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The map label for this gene is metG [H]

Identifier: 113475475

GI number: 113475475

Start: 2754328

End: 2755920

Strand: Reverse

Name: metG [H]

Synonym: Tery_1806

Alternate gene names: 113475475

Gene position: 2755920-2754328 (Counterclockwise)

Preceding gene: 113475477

Following gene: 113475474

Centisome position: 35.56

GC content: 35.59

Gene sequence:

>1593_bases
ATGAAAAACATGTATACAGATAAAAACACTTTTGCAATTACAACTCCCCTTTACTATGTTAACGATTTACCACATATAGG
TAGTGCTTATACAACTATTGCTGCTGATACGTTAGCTCGTTTTCAAAGGCTACAAGGTAGATCGGTGTTGATGATTACTG
GTACAGATGAGCATGGCCAGAAAATTCAAAGAACAGCTGAAAATAAAGGAAGAAACCCTAAAGAACACTGTGACTCAGTA
GTTAGAGGATTTGAATCTCTTTGGGAACAACTAAATATTCAATATGACCGTTTTATTCGTACTACTGCACCTAACCACGA
AAAAATTGTCAAAGAATTTTTCCAAAGAGTTTGGGAAAAAGAGGATATCTACTTAAGTCAGCAAAAAGGATGGTATTGCG
TATCTTGTGAGGAATTTAAAGAAGAGCGGGAACTTACCGAAGATAAACATTGTGTTATTCATACCAACCAAAAAGTAGAA
TGGCGCGATGAGCAGAACTATTTCTTTCGTCTCTCCAGGTATCAGGAACGACTACAAGCTTTCTACCAAGATAGGCAGGA
ATTTATTCAACCCCAAAGCCGTAGGAATGAAGTCTTAAGTTTTGTAAACCAAGGATTGCAAGACTTCTCAATCTCTAGAG
TTAATGTGGATTGGGCTTTTAAACTACCTGTTGATTCTAGTCATACTATCTATGTTTGGTTTGATGCTCTATTAGGTTAT
GTTACAGCCCTTTTAGATCCTGATAGTGAACCAACTCTAGAGAATGCTTTATCGAAATGGTGGCCGATTAATTTGCACCT
AATTGGGAAAGATATATTACGCTTCCATGCTGTTTATTGGCCAGCAATGCTAATGTCAGCAGATTTGCCTCTACCTGAAC
GTGTATTTGGACATGGATTTCTAACTAAAGATGGGAAGAAGATGGGTAAATCCCTAAATAACACTTTAGATCCTTTTGAA
TTAATCCAAAAATACGGGTCTGACGCAGTTCGTTACTATTTTCTCAAAGAAATCGAATTTGGAGTTGATGGAGATTTTAA
TGAAAACCGCTTTATCAATGTACTAAATGCTGACTTAGCAAACGACTTAGGTAATTTACTAAATCGTACTCTGAAAATGG
CTCATAAATACTTCAATGGTCAAATTCCTAAAATTAATGTTCAGGAGGTAGAAGTTACCCATCCACTCAAAAAAATAGGC
ATGGGTTTGGGTGAAAAAGTTACCCAAGCTTACACTTCTTTAGACTTTAGTCAAGTTTGTGAAGCTGTATTAATTTTAGT
CAGAACTGGCAATAAATATATAGACGAAACTGCTCCATGGAGTTTATATAAACAAGGCCAATTAGAAGCCTTAACAGAAG
TTTTATATTCTGTGTTGGAGTCTGTTAGATTAGTGGCCTATCTTTTGTCACCAATTATTCCCAATATTAGCAATGCTATC
TATCAACAACTAGGTTTCTCAAATAACTTTAATGATAAATCAGCAATTAATAGTTCAGAAACTTTTGTGAAACAAGTAAG
TTGGGGAGCTTTACCAGGAAATCAACTTCTAGGGCAACCTCAACCTATTTTTCAAAGAATAGATATGATATAA

Upstream 100 bases:

>100_bases
ATTAGCCATCGTAGTAAATTATTCGAGGTTAGTACTACTAAACTCATTATGATTATTACCATTGCTAGTTCAAATCAAAA
GTATTTAAGCCTGATTCTCT

Downstream 100 bases:

>100_bases
ACCTTTGCTTAAAAATATAATTGTACCCTTTTCTACTGCATAGCTTTTTTTCTGTTACAAATTATCTCTGATTAAGAATT
AATTTTTTTTATTTAATAAA

Product: methionyl-tRNA synthetase

Products: NA

Alternate protein names: Methionine--tRNA ligase; MetRS [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MKNMYTDKNTFAITTPLYYVNDLPHIGSAYTTIAADTLARFQRLQGRSVLMITGTDEHGQKIQRTAENKGRNPKEHCDSV
VRGFESLWEQLNIQYDRFIRTTAPNHEKIVKEFFQRVWEKEDIYLSQQKGWYCVSCEEFKEERELTEDKHCVIHTNQKVE
WRDEQNYFFRLSRYQERLQAFYQDRQEFIQPQSRRNEVLSFVNQGLQDFSISRVNVDWAFKLPVDSSHTIYVWFDALLGY
VTALLDPDSEPTLENALSKWWPINLHLIGKDILRFHAVYWPAMLMSADLPLPERVFGHGFLTKDGKKMGKSLNNTLDPFE
LIQKYGSDAVRYYFLKEIEFGVDGDFNENRFINVLNADLANDLGNLLNRTLKMAHKYFNGQIPKINVQEVEVTHPLKKIG
MGLGEKVTQAYTSLDFSQVCEAVLILVRTGNKYIDETAPWSLYKQGQLEALTEVLYSVLESVRLVAYLLSPIIPNISNAI
YQQLGFSNNFNDKSAINSSETFVKQVSWGALPGNQLLGQPQPIFQRIDMI

Sequences:

>Translated_530_residues
MKNMYTDKNTFAITTPLYYVNDLPHIGSAYTTIAADTLARFQRLQGRSVLMITGTDEHGQKIQRTAENKGRNPKEHCDSV
VRGFESLWEQLNIQYDRFIRTTAPNHEKIVKEFFQRVWEKEDIYLSQQKGWYCVSCEEFKEERELTEDKHCVIHTNQKVE
WRDEQNYFFRLSRYQERLQAFYQDRQEFIQPQSRRNEVLSFVNQGLQDFSISRVNVDWAFKLPVDSSHTIYVWFDALLGY
VTALLDPDSEPTLENALSKWWPINLHLIGKDILRFHAVYWPAMLMSADLPLPERVFGHGFLTKDGKKMGKSLNNTLDPFE
LIQKYGSDAVRYYFLKEIEFGVDGDFNENRFINVLNADLANDLGNLLNRTLKMAHKYFNGQIPKINVQEVEVTHPLKKIG
MGLGEKVTQAYTSLDFSQVCEAVLILVRTGNKYIDETAPWSLYKQGQLEALTEVLYSVLESVRLVAYLLSPIIPNISNAI
YQQLGFSNNFNDKSAINSSETFVKQVSWGALPGNQLLGQPQPIFQRIDMI
>Mature_530_residues
MKNMYTDKNTFAITTPLYYVNDLPHIGSAYTTIAADTLARFQRLQGRSVLMITGTDEHGQKIQRTAENKGRNPKEHCDSV
VRGFESLWEQLNIQYDRFIRTTAPNHEKIVKEFFQRVWEKEDIYLSQQKGWYCVSCEEFKEERELTEDKHCVIHTNQKVE
WRDEQNYFFRLSRYQERLQAFYQDRQEFIQPQSRRNEVLSFVNQGLQDFSISRVNVDWAFKLPVDSSHTIYVWFDALLGY
VTALLDPDSEPTLENALSKWWPINLHLIGKDILRFHAVYWPAMLMSADLPLPERVFGHGFLTKDGKKMGKSLNNTLDPFE
LIQKYGSDAVRYYFLKEIEFGVDGDFNENRFINVLNADLANDLGNLLNRTLKMAHKYFNGQIPKINVQEVEVTHPLKKIG
MGLGEKVTQAYTSLDFSQVCEAVLILVRTGNKYIDETAPWSLYKQGQLEALTEVLYSVLESVRLVAYLLSPIIPNISNAI
YQQLGFSNNFNDKSAINSSETFVKQVSWGALPGNQLLGQPQPIFQRIDMI

Specific function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation [H]

COG id: COG0143

COG function: function code J; Methionyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily [H]

Homologues:

