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The map label for this gene is rnz

Identifier: 113474494

GI number: 113474494

Start: 1044189

End: 1045154

Strand: Reverse

Name: rnz

Synonym: Tery_0641

Alternate gene names: 113474494

Gene position: 1045154-1044189 (Counterclockwise)

Preceding gene: 113474496

Following gene: 113474492

Centisome position: 13.49

GC content: 41.41

Gene sequence:

>966_bases
TTGCAGATAACTTTTCTAGGAACTAGTTCTGGTGTTCCAACGCGATCACGTAATGTTTCAAGTATTGCTTTACGTTTACC
TCAAAGGGCTGAGTTATGGTTGTTTGATTGTGGTGAAGGAACTCAACATCAGTTTCTCCGTAGTGATCTTAAAGTCAGTC
AACTTAGTCGTATTTTTATTACCCACATGCATGGAGACCATGTTTTTGGTTTGATGGGGTTGTTAGCTAGTTGTGGTTTA
GGGGGAAATGTTAAAAGTGTTACTTTATATGGTCCACCTGCTTTAGAGGATTATCTCCAAGCTGGTCTTCGATACTCTCA
AACTCATTTAGCTTATCCAATTAAAGTTCATAAGAGTAAGCCTGGTGTGATTTATGAGGATGATGAGTATGTTGTTAGTT
GTGCTTATTTGAAGCATCGGGTTACTGCTTTTGGTTATCGGGTAACAGAAAAGGATCGACCAGGACATTTTAATGTGGAA
AAGGCAAAGGCTTTAGGGATTCCTCCTGGCCCTATCTATAGGAAGCTGAAACAGGGTGAGTTTGTTACTTTGCCTGATGG
GCGGAAAATTAATGGGGCTGATTTGTGTGGCGCACCCCATGTCGGCCGGAAGTTTGTTTATTGTACTGATACTGTGTTTT
GTGATGGGGCTGTGGAATTGTCACAGGGGGCAGATTTACTTGTTCACGAGGCTACTTTTTCTCATCAGGATGCTGAAATG
GCCTTTCAAAGATTGCATTCTACTTCAACTATGGCGGCACAGGTGGCTTTAGCTGCAGGTGTTAAGCATTTGATGATGAC
TCATTTTAGTCCTAGGTATGCTCCTGGAAATTCGGTTTTGTTGGATGATTTGCTGCAGGAGGCGCGGGCTATTTTTCCTA
ATACTGATATGGCTTATGATTTTCTAAGTTATGAGATTCCTAGATGGAATGAAGTTTCACAGTTGCTAGCAAAAGCTAGA
TCTTAG

Upstream 100 bases:

>100_bases
GTGGAGTTCGACGGCATACCGGGACTAGAAAACGAGAAGGTAACCCCATATTGTAAAGTTGGCGTAGGAGTACATTACTT
TATTGAGGAAGTTTTAGATT

Downstream 100 bases:

>100_bases
TCTTTTCATTTTCTGAAGCTCCTAAAAAACTTGAAATTACCAAAAAATTGGGGTTAAAATCTCGTCCTTCTAGGGCGAGT
TTTTGGTGTTTTTTTTTGAA

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MQITFLGTSSGVPTRSRNVSSIALRLPQRAELWLFDCGEGTQHQFLRSDLKVSQLSRIFITHMHGDHVFGLMGLLASCGL
GGNVKSVTLYGPPALEDYLQAGLRYSQTHLAYPIKVHKSKPGVIYEDDEYVVSCAYLKHRVTAFGYRVTEKDRPGHFNVE
KAKALGIPPGPIYRKLKQGEFVTLPDGRKINGADLCGAPHVGRKFVYCTDTVFCDGAVELSQGADLLVHEATFSHQDAEM
AFQRLHSTSTMAAQVALAAGVKHLMMTHFSPRYAPGNSVLLDDLLQEARAIFPNTDMAYDFLSYEIPRWNEVSQLLAKAR
S

Sequences:

