity=25.6637168141593, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17539558, Length=451, Percent_Identity=26.6075388026608, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI86575075, Length=448, Percent_Identity=25, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322218, Length=394, Percent_Identity=28.1725888324873, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24642586, Length=378, Percent_Identity=32.010582010582, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI18859883, Length=476, Percent_Identity=26.890756302521, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI221377917, Length=409, Percent_Identity=25.4278728606357, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137462, Length=404, Percent_Identity=25.990099009901, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48444; Mature: 48313

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPISSLLIRRARILLPDGTFLIGDVQTQGREIIQVAPEISSSEAPEKIIDAEGLTLLPG
CCCHHHHHHHHHHEECCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHCCCCCEECCC
VIDPQVHFREPGLEHKEDLFTASRACVKGGVTSFLEMPNTKPLTTTQGALDDKLRRAEQK
CCCCCCEECCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
CVANFGFFIGATAENLPDLLTANPTPGIKIFMGSMHGPLLVDTEEKLEPIFARGKRLIAV
HHHHCCCEEECCHHCCCHHHCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHCCCEEEEE
HAENQARIDERKKQFAGISDPAIHSQIQDNEAALLATKMALKLSKKYERRLHILHTSTGD
ECCCCHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCC
EAELLRQDKPSWVTAEVTPQHLFLNTSAYEKIGTLAQMNPPLKSAGDNDILWRALLDGVI
HHHHHHCCCCCEEEEEECCCEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
DFIATDHAPHTLAEKGKGYPNTPSGMPGVETSLPLMLTQAIEGRCSVAQVSNWMSTAVAK
HHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GYGILKKGAIAPGFDADLVLVDLNNYRPVLREELMTKCRWSPFEGWSLTGWPVVTIVGGE
CCCHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCE
VAFNRGEFNSEVRGRALIFSEIA
EEECCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
APISSLLIRRARILLPDGTFLIGDVQTQGREIIQVAPEISSSEAPEKIIDAEGLTLLPG
CCHHHHHHHHHHEECCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHCCCCCEECCC
VIDPQVHFREPGLEHKEDLFTASRACVKGGVTSFLEMPNTKPLTTTQGALDDKLRRAEQK
CCCCCCEECCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
CVANFGFFIGATAENLPDLLTANPTPGIKIFMGSMHGPLLVDTEEKLEPIFARGKRLIAV
HHHHCCCEEECCHHCCCHHHCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHCCCEEEEE
HAENQARIDERKKQFAGISDPAIHSQIQDNEAALLATKMALKLSKKYERRLHILHTSTGD
ECCCCHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCC
EAELLRQDKPSWVTAEVTPQHLFLNTSAYEKIGTLAQMNPPLKSAGDNDILWRALLDGVI
HHHHHHCCCCCEEEEEECCCEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
DFIATDHAPHTLAEKGKGYPNTPSGMPGVETSLPLMLTQAIEGRCSVAQVSNWMSTAVAK
HHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GYGILKKGAIAPGFDADLVLVDLNNYRPVLREELMTKCRWSPFEGWSLTGWPVVTIVGGE
CCCHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCE
VAFNRGEFNSEVRGRALIFSEIA
EEECCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]