Organism=Homo sapiens, GI24308436, Length=506, Percent_Identity=34.5849802371541, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI14043022, Length=569, Percent_Identity=23.725834797891, Blast_Score=142, Evalue=1e-33,
Organism=Escherichia coli, GI1788432, Length=502, Percent_Identity=27.0916334661355, Blast_Score=191, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI212645096, Length=503, Percent_Identity=31.610337972167, Blast_Score=278, Evalue=6e-75,
Organism=Caenorhabditis elegans, GI71992781, Length=381, Percent_Identity=30.1837270341207, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17540794, Length=573, Percent_Identity=25.6544502617801, Blast_Score=161, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6321610, Length=542, Percent_Identity=30.6273062730627, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6321704, Length=524, Percent_Identity=22.5190839694656, Blast_Score=113, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21358483, Length=541, Percent_Identity=32.5323475046211, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24655311, Length=572, Percent_Identity=24.3006993006993, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: 871 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015413
- InterPro:   IPR014758
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155 [H]

Pfam domain/function: PF08264 Anticodon_1; PF09334 tRNA-synt_1g [H]

EC number: =6.1.1.10 [H]

Molecular weight: Translated: 61444; Mature: 61444

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNMYTDKNTFAITTPLYYVNDLPHIGSAYTTIAADTLARFQRLQGRSVLMITGTDEHGQ
CCCCCCCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
KIQRTAENKGRNPKEHCDSVVRGFESLWEQLNIQYDRFIRTTAPNHEKIVKEFFQRVWEK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHCCC
EDIYLSQQKGWYCVSCEEFKEERELTEDKHCVIHTNQKVEWRDEQNYFFRLSRYQERLQA
CCEEEECCCCEEEEEHHHHHHHHHCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHH
FYQDRQEFIQPQSRRNEVLSFVNQGLQDFSISRVNVDWAFKLPVDSSHTIYVWFDALLGY
HHHHHHHHHCCHHHHHHHHHHHHCCHHHCCEEEEEEEEEEECCCCCCCEEEEEHHHHHHH
VTALLDPDSEPTLENALSKWWPINLHLIGKDILRFHAVYWPAMLMSADLPLPERVFGHGF
HHHHCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCC
LTKDGKKMGKSLNNTLDPFELIQKYGSDAVRYYFLKEIEFGVDGDFNENRFINVLNADLA
CCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHH
NDLGNLLNRTLKMAHKYFNGQIPKINVQEVEVTHPLKKIGMGLGEKVTQAYTSLDFSQVC
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHH
EAVLILVRTGNKYIDETAPWSLYKQGQLEALTEVLYSVLESVRLVAYLLSPIIPNISNAI
HHHHHHHHCCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
YQQLGFSNNFNDKSAINSSETFVKQVSWGALPGNQLLGQPQPIFQRIDMI
HHHHCCCCCCCCHHCCCCHHHHHHHHHCCCCCCHHHCCCCCHHHHHHCCC
>Mature Secondary Structure
MKNMYTDKNTFAITTPLYYVNDLPHIGSAYTTIAADTLARFQRLQGRSVLMITGTDEHGQ
CCCCCCCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHH
KIQRTAENKGRNPKEHCDSVVRGFESLWEQLNIQYDRFIRTTAPNHEKIVKEFFQRVWEK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHCCC
EDIYLSQQKGWYCVSCEEFKEERELTEDKHCVIHTNQKVEWRDEQNYFFRLSRYQERLQA
CCEEEECCCCEEEEEHHHHHHHHHCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHH
FYQDRQEFIQPQSRRNEVLSFVNQGLQDFSISRVNVDWAFKLPVDSSHTIYVWFDALLGY
HHHHHHHHHCCHHHHHHHHHHHHCCHHHCCEEEEEEEEEEECCCCCCCEEEEEHHHHHHH
VTALLDPDSEPTLENALSKWWPINLHLIGKDILRFHAVYWPAMLMSADLPLPERVFGHGF
HHHHCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCC
LTKDGKKMGKSLNNTLDPFELIQKYGSDAVRYYFLKEIEFGVDGDFNENRFINVLNADLA
CCCCHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHH
NDLGNLLNRTLKMAHKYFNGQIPKINVQEVEVTHPLKKIGMGLGEKVTQAYTSLDFSQVC
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHH
EAVLILVRTGNKYIDETAPWSLYKQGQLEALTEVLYSVLESVRLVAYLLSPIIPNISNAI
HHHHHHHHCCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
YQQLGFSNNFNDKSAINSSETFVKQVSWGALPGNQLLGQPQPIFQRIDMI
HHHHCCCCCCCCHHCCCCHHHHHHHHHCCCCCCHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]