>Translated_321_residues
MQITFLGTSSGVPTRSRNVSSIALRLPQRAELWLFDCGEGTQHQFLRSDLKVSQLSRIFITHMHGDHVFGLMGLLASCGL
GGNVKSVTLYGPPALEDYLQAGLRYSQTHLAYPIKVHKSKPGVIYEDDEYVVSCAYLKHRVTAFGYRVTEKDRPGHFNVE
KAKALGIPPGPIYRKLKQGEFVTLPDGRKINGADLCGAPHVGRKFVYCTDTVFCDGAVELSQGADLLVHEATFSHQDAEM
AFQRLHSTSTMAAQVALAAGVKHLMMTHFSPRYAPGNSVLLDDLLQEARAIFPNTDMAYDFLSYEIPRWNEVSQLLAKAR
S
>Mature_321_residues
MQITFLGTSSGVPTRSRNVSSIALRLPQRAELWLFDCGEGTQHQFLRSDLKVSQLSRIFITHMHGDHVFGLMGLLASCGL
GGNVKSVTLYGPPALEDYLQAGLRYSQTHLAYPIKVHKSKPGVIYEDDEYVVSCAYLKHRVTAFGYRVTEKDRPGHFNVE
KAKALGIPPGPIYRKLKQGEFVTLPDGRKINGADLCGAPHVGRKFVYCTDTVFCDGAVELSQGADLLVHEATFSHQDAEM
AFQRLHSTSTMAAQVALAAGVKHLMMTHFSPRYAPGNSVLLDDLLQEARAIFPNTDMAYDFLSYEIPRWNEVSQLLAKAR
S

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=360, Percent_Identity=36.6666666666667, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI260166619, Length=209, Percent_Identity=34.4497607655502, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI87082078, Length=308, Percent_Identity=43.8311688311688, Blast_Score=274, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24652403, Length=179, Percent_Identity=30.7262569832402, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_TRIEI (Q118J2)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720555.1
- ProteinModelPortal:   Q118J2
- SMR:   Q118J2
- STRING:   Q118J2
- GeneID:   4242779
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0641
- NMPDR:   fig|203124.1.peg.588
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- PhylomeDB:   Q118J2
- ProtClustDB:   PRK00055
- BioCyc:   TERY203124:TERY_0641-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 35546; Mature: 35546

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITFLGTSSGVPTRSRNVSSIALRLPQRAELWLFDCGEGTQHQFLRSDLKVSQLSRIFI
CEEEEEECCCCCCCCCCCHHHHEEECCCCCCEEEEECCCCHHHHHHHHHCCHHHHHEEEE
THMHGDHVFGLMGLLASCGLGGNVKSVTLYGPPALEDYLQAGLRYSQTHLAYPIKVHKSK
EECCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCEEEEEEEEECCC
PGVIYEDDEYVVSCAYLKHRVTAFGYRVTEKDRPGHFNVEKAKALGIPPGPIYRKLKQGE
CCEEEECCCCEEEHHHHHHHHHHHEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHCCCC
FVTLPDGRKINGADLCGAPHVGRKFVYCTDTVFCDGAVELSQGADLLVHEATFSHQDAEM
EEECCCCCEECCCCCCCCCCCCCEEEEEECEEEECCCEEECCCCCEEEEECCCCCCHHHH
AFQRLHSTSTMAAQVALAAGVKHLMMTHFSPRYAPGNSVLLDDLLQEARAIFPNTDMAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
FLSYEIPRWNEVSQLLAKARS
HHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MQITFLGTSSGVPTRSRNVSSIALRLPQRAELWLFDCGEGTQHQFLRSDLKVSQLSRIFI
CEEEEEECCCCCCCCCCCHHHHEEECCCCCCEEEEECCCCHHHHHHHHHCCHHHHHEEEE
THMHGDHVFGLMGLLASCGLGGNVKSVTLYGPPALEDYLQAGLRYSQTHLAYPIKVHKSK
EECCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCEEEEEEEEECCC
PGVIYEDDEYVVSCAYLKHRVTAFGYRVTEKDRPGHFNVEKAKALGIPPGPIYRKLKQGE
CCEEEECCCCEEEHHHHHHHHHHHEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHCCCC
FVTLPDGRKINGADLCGAPHVGRKFVYCTDTVFCDGAVELSQGADLLVHEATFSHQDAEM
EEECCCCCEECCCCCCCCCCCCCEEEEEECEEEECCCEEECCCCCEEEEECCCCCCHHHH
AFQRLHSTSTMAAQVALAAGVKHLMMTHFSPRYAPGNSVLLDDLLQEARAIFPNTDMAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
FLSYEIPRWNEVSQLLAKARS
HHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA