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The map label for this gene is pyrC' [H]

Identifier: 113475822

GI number: 113475822

Start: 3402944

End: 3404242

Strand: Reverse

Name: pyrC' [H]

Synonym: Tery_2179

Alternate gene names: 113475822

Gene position: 3404242-3402944 (Counterclockwise)

Preceding gene: 113475823

Following gene: 113475820

Centisome position: 43.93

GC content: 38.8

Gene sequence:

>1299_bases
ATGAATAGCAAATTACTTCAAAAAGTCCGAATATTAGACCCTGTTTACGACACAGACAGAGTTGCTGATGTTTTAATTAT
TGATGGAAAAATAGCCACAGTTGAGGAAAATATTTCCGAGTTTCCAACTAAAACAGATATTCAAGACTGTCAGGGATTAA
TTTTAGGTCCTGGTTTAGTAGATTTATATTGTCATAGCGGAGAACCTGGGTTTGAGGAACGGGAAACTATAGAATCTCTA
ATGCAAGCTTCTAAGGCAGGTGGTTTTACCAGGTTAGCAATTTTGCCGGATACTTTTCCTCCTGTGGATAATTTGTCTGG
TTTGGCAAGATTACAAAATTTGGCAACTCAGGTAAATAATAATTCTACTTTTCCTCTCTTTTATTATTGGGGTGCTATTA
CTCAGGGTGTAAAAGGTAAGGAAATGACTGAGTTGGGGGAATTAGCTGCATCAGGTGTTATAGGGTTTGCTGATGGTTTG
GCTCTAGAAAATCTTGGTTTGTTACGACGAGTTTTGGAATATTTGAAACCTCTGAATAAATCTGTTGCTTTATTTTGCAA
AAATTCTGGGTTAGCAGGTAATGGGGTGATGCGAGAGGGGTATGATTCTATTCGTTTGGGTTTGCCTGGGGTTTCGACTA
TGGCTGAAACTTCTGCTTTGGCTGCTGTTTTAGAGTTAGTAGATGCTATTGGTACTCCGGTTCATATTATGCGGGTCTCT
ACTGCTCGGAGTGTAGAGTTAATTGCAAATGCTAAAAGTAGGGGTTTGCCTATTACTGCTAGTACGACTTGGATGCATTT
GTTGTTGGATAGTCTGGCTATTGAGGGTAAGTCTCTTCTGGATAATTATTTTTTTCCTTATGACCCGAATTTACGTTTGG
AACCTCCTCTAGGAAGTCAGAGCGATCGCTTAACTTTACTTGAAGGTATTAGGGATGGGGTTTTAGATGCTATTGCTATT
GACCATGCTCCTTATACTTATGAAGAGAAAACTGTTGCTTTTTCTGAAGCACCCACAGGAGCAATAGGACTACAAATAGC
ATTACCTTTATTATGGCAGAGTTTTGTCAACACAGGACAGATGTCGGCTTTAGAGTTATGGAGATTATTAAGTACGTCTC
CTAGCAAATGTTTAGGATTAATTCCTGGAGATATCAGACCCCAAAAGTCAGCAGAAGTGACTTTATTTGCTCCTCAAGAA
ACTTGGGTAGTAGAAAAACAAACTTTGAAATCTCGTTCTTTTAATACACCTTGGTTAGGAAAACAAATTCAAGGTCGTGT
CCTAGAGTGGGAGTTTTAA

Upstream 100 bases:

>100_bases
AGGTTTGGTTGAGGTATGGAAACCCAAAATTAGCATAACAAGGTTTTGTTGGGTTTCACTATCGTTCTAACCAACCTACA
TTCTTCTGACTTCTATAGAA

Downstream 100 bases:

>100_bases
AGGATATTATTTGTTATGAAGCACCTAGACATGAAGATATGAATTAAGGAATTCATTACCTTGAAATTGATAAAAACTTT
TGATATTTTAAAAGTTTTTC

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 42 kDa non-catalytic chain [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNSKLLQKVRILDPVYDTDRVADVLIIDGKIATVEENISEFPTKTDIQDCQGLILGPGLVDLYCHSGEPGFEERETIESL
MQASKAGGFTRLAILPDTFPPVDNLSGLARLQNLATQVNNNSTFPLFYYWGAITQGVKGKEMTELGELAASGVIGFADGL
ALENLGLLRRVLEYLKPLNKSVALFCKNSGLAGNGVMREGYDSIRLGLPGVSTMAETSALAAVLELVDAIGTPVHIMRVS
TARSVELIANAKSRGLPITASTTWMHLLLDSLAIEGKSLLDNYFFPYDPNLRLEPPLGSQSDRLTLLEGIRDGVLDAIAI
DHAPYTYEEKTVAFSEAPTGAIGLQIALPLLWQSFVNTGQMSALELWRLLSTSPSKCLGLIPGDIRPQKSAEVTLFAPQE
TWVVEKQTLKSRSFNTPWLGKQIQGRVLEWEF

Sequences:

>Translated_432_residues
MNSKLLQKVRILDPVYDTDRVADVLIIDGKIATVEENISEFPTKTDIQDCQGLILGPGLVDLYCHSGEPGFEERETIESL
MQASKAGGFTRLAILPDTFPPVDNLSGLARLQNLATQVNNNSTFPLFYYWGAITQGVKGKEMTELGELAASGVIGFADGL
ALENLGLLRRVLEYLKPLNKSVALFCKNSGLAGNGVMREGYDSIRLGLPGVSTMAETSALAAVLELVDAIGTPVHIMRVS
TARSVELIANAKSRGLPITASTTWMHLLLDSLAIEGKSLLDNYFFPYDPNLRLEPPLGSQSDRLTLLEGIRDGVLDAIAI
DHAPYTYEEKTVAFSEAPTGAIGLQIALPLLWQSFVNTGQMSALELWRLLSTSPSKCLGLIPGDIRPQKSAEVTLFAPQE
TWVVEKQTLKSRSFNTPWLGKQIQGRVLEWEF
>Mature_432_residues
MNSKLLQKVRILDPVYDTDRVADVLIIDGKIATVEENISEFPTKTDIQDCQGLILGPGLVDLYCHSGEPGFEERETIESL
MQASKAGGFTRLAILPDTFPPVDNLSGLARLQNLATQVNNNSTFPLFYYWGAITQGVKGKEMTELGELAASGVIGFADGL
ALENLGLLRRVLEYLKPLNKSVALFCKNSGLAGNGVMREGYDSIRLGLPGVSTMAETSALAAVLELVDAIGTPVHIMRVS
TARSVELIANAKSRGLPITASTTWMHLLLDSLAIEGKSLLDNYFFPYDPNLRLEPPLGSQSDRLTLLEGIRDGVLDAIAI
DHAPYTYEEKTVAFSEAPTGAIGLQIALPLLWQSFVNTGQMSALELWRLLSTSPSKCLGLIPGDIRPQKSAEVTLFAPQE
TWVVEKQTLKSRSFNTPWLGKQIQGRVLEWEF

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=391, Percent_Identity=30.9462915601023, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI19923821, Length=423, Percent_Identity=24.3498817966903, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786722, Length=424, Percent_Identity=24.0566037735849, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87082175, Length=433, Percent_Identity=22.8637413394919, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=398, Percent_Identity=27.1356783919598, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322218, Length=432, Percent_Identity=24.0740740740741, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24642586, Length=427, Percent_Identity=25.7611241217799, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004722 [H]

Pfam domain/function: NA

EC number: 3.5.2.3

Molecular weight: Translated: 47151; Mature: 47151

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKLLQKVRILDPVYDTDRVADVLIIDGKIATVEENISEFPTKTDIQDCQGLILGPGLV
CCHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEHHHHHHHCCCCCCHHHCCCEEECCCEE
DLYCHSGEPGFEERETIESLMQASKAGGFTRLAILPDTFPPVDNLSGLARLQNLATQVNN
EEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
NSTFPLFYYWGAITQGVKGKEMTELGELAASGVIGFADGLALENLGLLRRVLEYLKPLNK
CCCCEEEEEEHHHHCCCCCCHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHCCCC
SVALFCKNSGLAGNGVMREGYDSIRLGLPGVSTMAETSALAAVLELVDAIGTPVHIMRVS
CEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TARSVELIANAKSRGLPITASTTWMHLLLDSLAIEGKSLLDNYFFPYDPNLRLEPPLGSQ
CCCHHHHEECCCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEECCCCCCC
SDRLTLLEGIRDGVLDAIAIDHAPYTYEEKTVAFSEAPTGAIGLQIALPLLWQSFVNTGQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
MSALELWRLLSTSPSKCLGLIPGDIRPQKSAEVTLFAPQETWVVEKQTLKSRSFNTPWLG
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEECCCCCEEHHHHHHHHCCCCCCCCC
KQIQGRVLEWEF
HHHCCCEEEECC
>Mature Secondary Structure
MNSKLLQKVRILDPVYDTDRVADVLIIDGKIATVEENISEFPTKTDIQDCQGLILGPGLV
CCHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEHHHHHHHCCCCCCHHHCCCEEECCCEE
DLYCHSGEPGFEERETIESLMQASKAGGFTRLAILPDTFPPVDNLSGLARLQNLATQVNN
EEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
NSTFPLFYYWGAITQGVKGKEMTELGELAASGVIGFADGLALENLGLLRRVLEYLKPLNK
CCCCEEEEEEHHHHCCCCCCHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHCCCC
SVALFCKNSGLAGNGVMREGYDSIRLGLPGVSTMAETSALAAVLELVDAIGTPVHIMRVS
CEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
TARSVELIANAKSRGLPITASTTWMHLLLDSLAIEGKSLLDNYFFPYDPNLRLEPPLGSQ
CCCHHHHEECCCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEECCCCCCC
SDRLTLLEGIRDGVLDAIAIDHAPYTYEEKTVAFSEAPTGAIGLQIALPLLWQSFVNTGQ
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
MSALELWRLLSTSPSKCLGLIPGDIRPQKSAEVTLFAPQETWVVEKQTLKSRSFNTPWLG
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEECCCCCEEHHHHHHHHCCCCCCCCC
KQIQGRVLEWEF
HHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]